{"id":"https://openalex.org/W2113804697","doi":"https://doi.org/10.1016/s0925-4439(99)00111-8","title":"A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice","display_name":"A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2113804697","doi":"https://doi.org/10.1016/s0925-4439(99)00111-8","mag":"2113804697","pmid":"https://pubmed.ncbi.nlm.nih.gov/10699369"},"language":"en","primary_location":{"id":"doi:10.1016/s0925-4439(99)00111-8","doi":"https://doi.org/10.1016/s0925-4439(99)00111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0925-4439(99)00111-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0925-4439(99)00111-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100987318","display_name":"Zhihui Zhao","orcid":"https://orcid.org/0000-0001-5114-1266","observed_orcids":["https://orcid.org/0000-0001-5114-1266"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihui Zhao","raw_affiliation_strings":["Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021615854","display_name":"Konstantinos P. Makaritsis","orcid":"https://orcid.org/0000-0002-8675-6583","observed_orcids":["https://orcid.org/0000-0002-8675-6583"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantinos Makaritsis","raw_affiliation_strings":["Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053709867","display_name":"Cynthia E. Francis","orcid":"https://orcid.org/0000-0003-0721-3474","observed_orcids":["https://orcid.org/0000-0003-0721-3474"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia E Francis","raw_affiliation_strings":["Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060042484","display_name":"Haralambos P. Gavras","orcid":"https://orcid.org/0000-0001-9675-9983","observed_orcids":["https://orcid.org/0000-0001-9675-9983"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haralambos Gavras","raw_affiliation_strings":["Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016693607","display_name":"Katya Ravid","orcid":"https://orcid.org/0000-0002-9918-3024","observed_orcids":["https://orcid.org/0000-0002-9918-3024"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katya Ravid","raw_affiliation_strings":["Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016693607"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":{"value":4010,"currency":"USD","value_usd":4010},"fwci":3.3863,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.93330111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1500","issue":"3","first_page":"280","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/a3-adenosine-receptor","display_name":"A3 adenosine receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7710000276565552},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/adenosine-a2-receptor","display_name":"adenosine A2 receptor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.8009999990463257},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.7829999923706055},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.9599999785423279},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.875},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.8403384685516357},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.8030667304992676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7293194532394409},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7113964557647705},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6055405139923096},{"id":"https://openalex.org/C158424129","wikidata":"https://www.wikidata.org/wiki/Q4682275","display_name":"Adenosine A3 receptor","level":5,"score":0.6005834937095642},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.556067168712616},{"id":"https://openalex.org/C172590197","wikidata":"https://www.wikidata.org/wiki/Q17165723","display_name":"Purinergic signalling","level":5,"score":0.5498865842819214},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5399017930030823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44926947355270386},{"id":"https://openalex.org/C182683403","wikidata":"https://www.wikidata.org/wiki/Q14888579","display_name":"Adenosine A1 receptor","level":5,"score":0.44320785999298096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4148215353488922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21078979969024658},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043684","descriptor_name":"Receptor, Adenosine A3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0925-4439(99)00111-8","doi":"https://doi.org/10.1016/s0925-4439(99)00111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0925-4439(99)00111-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},{"id":"pmid:10699369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10699369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0925-4439(99)00111-8","doi":"https://doi.org/10.1016/s0925-4439(99)00111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0925-4439(99)00111-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5048251017","display_name":"Role of the Arterial Wall in Atherosclerosis","funder_award_id":"P01HL013262","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W74277281","https://openalex.org/W234369002","https://openalex.org/W982796945","https://openalex.org/W1493851469","https://openalex.org/W1505825861","https://openalex.org/W1545688394","https://openalex.org/W1592859578","https://openalex.org/W1892265043","https://openalex.org/W1896310453","https://openalex.org/W1898241113","https://openalex.org/W1929910100","https://openalex.org/W1966657000","https://openalex.org/W1970131163","https://openalex.org/W1970592808","https://openalex.org/W1971024460","https://openalex.org/W1983986442","https://openalex.org/W1987767920","https://openalex.org/W1989072761","https://openalex.org/W2001110103","https://openalex.org/W2001234234","https://openalex.org/W2018473024","https://openalex.org/W2028613745","https://openalex.org/W2031151908","https://openalex.org/W2035054244","https://openalex.org/W2054120258","https://openalex.org/W2054144764","https://openalex.org/W2054906104","https://openalex.org/W2065562160","https://openalex.org/W2065762008","https://openalex.org/W2067182243","https://openalex.org/W2075206212","https://openalex.org/W2075587285","https://openalex.org/W2076782992","https://openalex.org/W2077747679","https://openalex.org/W2079265669","https://openalex.org/W2084839593","https://openalex.org/W2088746083","https://openalex.org/W2089531408","https://openalex.org/W2093209630","https://openalex.org/W2109353832","https://openalex.org/W2116068979","https://openalex.org/W2119586908","https://openalex.org/W2124101879","https://openalex.org/W2125621237","https://openalex.org/W2146490125","https://openalex.org/W2173637498","https://openalex.org/W2224807922","https://openalex.org/W2310461175","https://openalex.org/W2402623645","https://openalex.org/W2437877470","https://openalex.org/W6685159256"],"related_works":["https://openalex.org/W1584069561","https://openalex.org/W2065762008","https://openalex.org/W7216788438","https://openalex.org/W1521659744","https://openalex.org/W1580931007","https://openalex.org/W2077747679","https://openalex.org/W2166735931","https://openalex.org/W2048946830","https://openalex.org/W2003248159","https://openalex.org/W2169114428"],"abstract_inverted_index":{"Adenosine":[0],"administration":[1],"has":[2],"been":[3,22],"reported":[4],"to":[5,25,56,150,173,209,258],"lower":[6],"blood":[7,83,170,205,254],"pressure":[8,171,255],"by":[9],"activating":[10],"specific":[11],"membrane":[12],"receptors.":[13,101],"The":[14,133],"rat":[15],"and":[16,19,35,69,80,98,143,196,200,249],"human":[17],"heart":[18,144,195],"aorta":[20,142],"have":[21],"previously":[23],"found":[24,86],"express":[26,92],"both":[27,225],"A2-type":[28,66,99],"adenosine":[29,37,51,67,100,217],"receptors,":[30],"which":[31,40],"activate":[32],"adenylyl":[33,42],"cyclase,":[34],"A3":[36,50],"receptors":[38,68],"(A3AR),":[39],"inhibit":[41],"cyclase.":[43],"In":[44,102,212],"the":[45,58,61,65,72,78,88,96,107,114,130,141,183,194,214,233,236,242,253],"current":[46],"study,":[47],"we":[48],"used":[49],"receptor":[52],"(A3AR)":[53],"knock-out":[54,90,131,146,166,184],"mice":[55,91,167,185],"examine":[57],"hypothesis":[59],"that":[60,87,106,232,250],"relative":[62],"levels":[63,74,94,192],"of":[64,75,95,109,119,136,145,216,227,239],"A3AR":[70,89,110,160,165,234],"determine":[71],"steady-state":[73,134,237],"cAMP":[76,137,191,240],"in":[77,113,129,140,157,175,190,193,204,224,241,256],"cells":[79],"may":[81],"affect":[82],"pressure.":[84],"We":[85],"normal":[93],"A1-":[97],"situ":[103],"hybridization":[104],"demonstrated":[105],"level":[108,135,238],"is":[111,126,138,154,161,222,246],"high":[112],"vascular":[115,197],"smooth":[116,198],"muscle":[117,199],"layer":[118],"aortas":[120],"derived":[121],"from":[122],"wild-type":[123,151,176,210],"mice,":[124,147,152],"but":[125,153],"not":[127,155,162],"detectable":[128],"mice.":[132,177,211,228],"elevated":[139],"as":[148,207],"compared":[149,208],"altered":[156],"platelets,":[158],"where":[159,244],"expressed":[163],"naturally.":[164],"possess":[168],"a":[169,187,201],"comparable":[172],"this":[174],"However,":[178],"when":[179],"challenged":[180],"with":[181],"adenosine,":[182],"display":[186],"further":[188],"increase":[189],"significant":[202],"decrease":[203],"pressure,":[206],"contrast,":[213],"effect":[215],"on":[218],"ADP-induced":[219],"platelet":[220],"aggregation":[221],"similar":[223],"types":[226],"These":[229],"studies":[230],"indicate":[231],"affects":[235],"tissues":[243],"it":[245,251],"naturally":[247],"expressed,":[248],"influences":[252],"response":[257],"adenosine.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}