{"id":"https://openalex.org/W2113992154","doi":"https://doi.org/10.1155/2012/798131","title":"WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern","display_name":"WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2113992154","doi":"https://doi.org/10.1155/2012/798131","mag":"2113992154","pmid":"https://pubmed.ncbi.nlm.nih.gov/22927882","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426177"},"language":"en","primary_location":{"id":"doi:10.1155/2012/798131","doi":"https://doi.org/10.1155/2012/798131","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/798131","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/798131.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2012/798131.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010125473","display_name":"Mi Mi Ko","orcid":"https://orcid.org/0000-0002-5758-4655","observed_orcids":["https://orcid.org/0000-0002-5758-4655"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi Mi Ko","raw_affiliation_strings":["Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae-Yong Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Yong Park","raw_affiliation_strings":["Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101432143","display_name":"Ji Hye Lim","orcid":"https://orcid.org/0000-0002-3768-2194","observed_orcids":["https://orcid.org/0000-0002-3768-2194"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hye Lim","raw_affiliation_strings":["Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021912975","display_name":"Min Ho","orcid":"https://orcid.org/0000-0002-9158-6769","observed_orcids":["https://orcid.org/0000-0002-9158-6769"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Min Ho Cha","raw_affiliation_strings":["Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100379084","display_name":"Myeong Soo Lee","orcid":"https://orcid.org/0000-0001-6651-7641","observed_orcids":["https://orcid.org/0000-0001-6651-7641"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeong Soo Lee","raw_affiliation_strings":["Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021912975"],"corresponding_institution_ids":["https://openalex.org/I4210087584"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":3.1166,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.91114084,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Medical Research and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt10b","display_name":"Wnt10b","score":1.0},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8360000252723694},{"id":"https://openalex.org/keywords/traditional-korean-medicine","display_name":"traditional Korean medicine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.9399999976158142},{"id":"https://openalex.org/keywords/genetic-markers","display_name":"genetic markers","score":0.6790000200271606},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6073830127716064},{"id":"https://openalex.org/C3020186874","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Yin deficiency","level":4,"score":0.5590641498565674},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5528400540351868},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4819645583629608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4772753119468689},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.440204381942749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3140825927257538},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.2502076029777527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20706939697265625},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.186696857213974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1520848572254181},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2012/798131","doi":"https://doi.org/10.1155/2012/798131","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/798131","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/798131.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3426177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426177","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmid:22927882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22927882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f969bbd5a479481ab289c7a340e4037c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f969bbd5a479481ab289c7a340e4037c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2012/798131","doi":"https://doi.org/10.1155/2012/798131","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/798131","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/798131.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2404354970","display_name":null,"funder_award_id":"K12130","funder_id":"https://openalex.org/F4320322113","funder_display_name":"Korea Institute of Oriental Medicine"}],"funders":[{"id":"https://openalex.org/F4320322113","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113992154.pdf","grobid_xml":"https://content.openalex.org/works/W2113992154.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1901220202","https://openalex.org/W1969375002","https://openalex.org/W1978006624","https://openalex.org/W1981152610","https://openalex.org/W1983609530","https://openalex.org/W1991528151","https://openalex.org/W2002252046","https://openalex.org/W2007220702","https://openalex.org/W2040324490","https://openalex.org/W2043129312","https://openalex.org/W2045408693","https://openalex.org/W2064968804","https://openalex.org/W2070808532","https://openalex.org/W2073998126","https://openalex.org/W2074288765","https://openalex.org/W2088139475","https://openalex.org/W2093282659","https://openalex.org/W2144511462","https://openalex.org/W2147864074","https://openalex.org/W2317326291","https://openalex.org/W2327703900","https://openalex.org/W2327942287","https://openalex.org/W2351250478","https://openalex.org/W2422178775","https://openalex.org/W3144050227"],"related_works":["https://openalex.org/W2284532461","https://openalex.org/W2045408693","https://openalex.org/W7097740061","https://openalex.org/W3155757481","https://openalex.org/W2078430307","https://openalex.org/W2052032034","https://openalex.org/W2222731109","https://openalex.org/W2186721865","https://openalex.org/W2093282659","https://openalex.org/W2236901929"],"abstract_inverted_index":{"WNT10B":[0,26,166],"has":[1],"been":[2],"indicated":[3],"as":[4,191],"a":[5,98,152,165,179,192],"potential":[6],"regulator":[7],"of":[8,16,25,46,79,90,118,122,173,207],"adipogenesis":[9],"in":[10,13,28,63,124,136,151,178,200,204],"vivo":[11],"and":[12,36,40,56,112,168,203],"vitro":[14],"models":[15],"obesity.":[17],"In":[18],"this":[19,64],"study,":[20],"we":[21],"analyzed":[22,96],"the":[23,88,91,105,109,119,125,137,157,169,205],"distribution":[24],"polymorphism":[27,167],"elderly":[29],"Korean":[30,175],"subjects":[31,80],"with":[32,52,58],"cerebral":[33],"infarction":[34],"(CI)":[35],"Yin":[37,53,113,126,170,197],"Deficiency":[38,42,54,60,114,127,139,171,198],"pattern":[39,55,128,140,172,199],"Non-Yin":[41,59,138],"pattern.":[43,115],"A":[44],"total":[45],"630":[47],"CI":[48,180],"patients,":[49],"including":[50],"75":[51],"555":[57],"pattern,":[61],"participated":[62],"study.":[65],"SNP":[66],"(G-607C)":[67],"genotyping":[68],"was":[69,131],"conducted":[70],"by":[71,83],"primer":[72],"extension":[73],"using":[74,97],"TaqMan":[75],"probe;":[76],"five":[77],"percent":[78],"were":[81,95],"regenotyped":[82],"direct":[84],"sequencing":[85],"to":[86,103,160],"confirm":[87],"accuracy":[89],"genotyping.":[92],"The":[93,116],"results":[94,184],"multiple":[99],"logistic":[100],"regression":[101],"model":[102],"evaluate":[104],"genetic":[106,194],"association":[107,163],"between":[108,164],"G-607C":[110,123,187],"variant":[111],"frequency":[117],"CC":[120],"genotype":[121],"group":[129,141],"(29.33%)":[130],"significantly":[132],"higher":[133],"than":[134],"that":[135,186],"(23.96%)":[142],"(P":[143],"=":[144,148],"0.0339":[145],",":[146],"OR":[147],"2.005":[149],"(1.054-3.814))":[150],"recessive":[153],"model.":[154],"This":[155],"is":[156],"first":[158],"study":[159],"demonstrate":[161],"an":[162],"traditional":[174],"medicine":[176],"(TKM)":[177],"patient":[181],"population.":[182],"These":[183],"suggest":[185],"might":[188],"be":[189],"used":[190],"diagnostic":[193],"marker":[195],"for":[196],"stroke":[201],"patients":[202],"development":[206],"personalized":[208],"medical":[209],"care.":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}