{"id":"https://openalex.org/W2114179392","doi":"https://doi.org/10.3748/wjg.v18.i23.2895","title":"Potential prospects of nanomedicine for targeted therapeutics in inflammatory bowel diseases","display_name":"Potential prospects of nanomedicine for targeted therapeutics in inflammatory bowel diseases","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2114179392","doi":"https://doi.org/10.3748/wjg.v18.i23.2895","mag":"2114179392","pmid":"https://pubmed.ncbi.nlm.nih.gov/22736912","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3380316"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v18.i23.2895","doi":"https://doi.org/10.3748/wjg.v18.i23.2895","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v18.i23.2895","pdf_url":"https://www.wjgnet.com/1007-9327/full/v18/i23/2895.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v18/i23/2895.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056464435","display_name":"Madharasi V A Pichai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","NZ","US"],"is_corresponding":true,"raw_author_name":"Madharasi VA Pichai","raw_affiliation_strings":["Department of Medicine, Gastroin-testinal Unit, GRJ 702, Massachusetts General Hospital, Boston, MA 02114, United States","Department of Pathology and Molecular Medicine, McMaster University, BBI-T3330, 50 Charlton Ave East, Hamilton, L8N 4A6, Canada;","Disci-pline of Nutrition, Faculty of Medical and Health Sciences, Uni-versity of Auckland, 85 Park Road, Grafton Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand","Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Gastroin-testinal Unit, GRJ 702, Massachusetts General Hospital, Boston, MA 02114, United States","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, McMaster University, BBI-T3330, 50 Charlton Ave East, Hamilton, L8N 4A6, Canada;","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Disci-pline of Nutrition, Faculty of Medical and Health Sciences, Uni-versity of Auckland, 85 Park Road, Grafton Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056464435"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210087915","https://openalex.org/I98251732"],"apc_list":null,"apc_paid":null,"fwci":0.6074,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.53707865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"23","first_page":"2895","last_page":"2895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ibd-pathogenesis","display_name":"IBD pathogenesis","score":0.753000020980835},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.5849999785423279},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.8069999814033508},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7877722978591919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7820414900779724},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.6859997510910034},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.6652270555496216},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5897424221038818},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5321133732795715},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5041662454605103},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43045035004615784},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4113110899925232},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3657522201538086},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13136625289916992},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08908453583717346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06373429298400879},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3748/wjg.v18.i23.2895","doi":"https://doi.org/10.3748/wjg.v18.i23.2895","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v18.i23.2895","pdf_url":"https://www.wjgnet.com/1007-9327/full/v18/i23/2895.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2385904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3380316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3380316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3380316","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:22736912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22736912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Editorial"},{"id":"mag:3152351506","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/201223/42509157.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v18.i23.2895","doi":"https://doi.org/10.3748/wjg.v18.i23.2895","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v18.i23.2895","pdf_url":"https://www.wjgnet.com/1007-9327/full/v18/i23/2895.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114179392.pdf","grobid_xml":"https://content.openalex.org/works/W2114179392.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W72719101","https://openalex.org/W136413805","https://openalex.org/W167876508","https://openalex.org/W1522978223","https://openalex.org/W1604192625","https://openalex.org/W1775025203","https://openalex.org/W1823279151","https://openalex.org/W1951491012","https://openalex.org/W1965395695","https://openalex.org/W1967644388","https://openalex.org/W1969767037","https://openalex.org/W1974829426","https://openalex.org/W1975077715","https://openalex.org/W1977158732","https://openalex.org/W1978974086","https://openalex.org/W1984426896","https://openalex.org/W1987956803","https://openalex.org/W1988658785","https://openalex.org/W1996268635","https://openalex.org/W1999388825","https://openalex.org/W1999732094","https://openalex.org/W2002785080","https://openalex.org/W2003075331","https://openalex.org/W2008275485","https://openalex.org/W2010209502","https://openalex.org/W2011179702","https://openalex.org/W2014605689","https://openalex.org/W2014989173","https://openalex.org/W2026756786","https://openalex.org/W2028221612","https://openalex.org/W2032175829","https://openalex.org/W2040907783","https://openalex.org/W2041269739","https://openalex.org/W2042529843","https://openalex.org/W2047828689","https://openalex.org/W2048405693","https://openalex.org/W2053546012","https://openalex.org/W2056978535","https://openalex.org/W2060056553","https://openalex.org/W2060941625","https://openalex.org/W2066620893","https://openalex.org/W2073869570","https://openalex.org/W2078621117","https://openalex.org/W2081601920","https://openalex.org/W2083323027","https://openalex.org/W2092643186","https://openalex.org/W2094565294","https://openalex.org/W2096630238","https://openalex.org/W2102357276","https://openalex.org/W2104512777","https://openalex.org/W2106453726","https://openalex.org/W2108229642","https://openalex.org/W2109899118","https://openalex.org/W2114466604","https://openalex.org/W2118042314","https://openalex.org/W2121469147","https://openalex.org/W2122039020","https://openalex.org/W2125710038","https://openalex.org/W2128791737","https://openalex.org/W2129855398","https://openalex.org/W2137064221","https://openalex.org/W2138281910","https://openalex.org/W2140610219","https://openalex.org/W2141335211","https://openalex.org/W2146178484","https://openalex.org/W2150550561","https://openalex.org/W2152429732","https://openalex.org/W2156224056","https://openalex.org/W2158558808","https://openalex.org/W2160969462","https://openalex.org/W2162831640","https://openalex.org/W2165872127","https://openalex.org/W2168169746","https://openalex.org/W2171116020","https://openalex.org/W2172168764","https://openalex.org/W2463260999","https://openalex.org/W4249819020"],"related_works":["https://openalex.org/W4362127577","https://openalex.org/W4327547010","https://openalex.org/W4391322371","https://openalex.org/W7135091415","https://openalex.org/W3177439903","https://openalex.org/W2020252548","https://openalex.org/W2975951873","https://openalex.org/W1980988152","https://openalex.org/W4406918034","https://openalex.org/W3112759075"],"abstract_inverted_index":{"Inflammatory":[0],"bowel":[1],"diseases":[2],"(IBDs)":[3],"such":[4],"as":[5,103],"Crohn's":[6],"disease":[7],"are":[8,12],"highly":[9],"debilitating.":[10],"There":[11],"inconsistencies":[13],"in":[14,20,26,39,58,74,77,84,92,126,130,142,150],"response":[15],"to":[16,35,50,107,114,145],"and":[17,30,76,122,137],"side":[18],"effects":[19],"the":[21,31,40,48,53,64,67,100,105,111,120],"current":[22,112],"conventional":[23,56,115],"medications,":[24],"failures":[25],"adequate":[27],"drug":[28],"delivery,":[29],"lack":[32],"of":[33,44,55,66,99,110,124,139],"therapeutics":[34],"offer":[36],"complete":[37],"remission":[38],"presently":[41],"available":[42],"treatments":[43],"IBD.":[45],"This":[46,61],"suggests":[47],"need":[49],"explore":[51],"beyond":[52],"horizons":[54],"approaches":[57],"IBD":[59,69,93,116,127,140],"therapeutics.":[60],"review":[62],"examines":[63],"arena":[65],"evolving":[68],"nanomedicine,":[70],"studied":[71,129],"so":[72,90],"far":[73,91],"animal":[75],"vitro":[78],"models,":[79,132],"before":[80],"comprehensive":[81],"clinical":[82],"testing":[83],"humans.":[85,151],"The":[86],"investigations":[87],"carried":[88],"out":[89],"models":[94],"have":[95],"provided":[96],"substantial":[97],"evidence":[98],"nanotherapeutic":[101],"approach":[102],"having":[104],"potential":[106],"overcome":[108],"some":[109],"drawbacks":[113],"therapy.":[117],"We":[118],"analyze":[119],"pros":[121],"cons":[123],"nanotechnology":[125],"therapies":[128],"different":[131,135],"aimed":[133],"at":[134],"targets":[136],"mechanisms":[138],"pathogenesis,":[141],"an":[143],"attempt":[144],"predict":[146],"its":[147],"possible":[148],"impact":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}