{"id":"https://openalex.org/W2113703163","doi":"https://doi.org/10.1016/j.ejphar.2009.09.015","title":"\u03b1-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress","display_name":"\u03b1-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress","publication_year":2009,"publication_date":"2009-09-16","ids":{"openalex":"https://openalex.org/W2113703163","doi":"https://doi.org/10.1016/j.ejphar.2009.09.015","mag":"2113703163","pmid":"https://pubmed.ncbi.nlm.nih.gov/19765573"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2009.09.015","doi":"https://doi.org/10.1016/j.ejphar.2009.09.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2009.09.015","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075191221","display_name":"Elias N. Katsoulieris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71637028","display_name":"University of Brighton","ror":"https://ror.org/04kp2b655","country_code":"GB","type":"education","lineage":["https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elias Katsoulieris","raw_affiliation_strings":["Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK","institution_ids":["https://openalex.org/I71637028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015112375","display_name":"Jon G. Mabley","orcid":"https://orcid.org/0000-0001-9423-6230","observed_orcids":["https://orcid.org/0000-0001-9423-6230"]},"institutions":[{"id":"https://openalex.org/I71637028","display_name":"University of Brighton","ror":"https://ror.org/04kp2b655","country_code":"GB","type":"education","lineage":["https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon G. Mabley","raw_affiliation_strings":["Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK","institution_ids":["https://openalex.org/I71637028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043524877","display_name":"Mohamed Hindolo Samai","orcid":"https://orcid.org/0000-0002-1427-9482","observed_orcids":["https://orcid.org/0000-0002-1427-9482"]},"institutions":[{"id":"https://openalex.org/I182377803","display_name":"University of Sierra Leone","ror":"https://ror.org/045rztm55","country_code":"SL","type":"education","lineage":["https://openalex.org/I182377803"]}],"countries":["SL"],"is_corresponding":false,"raw_author_name":"Mohamed Samai","raw_affiliation_strings":["College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone","institution_ids":["https://openalex.org/I182377803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002911601","display_name":"Irene C. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71637028","display_name":"University of Brighton","ror":"https://ror.org/04kp2b655","country_code":"GB","type":"education","lineage":["https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Irene C. Green","raw_affiliation_strings":["Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK","institution_ids":["https://openalex.org/I71637028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113512390","display_name":"Prabal Kumar Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71637028","display_name":"University of Brighton","ror":"https://ror.org/04kp2b655","country_code":"GB","type":"education","lineage":["https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Prabal K. Chatterjee","raw_affiliation_strings":["Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Research Group, Centre for Biomedical and Health Science Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK","institution_ids":["https://openalex.org/I71637028"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113512390"],"corresponding_institution_ids":["https://openalex.org/I71637028"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.1803,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.73135941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"623","issue":"1-3","first_page":"107","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9829999804496765},{"id":"https://openalex.org/keywords/renal-proximal-tubular-cells","display_name":"renal proximal tubular cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.9959999918937683},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/salubrinal","display_name":"salubrinal","score":0.9950000047683716},{"id":"https://openalex.org/keywords/palmitoleic-acid","display_name":"palmitoleic acid","score":0.8629999756813049},{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.968999981880188},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.7609999775886536},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.8994076251983643},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.822224497795105},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7828254699707031},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5986052751541138},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.5984950661659241},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5549644231796265},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.5230404138565063},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46518391370773315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4524272382259369},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.45197176933288574},{"id":"https://openalex.org/C2776176469","wikidata":"https://www.wikidata.org/wiki/Q418650","display_name":"Linolenic acid","level":4,"score":0.4509075880050659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4105384051799774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3985198140144348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3217862844467163},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31227990984916687},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.26804816722869873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11463114619255066},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.046854615211486816},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017962","descriptor_name":"alpha-Linolenic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ejphar.2009.09.015","doi":"https://doi.org/10.1016/j.ejphar.2009.09.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2009.09.015","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:19765573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19765573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/7c3772c4-0745-48c1-a37c-93bbc9fc6483","doi":null,"is_oa":false,"landing_page_url":"https://research.brighton.ac.uk/en/publications/7c3772c4-0745-48c1-a37c-93bbc9fc6483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401758","display_name":"University of Brighton Repository (University of Brighton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71637028","host_organization_name":"University of Brighton","host_organization_lineage":["https://openalex.org/I71637028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Katsoulieris, E, Mabley, J, Samai, M, Green, I C & Chatterjee, P 2009, 'Alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress', European Journal of Pharmacology, vol. 623, no. 1-3, pp. 107-112. https://doi.org/10.1016/j.ejphar.2009.09.015","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320008","display_name":"Kidney Research UK","ror":"https://ror.org/02kx7se86"},{"id":"https://openalex.org/F4320320351","display_name":"Commonwealth Scholarship Commission","ror":"https://ror.org/051x4wh35"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W16955100","https://openalex.org/W1566051075","https://openalex.org/W1964957919","https://openalex.org/W1967659527","https://openalex.org/W1970303002","https://openalex.org/W1970420856","https://openalex.org/W1972095168","https://openalex.org/W1976152328","https://openalex.org/W1979938527","https://openalex.org/W1983472131","https://openalex.org/W1985134752","https://openalex.org/W1991997774","https://openalex.org/W1993941112","https://openalex.org/W2005404208","https://openalex.org/W2014448934","https://openalex.org/W2020207634","https://openalex.org/W2023316050","https://openalex.org/W2023800753","https://openalex.org/W2024397718","https://openalex.org/W2031462278","https://openalex.org/W2037735107","https://openalex.org/W2041836907","https://openalex.org/W2043513860","https://openalex.org/W2043572202","https://openalex.org/W2044237821","https://openalex.org/W2049432355","https://openalex.org/W2054393454","https://openalex.org/W2066765509","https://openalex.org/W2069136915","https://openalex.org/W2079837239","https://openalex.org/W2089198803","https://openalex.org/W2091378660","https://openalex.org/W2092982390","https://openalex.org/W2094381745","https://openalex.org/W2095498345","https://openalex.org/W2096396734","https://openalex.org/W2099125910","https://openalex.org/W2104726084","https://openalex.org/W2114679053","https://openalex.org/W2118338384","https://openalex.org/W2121596834","https://openalex.org/W2124400697","https://openalex.org/W2128635872","https://openalex.org/W2129125398","https://openalex.org/W2133122560","https://openalex.org/W2134569843","https://openalex.org/W2135805245","https://openalex.org/W2145133410","https://openalex.org/W2146024901","https://openalex.org/W2157700058","https://openalex.org/W2162679859","https://openalex.org/W2162887701","https://openalex.org/W2171988255","https://openalex.org/W2172197317","https://openalex.org/W2473343559","https://openalex.org/W6633856480"],"related_works":["https://openalex.org/W2120496938","https://openalex.org/W2152211430","https://openalex.org/W2133122560","https://openalex.org/W2916566038","https://openalex.org/W2997147418","https://openalex.org/W7095840764","https://openalex.org/W3034042022","https://openalex.org/W2167832002","https://openalex.org/W2157327705","https://openalex.org/W2098618462"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}