{"id":"https://openalex.org/W2114708447","doi":"https://doi.org/10.1016/j.cell.2006.08.036","title":"P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from \u03b2-Catenin","display_name":"P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from \u03b2-Catenin","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W2114708447","doi":"https://doi.org/10.1016/j.cell.2006.08.036","mag":"2114708447","pmid":"https://pubmed.ncbi.nlm.nih.gov/17018282"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2006.08.036","doi":"https://doi.org/10.1016/j.cell.2006.08.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2006.08.036","pdf_url":"http://www.cell.com/article/S0092867406011585/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867406011585/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002538698","display_name":"Liuqing Yang","orcid":"https://orcid.org/0000-0002-0086-2909","observed_orcids":["https://orcid.org/0000-0002-0086-2909"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liuqing Yang","raw_affiliation_strings":["Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002078440","display_name":"Chunru Lin","orcid":"https://orcid.org/0000-0002-6473-8229","observed_orcids":["https://orcid.org/0000-0002-6473-8229"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunru Lin","raw_affiliation_strings":["Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017015607","display_name":"Zhi-Ren Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhi-Ren Liu","raw_affiliation_strings":["Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017015607"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":6.423,"has_fulltext":false,"cited_by_count":286,"citation_normalized_percentile":{"value":0.97961697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"127","issue":"1","first_page":"139","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p68-rna-helicase","display_name":"p68 RNA helicase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dead-box-rna-helicase","display_name":"DEAD-box RNA helicase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/beta-catenin-nuclear-translocation","display_name":"\u03b2-catenin nuclear translocation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/axin","display_name":"Axin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.925000011920929},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7513439655303955},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7459595203399658},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6830108165740967},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.6041820645332336},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.571927011013031},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5535078644752502},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5184328556060791},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.49440526962280273},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.48873400688171387},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.48406782746315},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.47352978587150574},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.39557212591171265},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.380079448223114},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.3660287857055664},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2883894145488739},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.22447988390922546},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.1573561131954193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14113649725914001},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05834752321243286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04942619800567627}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051822","descriptor_name":"T Cell Transcription Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051822","descriptor_name":"T Cell Transcription Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060466","descriptor_name":"Axin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cell.2006.08.036","doi":"https://doi.org/10.1016/j.cell.2006.08.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2006.08.036","pdf_url":"http://www.cell.com/article/S0092867406011585/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:17018282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17018282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2006.08.036","doi":"https://doi.org/10.1016/j.cell.2006.08.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2006.08.036","pdf_url":"http://www.cell.com/article/S0092867406011585/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3946112768","display_name":null,"funder_award_id":"GM063874","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8295185143","display_name":"Biochemical Characterization of p68 RNA Helicase","funder_award_id":"R01GM063874","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114708447.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W66793087","https://openalex.org/W1490283529","https://openalex.org/W1596348751","https://openalex.org/W1639582946","https://openalex.org/W1656708631","https://openalex.org/W1712759494","https://openalex.org/W1850975011","https://openalex.org/W1965204519","https://openalex.org/W1967803088","https://openalex.org/W1978862778","https://openalex.org/W2000099153","https://openalex.org/W2001027289","https://openalex.org/W2007752398","https://openalex.org/W2012095617","https://openalex.org/W2013480667","https://openalex.org/W2016533385","https://openalex.org/W2017042657","https://openalex.org/W2032103583","https://openalex.org/W2032942532","https://openalex.org/W2035391407","https://openalex.org/W2036008499","https://openalex.org/W2040942754","https://openalex.org/W2046436308","https://openalex.org/W2052459095","https://openalex.org/W2058332866","https://openalex.org/W2062883197","https://openalex.org/W2065735031","https://openalex.org/W2065868028","https://openalex.org/W2065919942","https://openalex.org/W2070058781","https://openalex.org/W2076491431","https://openalex.org/W2083428565","https://openalex.org/W2085194817","https://openalex.org/W2086627696","https://openalex.org/W2087947512","https://openalex.org/W2093265249","https://openalex.org/W2105602573","https://openalex.org/W2112688349","https://openalex.org/W2119528486","https://openalex.org/W2141931281","https://openalex.org/W2142415827","https://openalex.org/W2145567340","https://openalex.org/W2146303849","https://openalex.org/W2148294117","https://openalex.org/W2158796507","https://openalex.org/W2161835431","https://openalex.org/W2165036501","https://openalex.org/W2166920678","https://openalex.org/W2170089635","https://openalex.org/W2314144775","https://openalex.org/W6602768672"],"related_works":["https://openalex.org/W2014209669","https://openalex.org/W790317239","https://openalex.org/W2171119641","https://openalex.org/W754049478","https://openalex.org/W1985589749","https://openalex.org/W850587154","https://openalex.org/W2087472062","https://openalex.org/W4389007513","https://openalex.org/W2046226025","https://openalex.org/W2799577473"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}