{"id":"https://openalex.org/W2114152259","doi":"https://doi.org/10.1517/14712598.3.5.759","title":"Neural stem cells as delivery vehicles","display_name":"Neural stem cells as delivery vehicles","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2114152259","doi":"https://doi.org/10.1517/14712598.3.5.759","mag":"2114152259","pmid":"https://pubmed.ncbi.nlm.nih.gov/12880376"},"language":"en","primary_location":{"id":"doi:10.1517/14712598.3.5.759","doi":"https://doi.org/10.1517/14712598.3.5.759","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.3.5.759","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044549116","display_name":"Peter Kabos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kabos","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA","Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020681666","display_name":"Moneeb Ehtesham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moneeb Ehtesham","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019253871","display_name":"Keith L. Black","orcid":"https://orcid.org/0000-0002-0546-4934","observed_orcids":["https://orcid.org/0000-0002-0546-4934"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L Black","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064689690","display_name":"John S. Yu","orcid":"https://orcid.org/0000-0003-1230-8494","observed_orcids":["https://orcid.org/0000-0003-1230-8494"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S Yu","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Ste. 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA. yuj@cshs.org","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":0.0917,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.0326087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"5","first_page":"759","last_page":"770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":1.0},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.460999995470047},{"id":"https://openalex.org/keywords/stem-cell-migration","display_name":"stem cell migration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cns-repair","display_name":"CNS repair","score":0.40799999237060547},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.8072426319122314},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7791481018066406},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.719569206237793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5849900245666504},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5441362857818604},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.5249317288398743},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5177011489868164},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4623618721961975},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41982796788215637},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.26703035831451416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18252593278884888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14528611302375793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1339583694934845},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1517/14712598.3.5.759","doi":"https://doi.org/10.1517/14712598.3.5.759","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.3.5.759","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"doi:10.1517/eobt.3.5.759.21233","doi":"https://doi.org/10.1517/eobt.3.5.759.21233","is_oa":false,"landing_page_url":"https://doi.org/10.1517/eobt.3.5.759.21233","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:12880376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12880376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6552726801","display_name":"ACTIVE IMMUNOTHERAPY FOR GLIOBLASTOMA","funder_award_id":"K23NS002232","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8428420930","display_name":null,"funder_award_id":"NS02232","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W199447113","https://openalex.org/W1482293895","https://openalex.org/W1487914405","https://openalex.org/W1504471840","https://openalex.org/W1562337573","https://openalex.org/W1570839422","https://openalex.org/W1574222606","https://openalex.org/W1606173244","https://openalex.org/W1611957532","https://openalex.org/W1718365317","https://openalex.org/W1866157615","https://openalex.org/W1926043920","https://openalex.org/W1965404154","https://openalex.org/W1973604867","https://openalex.org/W1980441719","https://openalex.org/W1983274440","https://openalex.org/W1988189150","https://openalex.org/W1988714795","https://openalex.org/W1991251782","https://openalex.org/W1996822067","https://openalex.org/W2003361736","https://openalex.org/W2007110771","https://openalex.org/W2013485257","https://openalex.org/W2017599428","https://openalex.org/W2019614067","https://openalex.org/W2019674238","https://openalex.org/W2020745529","https://openalex.org/W2022671203","https://openalex.org/W2024573693","https://openalex.org/W2024667339","https://openalex.org/W2027246053","https://openalex.org/W2027898789","https://openalex.org/W2028968056","https://openalex.org/W2029969176","https://openalex.org/W2030855886","https://openalex.org/W2038340756","https://openalex.org/W2044186868","https://openalex.org/W2048597358","https://openalex.org/W2050142708","https://openalex.org/W2054438521","https://openalex.org/W2054507508","https://openalex.org/W2054578235","https://openalex.org/W2057962057","https://openalex.org/W2058566746","https://openalex.org/W2064496329","https://openalex.org/W2064668202","https://openalex.org/W2073221687","https://openalex.org/W2079883031","https://openalex.org/W2081768529","https://openalex.org/W2084652820","https://openalex.org/W2084653857","https://openalex.org/W2089735370","https://openalex.org/W2092773273","https://openalex.org/W2094505884","https://openalex.org/W2094827231","https://openalex.org/W2100479578","https://openalex.org/W2104793567","https://openalex.org/W2113964043","https://openalex.org/W2123285567","https://openalex.org/W2123885452","https://openalex.org/W2126002582","https://openalex.org/W2129403219","https://openalex.org/W2134105401","https://openalex.org/W2141310245","https://openalex.org/W2147640763","https://openalex.org/W2148593514","https://openalex.org/W2151426020","https://openalex.org/W2158048826","https://openalex.org/W2163772331","https://openalex.org/W2165867905","https://openalex.org/W2168341415","https://openalex.org/W2183194452","https://openalex.org/W2330000827"],"related_works":["https://openalex.org/W2041095116","https://openalex.org/W3101424813","https://openalex.org/W130355724","https://openalex.org/W2115899072","https://openalex.org/W2069406495","https://openalex.org/W66315898","https://openalex.org/W52615678","https://openalex.org/W133708399","https://openalex.org/W4821093","https://openalex.org/W2018831921"],"abstract_inverted_index":{"The":[0,28,75,105],"discovery":[1],"of":[2,30,58,78,98,107,122,129,141,146,155],"neural":[3,87],"stem":[4],"cells":[5],"(NSCs)":[6],"has":[7],"changed":[8],"our":[9],"long-held":[10],"view":[11],"that":[12],"the":[13,24,38,96,116,120,126,134,139,144,153,160,166],"adult":[14],"mammalian":[15],"central":[16],"nervous":[17,167],"system":[18],"(CNS)":[19],"is":[20,40,65],"postmitotic":[21],"and":[22,34,52,69,80,101,124,159],"lacks":[23],"capability":[25],"for":[26,95,143],"self-repair.":[27],"role":[29],"NSCs":[31,79,111,142],"in":[32,37,115,138,151,165],"physiological":[33],"pathological":[35],"processes":[36],"brain":[39,73],"slowly":[41],"emerging.":[42],"We":[43],"are":[44,149],"now":[45],"able":[46],"to":[47,72,83,112,163],"isolate,":[48],"expand,":[49],"genetically":[50],"engineer":[51],"transplant":[53],"NSCs.":[54],"An":[55],"important":[56],"characteristic":[57],"NSCs,":[59],"not":[60],"fully":[61],"understood":[62],"so":[63],"far,":[64],"their":[66,70,81,156],"migratory":[67,76,157],"ability":[68,77,162],"tropism":[71],"pathology.":[74],"capacity":[82],"differentiate":[84],"into":[85],"all":[86],"phenotypes":[88],"gives":[89],"us":[90],"a":[91],"potentially":[92],"powerful":[93],"tool":[94],"treatment":[97],"both":[99],"diffuse":[100],"localised":[102],"neurologic":[103],"disorders.":[104],"delivery":[106,123,145],"gene":[108],"products":[109,148],"by":[110],"specific":[113],"sites":[114],"CNS":[117],"can":[118],"maximise":[119],"efficiency":[121],"minimise":[125],"unwanted":[127],"exposure":[128],"surrounding":[130],"intact":[131],"tissue.":[132],"Here,":[133],"recent":[135],"preclinical":[136],"advances":[137],"use":[140],"therapeutic":[147],"reviewed,":[150],"particular":[152],"employment":[154],"potential":[158],"homing":[161],"pathology":[164],"system.":[168]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
