{"id":"https://openalex.org/W2114709164","doi":"https://doi.org/10.1016/j.ejpain.2005.12.005","title":"Reward\u2010aversion circuitry in analgesia and pain: Implications for psychiatric disorders","display_name":"Reward\u2010aversion circuitry in analgesia and pain: Implications for psychiatric disorders","publication_year":2006,"publication_date":"2006-02-22","ids":{"openalex":"https://openalex.org/W2114709164","doi":"https://doi.org/10.1016/j.ejpain.2005.12.005","mag":"2114709164","pmid":"https://pubmed.ncbi.nlm.nih.gov/16495096"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejpain.2005.12.005","doi":"https://doi.org/10.1016/j.ejpain.2005.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpain.2005.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S143744428","display_name":"European Journal of Pain","issn_l":"1090-3801","issn":["1090-3801","1532-2149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091764355","display_name":"David Borsook","orcid":"https://orcid.org/0000-0001-9825-0064","observed_orcids":["https://orcid.org/0000-0001-9825-0064"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Borsook","raw_affiliation_strings":["PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States. dborsook@mclean.harvard.edu","PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States. dborsook@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062546791","display_name":"Lino R. Becerra","orcid":"https://orcid.org/0000-0002-5840-1160","observed_orcids":["https://orcid.org/0000-0002-5840-1160"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lino Becerra","raw_affiliation_strings":["PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024383091","display_name":"William A. Carlezon","orcid":"https://orcid.org/0000-0002-4162-3947","observed_orcids":["https://orcid.org/0000-0002-4162-3947"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Carlezon","raw_affiliation_strings":["Behavioral Genetics Laboratory, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Genetics Laboratory, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077037655","display_name":"Marnie  Evelyn Shaw","orcid":"https://orcid.org/0000-0002-9834-6725","observed_orcids":["https://orcid.org/0000-0002-9834-6725"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marnie Shaw","raw_affiliation_strings":["PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057767291","display_name":"Perry Franklin Renshaw","orcid":"https://orcid.org/0000-0002-8888-4503","observed_orcids":["https://orcid.org/0000-0002-8888-4503"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Perry Renshaw","raw_affiliation_strings":["PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067068796","display_name":"Igor Elman","orcid":"https://orcid.org/0000-0002-1345-2677","observed_orcids":["https://orcid.org/0000-0002-1345-2677"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Elman","raw_affiliation_strings":["Behavioral Psychopharmacology Research Laboratory, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Psychopharmacology Research Laboratory, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037181353","display_name":"Jon D. Levine","orcid":"https://orcid.org/0000-0003-0681-5545","observed_orcids":["https://orcid.org/0000-0003-0681-5545"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Levine","raw_affiliation_strings":["Department of Medicine, UCSF, San Francisco, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UCSF, San Francisco, CA, United States","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062546791","https://openalex.org/A5077037655","https://openalex.org/A5091764355"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":null,"fwci":3.527,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.92139984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.925000011920929},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8679999709129333},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-disorders","display_name":"functional disorders","score":0.5260000228881836},{"id":"https://openalex.org/keywords/maladaptive-behavior","display_name":"maladaptive behavior","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neurobiology-of-pain","display_name":"neurobiology of pain","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6316726207733154},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6211246848106384},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.610105037689209},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5119286775588989},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.48994535207748413},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.4891226887702942},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.461779922246933},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.44105812907218933},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2829972207546234},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Pain, Intractable","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejpain.2005.12.005","doi":"https://doi.org/10.1016/j.ejpain.2005.12.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejpain.2005.12.005","pdf_url":null,"source":{"id":"https://openalex.org/S143744428","display_name":"European Journal of Pain","issn_l":"1090-3801","issn":["1090-3801","1532-2149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pain","raw_type":"journal-article"},{"id":"pmid:16495096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16495096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pain (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":192,"referenced_works":["https://openalex.org/W64763342","https://openalex.org/W82863359","https://openalex.org/W137955242","https://openalex.org/W146740744","https://openalex.org/W181509621","https://openalex.org/W199967300","https://openalex.org/W1040118332","https://openalex.org/W1497153995","https://openalex.org/W1507404953","https://openalex.org/W1512847190","https://openalex.org/W1513763202","https://openalex.org/W1520279806","https://openalex.org/W1530377380","https://openalex.org/W1534340867","https://openalex.org/W1561198779","https://openalex.org/W1563873975","https://openalex.org/W1580932738","https://openalex.org/W1600952076","https://openalex.org/W1601224916","https://openalex.org/W1630671347","https://openalex.org/W1654467375","https://openalex.org/W1697645181","https://openalex.org/W1698622206","https://openalex.org/W1719563198","https://openalex.org/W1737683501","https://openalex.org/W1764814382","https://openalex.org/W1773001224","https://openalex.org/W1817985333","https://openalex.org/W1828259239","https://openalex.org/W1883044208","https://openalex.org/W1934272990","https://openalex.org/W1942675895","https://openalex.org/W1966724162","https://openalex.org/W1969716910","https://openalex.org/W1972220137","https://openalex.org/W1972239943","https://openalex.org/W1973752193","https://openalex.org/W1976413564","https://openalex.org/W1977013150","https://openalex.org/W1977195714","https://openalex.org/W1977836351","https://openalex.org/W1978774896","https://openalex.org/W1979780478","https://openalex.org/W1981115201","https://openalex.org/W1981583264","https://openalex.org/W1982203744","https://openalex.org/W1982327643","https://openalex.org/W1983643872","https://openalex.org/W1983716232","https://openalex.org/W1984010212","https://openalex.org/W1984866428","https://openalex.org/W1985427696","https://openalex.org/W1986009248","https://openalex.org/W1987916104","https://openalex.org/W1991707775","https://openalex.org/W1992795892","https://openalex.org/W1996543933","https://openalex.org/W2001706056","https://openalex.org/W2002942099","https://openalex.org/W2003207603","https://openalex.org/W2003317415","https://openalex.org/W2005857607","https://openalex.org/W2006549080","https://openalex.org/W2007736868","https://openalex.org/W2007938882","https://openalex.org/W2010569958","https://openalex.org/W2011561395","https://openalex.org/W2013645250","https://openalex.org/W2014793146","https://openalex.org/W2015316524","https://openalex.org/W2015602085","https://openalex.org/W2017170791","https://openalex.org/W2017860510","https://openalex.org/W2021164183","https://openalex.org/W2022452838","https://openalex.org/W2022607137","https://openalex.org/W2022723884","https://openalex.org/W2023504580","https://openalex.org/W2023546642","https://openalex.org/W2026399507","https://openalex.org/W2026468472","https://openalex.org/W2030258997","https://openalex.org/W2030751218","https://openalex.org/W2032119183","https://openalex.org/W2032400888","https://openalex.org/W2032509243","https://openalex.org/W2034603498","https://openalex.org/W2036344281","https://openalex.org/W2036362441","https://openalex.org/W2036747051","https://openalex.org/W2037457092","https://openalex.org/W2038201409","https://openalex.org/W2039851483","https://openalex.org/W2040295810","https://openalex.org/W2040477222","https://openalex.org/W2043026472","https://openalex.org/W2048081411","https://openalex.org/W2049027831","https://openalex.org/W2051508663","https://openalex.org/W2051724610","https://openalex.org/W2052524410","https://openalex.org/W2052715999","https://openalex.org/W2054260401","https://openalex.org/W2056552590","https://openalex.org/W2056959797","https://openalex.org/W2059820226","https://openalex.org/W2062184437","https://openalex.org/W2062800371","https://openalex.org/W2062952985","https://openalex.org/W2063700529","https://openalex.org/W2065296100","https://openalex.org/W2066328174","https://openalex.org/W2066517347","https://openalex.org/W2066644653","https://openalex.org/W2067849553","https://openalex.org/W2068237121","https://openalex.org/W2068437254","https://openalex.org/W2070656423","https://openalex.org/W2073496569","https://openalex.org/W2073939477","https://openalex.org/W2076632450","https://openalex.org/W2078308586","https://openalex.org/W2079872791","https://openalex.org/W2080693675","https://openalex.org/W2082091099","https://openalex.org/W2084170698","https://openalex.org/W2085971650","https://openalex.org/W2086372244","https://openalex.org/W2088910087","https://openalex.org/W2090202944","https://openalex.org/W2091308025","https://openalex.org/W2091696767","https://openalex.org/W2092767025","https://openalex.org/W2093196756","https://openalex.org/W2094347820","https://openalex.org/W2094712734","https://openalex.org/W2095901107","https://openalex.org/W2102080095","https://openalex.org/W2103124605","https://openalex.org/W2105109101","https://openalex.org/W2105808200","https://openalex.org/W2106876543","https://openalex.org/W2109059823","https://openalex.org/W2113617929","https://openalex.org/W2114005706","https://openalex.org/W2114943199","https://openalex.org/W2116119047","https://openalex.org/W2119128116","https://openalex.org/W2121270079","https://openalex.org/W2121853679","https://openalex.org/W2123375790","https://openalex.org/W2124284324","https://openalex.org/W2125079193","https://openalex.org/W2125591713","https://openalex.org/W2128571861","https://openalex.org/W2130690736","https://openalex.org/W2132270420","https://openalex.org/W2132277863","https://openalex.org/W2132473069","https://openalex.org/W2133316133","https://openalex.org/W2135382170","https://openalex.org/W2135890562","https://openalex.org/W2140257707","https://openalex.org/W2142607990","https://openalex.org/W2142738038","https://openalex.org/W2144598750","https://openalex.org/W2144854156","https://openalex.org/W2144933081","https://openalex.org/W2147464816","https://openalex.org/W2151651036","https://openalex.org/W2154546113","https://openalex.org/W2157737392","https://openalex.org/W2157815289","https://openalex.org/W2159223986","https://openalex.org/W2159594385","https://openalex.org/W2164402789","https://openalex.org/W2165387222","https://openalex.org/W2165976792","https://openalex.org/W2168602546","https://openalex.org/W2170380292","https://openalex.org/W2175469462","https://openalex.org/W2241616961","https://openalex.org/W2243322739","https://openalex.org/W2254793667","https://openalex.org/W2297226400","https://openalex.org/W2313074994","https://openalex.org/W2328445755","https://openalex.org/W2338878428","https://openalex.org/W2411011840","https://openalex.org/W2417452380","https://openalex.org/W4241090263","https://openalex.org/W4293872372"],"related_works":["https://openalex.org/W3042900911","https://openalex.org/W427449036","https://openalex.org/W2126869480","https://openalex.org/W4319337864","https://openalex.org/W3013186914","https://openalex.org/W2964000526","https://openalex.org/W2378173657","https://openalex.org/W4220705158","https://openalex.org/W2403540371","https://openalex.org/W2093880072"],"abstract_inverted_index":{"Sensory":[0],"and":[1,18,22,32,75,82,96,98,113,132,134,138],"emotional":[2,76],"systems":[3,77],"normally":[4],"interact":[5],"in":[6,62,79,84,94,104,107],"a":[7],"manner":[8],"that":[9,35],"optimizes":[10],"an":[11],"organism's":[12],"ability":[13],"to":[14],"survive":[15],"using":[16],"conscious":[17],"unconscious":[19],"processing.":[20],"Pain":[21],"analgesia":[23,83],"are":[24,46],"interpreted":[25],"by":[26],"the":[27,56,71,85,89,100,108,124,136],"nervous":[28,58],"system":[29,59],"as":[30,130],"aversive":[31],"rewarding":[33],"processes":[34,45],"trigger":[36],"specific":[37],"behavioral":[38],"responses.":[39],"Under":[40],"normal":[41],"physiological":[42,86],"conditions":[43],"these":[44],"adaptive.":[47],"However,":[48],"under":[49],"chronic":[50,111],"pain":[51,81,95,112],"conditions,":[52],"functional":[53,127],"alterations":[54,103],"of":[55,91,102,110,126,140],"central":[57],"frequently":[60],"result":[61],"maladaptive":[63],"behaviors.":[64],"In":[65],"this":[66],"review,":[67],"we":[68],"examine:":[69],"(a)":[70],"interactions":[72],"between":[73],"sensory":[74],"involved":[78],"processing":[80],"state;":[87],"(b)":[88],"role":[90,101],"reward/aversion":[92,105],"circuitry":[93,106],"analgesia;":[97],"(c)":[99],"development":[109,137],"co-morbid":[114],"psychiatric":[115],"disorders.":[116],"These":[117],"underlying":[118],"features":[119],"have":[120],"implications":[121],"for":[122,135],"understanding":[123],"neurobiology":[125],"illnesses":[128],"such":[129],"depression":[131],"anxiety":[133],"evaluation":[139],"novel":[141],"therapeutic":[142],"interventions.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}