{"id":"https://openalex.org/W2114590599","doi":"https://doi.org/10.1371/journal.pone.0073496","title":"High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice","display_name":"High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice","publication_year":2013,"publication_date":"2013-09-09","ids":{"openalex":"https://openalex.org/W2114590599","doi":"https://doi.org/10.1371/journal.pone.0073496","mag":"2114590599","pmid":"https://pubmed.ncbi.nlm.nih.gov/24039963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3767788"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0073496","doi":"https://doi.org/10.1371/journal.pone.0073496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0073496","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073496&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073496&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045588828","display_name":"Silvia Gravina","orcid":"https://orcid.org/0000-0001-8558-3142","observed_orcids":["https://orcid.org/0000-0001-8558-3142"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Silvia Gravina","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035765579","display_name":"Martijn E.T. Doll\u00e9","orcid":"https://orcid.org/0000-0001-6137-6544","observed_orcids":["https://orcid.org/0000-0001-6137-6544"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martijn E. T. Doll\u00e9","raw_affiliation_strings":["National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453738","display_name":"Tao Wang","orcid":"https://orcid.org/0009-0009-0015-3756","observed_orcids":["https://orcid.org/0009-0009-0015-3756"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062870063","display_name":"Harry VAN STEEG","orcid":"https://orcid.org/0000-0001-7490-6137","observed_orcids":["https://orcid.org/0000-0001-7490-6137"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Harry van Steeg","raw_affiliation_strings":["National Institute of Public Health and the Environment, Bilthoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020966290","display_name":"Paul Hasty","orcid":"https://orcid.org/0000-0003-3046-0131","observed_orcids":["https://orcid.org/0000-0003-3046-0131"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Hasty","raw_affiliation_strings":["Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052209499","display_name":"Jan H.J. Hoeijmakers","orcid":"https://orcid.org/0000-0003-3526-7795","observed_orcids":["https://orcid.org/0000-0003-3526-7795"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Hoeijmakers","raw_affiliation_strings":["MGC Department of Genetics, CBG Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGC Department of Genetics, CBG Cancer Genomics Center, Erasmus Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012398734","display_name":"Jan Vijg","orcid":"https://orcid.org/0000-0002-8457-9595","observed_orcids":["https://orcid.org/0000-0002-8457-9595"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jan Vijg","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012398734","https://openalex.org/A5045588828"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.562,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62825961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"e73496","last_page":"e73496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9810000061988831},{"id":"https://openalex.org/keywords/imprinted-genes","display_name":"imprinted genes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9670000076293945},{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.7509999871253967},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7820000052452087},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.671999990940094},{"id":"https://openalex.org/keywords/postmitotic-tissues","display_name":"postmitotic tissues","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8783557415008545},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7557079195976257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7317111492156982},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6559479236602783},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.5955483913421631},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5439727902412415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5412726998329163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5139191150665283},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.48426100611686707},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.45864516496658325},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33052968978881836}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0073496","doi":"https://doi.org/10.1371/journal.pone.0073496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0073496","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073496&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2764359","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3767788","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3767788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3767788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24039963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24039963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.9765","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.9765","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0f/2f/pone.0073496.PMC3767788.pdf","raw_type":"text"},{"id":"pmh:eur:oai:repub.eur.nl:60500","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/60500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 8(9)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6829ad199ed34c4b9b7b3a740b352731","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6829ad199ed34c4b9b7b3a740b352731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e73496 (2013)","raw_type":"article"},{"id":"pmh:oai:repub.eur.nl:60500","doi":null,"is_oa":false,"landing_page_url":"http://repub.eur.nl/pub/60500","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE vol. 8 no. 9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:rivm.openrepository.com:10029/647082","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/647082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401814","display_name":"Rivm Repository (Netherlands National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0073496","doi":"https://doi.org/10.1371/journal.pone.0073496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0073496","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073496&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8093415072","display_name":"DNA Repair, Mutations and Cellular Aging","funder_award_id":"P01AG017242","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000265605","display_name":null,"funder_award_id":"AG 17242","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114590599.pdf","grobid_xml":"https://content.openalex.org/works/W2114590599.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1562453891","https://openalex.org/W1985966076","https://openalex.org/W1987297410","https://openalex.org/W2002370374","https://openalex.org/W2003006766","https://openalex.org/W2006287843","https://openalex.org/W2014766736","https://openalex.org/W2017595171","https://openalex.org/W2037846776","https://openalex.org/W2046964473","https://openalex.org/W2050646440","https://openalex.org/W2053901332","https://openalex.org/W2054742531","https://openalex.org/W2067432938","https://openalex.org/W2075744925","https://openalex.org/W2082550660","https://openalex.org/W2085745662","https://openalex.org/W2096107919","https://openalex.org/W2096177579","https://openalex.org/W2098362718","https://openalex.org/W2099042456","https://openalex.org/W2130222411","https://openalex.org/W2133469432","https://openalex.org/W2134555277","https://openalex.org/W2143858605","https://openalex.org/W2149585679","https://openalex.org/W2155447972","https://openalex.org/W2157989003","https://openalex.org/W2170920022","https://openalex.org/W2170970288","https://openalex.org/W2171788646"],"related_works":["https://openalex.org/W2022526122","https://openalex.org/W2123075558","https://openalex.org/W4409000869","https://openalex.org/W1977801544","https://openalex.org/W2149585679","https://openalex.org/W2063803934","https://openalex.org/W2783950301","https://openalex.org/W7098392823","https://openalex.org/W22645164","https://openalex.org/W2793875050"],"abstract_inverted_index":{"A":[0],"gradual":[1],"loss":[2],"of":[3,7,29,44,61,80,88,99,114,149,165,175,183,189],"the":[4,42,45,118,163,203],"correct":[5],"patterning":[6],"5-methyl":[8],"cytosine":[9],"marks":[10,116],"in":[11,18,35,65,69,85,94,121,153,159,186,197],"gene":[12,187],"promoter":[13,86],"regions":[14,87],"has":[15],"been":[16],"implicated":[17],"aging":[19,119,133,151],"and":[20,91,96,101,155,201],"age-related":[21,58,224],"diseases,":[22],"most":[23],"notably":[24],"cancer.":[25],"While":[26],"a":[27,78,110,147,171],"number":[28],"studies":[30],"have":[31],"examined":[32],"DNA":[33,136,141,176,184],"methylation":[34,115,137,177,185],"aging,":[36],"there":[37],"is":[38],"no":[39],"consensus":[40],"on":[41],"magnitude":[43],"effects,":[46],"particularly":[47],"at":[48,162],"imprinted":[49,90,190],"loci.":[50],"Imprinted":[51],"genes":[52,93,191],"are":[53,192,209],"likely":[54,210],"candidate":[55],"to":[56,71,211,214,223],"undergo":[57],"changes":[59,206,225],"because":[60],"their":[62,166],"demonstrated":[63],"plasticity":[64],"utero,":[66],"for":[67],"example,":[68],"response":[70],"environmental":[72],"cues.":[73],"Here":[74],"we":[75,138,169],"quantitatively":[76],"analyzed":[77,139],"total":[79],"100":[81],"individual":[82],"CpG":[83],"sites":[84],"11":[89],"non-imprinted":[92],"liver":[95,154],"cerebral":[97],"cortex":[98],"young":[100],"old":[102],"mice":[103],"using":[104],"mass":[105],"spectrometry.":[106],"The":[107],"results":[108],"indicate":[109],"remarkably":[111],"high":[112,173],"preservation":[113,174],"during":[117],"process":[120],"both":[122],"organs.":[123],"To":[124],"test":[125],"if":[126],"increased":[127],"genotoxic":[128,228],"stress":[129],"associated":[130,218],"with":[131,207,219],"premature":[132,150],"would":[134],"destabilize":[135],"two":[140],"repair":[142],"defective":[143],"mouse":[144],"models":[145],"showing":[146],"host":[148],"symptoms":[152],"brain.":[156],"However,":[157],"also":[158],"these":[160],"animals,":[161],"end":[164],"life":[167],"span,":[168],"found":[170],"similarly":[172],"marks.":[178],"We":[179],"conclude":[180],"that":[181,202],"patterns":[182],"promoters":[188],"surprisingly":[193],"stable":[194],"over":[195],"time":[196],"normal,":[198],"postmitotic":[199],"tissues":[200],"multiple":[204],"documented":[205],"age":[208],"involve":[212],"exceptions":[213],"this":[215],"pattern,":[216],"possibly":[217],"specific":[220],"cellular":[221],"responses":[222],"other":[226],"than":[227],"stress.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}