{"id":"https://openalex.org/W2114319271","doi":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","title":"Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells","display_name":"Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells","publication_year":2010,"publication_date":"2010-03-26","ids":{"openalex":"https://openalex.org/W2114319271","doi":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","mag":"2114319271","pmid":"https://pubmed.ncbi.nlm.nih.gov/20456365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8094740"},"language":"en","primary_location":{"id":"doi:10.1111/j.1750-3639.2010.00399.x","doi":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8094740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083269453","display_name":"Hema Mohan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]},{"id":"https://openalex.org/I4405261172","display_name":"Institut f\u00fcr Klinische Neuroimmunologie","ror":"https://ror.org/04x6wax64","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261172","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hema Mohan","raw_affiliation_strings":["Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany","Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany","institution_ids":["https://openalex.org/I4405261172","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071258405","display_name":"Markus Krumbholz","orcid":"https://orcid.org/0000-0003-0902-6517","observed_orcids":["https://orcid.org/0000-0003-0902-6517"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Krumbholz","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100660474","display_name":"Rakhi Dey Sharma","orcid":"https://orcid.org/0000-0002-1184-5311","observed_orcids":["https://orcid.org/0000-0002-1184-5311"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","GB"],"is_corresponding":false,"raw_author_name":"Rakhi Sharma","raw_affiliation_strings":["[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I45129253","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020955875","display_name":"Sylvia C. Eisele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvia Eisele","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069736561","display_name":"Andreas Junker","orcid":"https://orcid.org/0000-0002-8063-9765","observed_orcids":["https://orcid.org/0000-0002-8063-9765"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Junker","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015575955","display_name":"Michael Sixt","orcid":"https://orcid.org/0000-0002-6620-9179","observed_orcids":["https://orcid.org/0000-0002-6620-9179"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","GB"],"is_corresponding":false,"raw_author_name":"Michael Sixt","raw_affiliation_strings":["[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I45129253","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057464823","display_name":"Jia Newcombe","orcid":"https://orcid.org/0000-0001-9609-7975","observed_orcids":["https://orcid.org/0000-0001-9609-7975"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","GB"],"is_corresponding":false,"raw_author_name":"Jia Newcombe","raw_affiliation_strings":["[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I45129253","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082308405","display_name":"Hartmut Wekerle","orcid":"https://orcid.org/0000-0002-8669-2954","observed_orcids":["https://orcid.org/0000-0002-8669-2954"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Wekerle","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028689651","display_name":"Reinhard Hohlfeld","orcid":"https://orcid.org/0000-0002-6302-1488","observed_orcids":["https://orcid.org/0000-0002-6302-1488"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Hohlfeld","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050861407","display_name":"Hans Lassmann","orcid":"https://orcid.org/0000-0001-8617-5052","observed_orcids":["https://orcid.org/0000-0001-8617-5052"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","GB"],"is_corresponding":false,"raw_author_name":"Hans Lassmann","raw_affiliation_strings":["[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Sixt, Michael] Max Planck Inst Biochem, Dept Mol Med, D-8033 Martinsried, Germany.; [Sharma, Rakhi; Lassmann, Hans] Med Univ Vienna, Ctr Brain Res, Vienna, Austria.; [Newcombe, Jia] UCL Inst Neurol, London, England","institution_ids":["https://openalex.org/I4210150093","https://openalex.org/I45129253","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028837006","display_name":"Edgar Meinl","orcid":"https://orcid.org/0000-0002-2570-6785","observed_orcids":["https://orcid.org/0000-0002-2570-6785"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210139319","display_name":"Max Planck Institute of Neurobiology","ror":"https://ror.org/03ap2av50","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210139319","https://openalex.org/I4387153642"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edgar Meinl","raw_affiliation_strings":["Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210139319"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":5.5574,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.96493061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"20","issue":"5","first_page":"966","last_page":"975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fibrillar-collagen","display_name":"fibrillar collagen","score":0.8830000162124634},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.8209999799728394},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-v-collagen","display_name":"type V collagen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.9890000224113464},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":1.0},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/glia-limitans","display_name":"glia limitans","score":0.7829999923706055},{"id":"https://openalex.org/keywords/infiltrating-immune-cells","display_name":"infiltrating immune cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemokine-production","display_name":"chemokine production","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lesion-activity","display_name":"lesion activity","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.9515469074249268},{"id":"https://openalex.org/C2778916964","wikidata":"https://www.wikidata.org/wiki/Q14905499","display_name":"Biglycan","level":5,"score":0.9003701210021973},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7291615009307861},{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.6483213305473328},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5447718501091003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5261791944503784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4796312749385834},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4372623562812805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40257903933525085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3387134075164795},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24722382426261902},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.1713266670703888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12326455116271973}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024022","descriptor_name":"Fibrillar Collagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058575","descriptor_name":"Decorin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058575","descriptor_name":"Decorin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058578","descriptor_name":"Biglycan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058578","descriptor_name":"Biglycan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1111/j.1750-3639.2010.00399.x","doi":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2010.00399.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8094740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8094740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},{"id":"pmid:20456365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20456365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain pathology (Zurich, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:493355","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/493355","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Pathology, v.20, 966-975 (2010)","raw_type":"Article"},{"id":"pmh:oai:edoc.mpg.de:493377","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/493377","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Pathology, v.20, 966-975 (2010)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1372178","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1372178/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BRAIN PATHOLOGY , 20 (5) pp. 966-975. (2010)","raw_type":"Article"},{"id":"pmh:oai:escidoc.org:escidoc:1130008","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0012-1F70-1","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1130008","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0012-1F70-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Pathology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1578762","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0010-55E7-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Pathology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8094740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8094740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W61719800","https://openalex.org/W576112343","https://openalex.org/W1593681077","https://openalex.org/W1636889788","https://openalex.org/W1913314522","https://openalex.org/W1965691708","https://openalex.org/W1970026337","https://openalex.org/W1974815300","https://openalex.org/W1975219368","https://openalex.org/W1975453736","https://openalex.org/W1977200209","https://openalex.org/W1978636950","https://openalex.org/W1979543876","https://openalex.org/W1987383242","https://openalex.org/W1989045342","https://openalex.org/W1996266076","https://openalex.org/W1999035675","https://openalex.org/W2001314174","https://openalex.org/W2001741486","https://openalex.org/W2002509647","https://openalex.org/W2006188134","https://openalex.org/W2017704712","https://openalex.org/W2025118259","https://openalex.org/W2025990173","https://openalex.org/W2027830942","https://openalex.org/W2027892036","https://openalex.org/W2028883349","https://openalex.org/W2032039569","https://openalex.org/W2034656098","https://openalex.org/W2034781062","https://openalex.org/W2039719564","https://openalex.org/W2040634082","https://openalex.org/W2046329404","https://openalex.org/W2055114143","https://openalex.org/W2057181320","https://openalex.org/W2058852699","https://openalex.org/W2060431203","https://openalex.org/W2060544102","https://openalex.org/W2061631515","https://openalex.org/W2066556226","https://openalex.org/W2066855129","https://openalex.org/W2067810471","https://openalex.org/W2070013317","https://openalex.org/W2071684114","https://openalex.org/W2072164463","https://openalex.org/W2084693759","https://openalex.org/W2084926626","https://openalex.org/W2086237072","https://openalex.org/W2094795539","https://openalex.org/W2108005154","https://openalex.org/W2116495710","https://openalex.org/W2122808924","https://openalex.org/W2130983270","https://openalex.org/W2132290892","https://openalex.org/W2144985870","https://openalex.org/W2154793195","https://openalex.org/W2158829691","https://openalex.org/W2341009032","https://openalex.org/W4300041622"],"related_works":["https://openalex.org/W853255157","https://openalex.org/W1558223250","https://openalex.org/W7140246006","https://openalex.org/W1700742133","https://openalex.org/W2037725018","https://openalex.org/W2106584208","https://openalex.org/W2002566288","https://openalex.org/W61719800","https://openalex.org/W4391026920","https://openalex.org/W2038782830"],"abstract_inverted_index":{"Extracellular":[0],"matrix":[1],"(ECM)":[2],"proteins":[3,177],"can":[4,89],"modify":[5],"immune":[6,19,128,164],"reactions,":[7],"e.g.":[8],"by":[9,16,26,195,201],"sequestering":[10],"or":[11],"displaying":[12],"growth":[13],"factors":[14],"and":[15,20,37,47,55,64,79,86,101,109,146,176],"interacting":[17],"with":[18,126,171],"glial":[21],"cells.":[22,129,165],"Here":[23],"we":[24],"quantified":[25,175],"quantitative":[27],"polymerase":[28],"chain":[29],"reaction":[30],"(qPCR)":[31],"expression":[32],"of":[33,154,163,192,199],"50":[34],"ECM":[35,39,167],"components":[36],"34":[38],"degrading":[40],"enzymes":[41],"in":[42,61,67,113,138,149,161,169],"multiple":[43],"sclerosis":[44],"(MS)":[45],"active":[46,62,131],"inactive":[48,68],"white":[49],"matter":[50],"lesions.":[51,69],"COL1A1,":[52],"COL3A1,":[53],"COL5A1":[54],"COL5A2":[56],"chains":[57,71],"were":[58,93,103,174,182],"induced":[59,95],"strongly":[60],"lesions":[63,132,170,194],"even":[65],"more":[66],"These":[70],"interact":[72],"to":[73,189],"form":[74],"collagen":[75,133],"types":[76],"I,":[77],"III":[78,147],"V,":[80],"which":[81,88,122],"are":[82],"fibrillar":[83,91,98,185],"collagens.":[84],"Biglycan":[85],"decorin,":[87],"decorate":[90],"collagens,":[92,99],"also":[94,136],"strongly.":[96],"The":[97],"biglycan":[100],"decorin":[102],"largely":[104],"found":[105],"between":[106],"the":[107,114,139,197],"endothelium":[108],"astrocytic":[110],"glia":[111],"limitans":[112],"perivascular":[115,180],"space":[116],"where":[117],"they":[118],"formed":[119],"a":[120,179],"meshwork":[121],"was":[123,135],"closely":[124],"associated":[125],"infiltrating":[127],"In":[130],"V":[134],"seen":[137],"heavily":[140],"infiltrated":[141],"parenchyma.":[142],"Fibrillar":[143],"collagens":[144,186],"I":[145],"inhibited":[148],"vitro":[150],"human":[151],"monocyte":[152],"production":[153,198],"CCL2":[155,200],"(MCP-1),":[156],"an":[157],"inflammatory":[158],"chemokine":[159],"involved":[160],"recruitment":[162],"Together,":[166],"changes":[168],"different":[172],"activities":[173],"forming":[178],"fibrosis":[181],"identified.":[183],"Induced":[184],"may":[187],"contribute":[188],"limiting":[190],"enlargement":[191],"MS":[193],"inhibiting":[196],"monocytes.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
