{"id":"https://openalex.org/W2114593009","doi":"https://doi.org/10.1530/rep-08-0438","title":"Recovery of suppressed male reproduction in mice exposed to progesterone during embryonic development by testosterone","display_name":"Recovery of suppressed male reproduction in mice exposed to progesterone during embryonic development by testosterone","publication_year":2008,"publication_date":"2008-11-28","ids":{"openalex":"https://openalex.org/W2114593009","doi":"https://doi.org/10.1530/rep-08-0438","mag":"2114593009","pmid":"https://pubmed.ncbi.nlm.nih.gov/19042983"},"language":"en","primary_location":{"id":"doi:10.1530/rep-08-0438","doi":"https://doi.org/10.1530/rep-08-0438","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep-08-0438","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/137/3/439.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/137/3/439.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058298845","display_name":"Challa Harini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170558118","display_name":"Sri Venkateswara University","ror":"https://ror.org/05weahn72","country_code":"IN","type":"education","lineage":["https://openalex.org/I170558118"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C Harini","raw_affiliation_strings":["Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","Department of Biotechnology, Sri Venkateswara University, Tirupati, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","institution_ids":["https://openalex.org/I170558118"]},{"raw_affiliation_string":"Department of Biotechnology, Sri Venkateswara University, Tirupati, India","institution_ids":["https://openalex.org/I170558118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008871734","display_name":"S.B. Sainath","orcid":"https://orcid.org/0000-0002-5495-776X","observed_orcids":["https://orcid.org/0000-0002-5495-776X"]},"institutions":[{"id":"https://openalex.org/I170558118","display_name":"Sri Venkateswara University","ror":"https://ror.org/05weahn72","country_code":"IN","type":"education","lineage":["https://openalex.org/I170558118"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S B Sainath","raw_affiliation_strings":["Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","Departments of 1 Biotechnology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","institution_ids":["https://openalex.org/I170558118"]},{"raw_affiliation_string":"Departments of 1 Biotechnology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061045827","display_name":"P. Sreenivasula Reddy","orcid":"https://orcid.org/0000-0002-4174-719X","observed_orcids":["https://orcid.org/0000-0002-4174-719X"]},"institutions":[{"id":"https://openalex.org/I170558118","display_name":"Sri Venkateswara University","ror":"https://ror.org/05weahn72","country_code":"IN","type":"education","lineage":["https://openalex.org/I170558118"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P Sreenivasula Reddy","raw_affiliation_strings":["Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","Zoology, Sri Venkateswara University, Tirupati 517 502, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Biotechnology 2Zoology Sri Venkateswara University, Tirupati 517 502, India","institution_ids":["https://openalex.org/I170558118"]},{"raw_affiliation_string":"Zoology, Sri Venkateswara University, Tirupati 517 502, India","institution_ids":["https://openalex.org/I170558118"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170558118"],"apc_list":null,"apc_paid":null,"fwci":0.2693,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.56199413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"137","issue":"3","first_page":"439","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.1469999998807907,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/testosterone-supplementation","display_name":"testosterone supplementation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sperm-count","display_name":"sperm count","score":0.5580000281333923},{"id":"https://openalex.org/keywords/sperm-membrane-integrity","display_name":"sperm membrane integrity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/testicular-steroidogenesis","display_name":"testicular steroidogenesis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hydroxysteroid-dehydrogenase","display_name":"hydroxysteroid dehydrogenase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fertility-decline","display_name":"fertility decline","score":0.49300000071525574},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.5270000100135803},{"id":"https://openalex.org/keywords/transplacental-exposure","display_name":"transplacental exposure","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7709456086158752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7650032639503479},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6596019864082336},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.6219865679740906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5240709781646729},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.48833152651786804},{"id":"https://openalex.org/C2778054371","wikidata":"https://www.wikidata.org/wiki/Q503431","display_name":"Seminiferous tubule","level":4,"score":0.48670342564582825},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43425649404525757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23363226652145386},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.06377109885215759}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012671","descriptor_name":"Seminiferous Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013076","descriptor_name":"Sperm Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/rep-08-0438","doi":"https://doi.org/10.1530/rep-08-0438","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep-08-0438","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/137/3/439.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:19042983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19042983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1530/rep-08-0438","doi":"https://doi.org/10.1530/rep-08-0438","is_oa":true,"landing_page_url":"https://doi.org/10.1530/rep-08-0438","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/137/3/439.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1218817662","display_name":null,"funder_award_id":"/2005","funder_id":"https://openalex.org/F4320320767","funder_display_name":"University Grants Commission"}],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114593009.pdf","grobid_xml":"https://content.openalex.org/works/W2114593009.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W36972926","https://openalex.org/W63938293","https://openalex.org/W135898729","https://openalex.org/W169184296","https://openalex.org/W270625501","https://openalex.org/W1234520200","https://openalex.org/W1427046507","https://openalex.org/W1479764216","https://openalex.org/W1533653469","https://openalex.org/W1612896483","https://openalex.org/W1640552731","https://openalex.org/W1775749144","https://openalex.org/W1864944252","https://openalex.org/W1867714524","https://openalex.org/W1893651774","https://openalex.org/W1966110694","https://openalex.org/W1967330120","https://openalex.org/W1967936354","https://openalex.org/W1971537607","https://openalex.org/W1972022922","https://openalex.org/W1975857480","https://openalex.org/W1980066996","https://openalex.org/W1984890236","https://openalex.org/W1991473296","https://openalex.org/W1991568351","https://openalex.org/W1993194063","https://openalex.org/W1996284676","https://openalex.org/W1997049000","https://openalex.org/W2000248813","https://openalex.org/W2007497599","https://openalex.org/W2011118373","https://openalex.org/W2025725752","https://openalex.org/W2026254092","https://openalex.org/W2027208794","https://openalex.org/W2028512392","https://openalex.org/W2032412091","https://openalex.org/W2032743237","https://openalex.org/W2035090088","https://openalex.org/W2036231378","https://openalex.org/W2047177978","https://openalex.org/W2050811911","https://openalex.org/W2051886115","https://openalex.org/W2052413474","https://openalex.org/W2056796734","https://openalex.org/W2058636110","https://openalex.org/W2073264207","https://openalex.org/W2074305712","https://openalex.org/W2074884352","https://openalex.org/W2081800082","https://openalex.org/W2081873302","https://openalex.org/W2083131582","https://openalex.org/W2087247861","https://openalex.org/W2089518644","https://openalex.org/W2097371988","https://openalex.org/W2101342713","https://openalex.org/W2109060290","https://openalex.org/W2112856057","https://openalex.org/W2128242453","https://openalex.org/W2146624085","https://openalex.org/W2158938197","https://openalex.org/W2322767049","https://openalex.org/W2333983519","https://openalex.org/W2419340860","https://openalex.org/W2977503837","https://openalex.org/W2980527074","https://openalex.org/W4387992548"],"related_works":["https://openalex.org/W41214939","https://openalex.org/W2024376759","https://openalex.org/W4385804247","https://openalex.org/W2007565235","https://openalex.org/W1612896483","https://openalex.org/W2341306090","https://openalex.org/W2030521516","https://openalex.org/W1988969124","https://openalex.org/W2129686440","https://openalex.org/W1967936354"],"abstract_inverted_index":{"The":[0,38,103,141,183],"present":[1],"study":[2],"aimed":[3],"to":[4,9,28,45,57,131,158,165,208,231,253],"examine":[5],"whether":[6,16],"transplacental":[7],"exposure":[8,56,164,252],"progesterone":[10,58,132,159,166,232,254],"caused":[11,167],"male":[12,39,217,226,256,266],"reproductive":[13,53,73],"abnormalities":[14],"and":[15,34,50,83,115,120,153,175,206,258],"the":[17,139,171,178,223,240,264],"changes":[18],"can":[19],"be":[20,237],"reversed":[21],"after":[22],"testosterone":[23,145,196,243,262],"administration.":[24],"Progesterone":[25],"was":[26,100],"injected":[27],"mice":[29,96,129,156,185,229],"on":[30,201],"day":[31,203],"1,":[32],"3,":[33],"7":[35],"of":[36,106,143,173,180,195,214,225,242,261],"pregnancy.":[37],"pups":[40],"(F1":[41],"generation)":[42],"were":[43],"allowed":[44],"grow":[46],"for":[47,52],"50":[48],"days":[49],"assessed":[51],"performance.":[54],"Gestational":[55],"(7":[59],"mg/kg":[60,198],"body":[61,66,199],"weight)":[62,200],"resulted":[63,211],"in":[64,72,76,87,128,150,155,170,177,212,228,250],"significant":[65,168],"weight":[67],"gain":[68],"with":[69,138,147,188],"a":[70],"decrease":[71],"tissue":[74],"indices":[75],"mice.":[77,89],"Total":[78],"sperm":[79,85,97],"count,":[80],"viable":[81],"sperm,":[82],"motile":[84],"decreased":[86,126,146],"experimental":[88,95,184],"Hypo-osmotic":[90],"swelling":[91],"test":[92],"revealed":[93],"that":[94,186,222,249,259],"membrane":[98],"integrity":[99],"severely":[101],"altered.":[102],"activity":[104],"levels":[105,142],"testicular":[107],"steroidogenic":[108],"marker":[109],"enzymes":[110],"(hydroxy-delta-5-steroid":[111],"dehydrogenase,":[112],"3":[113],"beta-":[114],"steroid":[116],"delta-isomerase":[117],"cluster":[118],"(HSD3B)":[119],"hydroxysteroid":[121],"(17-beta)":[122],"dehydrogenase":[123],"1":[124],"(HSD17B))":[125],"significantly":[127],"exposed":[130,157,230],"during":[133,160,233],"embryonic":[134,161,234],"development":[135,235],"when":[136],"compared":[137],"controls.":[140],"serum":[144,151],"an":[148],"increase":[149,176],"FSH":[152],"LH":[154],"development.":[162],"Prenatal":[163],"reduction":[169],"number":[172],"spermatozoa":[174],"lumen":[179],"seminiferous":[181],"tubule.":[182],"cohabited":[187],"normal":[189],"females":[190],"showed":[191],"fertility":[192],"reduction.":[193],"Administration":[194],"(4.16":[197],"postnatal":[202],"20,":[204],"30,":[205],"40":[207],"progesterone-exposed":[209],"prenates":[210],"recovery":[213],"progesterone-induced":[215],"suppressed":[216,265],"reproduction.":[218,267],"It":[219],"is":[220],"suggested":[221],"impairment":[224],"reproduction":[227,257],"could":[236],"mediated":[238],"through":[239],"inhibition":[241],"production.":[244],"These":[245],"results":[246],"also":[247],"indicate":[248],"utero":[251],"affects":[255],"supplementation":[260],"restores":[263]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}