{"id":"https://openalex.org/W2113707955","doi":null,"title":"INTERFERON-ALPHA SIGNALING PATHWAY IN THE SENSORY AUDITORY NEUROEPITHELIAL CELLS","display_name":"INTERFERON-ALPHA SIGNALING PATHWAY IN THE SENSORY AUDITORY NEUROEPITHELIAL CELLS","publication_year":2010,"publication_date":"2010-08-19","ids":{"openalex":"https://openalex.org/W2113707955","mag":"2113707955"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8632","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","pdf_url":"http://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057184725","display_name":"Mona Anwar M. H. El-Kady","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mona Anwar M. H. El-Kady","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057184725"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cochlear-cells","display_name":"cochlear cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6539999842643738},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.9760000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.7710000276565552},{"id":"https://openalex.org/keywords/inner-ear-protection","display_name":"inner ear protection","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dose-and-time-dependent-effects","display_name":"dose- and time-dependent effects","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7380185127258301},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6194968819618225},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6012627482414246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5167614817619324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4719366729259491},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.4631834030151367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4358440637588501},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.416111558675766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4033352732658386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38555675745010376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3265352249145508},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21212729811668396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17633739113807678}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:8632","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","pdf_url":"http://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2113707955","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8632","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","pdf_url":"http://d-scholarship.pitt.edu/8632/1/MonaElkady7-30-09.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113707955.pdf","grobid_xml":"https://content.openalex.org/works/W2113707955.grobid-xml"},"referenced_works_count":211,"referenced_works":["https://openalex.org/W13024533","https://openalex.org/W28339017","https://openalex.org/W83138054","https://openalex.org/W86329002","https://openalex.org/W128396251","https://openalex.org/W183069189","https://openalex.org/W207654541","https://openalex.org/W216483547","https://openalex.org/W329201058","https://openalex.org/W344789099","https://openalex.org/W370907414","https://openalex.org/W1482195803","https://openalex.org/W1484131343","https://openalex.org/W1510533289","https://openalex.org/W1511825494","https://openalex.org/W1515994079","https://openalex.org/W1521200617","https://openalex.org/W1534879090","https://openalex.org/W1563458559","https://openalex.org/W1567392757","https://openalex.org/W1571320643","https://openalex.org/W1582497576","https://openalex.org/W1594336957","https://openalex.org/W1595972372","https://openalex.org/W1602715853","https://openalex.org/W1607777232","https://openalex.org/W1891664461","https://openalex.org/W1931571693","https://openalex.org/W1951046932","https://openalex.org/W1954625420","https://openalex.org/W1960601565","https://openalex.org/W1964733610","https://openalex.org/W1966677529","https://openalex.org/W1967678110","https://openalex.org/W1969638562","https://openalex.org/W1969914430","https://openalex.org/W1971793836","https://openalex.org/W1974004289","https://openalex.org/W1975202136","https://openalex.org/W1977108818","https://openalex.org/W1977389667","https://openalex.org/W1977748264","https://openalex.org/W1978437791","https://openalex.org/W1979411434","https://openalex.org/W1981195126","https://openalex.org/W1981593238","https://openalex.org/W1982677778","https://openalex.org/W1984308009","https://openalex.org/W1987009823","https://openalex.org/W1987145582","https://openalex.org/W1987154737","https://openalex.org/W1988157743","https://openalex.org/W1991547851","https://openalex.org/W1991865867","https://openalex.org/W1993979452","https://openalex.org/W1996345632","https://openalex.org/W1996518557","https://openalex.org/W1999443534","https://openalex.org/W2002301799","https://openalex.org/W2003979883","https://openalex.org/W2004487378","https://openalex.org/W2006027051","https://openalex.org/W2007549963","https://openalex.org/W2010020234","https://openalex.org/W2010214756","https://openalex.org/W2010857566","https://openalex.org/W2012337697","https://openalex.org/W2013787067","https://openalex.org/W2015037700","https://openalex.org/W2019355116","https://openalex.org/W2020432612","https://openalex.org/W2023613221","https://openalex.org/W2024861915","https://openalex.org/W2025492442","https://openalex.org/W2026512054","https://openalex.org/W2026907366","https://openalex.org/W2028194374","https://openalex.org/W2030167054","https://openalex.org/W2032494271","https://openalex.org/W2033881945","https://openalex.org/W2033989357","https://openalex.org/W2035829935","https://openalex.org/W2035900146","https://openalex.org/W2035960655","https://openalex.org/W2036274051","https://openalex.org/W2036587157","https://openalex.org/W2038428454","https://openalex.org/W2040024128","https://openalex.org/W2040648637","https://openalex.org/W2042485082","https://openalex.org/W2042511952","https://openalex.org/W2042581554","https://openalex.org/W2044117808","https://openalex.org/W2044315590","https://openalex.org/W2045711089","https://openalex.org/W2046707517","https://openalex.org/W2047206582","https://openalex.org/W2047739035","https://openalex.org/W2049998759","https://openalex.org/W2050941612","https://openalex.org/W2051807881","https://openalex.org/W2052160940","https://openalex.org/W2052982889","https://openalex.org/W2053124569","https://openalex.org/W2054467054","https://openalex.org/W2055090334","https://openalex.org/W2056572393","https://openalex.org/W2057259086","https://openalex.org/W2057637356","https://openalex.org/W2058072615","https://openalex.org/W2060359113","https://openalex.org/W2060820237","https://openalex.org/W2060926084","https://openalex.org/W2067724561","https://openalex.org/W2068387198","https://openalex.org/W2071340776","https://openalex.org/W2072190423","https://openalex.org/W2072421057","https://openalex.org/W2073392504","https://openalex.org/W2073836556","https://openalex.org/W2074152898","https://openalex.org/W2075637013","https://openalex.org/W2076052906","https://openalex.org/W2076292802","https://openalex.org/W2079357798","https://openalex.org/W2079637334","https://openalex.org/W2083803103","https://openalex.org/W2084057573","https://openalex.org/W2084889955","https://openalex.org/W2085184913","https://openalex.org/W2085218382","https://openalex.org/W2085384499","https://openalex.org/W2085669605","https://openalex.org/W2085993356","https://openalex.org/W2088217295","https://openalex.org/W2088973205","https://openalex.org/W2088988430","https://openalex.org/W2089077679","https://openalex.org/W2089738808","https://openalex.org/W2091303557","https://openalex.org/W2091412371","https://openalex.org/W2097224767","https://openalex.org/W2097366004","https://openalex.org/W2099019634","https://openalex.org/W2102713850","https://openalex.org/W2103399712","https://openalex.org/W2103565638","https://openalex.org/W2105533119","https://openalex.org/W2106184194","https://openalex.org/W2107277218","https://openalex.org/W2108244474","https://openalex.org/W2112585447","https://openalex.org/W2114709438","https://openalex.org/W2119683782","https://openalex.org/W2120692382","https://openalex.org/W2122134062","https://openalex.org/W2123149665","https://openalex.org/W2123325948","https://openalex.org/W2123335694","https://openalex.org/W2124926343","https://openalex.org/W2125030042","https://openalex.org/W2125252759","https://openalex.org/W2125366323","https://openalex.org/W2126548430","https://openalex.org/W2128172622","https://openalex.org/W2128648689","https://openalex.org/W2129040674","https://openalex.org/W2129739654","https://openalex.org/W2130576390","https://openalex.org/W2131666890","https://openalex.org/W2135325091","https://openalex.org/W2135940439","https://openalex.org/W2136811387","https://openalex.org/W2137015473","https://openalex.org/W2138280158","https://openalex.org/W2139367012","https://openalex.org/W2140083987","https://openalex.org/W2140956597","https://openalex.org/W2141779237","https://openalex.org/W2142900475","https://openalex.org/W2144857397","https://openalex.org/W2145879504","https://openalex.org/W2147889096","https://openalex.org/W2151501496","https://openalex.org/W2154161526","https://openalex.org/W2156947910","https://openalex.org/W2157135427","https://openalex.org/W2158210715","https://openalex.org/W2159250989","https://openalex.org/W2164095252","https://openalex.org/W2165178639","https://openalex.org/W2165857884","https://openalex.org/W2166924755","https://openalex.org/W2168683474","https://openalex.org/W2169758620","https://openalex.org/W2173897665","https://openalex.org/W2177943720","https://openalex.org/W2198773632","https://openalex.org/W2286452474","https://openalex.org/W2318780101","https://openalex.org/W2328739188","https://openalex.org/W2335968781","https://openalex.org/W2394809618","https://openalex.org/W2399912726","https://openalex.org/W2402049559","https://openalex.org/W2407269323","https://openalex.org/W2414568716","https://openalex.org/W2429400489","https://openalex.org/W2434130353","https://openalex.org/W3144580160","https://openalex.org/W4313341495"],"related_works":["https://openalex.org/W2654300612","https://openalex.org/W6902306527","https://openalex.org/W1971793836","https://openalex.org/W2026512054","https://openalex.org/W1993979452","https://openalex.org/W2225105679","https://openalex.org/W2114709438","https://openalex.org/W2464181197","https://openalex.org/W2112585447","https://openalex.org/W2945591636"],"abstract_inverted_index":{"The":[0,106,163,245],"current":[1,180],"study":[2,182],"investigated":[3],"the":[4,10,18,37,68,71,151,167,173,179,185,188,195,200,297,301],"effect":[5,242,303],"of":[6,39,70,87,108,115,141,150,222,230,257,267,274,304,336],"interferon-\u00e1":[7],"(IFN-\u00e1)":[8],"on":[9,17,243],"cochlear":[11,152,338],"cell":[12,28,161],"line":[13,29],"to":[14,35,139,235,238],"shed":[15],"light":[16],"mechanisms":[19,197],"by":[20,157],"which":[21,154],"interferon":[22],"alpha":[23],"may":[24],"affect":[25],"hearing.":[26,244],"HEI-OC1":[27],"and":[30,55,95,121,129,148,191,276,309,313,334],"real":[31],"time-PCR":[32],"were":[33,176],"used":[34],"determine":[36],"expression":[38,65,114],"those":[40],"genes":[41,120,123],"that":[42,111,135,184,213,249,260,294],"might":[43,193,261,287,324],"be":[44,194,262],"involved":[45,198,263],"in":[46,63,126,160,199,205,225,264,307,311,326],"these":[47],"mechanisms.":[48],"Dose-":[49],"(20,":[50],"40,":[51],"&":[52,93,101],"80":[53],"U/ml)":[54],"time-dependent":[56,130],"experiment-1":[57],"did":[58],"not":[59],"show":[60],"significant":[61,112],"alteration":[62],"gene":[64],"associated":[66],"with":[67],"stimulations":[69],"IFN-\u00e1":[72,136,208,231,310],"receptors.":[73],"Therefore,":[74,178],"a":[75,127,158,252],"second":[76],"experiment":[77],"was":[78,104,155,166],"planned.":[79],"A":[80],"3":[81],"X":[82],"4":[83],"factorial":[84],"design,":[85],"consisting":[86],"three":[88],"treatment":[89,137],"conditions":[90],"(0,":[91],"200":[92],"2000U/ml)":[94],"four":[96],"time-points":[97],"(6,":[98],"12,":[99],"24":[100],"48":[102],"Hrs),":[103],"employed.":[105],"results":[107,211,246],"experiment-2":[109],"revealed":[110],"differential":[113],"inflammatory":[116,143,172,186],"genes,":[117],"immune":[118,146,164,189],"response":[119,147,165,190],"apoptotic":[122,174],"is":[124,251],"found":[125],"dose-":[128],"manner.":[131],"This":[132,285],"outcome":[133],"indicates":[134,183],"led":[138],"initiation":[140],"an":[142,145,289],"response,":[144,187],"apoptosis":[149,192,275],"cells,":[153],"confirmed":[156],"reduction":[159],"viability.":[162],"most":[168],"pronounced":[169],"response;":[170],"whereas":[171],"responses":[175],"transient.":[177],"in-vitro":[181],"underlying":[196],"hearing":[201,215,223],"impairment":[202],"previously":[203],"reported":[204],"patients":[206,226],"under":[207],"therapy.":[209],"These":[210],"imply":[212],"pre-treatment":[214],"evaluation":[216],"as":[217,219,279,281],"well":[218,280],"close":[220],"monitoring":[221],"function":[224],"undergoing":[227],"long-term":[228],"high-dose":[229],"therapy":[232],"are":[233],"necessary":[234],"avoid":[236],"or":[237],"minimize":[239],"its":[240],"adverse":[241],"also":[247],"indicate":[248],"there":[250],"need":[253],"for":[254,271,283,291,331],"further":[255],"investigation":[256],"other":[258],"markers":[259,270,278,282,330],"signaling":[265],"pathways":[266],"IFN-\u00e1,":[268],"including":[269],"intrinsic":[272],"pathway":[273],"antiapoptotic":[277],"necrosis.":[284],"information":[286,323],"open":[288],"avenue":[290],"therapeutic":[292],"intervention":[293],"can":[295],"protect":[296],"inner":[298,317],"ear":[299,318],"from":[300],"ototoxic":[302],"some":[305,315],"medications":[306],"general":[308],"particular":[312],"treat":[314],"immune-mediated":[316],"disorders.":[319],"In":[320],"addition,":[321],"this":[322],"help":[325],"identifying":[327],"novel":[328],"diagnostic":[329],"vulnerability,":[332],"severity,":[333],"outcomes":[335],"any":[337],"pathology.":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}