{"id":"https://openalex.org/W2113987232","doi":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","title":"Neutralization of Shiga Toxins Stx1, Stx2c, and Stx2e by Recombinant Bacteria Expressing Mimics of Globotriose and Globotetraose","display_name":"Neutralization of Shiga Toxins Stx1, Stx2c, and Stx2e by Recombinant Bacteria Expressing Mimics of Globotriose and Globotetraose","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2113987232","doi":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","mag":"2113987232","pmid":"https://pubmed.ncbi.nlm.nih.gov/11179385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/98114"},"language":"en","primary_location":{"id":"doi:10.1128/iai.69.3.1967-1970.2001","doi":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/98114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038494526","display_name":"Adrienne W. Paton","orcid":"https://orcid.org/0000-0002-2996-5733","observed_orcids":["https://orcid.org/0000-0002-2996-5733"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrienne W. Paton","raw_affiliation_strings":["<!--label omitted: 1-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","institution_ids":["https://openalex.org/I2801308011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023033615","display_name":"Renato Morona","orcid":"https://orcid.org/0000-0001-7009-7440","observed_orcids":["https://orcid.org/0000-0001-7009-7440"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Renato Morona","raw_affiliation_strings":["<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055597053","display_name":"James C. Paton","orcid":"https://orcid.org/0000-0001-9807-5278","observed_orcids":["https://orcid.org/0000-0001-9807-5278"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James C. Paton","raw_affiliation_strings":["<!--label omitted: 1-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"<!--label omitted: 2-->Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005,2 Australia","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006,1 and","institution_ids":["https://openalex.org/I2801308011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7796,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.83275862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"3","first_page":"1967","last_page":"1970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shiga-toxin","display_name":"Shiga toxin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/stx1","display_name":"stx1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/stx2c","display_name":"stx2c","score":0.9890000224113464},{"id":"https://openalex.org/keywords/stx2e","display_name":"stx2e","score":0.9739999771118164},{"id":"https://openalex.org/keywords/toxin-neutralization","display_name":"toxin neutralization","score":0.8759999871253967},{"id":"https://openalex.org/keywords/recombinant-escherichia-coli","display_name":"recombinant Escherichia coli","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hemolytic-uremic-syndrome","display_name":"hemolytic uremic syndrome","score":0.902999997138977},{"id":"https://openalex.org/keywords/toxin-adsorption","display_name":"toxin adsorption","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2778411228","wikidata":"https://www.wikidata.org/wiki/Q424753","display_name":"Shiga toxin","level":4,"score":0.9413321614265442},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8013560771942139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7783157825469971},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7178491353988647},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6367729902267456},{"id":"https://openalex.org/C2775925610","wikidata":"https://www.wikidata.org/wiki/Q424753","display_name":"Shiga-like toxin","level":5,"score":0.6075546741485596},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.5450671911239624},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.528455913066864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21546196937561035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17403337359428406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05976858735084534}],"mesh":[{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005915","descriptor_name":"Globosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022622","descriptor_name":"Shiga Toxin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022641","descriptor_name":"Shiga Toxin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.69.3.1967-1970.2001","doi":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:979783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/98114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:98114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/98114","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:11179385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11179385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/28069","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/28069","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1128/iai.69.3.1967-1970.2001","raw_type":"Journal article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:979783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/98114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1486601410","https://openalex.org/W1518827890","https://openalex.org/W1749990518","https://openalex.org/W1942715185","https://openalex.org/W1981720553","https://openalex.org/W1985027846","https://openalex.org/W1985604744","https://openalex.org/W1999650545","https://openalex.org/W2028622989","https://openalex.org/W2033626553","https://openalex.org/W2035053848","https://openalex.org/W2054695679","https://openalex.org/W2079179705","https://openalex.org/W2086124562","https://openalex.org/W2103798600","https://openalex.org/W2112111992","https://openalex.org/W2128178006","https://openalex.org/W2129575453","https://openalex.org/W2138088531","https://openalex.org/W2145458242","https://openalex.org/W2155915806","https://openalex.org/W2156080241"],"related_works":["https://openalex.org/W7098927026","https://openalex.org/W2004617480","https://openalex.org/W2142995110","https://openalex.org/W2163432797","https://openalex.org/W1518827890","https://openalex.org/W7100721122","https://openalex.org/W2161013345","https://openalex.org/W1973104483","https://openalex.org/W4206779547","https://openalex.org/W7098428299"],"abstract_inverted_index":{"Strains":[0],"of":[1,58,89,145,153,158,181],"Escherichia":[2],"coli":[3,64,160],"producing":[4],"Shiga":[5,44],"toxins":[6,45],"Stx1,":[7],"Stx2,":[8],"Stx2c,":[9],"and":[10,15,39,41,118,130],"Stx2d":[11],"cause":[12,67],"gastrointestinal":[13],"disease":[14,69,183],"the":[16,56,86,90,97,146,154],"hemolytic-uremic":[17],"syndrome":[18],"in":[19,70,132,156,184],"humans.":[20],"We":[21,93],"have":[22,94],"recently":[23],"constructed":[24],"a":[25,73,79,115,119,124],"recombinant":[26],"bacterium":[27,99,122],"which":[28,66,77],"displays":[29],"globotriose":[30],"(the":[31,105],"receptor":[32,81,107],"for":[33,55,85,108,177],"these":[34,43],"toxins)":[35],"on":[36],"its":[37,136],"surface":[38],"adsorbs":[40],"neutralizes":[42],"with":[46,60],"very":[47],"high":[48],"efficiency.":[49],"This":[50,121],"agent":[51],"has":[52,78],"great":[53],"potential":[54],"treatment":[57,178],"humans":[59],"such":[61,100],"infections.":[62],"E.":[63,159],"strains":[65],"edema":[68,182],"pigs":[71],"produce":[72],"variant":[74],"toxin,":[75],"Stx2e,":[76],"different":[80],"specificity":[82],"from":[83],"that":[84,101,144,168],"other":[87],"members":[88],"Stx":[91],"family.":[92],"now":[95],"modified":[96],"globotriose-expressing":[98,147],"it":[102],"expresses":[103],"globotetraose":[104],"preferred":[106],"Stx2e)":[109],"by":[110],"introducing":[111],"additional":[112],"genes":[113],"encoding":[114],"N-acetylgalactosamine":[116],"transferase":[117],"UDP-N-acetylgalactosamine-4-epimerase.":[120],"had":[123],"reduced":[125],"capacity":[126,137],"to":[127,138,143],"neutralize":[128],"Stx1":[129],"Stx2c":[131],"vitro,":[133],"but":[134],"remarkably,":[135],"bind":[139],"Stx2e":[140],"was":[141],"similar":[142],"construct;":[148],"both":[149],"constructs":[150,173],"neutralized":[151],"98.4%":[152],"cytotoxicity":[155],"lysates":[157],"JM109":[161],"expressing":[162],"cloned":[163],"stx2e.":[164],"These":[165],"data":[166],"suggest":[167],"either":[169],"globotriose-":[170],"or":[171],"globotetraose-expressing":[172],"may":[174],"be":[175],"suitable":[176],"and/or":[179],"prevention":[180],"pigs.":[185]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}