{"id":"https://openalex.org/W2114266263","doi":"https://doi.org/10.1093/cvr/cvm002","title":"t-tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes","display_name":"t-tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes","publication_year":2007,"publication_date":"2007-08-14","ids":{"openalex":"https://openalex.org/W2114266263","doi":"https://doi.org/10.1093/cvr/cvm002","mag":"2114266263","pmid":"https://pubmed.ncbi.nlm.nih.gov/18006490"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvm002","doi":"https://doi.org/10.1093/cvr/cvm002","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvm002","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080513991","display_name":"Clive H. Orchard","orcid":"https://orcid.org/0000-0001-7714-5900","observed_orcids":["https://orcid.org/0000-0001-7714-5900"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"C. Orchard","raw_affiliation_strings":["Department of Physiology, University of Bristol, Bristol, BS8 1TD, UK. clive.orchard@bristol.ac.uk","Department of Physiology, University of Bristol, Bristol, BS8 1TD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Bristol, Bristol, BS8 1TD, UK. clive.orchard@bristol.ac.uk","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Physiology, University of Bristol, Bristol, BS8 1TD, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078489757","display_name":"Fabien Brette","orcid":"https://orcid.org/0000-0002-5406-4531","observed_orcids":["https://orcid.org/0000-0002-5406-4531"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Brette","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, M13 9NT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, M13 9NT, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080513991"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":4.2403,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.94636092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"77","issue":"2","first_page":"237","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.996999979019165},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.9369999766349792},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.7889999747276306},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.5709999799728394},{"id":"https://openalex.org/keywords/calcium-uptake","display_name":"calcium uptake","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cardiac-pathophysiology","display_name":"cardiac pathophysiology","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8457155823707581},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6654901504516602},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5920042991638184},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49357712268829346},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49192237854003906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4866564869880676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48348814249038696},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.4695870280265808},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44139835238456726},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.44117239117622375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4353371858596802},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4295434057712555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3919760584831238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15226155519485474}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/cvr/cvm002","doi":"https://doi.org/10.1093/cvr/cvm002","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvm002","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:18006490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18006490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/89063d73-87e6-4a75-806a-f451de214d36","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/89063d73-87e6-4a75-806a-f451de214d36","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orchard, C & Brette, F 2008, 't-tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes', Cardiovascular research, vol. 77, no. 2, pp. 237-244. https://doi.org/10.1093/cvr/cvm002","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/6b22e7c2-9afd-4fc5-a27a-94652a9193ed","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/6b22e7c2-9afd-4fc5-a27a-94652a9193ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orchard, CH & Brette, F 2008, 'T-tubules and SR function in cardiac ventricular myocytes', Cardiovascular Research, vol. 77, pp. 237 - 244.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W143148149","https://openalex.org/W1492161308","https://openalex.org/W1513594647","https://openalex.org/W1515619928","https://openalex.org/W1965035060","https://openalex.org/W1971033431","https://openalex.org/W1971214746","https://openalex.org/W1974157686","https://openalex.org/W1980002181","https://openalex.org/W1981335687","https://openalex.org/W1985578759","https://openalex.org/W1991731300","https://openalex.org/W1998676952","https://openalex.org/W2000683352","https://openalex.org/W2003046582","https://openalex.org/W2004169102","https://openalex.org/W2011038097","https://openalex.org/W2012751980","https://openalex.org/W2014933196","https://openalex.org/W2020587550","https://openalex.org/W2022901757","https://openalex.org/W2023758830","https://openalex.org/W2024116142","https://openalex.org/W2026425082","https://openalex.org/W2030295605","https://openalex.org/W2036424054","https://openalex.org/W2037568202","https://openalex.org/W2041750868","https://openalex.org/W2042391144","https://openalex.org/W2046026670","https://openalex.org/W2050824263","https://openalex.org/W2054225000","https://openalex.org/W2054554932","https://openalex.org/W2058607911","https://openalex.org/W2062684112","https://openalex.org/W2068613600","https://openalex.org/W2070500034","https://openalex.org/W2071404442","https://openalex.org/W2071726808","https://openalex.org/W2082534634","https://openalex.org/W2083310303","https://openalex.org/W2088264606","https://openalex.org/W2090116945","https://openalex.org/W2095062180","https://openalex.org/W2096667649","https://openalex.org/W2099955498","https://openalex.org/W2102878096","https://openalex.org/W2103905232","https://openalex.org/W2104750607","https://openalex.org/W2107088261","https://openalex.org/W2107992067","https://openalex.org/W2109665703","https://openalex.org/W2118810404","https://openalex.org/W2120076709","https://openalex.org/W2121580874","https://openalex.org/W2121722537","https://openalex.org/W2124910398","https://openalex.org/W2125558148","https://openalex.org/W2125738242","https://openalex.org/W2131133264","https://openalex.org/W2132386089","https://openalex.org/W2134126004","https://openalex.org/W2134338008","https://openalex.org/W2135596278","https://openalex.org/W2137974601","https://openalex.org/W2138610459","https://openalex.org/W2140313980","https://openalex.org/W2144975424","https://openalex.org/W2145484503","https://openalex.org/W2148750197","https://openalex.org/W2151909975","https://openalex.org/W2152263043","https://openalex.org/W2159258890","https://openalex.org/W2159757106","https://openalex.org/W2168293002","https://openalex.org/W2170220392","https://openalex.org/W2170853736","https://openalex.org/W2172519975","https://openalex.org/W2334186356","https://openalex.org/W2405695988","https://openalex.org/W2977097895"],"related_works":["https://openalex.org/W2170853736","https://openalex.org/W2170473383","https://openalex.org/W2148750197","https://openalex.org/W3018828842","https://openalex.org/W2031969073","https://openalex.org/W1508592597","https://openalex.org/W7100162024","https://openalex.org/W2065462886","https://openalex.org/W1872154988","https://openalex.org/W4389462673"],"abstract_inverted_index":{"Although":[0],"the":[1,39,49,57,71,83,87,98,119,129,141,147,153,170,179,187,193,207],"existence":[2],"of":[3,38,140,184,192],"t-tubules":[4,88,171,194],"in":[5,161,178,198,206,215],"mammalian":[6],"cardiac":[7,199],"ventricular":[8],"myocytes":[9],"has":[10,33,195],"been":[11,196],"recognized":[12],"for":[13],"a":[14,61,175,204],"long":[15],"time,":[16],"it":[17],"now":[18],"appears":[19,90],"that":[20,36,66,96,138,143],"their":[21],"structure":[22],"and":[23,78,106,124,164,181,201,210],"function":[24,213],"are":[25,45,149],"more":[26,93],"complex":[27],"than":[28,95],"previously":[29],"believed.":[30],"Recent":[31],"work":[32],"provided":[34],"evidence":[35,137],"many":[37,139],"key":[40],"proteins":[41],"underlying":[42],"excitation-contraction":[43],"coupling":[44],"located":[46,150],"predominantly":[47,151],"at":[48,86,97,152],"t-tubules.":[50],"L-type":[51],"Ca(2+)":[52,64,68,80,145,167,185,189],"current":[53],"(I(Ca))":[54],"flowing":[55,117],"across":[56,118],"t-tubule":[58],"membrane":[59,100,121],"provides":[60],"rapidly":[62],"inactivating":[63],"influx":[65],"triggers":[67],"release":[69,81],"from":[70,146],"sarcoplasmic":[72],"reticulum":[73],"(SR),":[74],"thereby":[75],"allowing":[76],"rapid":[77],"synchronous":[79],"throughout":[82],"cell;":[84],"I(Ca)":[85,116],"also":[89,135],"to":[91,101,173],"be":[92],"sensitive":[94],"surface":[99,120],"regulation":[102],"by":[103],"beta-adrenergic":[104],"stimulation":[105],"intracellular":[107],"Ca(2+).":[108,132],"In":[109],"contrast,":[110],"although":[111],"its":[112],"density":[113],"is":[114,134],"lower,":[115],"inactivates":[122],"slowly,":[123],"thus":[125],"may":[126,202],"help":[127],"load":[128],"SR":[130],"with":[131],"There":[133],"increasing":[136],"mechanisms":[142],"remove":[144],"cytoplasm":[148],"t-tubules,":[154],"which":[155],"therefore":[156],"play":[157,174,203],"an":[158],"important":[159],"role":[160,177,205],"determining":[162],"cellular,":[163,209],"hence":[165,211],"SR,":[166],"content.":[168],"Thus,":[169],"appear":[172],"central":[176],"increase":[180],"subsequent":[182],"decrease":[183],"during":[186],"systolic":[188],"transient.":[190],"Remodelling":[191],"reported":[197],"pathologies,":[200],"altered":[208],"cardiac,":[212],"observed":[214],"such":[216],"conditions.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
