{"id":"https://openalex.org/W2114684542","doi":"https://doi.org/10.1096/fasebj.13.1.63","title":"TNF\u03b1 plus IFN\u03b3 induce the production of Alzheimer \u03b2\u2010amyloid peptides and decrease the secretion of APPs","display_name":"TNF\u03b1 plus IFN\u03b3 induce the production of Alzheimer \u03b2\u2010amyloid peptides and decrease the secretion of APPs","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2114684542","doi":"https://doi.org/10.1096/fasebj.13.1.63","mag":"2114684542","pmid":"https://pubmed.ncbi.nlm.nih.gov/9872930"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.13.1.63","doi":"https://doi.org/10.1096/fasebj.13.1.63","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.13.1.63","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074903941","display_name":"Imrich Blasko","orcid":"https://orcid.org/0000-0003-3625-5104","observed_orcids":["https://orcid.org/0000-0003-3625-5104"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"I. BLASKO","raw_affiliation_strings":["Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048277918","display_name":"Florentine Marx","orcid":"https://orcid.org/0000-0002-8408-1842","observed_orcids":["https://orcid.org/0000-0002-8408-1842"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. MARX","raw_affiliation_strings":["Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069112087","display_name":"Eberhard Steiner","orcid":"https://orcid.org/0009-0006-5798-5746","observed_orcids":["https://orcid.org/0009-0006-5798-5746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. STEINER","raw_affiliation_strings":["Department of Surgery\u2018Bezirkskrankenhaus\u2019 Hall Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery\u2018Bezirkskrankenhaus\u2019 Hall Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009977783","display_name":"Tobias Hartmann","orcid":"https://orcid.org/0000-0001-7481-6430","observed_orcids":["https://orcid.org/0000-0001-7481-6430"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. HARTMANN","raw_affiliation_strings":["Center for Molecular Biology Heidelberg (ZMBH)University of Heidelberg Heidelberg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology Heidelberg (ZMBH)University of Heidelberg Heidelberg Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038748962","display_name":"Beatrix Grubeck-Loebenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"B. GRUBECK\u2010LOEBENSTEIN","raw_affiliation_strings":["Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria","institution_ids":["https://openalex.org/I138211613"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038748962"],"corresponding_institution_ids":["https://openalex.org/I138211613"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":3.2579,"has_fulltext":false,"cited_by_count":279,"citation_normalized_percentile":{"value":0.93594358,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"63","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7049999833106995},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8930000066757202},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.6349999904632568},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7436378598213196},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6352277398109436},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6064774990081787},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5805134773254395},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5390251874923706},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47673285007476807},{"id":"https://openalex.org/C3019216857","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"\u03b2 amyloid","level":4,"score":0.46189960837364197},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42470160126686096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42369601130485535},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.416287899017334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3877641260623932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3657907247543335},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36207133531570435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3352571129798889},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13701361417770386}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1096/fasebj.13.1.63","doi":"https://doi.org/10.1096/fasebj.13.1.63","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.13.1.63","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:9872930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9872930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.579.5844","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.579.5844","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.alzheimer-forschung.de/images/user-images/forschung_publikatonen/Forscher 1997/Hartmann_Publication_1.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G197085704","display_name":null,"funder_award_id":"P12440\u2010MED","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1549447146","https://openalex.org/W1960543132","https://openalex.org/W1965281076","https://openalex.org/W1967237003","https://openalex.org/W1972168107","https://openalex.org/W1973573758","https://openalex.org/W1979129905","https://openalex.org/W1979543098","https://openalex.org/W1979773315","https://openalex.org/W1981513372","https://openalex.org/W1983996266","https://openalex.org/W2005320724","https://openalex.org/W2005814061","https://openalex.org/W2012983715","https://openalex.org/W2014237818","https://openalex.org/W2045072700","https://openalex.org/W2066347230","https://openalex.org/W2068225545","https://openalex.org/W2070045579","https://openalex.org/W2076973891","https://openalex.org/W2078039302","https://openalex.org/W2079438371","https://openalex.org/W2082795767","https://openalex.org/W2090930997","https://openalex.org/W2108676263","https://openalex.org/W2113729717","https://openalex.org/W2131851314","https://openalex.org/W2149818957","https://openalex.org/W2162059739"],"related_works":["https://openalex.org/W7095310992","https://openalex.org/W2432599931","https://openalex.org/W2062084653","https://openalex.org/W2156877034","https://openalex.org/W2898432193","https://openalex.org/W2005814061","https://openalex.org/W2002878632","https://openalex.org/W2052077459","https://openalex.org/W143322292","https://openalex.org/W2011284720"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,86],"appearance":[2],"of":[3,13,34,48,59,70,77,118,126],"inflammatory":[4,42,94],"markers":[5],"associated":[6],"with":[7],"amyloid":[8],"plaques":[9],"indicates":[10],"a":[11,31,89],"state":[12],"chronic":[14],"inflammation":[15],"in":[16,101],"Alzheimer's":[17],"disease":[18],"(AD).":[19],"Multiple":[20],"epidemiological":[21],"studies":[22],"also":[23],"suggest":[24],"that":[25,41,56],"patients":[26],"taking":[27],"anti\u2010inflammatory":[28],"drugs":[29],"have":[30],"decreased":[32],"risk":[33],"developing":[35],"AD.":[36],"Here":[37],"we":[38],"present":[39],"evidence":[40],"cytokines":[43],"can":[44,96],"alter":[45],"the":[46,49,57,68,75,98,116,124],"metabolism":[47],"\u03b2\u2010am\u2010yloid":[50],"precursor":[51],"protein":[52],"(\u03b2APP).":[53],"We":[54],"show":[55],"combination":[58],"tumor":[60],"necrosis":[61],"factor":[62],"\u03b1":[63],"and":[64,73,83,122],"interferon":[65],"\u03b3":[66],"triggers":[67],"production":[69,117],"\u03b2\u2010amyloid":[71,120],"peptides":[72,121],"inhibits":[74],"secretion":[76,125],"soluble":[78],"APPs":[79],"by":[80,92],"human":[81],"neuronal":[82],"extraneuronal":[84],"cells.":[85],"results":[87],"demonstrate":[88],"new":[90],"mechanism":[91],"which":[93],"components":[95],"exacerbate":[97],"fundamental":[99],"pathology":[100],"AD.\u2014Blasko,":[102],"I.,":[103],"Marx,":[104],"F.,":[105],"Steiner,":[106],"E.,":[107],"Hartmann,":[108],"T.,":[109],"Grubeck\u2010Loebenstein,":[110],"B.":[111],"TNF\u03b1":[112],"plus":[113],"IFN\u03b3":[114],"induce":[115],"Alzheimer":[119],"decrease":[123],"APPs.":[127],"FASEB":[128],"J.":[129],"13,":[130],"63\u201368":[131],"(1999)":[132]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}