{"id":"https://openalex.org/W2114306641","doi":"https://doi.org/10.1080/01902140150216774","title":"DIFFERENTIAL SENSITIVITY TO LUNG TUMORIGENESIS FOLLOWING TRANSPLACENTAL EXPOSURE OF MICE TO POLYCYCLIC HYDROCARBONS, HETEROCYCLIC AMINES, AND LUNG TUMOR PROMOTERS","display_name":"DIFFERENTIAL SENSITIVITY TO LUNG TUMORIGENESIS FOLLOWING TRANSPLACENTAL EXPOSURE OF MICE TO POLYCYCLIC HYDROCARBONS, HETEROCYCLIC AMINES, AND LUNG TUMOR PROMOTERS","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2114306641","doi":"https://doi.org/10.1080/01902140150216774","mag":"2114306641","pmid":"https://pubmed.ncbi.nlm.nih.gov/11195466"},"language":"en","primary_location":{"id":"doi:10.1080/01902140150216774","doi":"https://doi.org/10.1080/01902140150216774","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902140150216774","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032241792","display_name":"Mark Steven Miller","orcid":"https://orcid.org/0000-0003-1191-0977","observed_orcids":["https://orcid.org/0000-0003-1191-0977"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Steven Miller","raw_affiliation_strings":["Departments of Cancer Biology and Physiology and Pharmacology Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1082, USA. msmiller@wfubmc.edu","Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology and Physiology and Pharmacology Comprehensive Cancer Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1082, USA. msmiller@wfubmc.edu","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054755442","display_name":"Kiersten M. Gressani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiersten M. Gressani","raw_affiliation_strings":["Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058977741","display_name":"Sandra Leone\u2010Kabler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Leone-Kabler","raw_affiliation_strings":["Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103759925","display_name":"Alan J. Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan J. Townsend","raw_affiliation_strings":["Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085283368","display_name":"Alvin M. Malkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvin M. Malkinson","raw_affiliation_strings":["Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087054051","display_name":"M. Gerard O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-9627-8431","observed_orcids":["https://orcid.org/0000-0002-9627-8431"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gerard O'Sullivan","raw_affiliation_strings":["Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmen ts of Can cer Biology an d Physiolog y an d Pharmacology Comprehen siv e Can cer Cen ter, Wake Forest Un iv ersity School of Medicin e, Win ston -Salem, North Carolin a, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8154,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71832781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"26","issue":"8","first_page":"709","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transplacental-carcinogenesis","display_name":"transplacental carcinogenesis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.921999990940094},{"id":"https://openalex.org/keywords/butylated-hydroxytoluene","display_name":"butylated hydroxytoluene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/2-amino-3-methylimidazo-4-5-f-quinoline","display_name":"2-amino-3-methylimidazo[4,5-f]quinoline","score":0.9440000057220459},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9700000286102295},{"id":"https://openalex.org/keywords/polycyclic-hydrocarbons","display_name":"polycyclic hydrocarbons","score":0.8629999756813049},{"id":"https://openalex.org/keywords/strain-dependent-susceptibility","display_name":"strain-dependent susceptibility","score":0.4959999918937683},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ki-ras-mutation","display_name":"Ki-ras mutation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.9810000061988831},{"id":"https://openalex.org/keywords/transversions","display_name":"transversions","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6961800456047058},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6627715229988098},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6009917855262756},{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.5980268120765686},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.5703259706497192},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4555072784423828},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.446493536233902},{"id":"https://openalex.org/C3018373657","wikidata":"https://www.wikidata.org/wiki/Q15124212","display_name":"Lung tumor","level":3,"score":0.436848908662796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4357950687408447},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.4266822338104248},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3865562975406647},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3756556808948517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37072718143463135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3321724534034729},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.323899507522583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2888973355293274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2050599753856659},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15234121680259705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14091387391090393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12258493900299072},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08442267775535583},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002084","descriptor_name":"Butylated Hydroxytoluene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002084","descriptor_name":"Butylated Hydroxytoluene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006912","descriptor_name":"Hydroxyquinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006912","descriptor_name":"Hydroxyquinolines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065633","descriptor_name":"Cytochrome P-450 CYP1B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/01902140150216774","doi":"https://doi.org/10.1080/01902140150216774","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902140150216774","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},{"id":"pmid:11195466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11195466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental lung research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4549591285","display_name":null,"funder_award_id":"R01 ES06501","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4690964154","display_name":null,"funder_award_id":"R01 ES08252","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G572449272","display_name":"ONCOGENES AND TRANSPLACENTAL CARCINOGENESIS","funder_award_id":"5r01es006501-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6943580745","display_name":"TRANSPLACENTAL CARCINOGENESIS OF HETEROCYCLIC AMINES","funder_award_id":"5r01es008252-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W84924379","https://openalex.org/W124095406","https://openalex.org/W143753117","https://openalex.org/W184194036","https://openalex.org/W1495525337","https://openalex.org/W1552426876","https://openalex.org/W1556164808","https://openalex.org/W1570847980","https://openalex.org/W1572023108","https://openalex.org/W1587749323","https://openalex.org/W1588528213","https://openalex.org/W1601604261","https://openalex.org/W1606893105","https://openalex.org/W1622943804","https://openalex.org/W1917370654","https://openalex.org/W1963488394","https://openalex.org/W1966009456","https://openalex.org/W1973886069","https://openalex.org/W1976128207","https://openalex.org/W1994800122","https://openalex.org/W1998778159","https://openalex.org/W1999674407","https://openalex.org/W2008151171","https://openalex.org/W2010161197","https://openalex.org/W2012425194","https://openalex.org/W2020300122","https://openalex.org/W2032198484","https://openalex.org/W2035037271","https://openalex.org/W2040900367","https://openalex.org/W2044066148","https://openalex.org/W2050514222","https://openalex.org/W2054066440","https://openalex.org/W2056166014","https://openalex.org/W2056920355","https://openalex.org/W2058298987","https://openalex.org/W2061582559","https://openalex.org/W2063043104","https://openalex.org/W2063852293","https://openalex.org/W2065572118","https://openalex.org/W2065918390","https://openalex.org/W2070333386","https://openalex.org/W2074512495","https://openalex.org/W2080666697","https://openalex.org/W2083578682","https://openalex.org/W2094473066","https://openalex.org/W2096215586","https://openalex.org/W2098911357","https://openalex.org/W2099214741","https://openalex.org/W2105007573","https://openalex.org/W2108461262","https://openalex.org/W2108745635","https://openalex.org/W2109063774","https://openalex.org/W2110511887","https://openalex.org/W2112568180","https://openalex.org/W2114281295","https://openalex.org/W2114311365","https://openalex.org/W2123019895","https://openalex.org/W2127804313","https://openalex.org/W2130198345","https://openalex.org/W2132087000","https://openalex.org/W2136422121","https://openalex.org/W2138748933","https://openalex.org/W2139234269","https://openalex.org/W2155490352","https://openalex.org/W2157928275","https://openalex.org/W2158097856","https://openalex.org/W2163650802","https://openalex.org/W2165150104","https://openalex.org/W2171030901","https://openalex.org/W2172248787","https://openalex.org/W2185991677","https://openalex.org/W2254720813","https://openalex.org/W2257427816","https://openalex.org/W2282423754","https://openalex.org/W2320138981","https://openalex.org/W2337201809","https://openalex.org/W2405588637","https://openalex.org/W2409978532","https://openalex.org/W2414701338","https://openalex.org/W2416789851","https://openalex.org/W2427003367","https://openalex.org/W4231223004"],"related_works":["https://openalex.org/W2012425194","https://openalex.org/W1981433654","https://openalex.org/W1998778159","https://openalex.org/W2029291103","https://openalex.org/W2108745635","https://openalex.org/W2132087000","https://openalex.org/W2104512196","https://openalex.org/W1969962763","https://openalex.org/W2158097856","https://openalex.org/W2109063774"],"abstract_inverted_index":{"Research":[0],"conducted":[1],"by":[2],"this":[3,38],"laboratory":[4],"over":[5],"the":[6,11,15,26,47,54,66,74,77,81,117,166,174,188,235,262,327],"past":[7],"decade":[8],"has":[9],"demonstrated":[10,149,243],"high":[12],"susceptibility":[13,337],"of":[14,25,32,49,71,76,80,96,102,104,110,131,139,153,173,238,269],"fetus":[16],"to":[17,34,233,307,338],"lung":[18,55,62,97,133,147,278,316,339],"tumor":[19,56,63,157,206,226,340],"formation":[20,64],"following":[21],"in":[22,65,86,100,116,128,141,165,176,185,194,213,217,240,261,276,318,326],"utero":[23,218],"exposure":[24],"resistant":[27,87,118,322],"C57BL/6":[28],"and":[29,51,73,108,171,181,190,279,321],"DBA/2N":[30],"strains":[31],"mice":[33,91,105,178,215,242],"3-methylcholanthrene":[35],"(MC).":[36],"In":[37],"review,":[39],"we":[40],"describe":[41],"our":[42],"more":[43],"recent":[44],"studies":[45],"on":[46,61,205],"effects":[48],"MC":[50],"cotreatment":[52],"with":[53,106,136,156,187,219,334],"promoter,":[57],"butylated":[58],"hydroxytoluene":[59],"(BHT),":[60],"intermediately":[67],"susceptible":[68],"BALB/c":[69,90,132,146,177,214],"strain":[70],"mice,":[72],"determination":[75],"potential":[78],"carcinogenicity":[79,237],"heterocyclic":[82],"amine,":[83],"2-amino-3-methylimidazo[4,5-f]quinoline":[84],"(IQ)":[85],"mouse":[88],"strains.":[89,323],"showed":[92],"a":[93,150,160,222,310],"similar":[94,151],"incidence":[95,138],"tumors,":[98],"both":[99,319],"terms":[101],"percentage":[103],"tumors":[107,111,258],"number":[109],"per":[112],"mouse,":[113],"as":[114],"found":[115,127,260],"[D2":[119,142,195],"x":[120,143,196],"B6D2F1]F2":[121,144,197],"mice.":[122,145,198],"Ki-ras":[123,154,210,308,328],"point":[124],"mutations":[125,155],"were":[126,259],"56%":[129],"(20/36)":[130],"lesions":[134,148,175],"compared":[135],"an":[137,296],"79%":[140],"association":[152],"stage.":[158],"Interestingly,":[159],"strain-dependent":[161],"difference":[162],"was":[163,228,267],"observed":[164,193],"mutational":[167,211,329],"spectrum,":[168],"where":[169],"62%":[170],"38%":[172],"exhibited":[179],"G-->C":[180],"G-->T":[182],"transversions,":[183],"respectively,":[184],"contrast":[186],"16%":[189],"84%":[191],"incidences":[192],"BHT":[199],"had":[200],"no":[201,249],"statistically":[202],"significant":[203],"effect":[204],"incidence,":[207],"multiplicity,":[208],"or":[209,251,256,272],"spectrum":[212,330],"treated":[216,264],"MC,":[220],"although":[221],"trend":[223],"toward":[224],"increased":[225],"multiplicity":[227],"observed.":[229,282],"Finally,":[230],"experiments":[231],"initiated":[232],"assess":[234],"transplacental":[236,298],"IQ":[239,292],"D2B6F1":[241],"that":[244,285,304],"1":[245],"year":[246],"after":[247],"birth,":[248],"macroscopically":[250],"microscopically":[252],"visible":[253],"liver,":[254],"lung,":[255],"colon":[257],"transplacentally":[263],"offspring,":[265],"nor":[266],"induction":[268],"Cyp1a1,":[270],"Cyp1b1,":[271],"glutathione":[273],"S-transferases":[274],"(GSTs)":[275],"fetal":[277],"liver":[280],"tissues":[281],"This":[283],"implies":[284],"at":[286],"least":[287],"under":[288],"these":[289,301],"experimental":[290],"conditions,":[291],"may":[293,331],"not":[294],"be":[295,332],"important":[297],"carcinogen.":[299],"Overall,":[300],"data":[302],"demonstrate":[303],"mutagenic":[305],"damage":[306],"is":[309],"critical":[311],"early":[312],"event":[313],"mediating":[314],"murine":[315],"tumorigenesis":[317],"sensitive":[320],"Strain-dependent":[324],"differences":[325],"associated":[333],"their":[335],"differential":[336],"initiation.":[341]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}