{"id":"https://openalex.org/W2113963672","doi":"https://doi.org/10.1002/jbmr.2724","title":"Decreased Serotonin Levels and Serotonin-Mediated Osteoblastic Inhibitory Signaling in Patients With Ankylosing Spondylitis","display_name":"Decreased Serotonin Levels and Serotonin-Mediated Osteoblastic Inhibitory Signaling in Patients With Ankylosing Spondylitis","publication_year":2015,"publication_date":"2015-09-30","ids":{"openalex":"https://openalex.org/W2113963672","doi":"https://doi.org/10.1002/jbmr.2724","mag":"2113963672","pmid":"https://pubmed.ncbi.nlm.nih.gov/26420546"},"language":"en","primary_location":{"id":"doi:10.1002/jbmr.2724","doi":"https://doi.org/10.1002/jbmr.2724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.2724","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.2724","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.2724","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002807035","display_name":"Kalliopi Klavdianou","orcid":"https://orcid.org/0000-0002-1267-1106","observed_orcids":["https://orcid.org/0000-0002-1267-1106"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Kalliopi Klavdianou","raw_affiliation_strings":["Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062248231","display_name":"Stamatis\u2010Nick C. Liossis","orcid":"https://orcid.org/0000-0003-2511-8083","observed_orcids":["https://orcid.org/0000-0003-2511-8083"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stamatis-Nick Liossis","raw_affiliation_strings":["Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046841245","display_name":"Dionysios J. Papachristou","orcid":"https://orcid.org/0000-0002-7676-6702","observed_orcids":["https://orcid.org/0000-0002-7676-6702"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dionysios J Papachristou","raw_affiliation_strings":["Department of Anatomy-Histology-Embryology, Laboratory of Bone and Soft Tissue Studies; University of Patras Medical School; Patras Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy-Histology-Embryology, Laboratory of Bone and Soft Tissue Studies; University of Patras Medical School; Patras Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065086442","display_name":"Georgios J Theocharis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Theocharis","raw_affiliation_strings":["Department of Gastroenterology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003731829","display_name":"Chaido Sirinian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Chaido Sirinian","raw_affiliation_strings":["Clinical and Molecular Oncology Laboratory; University of Patras Medical School, Patras University Hospital; Patras Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Molecular Oncology Laboratory; University of Patras Medical School, Patras University Hospital; Patras Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046684541","display_name":"Anastasia E Kottorou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Kottorou","raw_affiliation_strings":["Clinical and Molecular Oncology Laboratory; University of Patras Medical School, Patras University Hospital; Patras Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Molecular Oncology Laboratory; University of Patras Medical School, Patras University Hospital; Patras Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051374041","display_name":"Alexandra Filippopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandra Filippopoulou","raw_affiliation_strings":["Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038304236","display_name":"Andrew P. Andonopoulos","orcid":"https://orcid.org/0000-0003-1794-8554","observed_orcids":["https://orcid.org/0000-0003-1794-8554"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andrew P Andonopoulos","raw_affiliation_strings":["Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039944418","display_name":"Dimitrios Daoussis","orcid":"https://orcid.org/0000-0001-8027-3655","observed_orcids":["https://orcid.org/0000-0001-8027-3655"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Daoussis","raw_affiliation_strings":["Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Patras Medical School, Patras University Hospital, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002807035"],"corresponding_institution_ids":["https://openalex.org/I174878644"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.3268,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77586582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"630","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bone-formation-inhibition","display_name":"bone formation inhibition","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.9009706974029541},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7447720170021057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.733331561088562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5990369319915771},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.5836492776870728},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5018484592437744},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1627381145954132}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003710","descriptor_name":"Demography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbmr.2724","doi":"https://doi.org/10.1002/jbmr.2724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.2724","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.2724","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:26420546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26420546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jbmr.2724","doi":"https://doi.org/10.1002/jbmr.2724","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.2724","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.2724","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321952","display_name":"Hellenic Rheumatology Society","ror":"https://ror.org/0499cjb39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113963672.pdf","grobid_xml":"https://content.openalex.org/works/W2113963672.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1621490964","https://openalex.org/W1965177628","https://openalex.org/W1966756689","https://openalex.org/W1981199578","https://openalex.org/W2001032998","https://openalex.org/W2007208081","https://openalex.org/W2012643422","https://openalex.org/W2015034253","https://openalex.org/W2028914771","https://openalex.org/W2035645263","https://openalex.org/W2036708533","https://openalex.org/W2039003857","https://openalex.org/W2041555178","https://openalex.org/W2042156452","https://openalex.org/W2057453181","https://openalex.org/W2058401616","https://openalex.org/W2063370698","https://openalex.org/W2073052871","https://openalex.org/W2076853076","https://openalex.org/W2090706622","https://openalex.org/W2090973045","https://openalex.org/W2092734189","https://openalex.org/W2095930129","https://openalex.org/W2096758623","https://openalex.org/W2098623286","https://openalex.org/W2103778140","https://openalex.org/W2109619502","https://openalex.org/W2110177517","https://openalex.org/W2111840934","https://openalex.org/W2114589447","https://openalex.org/W2115754896","https://openalex.org/W2119193370","https://openalex.org/W2121308402","https://openalex.org/W2123011275","https://openalex.org/W2123649103","https://openalex.org/W2126484947","https://openalex.org/W2135190897","https://openalex.org/W2137332217","https://openalex.org/W2138829209","https://openalex.org/W2138976301","https://openalex.org/W2149548143","https://openalex.org/W2149713883","https://openalex.org/W2151838254","https://openalex.org/W2152348310","https://openalex.org/W2153596585","https://openalex.org/W2155680098","https://openalex.org/W4247658550"],"related_works":["https://openalex.org/W2332244561","https://openalex.org/W2761340169","https://openalex.org/W1974619242","https://openalex.org/W2093949819","https://openalex.org/W4238000838","https://openalex.org/W3122482540","https://openalex.org/W307948885","https://openalex.org/W2165188789","https://openalex.org/W2324319439","https://openalex.org/W2928991485"],"abstract_inverted_index":{"Evidence":[0],"suggests":[1],"that":[2],"serotonin":[3,16,46,64,67,100,169,224,238],"is":[4],"an":[5],"inhibitor":[6],"of":[7,41,58,60,97,113],"bone":[8,244],"formation.":[9],"We":[10],"aimed":[11],"to":[12,90,228],"assess:":[13],"1)":[14],"serum":[15,45,59,98,119,195],"levels":[17,47,68,112,120,170,196,208,225],"in":[18,48,71,124,203,211,223,242,246],"patients":[19,30,49,62,73,77,125,147,173,212],"with":[20,29,31,50,74,78,126,129,148,161,172,174,200,213],"ankylosing":[21],"spondylitis":[22],"(AS),":[23],"a":[24,230],"prototype":[25],"bone-forming":[26],"disease,":[27],"compared":[28,128,171],"rheumatoid":[32],"arthritis":[33],"(RA)":[34],"and":[35,52,54,80,146,215],"healthy":[36,82,130],"subjects;":[37],"2)":[38],"the":[39,56,105],"effect(s)":[40,57],"TNF\u03b1":[42,164],"blockers":[43,165],"on":[44,63,99,177,233],"AS":[51,61,127,162,175,214],"RA;":[53],"3)":[55],"signaling.":[65],"Serum":[66],"were":[69,121,197],"measured":[70],"47":[72],"AS,":[75],"28":[76],"RA,":[79],"40":[81],"subjects":[83,131],"by":[84,115],"radioimmunoassay;":[85],"t":[86],"test":[87],"was":[88,102],"used":[89],"assess":[91],"differences":[92],"between":[93],"groups.":[94],"The":[95],"effect":[96],"signaling":[101],"assessed":[103],"using":[104],"human":[106],"osteoblastic":[107],"cell":[108],"line":[109],"Saos2,":[110],"evaluating":[111],"phospho-CREB":[114],"Western":[116],"immunoblots.":[117],"Serotonin":[118,194,207],"significantly":[122,167],"lower":[123,168],"(mean":[132,150,180],"\u00b1":[133,137,141,151,155,181,185,189],"SEM":[134,152,182],"ng/mL":[135,153,183],"122.9":[136],"11.6":[138],"versus":[139,187],"177.4":[140],"24.58,":[142],"p":[143,157,191],"=":[144,158,192],"0.038)":[145],"RA":[149],"244.8":[154],"37.5,":[156],"0.0004).":[159],"Patients":[160],"receiving":[163],"had":[166],"not":[176],"such":[178],"treatment":[179],"95.8":[184],"14.9":[186],"149.2":[188],"16.0,":[190],"0.019).":[193],"inversely":[198],"correlated":[199],"pCREB":[201],"induction":[202],"osteoblast-like":[204,234],"Saos-2":[205,235],"cells.":[206,236],"are":[209,226],"low":[210],"decrease":[216],"even":[217],"further":[218],"during":[219],"anti-TNF\u03b1":[220],"treatment.":[221],"Differences":[222],"shown":[227],"have":[229],"functional":[231],"impact":[232],"Therefore,":[237],"may":[239],"be":[240],"involved":[241],"new":[243],"formation":[245],"AS.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}