{"id":"https://openalex.org/W2114594791","doi":"https://doi.org/10.1159/000329132","title":"German Cockroach Proteases and Protease-Activated Receptor-2 Regulate Chemokine Production and Dendritic Cell Recruitment","display_name":"German Cockroach Proteases and Protease-Activated Receptor-2 Regulate Chemokine Production and Dendritic Cell Recruitment","publication_year":2011,"publication_date":"2011-08-29","ids":{"openalex":"https://openalex.org/W2114594791","doi":"https://doi.org/10.1159/000329132","mag":"2114594791","pmid":"https://pubmed.ncbi.nlm.nih.gov/21876326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250658"},"language":"en","primary_location":{"id":"doi:10.1159/000329132","doi":"https://doi.org/10.1159/000329132","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000329132","pdf_url":"https://karger.com/jin/article-pdf/4/1/100/3015144/000329132.pdf","source":{"id":"https://openalex.org/S161267757","display_name":"Journal of Innate Immunity","issn_l":"1662-811X","issn":["1662-811X","1662-8128"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Innate Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://karger.com/jin/article-pdf/4/1/100/3015144/000329132.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075551383","display_name":"Scottie B. Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scottie B. Day","raw_affiliation_strings":["Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA","Divisions of Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Divisions of Critical Care Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109235083","display_name":"John R. Ledford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Ledford","raw_affiliation_strings":["Divisions of Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Critical Care Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074147654","display_name":"Ping Zhou","orcid":"https://orcid.org/0000-0002-1738-2864","observed_orcids":["https://orcid.org/0000-0002-1738-2864","https://orcid.org/0009-0002-0451-9558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Zhou","raw_affiliation_strings":["Divisions of Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Critical Care Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047392866","display_name":"Ian Paul Lewkowich","orcid":"https://orcid.org/0000-0001-8133-3568","observed_orcids":["https://orcid.org/0000-0001-8133-3568"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian P. Lewkowich","raw_affiliation_strings":["Immunobiology, Cincinnati Children\u2019s Hospital Medical Center and Cincinnati Children\u2019s Research Foundation, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology, Cincinnati Children\u2019s Hospital Medical Center and Cincinnati Children\u2019s Research Foundation, and","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109109079","display_name":"Kristen Page","orcid":"https://orcid.org/0009-0001-7642-2264","observed_orcids":["https://orcid.org/0009-0001-7642-2264"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Page","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA","Divisions of Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Divisions of Critical Care Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":2.8377,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89684346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"100","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blattella-germanica","display_name":"Blattella germanica","score":0.9700000286102295},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.781000018119812},{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ccl20","display_name":"CCL20","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dendritic-cell-recruitment","display_name":"dendritic cell recruitment","score":0.7990000247955322},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.828000009059906},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/airway-epithelial-cells","display_name":"airway epithelial cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/allergen-exposure","display_name":"allergen exposure","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8341919779777527},{"id":"https://openalex.org/C109982019","wikidata":"https://www.wikidata.org/wiki/Q2098762","display_name":"Frass","level":3,"score":0.7442173957824707},{"id":"https://openalex.org/C83360876","wikidata":"https://www.wikidata.org/wiki/Q5009615","display_name":"CCL20","level":5,"score":0.6388005018234253},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5447354316711426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5200685858726501},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5023119449615479},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38867899775505066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38057011365890503},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.34990838170051575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3494280278682709},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34455692768096924},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30187249183654785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24003931879997253},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.055321693420410156},{"id":"https://openalex.org/C177756618","wikidata":"https://www.wikidata.org/wiki/Q6527674","display_name":"Lepidoptera genitalia","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020048","descriptor_name":"Blattellidae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054418","descriptor_name":"Chemokine CCL20","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054418","descriptor_name":"Chemokine CCL20","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1159/000329132","doi":"https://doi.org/10.1159/000329132","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000329132","pdf_url":"https://karger.com/jin/article-pdf/4/1/100/3015144/000329132.pdf","source":{"id":"https://openalex.org/S161267757","display_name":"Journal of Innate Immunity","issn_l":"1662-811X","issn":["1662-811X","1662-8128"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Innate Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2509741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3250658","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3250658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Innate Immun","raw_type":"Text"},{"id":"pmid:21876326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21876326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of innate immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1159/000329132","doi":"https://doi.org/10.1159/000329132","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000329132","pdf_url":"https://karger.com/jin/article-pdf/4/1/100/3015144/000329132.pdf","source":{"id":"https://openalex.org/S161267757","display_name":"Journal of Innate Immunity","issn_l":"1662-811X","issn":["1662-811X","1662-8128"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Innate Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3281931338","display_name":null,"funder_award_id":"AR47363","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G359101439","display_name":null,"funder_award_id":"HL075568","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8207665861","display_name":"Cincinnati Rheumatic Disease Core Center","funder_award_id":"P30AR047363","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8585556532","display_name":"Role of cockroach proteases in airway inflammation","funder_award_id":"R01HL075568","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000261979","display_name":null,"funder_award_id":"AR\u201047363","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114594791.pdf","grobid_xml":"https://content.openalex.org/works/W2114594791.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1491240040","https://openalex.org/W1495307817","https://openalex.org/W1500679955","https://openalex.org/W1766627147","https://openalex.org/W1811719059","https://openalex.org/W1968248360","https://openalex.org/W1981253936","https://openalex.org/W1984876912","https://openalex.org/W1985375860","https://openalex.org/W1992800099","https://openalex.org/W2016727408","https://openalex.org/W2019824784","https://openalex.org/W2025662587","https://openalex.org/W2033425354","https://openalex.org/W2034766013","https://openalex.org/W2035532433","https://openalex.org/W2051184495","https://openalex.org/W2053004957","https://openalex.org/W2073439873","https://openalex.org/W2095814247","https://openalex.org/W2096843723","https://openalex.org/W2097057875","https://openalex.org/W2099289777","https://openalex.org/W2100495859","https://openalex.org/W2102739523","https://openalex.org/W2109078794","https://openalex.org/W2112282810","https://openalex.org/W2112612062","https://openalex.org/W2132698003","https://openalex.org/W2138686669","https://openalex.org/W2138927721","https://openalex.org/W2157069655","https://openalex.org/W2158722408","https://openalex.org/W2161357694","https://openalex.org/W2164402028","https://openalex.org/W2170147946"],"related_works":["https://openalex.org/W2080177384","https://openalex.org/W7096855804","https://openalex.org/W1997495128","https://openalex.org/W2136666528","https://openalex.org/W2112612062","https://openalex.org/W1969235413","https://openalex.org/W7098481910","https://openalex.org/W1980307267","https://openalex.org/W7054630755","https://openalex.org/W1985375860"],"abstract_inverted_index":{"We":[0],"recently":[1],"showed":[2],"that":[3,59,139],"serine":[4],"proteases":[5,42,209],"in":[6,30,43,70,76,82,84,99,127,151,162,177,183,195,218,232,241],"German":[7],"cockroach":[8],"(GC)":[9],"feces":[10],"(frass)":[11],"decreased":[12,103,172],"experimental":[13],"asthma":[14],"through":[15,203],"the":[16,31,37,85,120,123,132,140,178,204,219,233,242],"activation":[17,205],"of":[18,33,39,87,90,96,122,174,206,228,244],"protease-activated":[19],"receptor":[20],"(PAR)-2.":[21],"Since":[22],"dendritic":[23],"cells":[24,156],"(DCs)":[25],"play":[26],"an":[27,238],"important":[28,239],"role":[29,38,121,240],"initiation":[32,243],"asthma,":[34],"we":[35,130,169],"queried":[36],"GC":[40,67,92,97,124,135,196],"frass":[41,68,93,98,125,136,197],"modulating":[44],"CCL20":[45,83,115,149,161,214],"(chemokine":[46],"C-C":[47],"motif":[48],"ligand":[49],"20)":[50],"and":[51,78,137,148,160,165,215,235],"granulocyte":[52],"macrophage":[53],"colony-stimulating":[54],"factor":[55],"(GM-CSF)":[56],"production,":[57],"factors":[58],"regulate":[60],"pulmonary":[61],"DCs.":[62],"A":[63,106],"single":[64],"exposure":[65,182],"to":[66,113,144,187,212,223],"resulted":[69],"a":[71,79,163,171],"rapid,":[72],"but":[73],"transient,":[74],"increase":[75,81],"GM-CSF":[77,147,159,216],"steady":[80],"airways":[86],"mice.":[88,189],"Instillation":[89],"protease-depleted":[91],"or":[94],"instillation":[95],"PAR-2-deficient":[100,184],"mice":[101,185],"significantly":[102],"chemokine":[104,128],"release.":[105],"specific":[107],"PAR-2-activating":[108],"peptide":[109],"was":[110,142,192],"also":[111],"sufficient":[112,143,211],"induce":[114,145,213],"production.":[116],"To":[117],"directly":[118],"assess":[119],"protease":[126,133,141],"release,":[129],"enriched":[131],"from":[134],"confirmed":[138],"both":[146,158],"production":[150,217],"vivo.":[152],"Primary":[153],"airway":[154,246],"epithelial":[155],"produced":[157],"protease-":[164],"PAR-2-dependent":[166],"manner.":[167],"Finally,":[168],"show":[170],"percentage":[173],"myeloid":[175,229],"DCs":[176],"lung":[179],"following":[180],"allergen":[181],"compared":[186],"wild-type":[188],"However,":[190],"there":[191],"no":[193],"difference":[194],"uptake.":[198],"Our":[199],"data":[200],"indicate":[201],"that,":[202],"PAR-2,":[207],"allergen-derived":[208],"are":[210],"airways.":[220],"This":[221],"leads":[222],"increased":[224],"recruitment":[225],"and/or":[226],"differentiation":[227],"DC":[230],"populations":[231],"lungs":[234],"likely":[236],"plays":[237],"allergic":[245],"responses.":[247]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}