{"id":"https://openalex.org/W2114709779","doi":"https://doi.org/10.1161/hs0901.094287","title":"Simvastatin Protects Against Long-Lasting Behavioral and Morphological Consequences of Neonatal Hypoxic/Ischemic Brain Injury","display_name":"Simvastatin Protects Against Long-Lasting Behavioral and Morphological Consequences of Neonatal Hypoxic/Ischemic Brain Injury","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2114709779","doi":"https://doi.org/10.1161/hs0901.094287","mag":"2114709779","pmid":"https://pubmed.ncbi.nlm.nih.gov/11546915"},"language":"en","primary_location":{"id":"doi:10.1161/hs0901.094287","doi":"https://doi.org/10.1161/hs0901.094287","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hs0901.094287","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hs0901.094287","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/hs0901.094287","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031476350","display_name":"Walter Balduini","orcid":"https://orcid.org/0000-0001-8438-9559","observed_orcids":["https://orcid.org/0000-0001-8438-9559"]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Walter Balduini","raw_affiliation_strings":["From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Valerio De Angelis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio De Angelis","raw_affiliation_strings":["From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000659220","display_name":"Erika Mazzoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erika Mazzoni","raw_affiliation_strings":["From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077095217","display_name":"Mauro Cimino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Cimino","raw_affiliation_strings":["From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Istituto di Farmacologia e Farmacognosia, Universita\u0300 degli Studi di Urbino, Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I190397597"],"apc_list":null,"apc_paid":null,"fwci":1.86,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.85379772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"9","first_page":"2185","last_page":"2191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.968999981880188},{"id":"https://openalex.org/keywords/neonatal-hypoxic-ischemic-brain-injury","display_name":"neonatal hypoxic-ischemic brain injury","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7789999842643738},{"id":"https://openalex.org/keywords/carotid-artery-ligation","display_name":"carotid artery ligation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.6610000133514404},{"id":"https://openalex.org/keywords/behavioral-asymmetry","display_name":"behavioral asymmetry","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/brain-damage","display_name":"brain damage","score":0.49000000953674316},{"id":"https://openalex.org/keywords/pharmacological-prophylaxis","display_name":"pharmacological prophylaxis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/fetal-asphyxia","display_name":"fetal asphyxia","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.924233078956604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8955600261688232},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.7510553598403931},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6403450965881348},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5677999258041382},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.539885938167572},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.5290122628211975},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4866562485694885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4680247902870178},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.4489061236381531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3100118041038513},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.27401697635650635},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002755","descriptor_name":"Choice Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002755","descriptor_name":"Choice Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002755","descriptor_name":"Choice Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/hs0901.094287","doi":"https://doi.org/10.1161/hs0901.094287","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hs0901.094287","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hs0901.094287","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:11546915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11546915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"pmh:oai:ora.uniurb.it:11576/1879395","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11576/1879395","pdf_url":null,"source":{"id":"https://openalex.org/S4377196377","display_name":"CINECA IRIS Institutional Research information system (University of Urbino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190397597","host_organization_name":"University of Urbino","host_organization_lineage":["https://openalex.org/I190397597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/hs0901.094287","doi":"https://doi.org/10.1161/hs0901.094287","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hs0901.094287","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hs0901.094287","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326524","display_name":"Universit\u00e0 degli Studi di Urbino Carlo Bo","ror":"https://ror.org/04q4kt073"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114709779.pdf","grobid_xml":"https://content.openalex.org/works/W2114709779.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1537398036","https://openalex.org/W1611256317","https://openalex.org/W1992560928","https://openalex.org/W1997451049","https://openalex.org/W1999822997","https://openalex.org/W2002371437","https://openalex.org/W2007032912","https://openalex.org/W2007478489","https://openalex.org/W2017169966","https://openalex.org/W2017885661","https://openalex.org/W2036048458","https://openalex.org/W2062575149","https://openalex.org/W2063094517","https://openalex.org/W2063738580","https://openalex.org/W2064308847","https://openalex.org/W2069570660","https://openalex.org/W2070013537","https://openalex.org/W2080131125","https://openalex.org/W2081136733","https://openalex.org/W2087664582","https://openalex.org/W2088318869","https://openalex.org/W2089308595","https://openalex.org/W2093944336","https://openalex.org/W2094894558","https://openalex.org/W2110106971","https://openalex.org/W2126305815","https://openalex.org/W2136967026","https://openalex.org/W2322095705"],"related_works":["https://openalex.org/W4386740662","https://openalex.org/W2386926241","https://openalex.org/W2375384524","https://openalex.org/W2359454541","https://openalex.org/W2388892545","https://openalex.org/W2350758716","https://openalex.org/W2792344067","https://openalex.org/W2007478489","https://openalex.org/W2350090998","https://openalex.org/W3151362271"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Recent":[3],"studies":[4],"suggest":[5],"that":[6,211,221],"statins":[7,50,225],"(3-hydroxy-3-methylglutaryl":[8],"coenzyme":[9],"A":[10],"reductase":[11],"inhibitors)":[12],"not":[13,33,198],"only":[14],"reduce":[15],"the":[16,40,46,115,122,145,165,169,174,189,255],"incidence":[17],"of":[18,43,49,63,85,109,121,131,140,154,224],"stroke":[19,52],"by":[20,128,134,150],"lowering":[21],"cholesterol":[22],"levels":[23],"but":[24],"may":[25,226],"also":[26],"exert":[27],"neuroprotective":[28,47,138,230],"effects":[29],"via":[30],"a":[31,60,82,152,228],"mechanism":[32],"related":[34],"to":[35,75,98,119,188,233,254],"their":[36],"lipid-lowering":[37],"effect.":[38],"Despite":[39],"growing":[41],"body":[42],"evidence,":[44],"however,":[45],"effect":[48,139],"in":[51,81,186,236,239],"is":[53],"still":[54],"controversial.":[55],"Herein,":[56],"we":[57,73],"studied":[58],"whether":[59],"prophylactic":[61,222],"administration":[62,223],"simvastatin":[64],"(Sim)":[65],"provides":[66],"significant":[67],"protection":[68],"against":[69],"brain":[70,212],"damage,":[71],"and":[72,157,173,202],"sought":[74],"determine":[76],"its":[77],"long-lasting":[78],"behavioral":[79,155,205],"consequences":[80],"neonatal":[83],"model":[84],"hypoxia/ischemia.":[86],"METHODS:":[87],"Newborn":[88],"male":[89],"rats":[90,116,146,163,193],"were":[91,117,197],"injected":[92],"daily":[93],"from":[94],"postnatal":[95,112],"days":[96],"1":[97],"7":[99],"with":[100,195],"activated":[101],"Sim":[102,141,196],"(20":[103],"mg/kg)":[104],"or":[105,133,258],"an":[106,234],"equivalent":[107],"volume":[108],"vehicle.":[110],"On":[111],"day":[113],"7,":[114],"subjected":[118],"ligation":[120],"right":[123],"common":[124],"carotid":[125],"artery,":[126],"followed":[127],"3":[129],"hours":[130],"hypoxia":[132],"sham":[135],"operation.":[136],"The":[137],"was":[142,209,214],"evaluated":[143],"after":[144],"had":[147],"achieved":[148],"adulthood":[149],"using":[151],"battery":[153],"tests":[156],"histological":[158],"analysis.":[159],"RESULTS:":[160],"Sim-treated":[161],"ischemic":[162,183,190,240],"performed":[164],"circular":[166],"water":[167,176],"maze,":[168,172],"radial":[170],"arm":[171],"multiple-choice":[175],"maze":[177],"significantly":[178,215],"better":[179],"than":[180],"did":[181],"vehicle-treated":[182],"rats.":[184],"Furthermore,":[185],"contrast":[187],"rats,":[191],"hypoxia/ischemia-injured":[192],"pretreated":[194],"hyperactive":[199],"at":[200],"weaning":[201],"showed":[203],"less":[204],"asymmetry.":[206],"Consistently,":[207],"it":[208],"found":[210],"damage":[213],"attenuated.":[216],"CONCLUSIONS:":[217],"These":[218],"findings":[219],"indicate":[220],"provide":[227],"potential":[229],"strategy":[231],"leading":[232],"improvement":[235],"functional":[237],"outcome":[238],"stroke.":[241],"However,":[242],"toxicity":[243],"concern":[244],"must":[245],"be":[246,252],"addressed":[247],"before":[248],"these":[249],"agents":[250],"can":[251],"directed":[253],"asphyxiated":[256],"fetus":[257],"newborn.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
