{"id":"https://openalex.org/W2114079866","doi":null,"title":"Regulation of prostanoid effects in whole blood : immediate-early anti-inflammatory effects of prostaglandin E2","display_name":"Regulation of prostanoid effects in whole blood : immediate-early anti-inflammatory effects of prostaglandin E2","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2114079866","mag":"2114079866"},"language":"en","primary_location":{"id":"pmh:oai:munin.uit.no:10037/1648","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10037/1648","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10037/1648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029096885","display_name":"Danh Phung","orcid":"https://orcid.org/0000-0001-8725-1563","observed_orcids":["https://orcid.org/0000-0001-8725-1563","https://orcid.org/0009-0000-5570-808X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Danh Phung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8725-1563","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029096885"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.753000020980835},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.871999979019165},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.8040000200271606},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7620000243186951},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776352991","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid","level":4,"score":0.8121975660324097},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6378841400146484},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.6035870909690857},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6012933850288391},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5987324714660645},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5271273255348206},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.4749719500541687},{"id":"https://openalex.org/C2908562933","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid metabolism","level":5,"score":0.4587332308292389},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4513319432735443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43236130475997925},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.4301113486289978},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.42764273285865784},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.42346733808517456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.419939249753952},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40785497426986694},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38752418756484985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22931382060050964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22847995162010193},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2126345932483673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21185964345932007},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21141266822814941},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17761492729187012},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.08075767755508423},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:munin.uit.no:10037/1648","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10037/1648","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2114079866","doi":null,"is_oa":false,"landing_page_url":"https://munin.uit.no/bitstream/10037/1648/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:munin.uit.no:10037/1648","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10037/1648","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W26056776","https://openalex.org/W51509219","https://openalex.org/W59627172","https://openalex.org/W84007045","https://openalex.org/W172858430","https://openalex.org/W181683792","https://openalex.org/W598198035","https://openalex.org/W1214608791","https://openalex.org/W1485904813","https://openalex.org/W1507312029","https://openalex.org/W1512071494","https://openalex.org/W1544712871","https://openalex.org/W1559795580","https://openalex.org/W1559908984","https://openalex.org/W1562579211","https://openalex.org/W1573189660","https://openalex.org/W1598421459","https://openalex.org/W1624405189","https://openalex.org/W1793993480","https://openalex.org/W1843026349","https://openalex.org/W1860085360","https://openalex.org/W1862355269","https://openalex.org/W1902187490","https://openalex.org/W1962559823","https://openalex.org/W1965052798","https://openalex.org/W1967641836","https://openalex.org/W1967816704","https://openalex.org/W1968625808","https://openalex.org/W1972489899","https://openalex.org/W1972647002","https://openalex.org/W1975742983","https://openalex.org/W1976832225","https://openalex.org/W1978643157","https://openalex.org/W1979266650","https://openalex.org/W1980023430","https://openalex.org/W1982129555","https://openalex.org/W1984264727","https://openalex.org/W1985110267","https://openalex.org/W1986215971","https://openalex.org/W1987212025","https://openalex.org/W1990949779","https://openalex.org/W1992803891","https://openalex.org/W1993619929","https://openalex.org/W1994528784","https://openalex.org/W1994768909","https://openalex.org/W2001127825","https://openalex.org/W2004016651","https://openalex.org/W2004047427","https://openalex.org/W2004351423","https://openalex.org/W2007010087","https://openalex.org/W2007187686","https://openalex.org/W2010713047","https://openalex.org/W2018178042","https://openalex.org/W2021835061","https://openalex.org/W2022707369","https://openalex.org/W2024608254","https://openalex.org/W2025960306","https://openalex.org/W2026185007","https://openalex.org/W2026535550","https://openalex.org/W2026805941","https://openalex.org/W2027152576","https://openalex.org/W2027588628","https://openalex.org/W2029303000","https://openalex.org/W2029747211","https://openalex.org/W2030087792","https://openalex.org/W2030109883","https://openalex.org/W2030148186","https://openalex.org/W2030281077","https://openalex.org/W2031507674","https://openalex.org/W2031778251","https://openalex.org/W2046226834","https://openalex.org/W2046628450","https://openalex.org/W2047719515","https://openalex.org/W2048929642","https://openalex.org/W2054766392","https://openalex.org/W2055809356","https://openalex.org/W2059079830","https://openalex.org/W2061813367","https://openalex.org/W2062818585","https://openalex.org/W2063678429","https://openalex.org/W2065318917","https://openalex.org/W2068673334","https://openalex.org/W2069023573","https://openalex.org/W2070386995","https://openalex.org/W2070584205","https://openalex.org/W2072190804","https://openalex.org/W2072408699","https://openalex.org/W2073474484","https://openalex.org/W2077647756","https://openalex.org/W2085289837","https://openalex.org/W2086745976","https://openalex.org/W2088433924","https://openalex.org/W2089932791","https://openalex.org/W2090544882","https://openalex.org/W2092583562","https://openalex.org/W2097322302","https://openalex.org/W2098656129","https://openalex.org/W2102667962","https://openalex.org/W2108244474","https://openalex.org/W2112982595","https://openalex.org/W2113745276","https://openalex.org/W2115390875","https://openalex.org/W2115645802","https://openalex.org/W2126342903","https://openalex.org/W2126853519","https://openalex.org/W2129428834","https://openalex.org/W2131091865","https://openalex.org/W2132721938","https://openalex.org/W2135047663","https://openalex.org/W2139922949","https://openalex.org/W2140212636","https://openalex.org/W2142649232","https://openalex.org/W2146387129","https://openalex.org/W2146948320","https://openalex.org/W2156275638","https://openalex.org/W2159973565","https://openalex.org/W2162299766","https://openalex.org/W2165191737","https://openalex.org/W2239812136","https://openalex.org/W2240026871","https://openalex.org/W2297307348","https://openalex.org/W2319969154","https://openalex.org/W2331216347","https://openalex.org/W2331511800","https://openalex.org/W2336689314","https://openalex.org/W2342974111","https://openalex.org/W2350813466","https://openalex.org/W2396560938","https://openalex.org/W2410958869","https://openalex.org/W2439830469","https://openalex.org/W2509293619","https://openalex.org/W2800526221","https://openalex.org/W2987591224","https://openalex.org/W4302046699"],"related_works":["https://openalex.org/W2331511800","https://openalex.org/W2106702180","https://openalex.org/W2287267415","https://openalex.org/W2069023573","https://openalex.org/W2461823425","https://openalex.org/W2001615886","https://openalex.org/W2083090431","https://openalex.org/W2418333827","https://openalex.org/W1603892300","https://openalex.org/W2058259319"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,5,20,40,67,78,93,97,105,120,125,163],"regulation":[3],"of":[4,38,42,69,83,119,154],"pathophysiological":[6],"processes,":[7],"such":[8],"as":[9],"inflammation,":[10],"thrombosis":[11],"and":[12,25,31,52,73,80,89,111,137,150],"atherosclerosis,":[13],"it":[14],"is":[15],"very":[16],"important":[17],"to":[18,30,65,146],"characterize":[19],"interactions":[21,46],"between":[22,108],"circulating":[23],"cells":[24,55],"which":[26],"molecules":[27],"that":[28,104],"contributes":[29],"promote":[32],"these":[33,75],"interactions.":[34],"As":[35],"a":[36,172],"part":[37],"this,":[39],"role":[41],"eicosanoids":[43,76],"in":[44,47,92,168],"cell-cell":[45],"whole":[48,128,169],"blood":[49,54,129],"ex":[50],"vivo":[51],"isolated":[53],"are":[56],"investigated.":[57],"In":[58],"this":[59],"study,":[60,99,127],"various":[61],"inhibitors":[62],"were":[63,131],"used":[64],"regulate":[66],"amount":[68],"prostaglandins":[70],"(and":[71],"leukotrienes)":[72],"how":[74],"affect":[77],"activity-":[79],"expression":[81],"level":[82],"tissue":[84],"factor":[85],"(TF),":[86],"cytokines,":[87],"enzymes,":[88],"receptors":[90],"involved":[91],"intercellular":[94],"communication.":[95],"Before":[96],"inhibition":[98,126],"time":[100],"course":[101],"experiments":[102],"revealed":[103],"incubation":[106],"times":[107],"1.5":[109],"h":[110,113],"2":[112],"was":[114,177],"sufficient":[115],"for":[116,142,174],"further":[117],"study":[118],"parameters":[121],"under":[122],"investigation.":[123],"\\nIn":[124],"samples":[130],"preincubated":[132],"with":[133,140],"different":[134],"eicosanoid":[135],"inhibitors,":[136],"then":[138],"stimulated":[139],"LPS":[141],"ninety":[143],"minutes":[144],"prior":[145],"TF":[147,166],"activity":[148,167],"measurement":[149],"real-time":[151],"PCR":[152],"analysis":[153],"cytokine":[155],"gene":[156],"expressions.":[157],"Aspirin":[158],"did":[159],"not":[160],"significantly":[161],"enhance":[162,175],"lipopolysaccharide":[164],"(LPS)-induced":[165],"blood,":[170],"however":[171],"trend":[173],"induction":[176],"indicated.":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}