{"id":"https://openalex.org/W2114871970","doi":null,"title":"Bacterial colonization of the respiratory tract in patients with cystic fibrosis","display_name":"Bacterial colonization of the respiratory tract in patients with cystic fibrosis","publication_year":2000,"publication_date":"2000-06-23","ids":{"openalex":"https://openalex.org/W2114871970","mag":"2114871970"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022848065","display_name":"Nicole H. M. Renders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicole H. M. Renders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022848065"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.9319999814033508},{"id":"https://openalex.org/keywords/respiratory-tract","display_name":"respiratory tract","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.777999997138977},{"id":"https://openalex.org/keywords/airway-mucus","display_name":"airway mucus","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.9330000281333923},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.5709999799728394},{"id":"https://openalex.org/keywords/bronchiectasis","display_name":"bronchiectasis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.44699999690055847},{"id":"https://openalex.org/keywords/chronic-airway-inflammation","display_name":"chronic airway inflammation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/chloride-secretion","display_name":"chloride secretion","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7956265211105347},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.661014199256897},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.4876057207584381},{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.4843050539493561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46590739488601685},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.46005719900131226},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.44844821095466614},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.44450873136520386},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.44406113028526306},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.412309467792511},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3728044033050537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3554484248161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34803181886672974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33875077962875366},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:20896","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/20896","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:20896","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/20896","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2114871970","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/20896/000623_RENDERS,%20Nicola%20Huberta%20Maria.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/ffdf4b8f-39aa-4b06-bf4f-b9579e0d88c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W85901280","https://openalex.org/W88723141","https://openalex.org/W644401563","https://openalex.org/W1485536220","https://openalex.org/W1519621381","https://openalex.org/W1522309498","https://openalex.org/W1602712533","https://openalex.org/W1741117899","https://openalex.org/W1766384518","https://openalex.org/W1802929309","https://openalex.org/W1818857281","https://openalex.org/W1821687280","https://openalex.org/W1833207062","https://openalex.org/W1848355102","https://openalex.org/W1917227837","https://openalex.org/W1955612312","https://openalex.org/W1958058459","https://openalex.org/W1974522161","https://openalex.org/W1974891558","https://openalex.org/W1975231997","https://openalex.org/W1980017808","https://openalex.org/W1984163525","https://openalex.org/W1987657081","https://openalex.org/W1993293753","https://openalex.org/W1995835261","https://openalex.org/W1997475003","https://openalex.org/W1997637703","https://openalex.org/W1998611708","https://openalex.org/W1999277244","https://openalex.org/W2001068421","https://openalex.org/W2014868025","https://openalex.org/W2017197251","https://openalex.org/W2022467415","https://openalex.org/W2033238263","https://openalex.org/W2034204770","https://openalex.org/W2037960923","https://openalex.org/W2043700378","https://openalex.org/W2050577849","https://openalex.org/W2051971329","https://openalex.org/W2055043387","https://openalex.org/W2057503060","https://openalex.org/W2060018051","https://openalex.org/W2061909665","https://openalex.org/W2061965039","https://openalex.org/W2065586679","https://openalex.org/W2070576480","https://openalex.org/W2081306834","https://openalex.org/W2098417983","https://openalex.org/W2103091271","https://openalex.org/W2103123638","https://openalex.org/W2106706383","https://openalex.org/W2111208677","https://openalex.org/W2114671452","https://openalex.org/W2118714899","https://openalex.org/W2119285461","https://openalex.org/W2121109925","https://openalex.org/W2122229497","https://openalex.org/W2122812652","https://openalex.org/W2123546399","https://openalex.org/W2125200552","https://openalex.org/W2133407214","https://openalex.org/W2136572457","https://openalex.org/W2137071946","https://openalex.org/W2137295250","https://openalex.org/W2144634347","https://openalex.org/W2156803185","https://openalex.org/W2158887145","https://openalex.org/W2161041932","https://openalex.org/W2165415752","https://openalex.org/W2165473008","https://openalex.org/W2166175221","https://openalex.org/W2166229810","https://openalex.org/W2166785990","https://openalex.org/W2167414706","https://openalex.org/W2170375601","https://openalex.org/W2171315493","https://openalex.org/W2313952066","https://openalex.org/W2400104264"],"related_works":["https://openalex.org/W134405480","https://openalex.org/W1608118231","https://openalex.org/W1838936354","https://openalex.org/W178272474","https://openalex.org/W7098298424","https://openalex.org/W1995835261","https://openalex.org/W2502225556","https://openalex.org/W2736173029","https://openalex.org/W2150212922","https://openalex.org/W4323653892"],"abstract_inverted_index":{"Cystic":[0],"fibrosis":[1,50],"(CF)":[2],"is":[3,68,155,172,217,234],"the":[4,48,69,79,88,107,120,150,153,170,176,181,196,218,240],"most":[5,62,246],"common":[6],"single":[7],"gene":[8,34,67,111],"disorder":[9],"in":[10,16,37,83,114,163,199,225,239,249,254],"The":[11,22,61,125,213],"Netherlands":[12],"and":[13,39,117,141,193,223],"occurs\\\\napproximately":[14],"once":[15],"every":[17],"3600":[18],"children":[19],"born":[20,253],"alive.":[21],"heterozygous":[23],"carrier":[24],"frequency\\\\nhas":[25],"been":[26,100],"estimated":[27],"to":[28,41,97,132,187,258,261],"be":[29,42],"approximately":[30],"1":[31],":30.\\\\nThe":[32],"defective":[33],"was":[35],"identified":[36,101],"1989":[38],"appeared":[40],"located":[43],"on":[44],"chromosome.\\\\nIt":[45],"codes":[46],"for":[47,87],"cystic":[49],"transmembrane":[51,58],"conductance":[52],"regulator":[53],"(CFTR),":[54],"which":[55,198],"acts":[56],"as\\\\na":[57],"chloride":[59,139],"channel.":[60],"frequent":[63],"mutation":[64],"of":[65,78,149,159,175,180,190,195,221,231,265],"this":[66],"deletion":[70],"of\\\\nphenylalanine":[71],"at":[72],"position":[73],"508":[74],"(\"F508).":[75],"Almost":[76],"60%":[77],"known":[80],"CF":[81,98,108,126],"patients":[82,226,247,252],"The\\\\nNetherlands":[84],"are":[85,256],"homozygous":[86],"\"F508":[89],"mutation.":[90],"More":[91],"than":[92],"700":[93],"additional":[94],"CFTR\\\\nmutations":[95],"related":[96],"have":[99],"as":[102],"oflate":[103],"May":[104],"1997":[105],"by":[106,157],"Genetic":[109],"Analysis\\\\nConsortium.\\\\nThe":[110],"defect":[112],"results":[113,146],"significant":[115],"morbidity":[116,222],"affects":[118],"mainly":[119],"respiratory":[121,211,232],"tract":[122],"and\\\\nthe":[123],"pancreas.":[124],"lung":[127],"presents":[128],"an":[129,142],"unique":[130],"environment":[131],"microbial":[133],"pathogens.":[134],"The\\\\ncombination":[135],"oflow":[136],"or":[137],"absent":[138],"secretion":[140,189],"increased":[143],"sodium":[144],"absorption":[145],"in\\\\nrelative":[147],"dehydration":[148],"ainvays.":[151],"Consequently,":[152],"disease":[154],"characterized":[156],"the\\\\nproduction":[158],"abnonnally":[160],"viscid":[161],"secretions":[162],"epithelial":[164],"tissues.":[165],"Mucociliary":[166],"clearance":[167],"of\\\\nbacteria":[168],"from":[169],"lungs":[171],"impaired":[173],"because":[174],"viscid,":[177],"dehydrated":[178],"nature":[179],"airway\\\\nepithelia.":[182],"Chronic":[183],"ainvay":[184],"inflammation":[185],"leads":[186],"excessive":[188],"purulent":[191],"mucus":[192],"to\\\\nobstmction":[194],"airway":[197],"turn":[200],"causes":[201],"bronchiectasis,":[202],"pulmonary":[203],"hypertension":[204],"with\\\\ncor":[205],"pulmonale,":[206],"haemoptysis,":[207],"pneumothorax":[208],"and,":[209],"finally,":[210],"failure.":[212],"exacerbation\\\\nof":[214],"puhnonary":[215],"infections":[216,233],"major":[219],"cause":[220],"mortality":[224],"with":[227],"CF.\\\\nAggressive":[228],"early":[229],"treatment":[230],"a":[235,262],"critical":[236],"success":[237],"factor":[238],"treatment\\\\nofCF":[241],"patients.":[242],"Thirty":[243],"years":[244],"ago,":[245],"died":[248],"infancy.":[250],"Nowadays,":[251],"the\\\\n1990\\\\'s":[255],"likely":[257],"live":[259],"up":[260],"median":[263],"age":[264],"40":[266],"years.":[267]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2016-06-24T00:00:00"}
