{"id":"https://openalex.org/W2114577396","doi":"https://doi.org/10.1113/jphysiol.2012.244517","title":"Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems","display_name":"Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems","publication_year":2013,"publication_date":"2013-02-12","ids":{"openalex":"https://openalex.org/W2114577396","doi":"https://doi.org/10.1113/jphysiol.2012.244517","mag":"2114577396","pmid":"https://pubmed.ncbi.nlm.nih.gov/23401610","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3678037"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2012.244517","doi":"https://doi.org/10.1113/jphysiol.2012.244517","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2012.244517","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3678037","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ming\u2010Yi Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming\u2010Yi Lin","raw_affiliation_strings":["Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064201755","display_name":"Joyce G. Rohan","orcid":"https://orcid.org/0000-0001-5102-6639","observed_orcids":["https://orcid.org/0000-0001-5102-6639"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce G. Rohan","raw_affiliation_strings":["Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California. Los Angeles, CA 90089-2821, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California. Los Angeles, CA 90089-2821, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016491243","display_name":"Haijiang Cai","orcid":"https://orcid.org/0000-0003-3775-903X","observed_orcids":["https://orcid.org/0000-0003-3775-903X"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haijiang Cai","raw_affiliation_strings":["Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA","Dept. of Biology, California Institute of Technology, Pasadena, CA, 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Dept. of Biology, California Institute of Technology, Pasadena, CA, 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053365941","display_name":"Kerstin Reim","orcid":"https://orcid.org/0000-0002-5448-8377","observed_orcids":["https://orcid.org/0000-0002-5448-8377"]},"institutions":[{"id":"https://openalex.org/I4210137682","display_name":"Max Planck Institute of Experimental Medicine","ror":"https://ror.org/04a7f6w43","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210137682","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Reim","raw_affiliation_strings":["Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Str. 3, Goettingen, Germany D-37075"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann-Rein-Str. 3, Goettingen, Germany D-37075","institution_ids":["https://openalex.org/I4210137682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023985201","display_name":"Chien\u2010Ping Ko","orcid":"https://orcid.org/0000-0002-3365-0005","observed_orcids":["https://orcid.org/0000-0002-3365-0005"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chien\u2010Ping Ko","raw_affiliation_strings":["Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064711406","display_name":"Robert Hsiu-Ping Chow","orcid":"https://orcid.org/0000-0002-1322-2070","observed_orcids":["https://orcid.org/0000-0002-1322-2070"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Chow","raw_affiliation_strings":["Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California. Los Angeles, CA 90089-2821, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California. Los Angeles, CA 90089-2821, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":3.0956,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.90545094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"591","issue":"10","first_page":"2463","last_page":"2473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complexin","display_name":"complexin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/complexin-1","display_name":"complexin-1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/calcium-triggered-exocytosis","display_name":"calcium-triggered exocytosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/synaptic-facilitation","display_name":"synaptic facilitation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/synaptic-depression","display_name":"synaptic depression","score":0.7749999761581421},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adrenal-chromaffin-cells","display_name":"adrenal chromaffin cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/calcium-buffering","display_name":"calcium buffering","score":0.7329999804496765},{"id":"https://openalex.org/keywords/vesicle-priming","display_name":"vesicle priming","score":0.9330000281333923},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.7049999833106995},{"id":"https://openalex.org/keywords/virus-rescue","display_name":"virus rescue","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8455912470817566},{"id":"https://openalex.org/C65972015","wikidata":"https://www.wikidata.org/wiki/Q6935634","display_name":"Munc-18","level":5,"score":0.704675018787384},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6654296517372131},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.6521743535995483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5953409075737},{"id":"https://openalex.org/C86473631","wikidata":"https://www.wikidata.org/wiki/Q18031809","display_name":"Synaptotagmin 1","level":5,"score":0.5596804618835449},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4281386137008667},{"id":"https://openalex.org/C53728453","wikidata":"https://www.wikidata.org/wiki/Q18031771","display_name":"STX1A","level":5,"score":0.424969345331192},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37915319204330444},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.29330623149871826},{"id":"https://openalex.org/C2778256703","wikidata":"https://www.wikidata.org/wiki/Q390407","display_name":"Syntaxin","level":4,"score":0.2927706241607666},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.19293388724327087},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18771669268608093},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14723420143127441},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11919108033180237},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019439","descriptor_name":"Chromaffin Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022142","descriptor_name":"Secretory Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1113/jphysiol.2012.244517","doi":"https://doi.org/10.1113/jphysiol.2012.244517","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2012.244517","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3678037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3678037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:23401610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23401610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:39015","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/39015/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:edoc.mpg.de:670193","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/670193","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physiology- London, v.591, 2463-2473 (2013)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_2186878","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002A-537B-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physiology- London","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3678037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3678037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1060378919","display_name":null,"funder_award_id":"DK 60623","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3045482409","display_name":"Insulin granule dynamics in pancreatic beta cells","funder_award_id":"R01DK060623","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3644160995","display_name":"Directed differentiation of human embryonic stem cells into glucose-responsive be","funder_award_id":"K18DK091445","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4000501893","display_name":null,"funder_award_id":"GM85791","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5019998097","display_name":"Synapse Loss in Spinal Muscular Atrophy","funder_award_id":"R21NS063296","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5512972312","display_name":"Imaging the Primed Vesicle Pool: A Novel Tool to Study Vesicle Priming","funder_award_id":"F32GM088967","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5916794957","display_name":null,"funder_award_id":"NS063296","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6555156273","display_name":"MOLECULAR CONTROL OF REGULATED EXOCYTOSIS","funder_award_id":"R01GM085791","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1916164999","https://openalex.org/W1963551844","https://openalex.org/W1963883410","https://openalex.org/W1964008139","https://openalex.org/W1970100121","https://openalex.org/W1971509671","https://openalex.org/W1975194767","https://openalex.org/W1985321331","https://openalex.org/W1986777984","https://openalex.org/W1990057321","https://openalex.org/W1991546697","https://openalex.org/W1994140164","https://openalex.org/W1994265121","https://openalex.org/W1995914589","https://openalex.org/W1998563999","https://openalex.org/W2009639277","https://openalex.org/W2010307853","https://openalex.org/W2011940688","https://openalex.org/W2013341912","https://openalex.org/W2017575945","https://openalex.org/W2021285837","https://openalex.org/W2023695373","https://openalex.org/W2033168611","https://openalex.org/W2038870054","https://openalex.org/W2063253418","https://openalex.org/W2073391931","https://openalex.org/W2073850595","https://openalex.org/W2074263866","https://openalex.org/W2076311985","https://openalex.org/W2083039379","https://openalex.org/W2083063898","https://openalex.org/W2083922554","https://openalex.org/W2091051573","https://openalex.org/W2093077098","https://openalex.org/W2106081526","https://openalex.org/W2115132771","https://openalex.org/W2136363679","https://openalex.org/W2139420483","https://openalex.org/W2151858671","https://openalex.org/W2159145659","https://openalex.org/W2165056042","https://openalex.org/W2165080214","https://openalex.org/W2166019608","https://openalex.org/W2166065571","https://openalex.org/W2168337214"],"related_works":["https://openalex.org/W2107031859","https://openalex.org/W785544367","https://openalex.org/W2520129155","https://openalex.org/W2046031428","https://openalex.org/W2143300213","https://openalex.org/W1986777984","https://openalex.org/W7140384427","https://openalex.org/W4242387325","https://openalex.org/W2074263866","https://openalex.org/W2076311985"],"abstract_inverted_index":{"Key":[0],"points":[1],"Knockout":[2],"(KO)":[3],"of":[4,28,45,57,79,126,139,142,152,164,181,188,196,244,251,272],"complexin":[5],"in":[6,21,23,37,66,121,128,148,219,261,277],"mouse":[7,156],"neuromuscular":[8,157],"junctions":[9,158],"(NMJs)":[10],"and":[11,18,42,93,123,146,169,185,210,214,248,253,268,275,281,300],"adrenal":[12,203],"chromaffin":[13,70,204],"cells":[14],"causes":[15],"a":[16,19,54,216,270],"reduction":[17,56,218],"loss":[20],"synchronicity":[22,250],"calcium\u2010mediated":[24],"exocytosis.":[25,109,154],"A":[26],"train":[27],"high\u2010frequency":[29,175],"stimuli":[30],"induces":[31],"synaptic":[32,172,178,183],"facilitation":[33,46,189],"rather":[34],"than":[35],"depression":[36],"Complexin":[38,67,81,84,86],"1":[39,82,145,166,237,274],"KO":[40,69],"NMJs,":[41],"the":[43,58,63,124,137,186,194,220,225,242,245,249,256,285],"degree":[44,187],"is":[47,53,131,190],"sensitive":[48,192],"to":[49,62,105,114,193,224,284],"calcium":[50,64,94,198,226,301],"buffering.":[51,199],"There":[52],"specific":[55],"vesicle":[59,88,92,221,279,292],"pool":[60,222],"close":[61,223],"channels":[65,227],"2":[68,239,276],"cells,":[71,205],"which":[72],"can":[73],"be":[74],"rescued":[75],"by":[76,294],"heterologous":[77],"expression":[78],"either":[80,115,235],"or":[83,238],"2.":[85],"synchronizes":[87],"release":[89,293],"through":[90],"facilitating":[91,278],"channel":[95],"coupling.":[96],"Abstract":[97],"Complexins":[98],"(Cplxs)":[99],"are":[100,265],"small,":[101],"SNARE\u2010associated":[102],"proteins":[103],"believed":[104],"regulate":[106],"fast,":[107],"calcium\u2010triggered":[108,171],"However,":[110],"studies":[111],"have":[112],"pointed":[113],"an":[116],"inhibitory":[117],"and/or":[118],"facilitatory":[119],"role":[120,125,271],"exocytosis,":[122],"Cplxs":[127,289],"synchronizing":[129],"exocytosis":[130],"relatively":[132],"unexplored.":[133],"Here,":[134],"we":[135,160,206],"compare":[136],"function":[138],"two":[140,149,262],"types":[141],"complexin,":[143],"Cplx":[144,165,201,236,273],"2,":[147],"model":[150,263],"systems":[151,264],"calcium\u2010dependent":[153],"In":[155,200],"(NMJs),":[159],"find":[161,208],"that":[162,288],"lack":[163],"significantly":[167],"reduces":[168],"desynchronizes":[170],"transmission;":[173],"furthermore,":[174],"stimulation":[176],"elicits":[177],"facilitation,":[179],"instead":[180],"normal":[182],"depression,":[184],"highly":[191],"amount":[195],"cytoplasmic":[197],"2\u2010null":[202],"also":[207,282],"decreased":[209],"desynchronized":[211],"evoked":[212,246],"release,":[213,252],"identify":[215],"significant":[217],"(immediately":[228],"releasable":[229],"pool,":[230],"IRP).":[231],"Viral":[232],"transduction":[233],"with":[234],"rescues":[240],"both":[241],"size":[243],"response":[247],"it":[254],"restores":[255],"IRP":[257],"size.":[258],"Our":[259],"findings":[260],"mutually":[266],"compatible":[267],"indicate":[269],"priming,":[280],"lead":[283],"new":[286],"hypothesis":[287],"may":[290],"synchronize":[291],"promoting":[295],"coupling":[296],"between":[297],"secretory":[298],"vesicles":[299],"channels.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
