{"id":"https://openalex.org/W2114966142","doi":"https://doi.org/10.1517/17425247.3.3.437","title":"The hair follicle and its stem cells as drug delivery targets","display_name":"The hair follicle and its stem cells as drug delivery targets","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W2114966142","doi":"https://doi.org/10.1517/17425247.3.3.437","mag":"2114966142","pmid":"https://pubmed.ncbi.nlm.nih.gov/16640502"},"language":"en","primary_location":{"id":"doi:10.1517/17425247.3.3.437","doi":"https://doi.org/10.1517/17425247.3.3.437","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425247.3.3.437","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert M Hoffman","raw_affiliation_strings":["AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA 92111, USA. all@anticancer.com","AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA 92111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA 92111, USA. all@anticancer.com","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA 92111, USA","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040819666"],"corresponding_institution_ids":["https://openalex.org/I4210121314"],"apc_list":null,"apc_paid":null,"fwci":0.2403,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.30645161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"3","issue":"3","first_page":"437","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hair-follicle-stem-cells","display_name":"hair follicle stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/liposome-targeting","display_name":"liposome targeting","score":0.5149999856948853},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.5929999947547913},{"id":"https://openalex.org/keywords/ex-vivo-gene-therapy","display_name":"ex vivo gene therapy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/hair-cycle","display_name":"hair cycle","score":0.5989999771118164},{"id":"https://openalex.org/keywords/anagen","display_name":"anagen","score":0.656000018119812},{"id":"https://openalex.org/keywords/catagen","display_name":"catagen","score":0.9350000023841858},{"id":"https://openalex.org/keywords/telogen","display_name":"telogen","score":0.996999979019165},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8090000152587891},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.8807631731033325},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6410057544708252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6264408826828003},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5893678665161133},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5868021845817566},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.5688464641571045},{"id":"https://openalex.org/C2781409172","wikidata":"https://www.wikidata.org/wiki/Q17056802","display_name":"Involution (esoterism)","level":3,"score":0.4654698371887207},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42719346284866333},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.42236340045928955},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4146592617034912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2688416838645935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24777409434318542},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.24195542931556702},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2217780351638794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18233099579811096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14554381370544434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08147528767585754},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/17425247.3.3.437","doi":"https://doi.org/10.1517/17425247.3.3.437","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425247.3.3.437","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},{"id":"pmid:16640502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16640502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1503578591","https://openalex.org/W1508809148","https://openalex.org/W1525454261","https://openalex.org/W1536355161","https://openalex.org/W1587376757","https://openalex.org/W1601145807","https://openalex.org/W1607627337","https://openalex.org/W1608876207","https://openalex.org/W1944552256","https://openalex.org/W1964468890","https://openalex.org/W1967802960","https://openalex.org/W1970672045","https://openalex.org/W1981572007","https://openalex.org/W1983604521","https://openalex.org/W2015887156","https://openalex.org/W2018249639","https://openalex.org/W2033414562","https://openalex.org/W2036908476","https://openalex.org/W2037717413","https://openalex.org/W2040002904","https://openalex.org/W2042744546","https://openalex.org/W2048303118","https://openalex.org/W2051349486","https://openalex.org/W2053501481","https://openalex.org/W2063568492","https://openalex.org/W2073130433","https://openalex.org/W2076538247","https://openalex.org/W2077269889","https://openalex.org/W2093390384","https://openalex.org/W2122731703","https://openalex.org/W2122993134","https://openalex.org/W2126078758","https://openalex.org/W2128912660","https://openalex.org/W2136704436","https://openalex.org/W2149756280","https://openalex.org/W2158579288","https://openalex.org/W2160499114","https://openalex.org/W2184447702","https://openalex.org/W2329424879","https://openalex.org/W2492711107"],"related_works":["https://openalex.org/W4205924866","https://openalex.org/W2298823232","https://openalex.org/W2116114431","https://openalex.org/W2001536021","https://openalex.org/W2202764092","https://openalex.org/W2053501481","https://openalex.org/W1969787754","https://openalex.org/W2141579922","https://openalex.org/W2006643073","https://openalex.org/W2058480491"],"abstract_inverted_index":{"The":[0,20,44],"hair":[1,21,31,91,113],"follicle":[2,22,45,92,114],"is":[3,23,29,40],"a":[4,8,25],"skin":[5],"appendage":[6],"with":[7,76],"complex":[9],"structure":[10],"containing":[11],"many":[12,47],"cell":[13,106],"types":[14],"that":[15,90,112],"produce":[16],"highly":[17,96],"specialised":[18],"proteins.":[19],"in":[24],"continuous":[26],"cycle:":[27],"anagen":[28],"the":[30,35,41,80],"growth":[32],"phase,":[33],"catagen":[34],"involution":[36],"phase":[37],"and":[38,52,63,98,104,108],"telogen":[39],"resting":[42],"phase.":[43],"offers":[46],"potential":[48],"therapeutic":[49],"targets.":[50],"Hoffman":[51],"colleagues":[53],"have":[54,69],"pioneered":[55,71],"hair-follicle-specific":[56],"targeting":[57,75],"using":[58],"liposomes":[59],"to":[60],"deliver":[61],"small":[62],"large":[64],"molecules,":[65],"including":[66],"genes.":[67],"They":[68],"also":[70],"ex":[72],"vivo":[73],"hair-follicle":[74],"continued":[77],"expression":[78],"of":[79],"introduced":[81],"gene":[82,120],"following":[83],"transplantation.":[84],"Recently,":[85],"it":[86],"has":[87,110],"been":[88],"discovered":[89],"stem":[93,115],"cells":[94,103,116],"are":[95],"pluripotent":[97],"can":[99],"form":[100],"neurons,":[101],"glial":[102],"other":[105],"types,":[107],"this":[109],"suggested":[111],"may":[117],"serve":[118],"as":[119],"therapy":[121],"targets":[122],"for":[123],"regenerative":[124],"medicine.":[125]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
