{"id":"https://openalex.org/W2114921702","doi":null,"title":"Lipopolysaccharide IP-PA1 from Pantoea agglomerans prevents suppression of macrophage function in stress-induced diseases.","display_name":"Lipopolysaccharide IP-PA1 from Pantoea agglomerans prevents suppression of macrophage function in stress-induced diseases.","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2114921702","mag":"2114921702","pmid":"https://pubmed.ncbi.nlm.nih.gov/21873156"},"language":"en","primary_location":{"id":"pmid:21873156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21873156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022303270","display_name":"Kazue Nakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazue Nakata","raw_affiliation_strings":["Department of Nutritional Science, Okayama Prefectural University, Kuboki, Soja, Okayama 719-1197, Japan. nakata@fhw.oka-pu.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Science, Okayama Prefectural University, Kuboki, Soja, Okayama 719-1197, Japan. nakata@fhw.oka-pu.ac.jp","institution_ids":["https://openalex.org/I193620225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016576073","display_name":"Hiroyuki Inagawa","orcid":"https://orcid.org/0000-0002-9740-986X","observed_orcids":["https://orcid.org/0000-0002-9740-986X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Inagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113955234","display_name":"Gen\u2010Ichiro Soma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gen-Ichiro Soma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5262,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64119171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"7","first_page":"2437","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.925000011920929},{"id":"https://openalex.org/keywords/pantoea-agglomerans","display_name":"Pantoea agglomerans","score":1.0},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/macrophage-suppression","display_name":"macrophage suppression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/chronic-psychological-stress","display_name":"chronic psychological stress","score":0.8289999961853027},{"id":"https://openalex.org/keywords/stress-induced-disease","display_name":"stress-induced disease","score":0.781000018119812},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7239999771118164},{"id":"https://openalex.org/keywords/surgical-stress","display_name":"surgical stress","score":0.6340000033378601},{"id":"https://openalex.org/keywords/macrophage-priming","display_name":"macrophage priming","score":0.6299999952316284},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5860000252723694},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6380000114440918},{"id":"https://openalex.org/keywords/symbiotic-bacteria","display_name":"symbiotic bacteria","score":0.5090000033378601},{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2780284704","wikidata":"https://www.wikidata.org/wiki/Q6336019","display_name":"Pantoea agglomerans","level":3,"score":0.8472917079925537},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7791991233825684},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6720179319381714},{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.5280367136001587},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5040956735610962},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46890345215797424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44871288537979126},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42696523666381836},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4155375063419342},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3204442858695984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28538399934768677},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.22456935048103333},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0940619707107544},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005516","descriptor_name":"Food Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010945","descriptor_name":"Plants, Edible","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020636","descriptor_name":"Pantoea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21873156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21873156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2114921702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21873156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W28539586","https://openalex.org/W123172487","https://openalex.org/W1482923715","https://openalex.org/W1511980389","https://openalex.org/W1512224161","https://openalex.org/W1516854118","https://openalex.org/W1549479378","https://openalex.org/W1984658591","https://openalex.org/W1991195369","https://openalex.org/W2000054651","https://openalex.org/W2001478903","https://openalex.org/W2004465286","https://openalex.org/W2023717389","https://openalex.org/W2024636147","https://openalex.org/W2030097812","https://openalex.org/W2038550540","https://openalex.org/W2039856121","https://openalex.org/W2040044004","https://openalex.org/W2041055986","https://openalex.org/W2042941780","https://openalex.org/W2044763085","https://openalex.org/W2045637647","https://openalex.org/W2064448848","https://openalex.org/W2073600248","https://openalex.org/W2077927980","https://openalex.org/W2082857624","https://openalex.org/W2086805594","https://openalex.org/W2101331467","https://openalex.org/W2108905212","https://openalex.org/W2117611261","https://openalex.org/W2120644740","https://openalex.org/W2122466408","https://openalex.org/W2130443317","https://openalex.org/W2131670325","https://openalex.org/W2154638384","https://openalex.org/W2158122675","https://openalex.org/W2164010813","https://openalex.org/W2165334726","https://openalex.org/W2169619812","https://openalex.org/W2169870204","https://openalex.org/W2409292794","https://openalex.org/W2412162177","https://openalex.org/W2468672744","https://openalex.org/W4313347964"],"related_works":["https://openalex.org/W2039856121","https://openalex.org/W2168364026","https://openalex.org/W2333509561","https://openalex.org/W2244130212","https://openalex.org/W2050269214","https://openalex.org/W1963887938","https://openalex.org/W1850569047","https://openalex.org/W7095557414","https://openalex.org/W4282921298","https://openalex.org/W2540349147"],"abstract_inverted_index":{"Chronic":[0],"psychological":[1],"stress":[2,45,104,121],"impairs":[3],"health":[4],"and":[5,17,83,90,142,154,160],"induces":[6],"various":[7],"diseases":[8],"by":[9,53,103,109],"causing":[10],"an":[11],"imbalance":[12],"in":[13,39,94,140],"the":[14,24,84,95,116,168],"immune,":[15],"neuropsychiatric":[16],"endocrine":[18],"systems.":[19],"The":[20],"primary":[21],"reason":[22],"for":[23,179],"development":[25],"of":[26,31,60,87,100,111,120,148,170,181],"stress-induced":[27,182],"disease":[28],"is":[29,184],"suppression":[30,82,99],"macrophage":[32,56,61,81,101,113,151,176],"function,":[33],"which":[34],"plays":[35],"a":[36,112,128,135,174],"pivotal":[37],"role":[38],"innate":[40],"immunity.":[41],"In":[42,165],"fact,":[43],"surgical":[44],"has":[46,75],"been":[47,76],"shown":[48,77],"to":[49,78],"exacerbate":[50],"opportunistic":[51],"infections":[52],"significantly":[54],"suppressing":[55],"function.":[57],"Conversely,":[58],"administration":[59,147],"activating":[62,114,177],"substances":[63],"before":[64],"surgery,":[65],"such":[66],"as":[67,173],"tumor":[68,92],"necrosis":[69],"factor":[70],"(TNF)-\u03b1":[71],"or":[72],"Picibanil":[73],"(OK-432),":[74],"protect":[79],"against":[80,91,157],"resulting":[85],"exacerbation":[86],"infectious":[88],"diseases,":[89],"metastasis":[93],"lungs.":[96],"Thus,":[97],"if":[98],"function":[102],"could":[105,122],"be":[106,123],"safely":[107],"prevented":[108],"use":[110],"substance,":[115],"detrimental":[117],"side":[118],"effects":[119,156],"reduced.":[124],"Recently,":[125],"we":[126],"identified":[127],"lipopolysaccharide,":[129],"IP-PA1,":[130],"derived":[131],"from":[132],"Pantoea":[133],"agglomerans,":[134],"symbiotic":[136],"Gram-negative":[137],"bacteria":[138],"found":[139],"wheat":[141],"other":[143],"food":[144],"plants.":[145],"Oral":[146],"IP-PA1":[149,172],"demonstrated":[150],"activation":[152],"(priming)":[153],"protective":[155],"infection,":[158],"allergy":[159],"cancer,":[161],"without":[162],"any":[163],"side-effects.":[164],"this":[166],"review,":[167],"possibility":[169],"using":[171],"safe,":[175],"substance":[178],"prevention":[180],"impairments":[183],"discussed.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}