{"id":"https://openalex.org/W2114635784","doi":"https://doi.org/10.1001/jama.2014.9646","title":"Reanalyses of Randomized Clinical Trial Data","display_name":"Reanalyses of Randomized Clinical Trial Data","publication_year":2014,"publication_date":"2014-09-09","ids":{"openalex":"https://openalex.org/W2114635784","doi":"https://doi.org/10.1001/jama.2014.9646","mag":"2114635784","pmid":"https://pubmed.ncbi.nlm.nih.gov/25203082"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2014.9646","doi":"https://doi.org/10.1001/jama.2014.9646","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2014.9646","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027793509","display_name":"Shanil Ebrahim","orcid":"https://orcid.org/0000-0001-9396-3321","observed_orcids":["https://orcid.org/0000-0001-9396-3321"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Shanil Ebrahim","raw_affiliation_strings":["Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada3Department of Anesthesia, McMaster University4Depa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada3Department of Anesthesia, McMaster University4Depa","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061970950","display_name":"Zahra N. Sohani","orcid":"https://orcid.org/0000-0002-0770-4962","observed_orcids":["https://orcid.org/0000-0002-0770-4962"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zahra N. Sohani","raw_affiliation_strings":["Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada5Population Genomics Program, McMaster University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada5Population Genomics Program, McMaster University","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062505124","display_name":"Luis Montoya","orcid":"https://orcid.org/0000-0002-1559-7490","observed_orcids":["https://orcid.org/0000-0002-1559-7490"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Luis Montoya","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020341898","display_name":"Arnav Agarwal","orcid":"https://orcid.org/0000-0002-0931-7851","observed_orcids":["https://orcid.org/0000-0002-0931-7851"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arnav Agarwal","raw_affiliation_strings":["Faculty of Health Sciences, McMaster University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, McMaster University","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001585828","display_name":"Kristian Thorlund","orcid":"https://orcid.org/0000-0001-5848-3111","observed_orcids":["https://orcid.org/0000-0001-5848-3111"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Kristian Thorlund","raw_affiliation_strings":["Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada","Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049279040","display_name":"Edward J. Mills","orcid":"https://orcid.org/0000-0003-3120-9694","observed_orcids":["https://orcid.org/0000-0003-3120-9694","https://orcid.org/0000-0002-3108-613X"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Edward J. Mills","raw_affiliation_strings":["Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada8Faculty of Health Sciences, University of Ottawa,","Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada","Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada8Faculty of Health Sciences, University of Ottawa,","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I97018004","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070446713","display_name":"John P. A. Ioannidis","orcid":"https://orcid.org/0000-0003-3118-6859","observed_orcids":["https://orcid.org/0000-0003-3118-6859"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. A. Ioannidis","raw_affiliation_strings":["Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California9Department of Health Research and Policy, Stanford University School of Medicine10Department of Statistics, Stanford University School of Humanities and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California9Department of Health Research and Policy, Stanford University School of Medicine10Department of Statistics, Stanford University School of Humanities and","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":28.9783,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.99696395,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"312","issue":"10","first_page":"1024","last_page":"1024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/individual-patient-data","display_name":"individual patient data","score":0.8539999723434448},{"id":"https://openalex.org/keywords/treatment-heterogeneity","display_name":"treatment effect heterogeneity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/number-needed-to-treat","display_name":"number needed to treat","score":0.6240000128746033},{"id":"https://openalex.org/keywords/outcome-definitions","display_name":"outcome definitions","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8720864653587341},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.8068143129348755},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.5259126424789429},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.47645309567451477},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44124433398246765},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.43511727452278137},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32192468643188477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2771211266517639},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.2014.9646","doi":"https://doi.org/10.1001/jama.2014.9646","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2014.9646","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:25203082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25203082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W18404003","https://openalex.org/W1502313580","https://openalex.org/W1580606228","https://openalex.org/W1759825643","https://openalex.org/W1863982351","https://openalex.org/W1965964441","https://openalex.org/W1968399615","https://openalex.org/W1971672766","https://openalex.org/W1972893464","https://openalex.org/W1983703135","https://openalex.org/W1988081220","https://openalex.org/W1989961471","https://openalex.org/W1992103610","https://openalex.org/W1992997426","https://openalex.org/W1996480320","https://openalex.org/W2014914411","https://openalex.org/W2015408656","https://openalex.org/W2021930866","https://openalex.org/W2026155804","https://openalex.org/W2026756548","https://openalex.org/W2044009235","https://openalex.org/W2067986419","https://openalex.org/W2070960668","https://openalex.org/W2087685293","https://openalex.org/W2088940197","https://openalex.org/W2090674043","https://openalex.org/W2092753278","https://openalex.org/W2111337143","https://openalex.org/W2120516766","https://openalex.org/W2124476451","https://openalex.org/W2139142148","https://openalex.org/W2139879375","https://openalex.org/W2142147900","https://openalex.org/W2147680588","https://openalex.org/W2154921238","https://openalex.org/W2155684087","https://openalex.org/W2159404520","https://openalex.org/W2169012367","https://openalex.org/W2334422428","https://openalex.org/W2394508430"],"related_works":["https://openalex.org/W3136307402","https://openalex.org/W2784864313","https://openalex.org/W3215804084","https://openalex.org/W2125422536","https://openalex.org/W1999169586","https://openalex.org/W2473256869","https://openalex.org/W2167280301","https://openalex.org/W2073700667","https://openalex.org/W2563605442","https://openalex.org/W2028853757"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Reanalyses":[1,187],"of":[2,16,25,44,66,78,95,129,141,158,204,207,222,233,244,280,282,300,314,323],"randomized":[3],"clinical":[4],"trial":[5,18,37],"(RCT)":[6],"data":[7,98,112,171,175,181],"may":[8],"help":[9],"the":[10,14,35,42,47,53,58,62,104,108,137,205,215,220,245,315,319],"scientific":[11],"community":[12],"assess":[13,51],"validity":[15],"reported":[17],"results.":[19],"OBJECTIVES:":[20],"To":[21],"identify":[22,87],"published":[23,89,101,155,286,301],"reanalyses":[24,152,213,236,281,302],"RCT":[26],"data,":[27],"to":[28,40,50,82,86,228,239,287,304],"characterize":[29],"methodological":[30],"and":[31,38,49,117,127,134,172,199,217,265,321],"other":[32],"differences":[33],"between":[34],"original":[36,59,109,246,316],"reanalysis,":[39],"evaluate":[41],"independence":[43],"authors":[45,165],"performing":[46],"reanalyses,":[48],"whether":[52],"reanalysis":[54,94],"changed":[55,214,219],"interpretations":[56,240],"from":[57,80,99,242,312],"article":[60,317],"about":[61,136,318],"types":[63,138,320],"or":[64,139,193,202],"numbers":[65,140],"patients":[67,142,253,261,270,324],"who":[68,143,325],"should":[69,144,254,262,271,326],"be":[70,145,255,263,272,327],"treated.":[71,146,273,328],"DESIGN:":[72],"We":[73,148],"completed":[74,92],"an":[75],"electronic":[76],"search":[77],"MEDLINE":[79],"inception":[81],"March":[83],"9,":[84],"2014,":[85],"all":[88],"studies":[90],"that":[91,176,243,251,259,268,308],"a":[93,290],"individual":[96],"patient":[97],"previously":[100],"RCTs":[102,283],"addressing":[103],"same":[105],"hypothesis":[106],"as":[107],"RCT.":[110],"Four":[111,212],"extractors":[113],"independently":[114],"screened":[115],"articles":[116],"extracted":[118],"data.":[119],"MAIN":[120],"OUTCOMES":[121],"AND":[122,275],"MEASURES:":[123],"Changes":[124],"in":[125,153,191,200,230,306],"direction":[126,216],"magnitude":[128,221],"treatment":[130,223],"effect,":[131,224],"statistical":[132,192,231],"significance,":[133],"interpretation":[135],"RESULTS:":[147],"identified":[149],"37":[150],"eligible":[151],"36":[154],"articles,":[156],"5":[157],"which":[159],"were":[160,177,292],"performed":[161],"by":[162,294],"entirely":[163,295],"independent":[164,296],"(2":[166],"based":[167],"on":[168,174,179],"publicly":[169],"available":[170],"2":[173,218],"provided":[178],"request;":[180],"availability":[182],"was":[183],"unclear":[184],"for":[185],"1).":[186],"differed":[188],"most":[189],"commonly":[190],"analytical":[194],"approaches":[195],"(n":[196,209],"=":[197,210],"18)":[198],"definitions":[201],"measurements":[203],"outcome":[206],"interest":[208],"12).":[211],"whereas":[225],"4":[226],"led":[227,238,303],"changes":[229,305],"significance":[232],"findings.":[234],"Thirteen":[235],"(35%)":[237],"different":[241,252,311],"article,":[247],"3":[248],"(8%)":[249],"showing":[250],"treated;":[256,264],"1":[257],"(3%),":[258],"fewer":[260],"9":[266],"(24%),":[267],"more":[269],"CONCLUSIONS":[274],"RELEVANCE:":[276],"A":[277],"small":[278],"number":[279,322],"have":[284],"been":[285],"date.":[288],"Only":[289],"few":[291],"conducted":[293],"authors.":[297],"Thirty-five":[298],"percent":[299],"findings":[307],"implied":[309],"conclusions":[310],"those":[313]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":8}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}