{"id":"https://openalex.org/W2114686010","doi":null,"title":"Studio del ruolo del sistema serotoninergico in un modello acuto murino di Morbo di Crohn","display_name":"Studio del ruolo del sistema serotoninergico in un modello acuto murino di Morbo di Crohn","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2114686010","mag":"2114686010"},"language":"it","primary_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/2506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/2506","pdf_url":"http://hdl.handle.net/1889/2506","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1889/2506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031637191","display_name":"Alberto Rapalli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alberto Rapalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031637191"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5989999771118164},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tnbs-induced-colitis","display_name":"TNBS-induced colitis","score":0.859000027179718},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.7940000295639038},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.9139999747276306},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/5-ht7-receptor","display_name":"5-HT7 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/8-oh-dpat","display_name":"8-OH-DPAT","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.996999979019165},{"id":"https://openalex.org/keywords/sb-269970","display_name":"SB-269970","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5889999866485596},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.4230000078678131},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5333592295646667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39547842741012573},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.234920471906662}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace-unipr.cineca.it:1889/2506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/2506","pdf_url":"http://hdl.handle.net/1889/2506","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2114686010","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.unipr.it/bitstream/1889/2506/1/Studio%20del%20ruolo%20del%20sistema%20serotoninergico%20in%20un%20modello%20acuto%20murino%20di%20Morbo%20di%20Crohn%20%28Rapalli%20Alberto%29.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace-unipr.cineca.it:1889/2506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1889/2506","pdf_url":"http://hdl.handle.net/1889/2506","source":{"id":"https://openalex.org/S4306401194","display_name":"DSpaceUnipr (University of Parma)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124601658","host_organization_name":"University of Parma","host_organization_lineage":["https://openalex.org/I124601658"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114686010.pdf","grobid_xml":"https://content.openalex.org/works/W2114686010.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W9552350","https://openalex.org/W80680796","https://openalex.org/W1496381585","https://openalex.org/W1512595753","https://openalex.org/W1597959509","https://openalex.org/W1603593764","https://openalex.org/W1642457845","https://openalex.org/W1790958593","https://openalex.org/W1942920640","https://openalex.org/W1969144895","https://openalex.org/W1972403965","https://openalex.org/W1978964535","https://openalex.org/W1981367331","https://openalex.org/W1981714996","https://openalex.org/W1992724461","https://openalex.org/W1993351522","https://openalex.org/W1994469526","https://openalex.org/W1994798728","https://openalex.org/W1997066133","https://openalex.org/W1997225712","https://openalex.org/W2003718301","https://openalex.org/W2003867490","https://openalex.org/W2006194008","https://openalex.org/W2006249161","https://openalex.org/W2010288553","https://openalex.org/W2011197968","https://openalex.org/W2014080590","https://openalex.org/W2016382432","https://openalex.org/W2017028855","https://openalex.org/W2021959823","https://openalex.org/W2024102230","https://openalex.org/W2026703453","https://openalex.org/W2033840433","https://openalex.org/W2033848049","https://openalex.org/W2039763012","https://openalex.org/W2046428971","https://openalex.org/W2047228952","https://openalex.org/W2048547607","https://openalex.org/W2051692635","https://openalex.org/W2053195651","https://openalex.org/W2053310078","https://openalex.org/W2054219549","https://openalex.org/W2066203385","https://openalex.org/W2066285585","https://openalex.org/W2066301620","https://openalex.org/W2066888686","https://openalex.org/W2072474941","https://openalex.org/W2073022365","https://openalex.org/W2073461076","https://openalex.org/W2074223424","https://openalex.org/W2076423355","https://openalex.org/W2077391876","https://openalex.org/W2079745078","https://openalex.org/W2081101034","https://openalex.org/W2081379412","https://openalex.org/W2083787933","https://openalex.org/W2088449391","https://openalex.org/W2091214043","https://openalex.org/W2092763591","https://openalex.org/W2094464340","https://openalex.org/W2095460819","https://openalex.org/W2101467275","https://openalex.org/W2101817799","https://openalex.org/W2101877357","https://openalex.org/W2104391253","https://openalex.org/W2107048440","https://openalex.org/W2108087913","https://openalex.org/W2116289754","https://openalex.org/W2118799663","https://openalex.org/W2121184314","https://openalex.org/W2122031852","https://openalex.org/W2122386753","https://openalex.org/W2125287098","https://openalex.org/W2125678621","https://openalex.org/W2134032226","https://openalex.org/W2134729501","https://openalex.org/W2135444798","https://openalex.org/W2141679700","https://openalex.org/W2149705807","https://openalex.org/W2156953890","https://openalex.org/W2158702309","https://openalex.org/W2165511099","https://openalex.org/W2165864117","https://openalex.org/W2167900561","https://openalex.org/W2293494973","https://openalex.org/W2311013179","https://openalex.org/W2398399650","https://openalex.org/W2409090002","https://openalex.org/W2441302380"],"related_works":["https://openalex.org/W4220827250","https://openalex.org/W2335488562","https://openalex.org/W2091034767","https://openalex.org/W4309087503","https://openalex.org/W2794446368","https://openalex.org/W2051692635","https://openalex.org/W3214279873","https://openalex.org/W2887363631","https://openalex.org/W4220830468","https://openalex.org/W2800022386"],"abstract_inverted_index":{"Il":[0],"Morbo":[1],"di":[2,11,23,41,56,67,105,128,131,136,141,153,164,176,202,280],"Crohn":[3],"(CD)":[4],"\u00e8":[5,38,69,78,86,99,151],"una":[6],"delle":[7],"forme":[8],"pi\u00f9":[9,89],"importante":[10],"Inflammatory":[12],"Bowel":[13],"Disease,":[14],"caratterizzata":[15],"dall\u2019infiammazione":[16],"della":[17,148],"parete":[18],"intestinale,":[19],"con":[20,168,292],"massiccia":[21],"infiltrazione":[22],"macrofagi":[24],"e":[25,95,133,198,265,274,297],"linfociti.":[26],"Questa":[27],"patologia":[28,132],"provoca":[29,244],"non":[30],"solo":[31],"importanti":[32,90],"manifestazione":[33],"a":[34,62],"livello":[35,63],"intestinale":[36],"ed":[37,60,75,184,216],"un":[39,102,161,177,185,203,236,245],"fattore":[40],"rischio":[42],"per":[43],"il":[44,120,155,258,267],"cancro":[45],"colonrettale,":[46],"ma":[47],"presenta":[48],"anche":[49],"manifestazioni":[50],"sistemiche,":[51],"come":[52],"osteoporosi":[53],",":[54],"diabete":[55],"tipo":[57,130],"II,":[58],"trombosi":[59],"ulcerazioni":[61],"epidermico":[64],".":[65,115],"L'incidenza":[66],"CD":[68,165],"aumentata":[70],"negli":[71],"ultimi":[72],"10":[73],"anni,":[74],"in":[76,160,290],"particolare":[77],"fortemente":[79],"incrementata":[80],"nei":[81],"centri":[82],"urbani.\\nLa":[83],"serotonina":[84],"(5-HT)":[85],"uno":[87],"dei":[88],"neurotrasmettitori":[91],"del":[92,145,179,187,195,205,225,232,241,247,253,282],"tratto":[93],"gastrointestinale,":[94],"la":[96,134,174,200],"sua":[97],"azione":[98],"modulata":[100],"da":[101],"gran":[103],"numero":[104],"recettori":[106],"(5":[107],"-":[108],"HTRs:":[109],"5-HT1A,":[110],"5-HT2,":[111],"5-HT3,":[112],"5-HT4,":[113,266],"5-HT7)":[114],"Diversi":[116],"autori":[117],"hanno":[118],"dimostrato":[119,229,257],"ruolo":[121,156,237,259,268],"fondamentale":[122],"svolto":[123,157,261,270],"dalla":[124,278],"5-HT":[125],"nello":[126],"sviluppo":[127],"questo":[129],"presenza":[135],"diversi":[137],"5-HTR":[138],"sulla":[139],"superficie":[140],"tutte":[142],"le":[143],"cellule":[144],"sistema":[146],"immunitario.\\nScopo":[147],"nostra":[149],"ricerca":[150],"quello":[152],"indagare":[154],"dai":[158],"5-HTRs":[159],"modello":[162],"murino":[163],"acuta,":[166],"realizzata":[167],"acido":[169],"solfonico":[170],"2,4,6-trinitrobenzene":[171],"(TNBS),":[172],"attraverso":[173,199],"somministrazione":[175,201,279],"antagonista":[178,204,210,213,217],"recettore":[180,188,206,233,242,272,283],"5-HT1A":[181,189,234,243],"(WAY100135":[182],")":[183],"agonista":[186],"(8-OH":[190],"DPAT\u2219HBr),":[191],"nella":[192,220,295],"prima":[193,223],"parte":[194,224,252],"nostro":[196,226,254],"studio,":[197,227],"5-":[207],"HT2":[208],"(Ketanserina),":[209],"5-HT3":[211],"(Ondansetron),":[212],"5-HT4":[214],"(GR125487)":[215],"5-HT7":[218,273],"(SB269970),":[219],"seconda":[221,251],"parte.\\nNella":[222],"abbiamo":[228,256],"che":[230],"agonisti":[231],"svolgono":[235],"protettivo,":[238],"mentre,":[239],"l'antagonismo":[240],"peggioramento":[246],"quadro":[248],"clinico.":[249],"Nella":[250],"studio":[255],"protettivo":[260],"dagli":[262],"antagonisti":[263,281],"5-HT2":[264],"marginale":[269],"dal":[271],"l\u2019effetto":[275],"aggravante":[276],"causatato":[277],"5-HT3.\\nTutti":[284],"gli":[285],"esperimenti":[286],"sono":[287],"stati":[288],"eseguiti":[289],"conformit\u00e0":[291],"principi":[293],"guida":[294],"cura":[296],"l'uso":[298],"degli":[299],"animali":[300],"(DL117/92).":[301]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
