{"id":"https://openalex.org/W2114254686","doi":"https://doi.org/10.1002/jca.21362","title":"Immunomodulation due to plasma or plasma\u2013platelet apheresis donation: Events occurring during donation procedures","display_name":"Immunomodulation due to plasma or plasma\u2013platelet apheresis donation: Events occurring during donation procedures","publication_year":2014,"publication_date":"2014-09-30","ids":{"openalex":"https://openalex.org/W2114254686","doi":"https://doi.org/10.1002/jca.21362","mag":"2114254686","pmid":"https://pubmed.ncbi.nlm.nih.gov/25266338"},"language":"en","primary_location":{"id":"doi:10.1002/jca.21362","doi":"https://doi.org/10.1002/jca.21362","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jca.21362","pdf_url":null,"source":{"id":"https://openalex.org/S189671064","display_name":"Journal of Clinical Apheresis","issn_l":"0733-2459","issn":["0733-2459","1098-1101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Apheresis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021752739","display_name":"Massimo Ghio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Massimo Ghio","raw_affiliation_strings":["Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","University of Genoa Viale Benedetto XV, 6 16132 Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"University of Genoa Viale Benedetto XV, 6 16132 Genova Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049096801","display_name":"Paola Contini","orcid":"https://orcid.org/0000-0001-9430-1928","observed_orcids":["https://orcid.org/0000-0001-9430-1928"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Contini","raw_affiliation_strings":["Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","University of Genoa Viale Benedetto XV, 6 16132 Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"University of Genoa Viale Benedetto XV, 6 16132 Genova Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035113511","display_name":"Filippo Ansaldi","orcid":"https://orcid.org/0009-0002-0099-9347","observed_orcids":["https://orcid.org/0009-0002-0099-9347"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Ansaldi","raw_affiliation_strings":["Department of Health Sciences I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","University of Genoa Viale Benedetto XV, 6 16132 Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"University of Genoa Viale Benedetto XV, 6 16132 Genova Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021958993","display_name":"Gianluca Ubezio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Ubezio","raw_affiliation_strings":["Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","University of Genoa Viale Benedetto XV, 6 16132 Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"University of Genoa Viale Benedetto XV, 6 16132 Genova Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054329673","display_name":"Maurizio Setti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Setti","raw_affiliation_strings":["Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","University of Genoa Viale Benedetto XV, 6 16132 Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I.R.C.C.S. \u201cA.O.U. San Martino\u2010IST,\u201d Genova Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"University of Genoa Viale Benedetto XV, 6 16132 Genova Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083622616","display_name":"Marco Risso","orcid":"https://orcid.org/0000-0002-2253-6493","observed_orcids":["https://orcid.org/0000-0002-2253-6493"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Risso","raw_affiliation_strings":["Immunohematology and Transfusion Centre Institute Giannina Gaslini Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology and Transfusion Centre Institute Giannina Gaslini Genova Italy","institution_ids":["https://openalex.org/I2801463291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105286316","display_name":"Gino Tripodi","orcid":"https://orcid.org/0000-0002-3259-4718","observed_orcids":["https://orcid.org/0000-0002-3259-4718"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gino Tripodi","raw_affiliation_strings":["Immunohematology and Transfusion Centre Institute Giannina Gaslini Genova Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunohematology and Transfusion Centre Institute Giannina Gaslini Genova Italy","institution_ids":["https://openalex.org/I2801463291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021752739"],"corresponding_institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":2.2549,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.90558906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"30","issue":"4","first_page":"204","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.14810000360012054,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-apheresis","display_name":"plasma apheresis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/platelet-apheresis","display_name":"platelet apheresis","score":0.972000002861023},{"id":"https://openalex.org/keywords/soluble-hla-class-i","display_name":"soluble HLA class I","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8759999871253967},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.8457260727882385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7337275147438049},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6377876996994019},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5971883535385132},{"id":"https://openalex.org/C2779867487","wikidata":"https://www.wikidata.org/wiki/Q952508","display_name":"Plateletpheresis","level":4,"score":0.5486449003219604},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5281669497489929},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5162746906280518},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.45571306347846985},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4490193724632263},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.43335235118865967},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010983","descriptor_name":"Plateletpheresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jca.21362","doi":"https://doi.org/10.1002/jca.21362","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jca.21362","pdf_url":null,"source":{"id":"https://openalex.org/S189671064","display_name":"Journal of Clinical Apheresis","issn_l":"0733-2459","issn":["0733-2459","1098-1101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Apheresis","raw_type":"journal-article"},{"id":"pmid:25266338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25266338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical apheresis","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/775149","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/775149","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6299999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W759047236","https://openalex.org/W1548222555","https://openalex.org/W1642619880","https://openalex.org/W1914110706","https://openalex.org/W1971673060","https://openalex.org/W1978997484","https://openalex.org/W1986434913","https://openalex.org/W1987318406","https://openalex.org/W1991774103","https://openalex.org/W1993382207","https://openalex.org/W2018600499","https://openalex.org/W2029055701","https://openalex.org/W2036862498","https://openalex.org/W2037034800","https://openalex.org/W2039932719","https://openalex.org/W2047663896","https://openalex.org/W2050066293","https://openalex.org/W2067368123","https://openalex.org/W2077260920","https://openalex.org/W2080435876","https://openalex.org/W2086239936","https://openalex.org/W2093922901","https://openalex.org/W2094095046","https://openalex.org/W2102166551","https://openalex.org/W2106270544","https://openalex.org/W2112191262","https://openalex.org/W2114066638","https://openalex.org/W2120457482","https://openalex.org/W2128827272","https://openalex.org/W2129561715","https://openalex.org/W2131244538","https://openalex.org/W2137163606","https://openalex.org/W2153039606","https://openalex.org/W2154488151","https://openalex.org/W2328903715","https://openalex.org/W2789426532"],"related_works":["https://openalex.org/W7095900447","https://openalex.org/W99238349","https://openalex.org/W147528389","https://openalex.org/W3216474683","https://openalex.org/W2081986210","https://openalex.org/W1997883355","https://openalex.org/W7061428745","https://openalex.org/W1992259315","https://openalex.org/W2900918500","https://openalex.org/W2102166551"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1,62],"has":[2],"been":[3],"recently":[4],"shown":[5],"that":[6,55,123],"during":[7,44,234],"therapeutic":[8],"apheresis":[9,23,46,99,129,218],"procedure,":[10],"a":[11,215],"large":[12],"amount":[13],"of":[14,176,217,232,237],"soluble":[15,160],"HLA":[16],"class":[17],"I":[18],"molecules":[19,125,144],"settles":[20],"onto":[21],"plastic":[22],"circuits,":[24],"inducing":[25],"sustained":[26],"TGF\u03b21":[27,157],"pre/post-transcriptional":[28],"modulation":[29,158],"in":[30,168,195,199,209],"activated":[31],"patients'":[32],"leukocytes.":[33],"Reportedly,":[34],"donors'":[35,137],"leukocytes":[36],"may":[37],"be":[38,53],"exposed":[39],"to":[40,127,141],"similar":[41],"immunosuppressing":[42],"activities":[43],"donor":[45,213],"procedures.":[47],"On":[48],"this":[49],"basis,":[50],"it":[51],"could":[52],"hypothesized":[54],"such":[56,93,152],"events":[57,94],"can":[58,133,145],"cause":[59],"immune":[60,150,185],"modulation.":[61],"is":[63,69,77],"uncertain":[64],"which":[65,142],"blood":[66],"cell":[67,174,197],"population":[68],"most":[70],"impacted":[71],"by":[72],"these":[73],"events.":[74],"This":[75],"study":[76],"focused":[78],"on":[79,82],"the":[80,83,128,240],"effects":[81],"T":[84,139],"lymphocytes.":[85],"STUDY":[86],"DESIGN":[87],"AND":[88],"METHODS:":[89],"To":[90],"assess":[91],"if":[92],"occur,":[95],"lymphocytes":[96,210],"from":[97,211],"20":[98],"donors":[100],"collected":[101],"before":[102],"and":[103,109,155,159,173,181],"after":[104,193,239],"three":[105],"closely":[106],"timed":[107],"plasma":[108],"platelet":[110],"donation":[111],"procedures":[112],"were":[113],"analyzed":[114],"for":[115],"sHLA-I":[116,124,143,204],"mediated":[117,205],"immunomodulation.":[118],"RESULTS:":[119],"The":[120],"results":[121],"confirmed":[122],"bind":[126],"circuit":[130],"surfaces.":[131],"Circuits":[132],"also":[134],"transiently":[135],"activate":[136],"CD8(+)":[138],"lymphocytes,":[140],"bind,":[146],"thus":[147],"modulating":[148],"short-lasting":[149],"effects,":[151],"as":[153,214],"transcriptional":[154],"post-transcriptional":[156],"Fas":[161],"ligand":[162],"release.":[163],"However,":[164],"no":[165,182,221],"significant":[166],"change":[167],"relative":[169],"proportions,":[170],"absolute":[171],"number":[172],"viability":[175],"lymphocyte":[177],"subpopulations":[178],"was":[179,187,207],"found":[180],"ex":[183],"vivo":[184],"effect":[186],"detectable":[188],"longer":[189],"than":[190],"14":[191],"days":[192],"procedure":[194],"any":[196,225,230],"type":[198],"all":[200],"donors.":[201],"CONCLUSION:":[202],"Short-lived":[203],"immunomodulation":[206],"demonstrable":[208],"every":[212],"consequence":[216],"procedures,":[219],"but":[220],"enrolled":[222],"subject":[223],"experienced":[224],"adverse":[226],"reaction":[227],"or":[228],"showed":[229],"sign":[231],"immunosuppression":[233],"24":[235],"months":[236],"follow-up":[238],"donations.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
