{"id":"https://openalex.org/W2114295374","doi":"https://doi.org/10.2337/diab.44.9.1093","title":"Isolation, Characterization, and Metabolism of the Glycated and Nonglycated Subfractions of Low-Density Lipoproteins Isolated from Type I Diabetic Patients and Nondiabetic Subjects","display_name":"Isolation, Characterization, and Metabolism of the Glycated and Nonglycated Subfractions of Low-Density Lipoproteins Isolated from Type I Diabetic Patients and Nondiabetic Subjects","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2114295374","doi":"https://doi.org/10.2337/diab.44.9.1093","mag":"2114295374","pmid":"https://pubmed.ncbi.nlm.nih.gov/7657034"},"language":"en","primary_location":{"id":"doi:10.2337/diab.44.9.1093","doi":"https://doi.org/10.2337/diab.44.9.1093","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.44.9.1093","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064715409","display_name":"Richard L. Klein","orcid":"https://orcid.org/0000-0002-0316-206X","observed_orcids":["https://orcid.org/0000-0002-0316-206X"]},"institutions":[{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L Klein","raw_affiliation_strings":["Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina","institution_ids":["https://openalex.org/I4210132004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034048983","display_name":"Marta Laimins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Laimins","raw_affiliation_strings":["Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina","institution_ids":["https://openalex.org/I4210132004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046063952","display_name":"Maria Fernanda Lopes-Virella","orcid":"https://orcid.org/0000-0001-5572-1700","observed_orcids":["https://orcid.org/0000-0001-5572-1700"]},"institutions":[{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria F Lopes-Virella","raw_affiliation_strings":["Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center\u2008Charleston, South Carolina","institution_ids":["https://openalex.org/I4210132004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210132004"],"apc_list":null,"apc_paid":null,"fwci":1.6969,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.8224261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"44","issue":"9","first_page":"1093","last_page":"1098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.45170000195503235,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.3718000054359436,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glycated-ldl","display_name":"glycated LDL","score":0.7419999837875366},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ldl-subfractions","display_name":"LDL subfractions","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ldl-metabolism","display_name":"LDL metabolism","score":0.5789999961853027},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.7039999961853027},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7609999775886536},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9660000205039978},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lipoprotein-degradation","display_name":"lipoprotein degradation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7663695812225342},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7518213391304016},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.6425058841705322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5426204204559326},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.5272554159164429},{"id":"https://openalex.org/C2776448209","wikidata":"https://www.wikidata.org/wiki/Q415555","display_name":"Cholesteryl ester","level":4,"score":0.5269466042518616},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5085011720657349},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5072488188743591},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48654142022132874},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45625054836273193},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4194953739643097},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4136420786380768},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.35447216033935547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2706138491630554}],"mesh":[{"descriptor_ui":"D000093844","descriptor_name":"Glycated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015243","descriptor_name":"Cholesterol, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.44.9.1093","doi":"https://doi.org/10.2337/diab.44.9.1093","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.44.9.1093","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.44.9.1093","doi":"https://doi.org/10.2337/diabetes.44.9.1093","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.44.9.1093","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:7657034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7657034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977585909","https://openalex.org/W2143572560","https://openalex.org/W1998854540","https://openalex.org/W2021402439","https://openalex.org/W2054450462","https://openalex.org/W2411624128","https://openalex.org/W2029739899","https://openalex.org/W2400574566","https://openalex.org/W2376285096","https://openalex.org/W1575630143"],"abstract_inverted_index":{"The":[0,20,90],"total":[1,48],"low-density":[2],"lipoprotein":[3],"(LDL)":[4],"fraction":[5],"was":[6,22,66,86,96],"isolated":[7,58,72,78,129,166],"from":[8,59,73,79,130,167,192],"21":[9],"patients":[10,52,62,82,135],"with":[11,155,211],"type":[12],"I":[13],"diabetes":[14],"and":[15,30,42,53,63,83,94,108,133],"7":[16],"nondiabetic":[17],"normolipemic":[18],"subjects.":[19],"LDL":[21,49,106,151,207],"separated":[23],"into":[24],"two":[25],"subfractions,":[26],"one":[27,31],"glycated":[28,69],"(G-LDL)":[29],"nonglycated":[32],"(N-LDL),":[33],"using":[34],"affinity":[35],"chromatography.":[36],"G-LDL":[37,57,77,95,165,184],"comprised":[38],"21.1":[39],"+/-":[40,44],"3.6":[41],"5.2":[43],"0.6%":[45],"of":[46,92,124,127,144,161,164,178,181,183,194],"the":[47,74,104,122,149,159],"in":[50,88,98,109],"diabetic":[51,61,81,134],"normal":[54,64,84,131],"subjects,":[55],"respectively.":[56],"both":[60,80,168],"subjects":[65,85,132],"significantly":[67,137,171,190],"more":[68],"than":[70,142,176],"N-LDL":[71,93,128,195],"same":[75,150],"subject.":[76],"enriched":[87],"triglycerides.":[89],"metabolism":[91],"investigated":[97],"human":[99,110,156,186],"fibroblasts,":[100,121],"which":[101,113],"express":[102,115],"only":[103],"classical":[105],"receptor,":[107],"monocyte-derived":[111,157],"macrophages,":[112,158],"also":[114],"a":[116],"receptor":[117],"for":[118,213],"G-LDL.":[119,145],"In":[120,146],"rates":[123,160],"receptor-mediated":[125,162],"accumulation":[126,163],"were":[136,153,170,188,209],"greater":[138,172],"(P":[139,173,203],"<":[140,174,204],"0.01)":[141,175],"those":[143,177,193],"contrast,":[147],"when":[148,206],"subfractions":[152,208],"incubated":[154,210],"groups":[169],"N-LDL.":[179],"Rates":[180],"degradation":[182],"by":[185],"macrophages":[187],"not":[189],"different":[191],"during":[196],"short-term":[197],"incubations":[198],"but":[199],"reached":[200],"statistical":[201],"significance":[202],"0.05)":[205],"cells":[212],"24":[214],"h.(ABSTRACT":[215],"TRUNCATED":[216],"AT":[217],"250":[218],"WORDS)":[219]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
