{"id":"https://openalex.org/W2114587318","doi":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","title":"Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia","display_name":"Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia","publication_year":2000,"publication_date":"2000-06-05","ids":{"openalex":"https://openalex.org/W2114587318","doi":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","mag":"2114587318","pmid":"https://pubmed.ncbi.nlm.nih.gov/10813794"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006874104","display_name":"Urs V. Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urs V. Berger","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","Department of Medicine Brigham and Women's Hospital, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Medicine Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115","Matthias A. Hediger, Membrane Biology Program, Brigham and Women's Hospital, Harvard Institutes of Medicine, Room 570, 77 Ave. Louis Pasteur, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Matthias A. Hediger, Membrane Biology Program, Brigham and Women's Hospital, Harvard Institutes of Medicine, Room 570, 77 Ave. Louis Pasteur, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078842111"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.1643,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.75471698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"421","issue":"3","first_page":"385","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/circumventricular-organs","display_name":"circumventricular organs","score":0.9509999752044678},{"id":"https://openalex.org/keywords/meninges","display_name":"meninges","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/subfornical-organ","display_name":"subfornical organ","score":0.9879999756813049},{"id":"https://openalex.org/keywords/area-postrema","display_name":"area postrema","score":0.8859999775886536},{"id":"https://openalex.org/keywords/subcommissural-organ","display_name":"subcommissural organ","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.890999972820282},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.9190000295639038},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.6700000166893005},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pinealocytes","display_name":"pinealocytes","score":0.6729999780654907},{"id":"https://openalex.org/keywords/glutamate-clearance","display_name":"glutamate clearance","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2777619780","wikidata":"https://www.wikidata.org/wiki/Q205925","display_name":"Circumventricular organs","level":3,"score":0.9114330410957336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8177853226661682},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.6939677596092224},{"id":"https://openalex.org/C2776459250","wikidata":"https://www.wikidata.org/wiki/Q640532","display_name":"Area postrema","level":3,"score":0.6820563077926636},{"id":"https://openalex.org/C2775857624","wikidata":"https://www.wikidata.org/wiki/Q2030058","display_name":"Subfornical organ","level":4,"score":0.6574016213417053},{"id":"https://openalex.org/C202023056","wikidata":"https://www.wikidata.org/wiki/Q3241787","display_name":"Pinealocyte","level":4,"score":0.6187558770179749},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.482869416475296},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.4675043523311615},{"id":"https://openalex.org/C2776403516","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Meninges","level":2,"score":0.45624226331710815},{"id":"https://openalex.org/C2777345201","wikidata":"https://www.wikidata.org/wiki/Q1423193","display_name":"Subcommissural organ","level":2,"score":0.41168057918548584},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39356642961502075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33484387397766113},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3031255006790161},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2949817180633545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2824033498764038},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.0},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008578","descriptor_name":"Meninges","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013356","descriptor_name":"Subfornical Organ","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9861(20000605)421:3<385::aid-cne7>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:10813794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10813794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6046472142","display_name":"MOLECULAR PHYSIOLOGY OF GLUTAMATE TRANSPORT IN THE BRAIN","funder_award_id":"R01NS032001","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1480042661","https://openalex.org/W1555605403","https://openalex.org/W1572795685","https://openalex.org/W1629378997","https://openalex.org/W1819969114","https://openalex.org/W1900227502","https://openalex.org/W1931173751","https://openalex.org/W1960685535","https://openalex.org/W1965902234","https://openalex.org/W1969400861","https://openalex.org/W1976387924","https://openalex.org/W1983197885","https://openalex.org/W1991701465","https://openalex.org/W1993297615","https://openalex.org/W1994773371","https://openalex.org/W1994859828","https://openalex.org/W1998140931","https://openalex.org/W1999613366","https://openalex.org/W2003410399","https://openalex.org/W2003865886","https://openalex.org/W2012487450","https://openalex.org/W2013501686","https://openalex.org/W2015740161","https://openalex.org/W2016332195","https://openalex.org/W2019784159","https://openalex.org/W2021191471","https://openalex.org/W2024908219","https://openalex.org/W2026265399","https://openalex.org/W2030352252","https://openalex.org/W2030468690","https://openalex.org/W2032117600","https://openalex.org/W2034183988","https://openalex.org/W2042671619","https://openalex.org/W2045569188","https://openalex.org/W2050393803","https://openalex.org/W2057832189","https://openalex.org/W2058948754","https://openalex.org/W2067515773","https://openalex.org/W2072078981","https://openalex.org/W2083092470","https://openalex.org/W2085099828","https://openalex.org/W2088893407","https://openalex.org/W2092358916","https://openalex.org/W2094673798","https://openalex.org/W2094996078","https://openalex.org/W2121792692","https://openalex.org/W2126033464","https://openalex.org/W2128744963","https://openalex.org/W2136412714","https://openalex.org/W2143517679","https://openalex.org/W2149497936","https://openalex.org/W2152055169","https://openalex.org/W2157853053","https://openalex.org/W2163314018","https://openalex.org/W2200963979","https://openalex.org/W2207799666","https://openalex.org/W2317733493"],"related_works":["https://openalex.org/W1976130596","https://openalex.org/W1900227502","https://openalex.org/W2143517679","https://openalex.org/W2049382869","https://openalex.org/W2063446664","https://openalex.org/W3156540403","https://openalex.org/W2087268155","https://openalex.org/W2030352252","https://openalex.org/W1974814621","https://openalex.org/W1932504146"],"abstract_inverted_index":{"The":[0,231],"glial":[1],"glutamate":[2,14,225,239],"transporters":[3,106,240],"GLAST":[4,25,94,115,127,150,221],"and":[5,26,39,55,90,113,167,175,208],"GLT-1":[6,27,99,138,183],"are":[7,107],"primarily":[8],"responsible":[9],"for":[10,65],"the":[11,22,30,34,37,41,62,66,70,80,83,87,91,110,120,124,134,144,147,158,172,179,188,192,206,213,223,228,246],"removal":[12],"of":[13,24,33,86,164,205],"from":[15,109],"brain":[16],"extracellular":[17],"fluid.":[18],"This":[19],"study":[20],"compares":[21],"distribution":[23],"expression":[28,63],"in":[29,36,40,51,61,119,157,171,178,191,212,227,245],"circumventricular":[31,73,229],"organs":[32,74],"brain,":[35],"meninges,":[38,207],"dorsal":[42,214],"root":[43,215],"ganglion.":[44,216],"By":[45],"using":[46],"a":[47,162],"highly":[48],"sensitive":[49],"nonisotopic":[50],"situ":[52],"hybridization":[53],"method":[54],"immunostaining,":[56],"we":[57],"demonstrate":[58],"marked":[59],"differences":[60],"patterns":[64],"two":[67,238],"transporters.":[68],"In":[69,123,146],"three":[71],"sensory":[72],"that":[75,220,236],"contain":[76],"neuronal":[77],"elements,":[78],"i.e.,":[79],"subfornical":[81],"organ,":[82],"vascular":[84],"organ":[85],"lamina":[88],"terminalis,":[89],"area":[92],"postrema,":[93],"is":[95,100,117,128,139,151,184,200,222],"strongly":[96],"expressed,":[97],"whereas":[98,137,182],"faintly":[101],"expressed":[102,129,140,153,185,201],"or":[103],"absent.":[104],"Both":[105],"absent":[108],"choroid":[111],"plexus,":[112],"only":[114,186],"mRNA":[116],"found":[118],"subcommisural":[121],"organ.":[122],"pineal":[125,135],"gland,":[126,149],"by":[130,141,154,161,168,176,187,202,209],"astrocytic":[131],"cells":[132,156,166,170,190,211],"near":[133],"stalk,":[136],"pinealocytes":[142],"throughout":[143],"gland.":[145],"pituitary":[148],"likely":[152],"folliculo-stellate":[155],"anterior":[159],"lobe,":[160,174,181],"group":[163],"astrocyte-like":[165,189],"marginal":[169],"intermediate":[173,193],"pituicytes":[177],"posterior":[180],"lobe.":[194],"Finally,":[195],"GLAST,":[196],"but":[197],"not":[198],"GLT-1,":[199],"specific":[203],"layers":[204],"satellite":[210],"These":[217],"results":[218],"show":[219],"primary":[224],"transporter":[226],"organs.":[230],"data":[232],"provide":[233],"further":[234],"evidence":[235],"these":[237],"fulfill":[241],"markedly":[242],"different":[243],"functions":[244],"nervous":[247],"system.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
