{"id":"https://openalex.org/W2113673352","doi":"https://doi.org/10.1089/cell.2009.0038","title":"Histone Deacetylase Inhibitors Improve In Vitro and In Vivo Developmental Competence of Somatic Cell Nuclear Transfer Porcine Embryos","display_name":"Histone Deacetylase Inhibitors Improve In Vitro and In Vivo Developmental Competence of Somatic Cell Nuclear Transfer Porcine Embryos","publication_year":2010,"publication_date":"2010-02-04","ids":{"openalex":"https://openalex.org/W2113673352","doi":"https://doi.org/10.1089/cell.2009.0038","mag":"2113673352","pmid":"https://pubmed.ncbi.nlm.nih.gov/20132015","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842950"},"language":"en","primary_location":{"id":"doi:10.1089/cell.2009.0038","doi":"https://doi.org/10.1089/cell.2009.0038","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cell.2009.0038","pdf_url":null,"source":{"id":"https://openalex.org/S180034465","display_name":"Cellular Reprogramming","issn_l":"2152-4971","issn":["2152-4971","2152-4998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Reprogramming","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842950","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057825204","display_name":"Jianguo Zhao","orcid":"https://orcid.org/0000-0001-6587-4823","observed_orcids":["https://orcid.org/0000-0001-6587-4823"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianguo Zhao","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri","National Swine Resource and Research Center, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"National Swine Resource and Research Center, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111715809","display_name":"Yanhong Hao","orcid":"https://orcid.org/0000-0002-8006-5263","observed_orcids":["https://orcid.org/0000-0002-8006-5263"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhong Hao","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068336149","display_name":"Jason W. Ross","orcid":"https://orcid.org/0000-0003-4950-2258","observed_orcids":["https://orcid.org/0000-0003-4950-2258"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason W. Ross","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080355462","display_name":"Lee D. Spate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee D. Spate","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065136298","display_name":"Eric M. Walters","orcid":"https://orcid.org/0000-0002-7888-8666","observed_orcids":["https://orcid.org/0000-0002-7888-8666"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Walters","raw_affiliation_strings":["University of Missouri","National Swine Resource and Research Center, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"National Swine Resource and Research Center, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103073446","display_name":"Melissa Samuel","orcid":"https://orcid.org/0000-0002-1416-7835","observed_orcids":["https://orcid.org/0000-0002-1416-7835"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa S. Samuel","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri","National Swine Resource and Research Center, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"National Swine Resource and Research Center, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016814708","display_name":"August Rieke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"August Rieke","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109240188","display_name":"Clifton N. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifton N. Murphy","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024184340","display_name":"Randall S. Prather","orcid":"https://orcid.org/0000-0002-6012-4035","observed_orcids":["https://orcid.org/0000-0002-6012-4035"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall S. Prather","raw_affiliation_strings":["University of Missouri","Division of Animal Sciences, University of Missouri, Columbia, Missouri","National Swine Resource and Research Center, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"National Swine Resource and Research Center, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024184340"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":8.7544,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.98610791,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"75","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/porcine-embryos","display_name":"porcine embryos","score":0.9710000157356262},{"id":"https://openalex.org/keywords/developmental-competence","display_name":"developmental competence","score":0.7850000262260437},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9480000138282776},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9330000281333923},{"id":"https://openalex.org/keywords/scriptaid","display_name":"Scriptaid","score":0.9879999756813049},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ear-fibroblasts","display_name":"ear fibroblasts","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cloning-efficiency","display_name":"cloning efficiency","score":0.8960000276565552},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.6700000166893005},{"id":"https://openalex.org/keywords/histone-h4-acetylation","display_name":"histone H4 acetylation","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C202438428","wikidata":"https://www.wikidata.org/wiki/Q1939923","display_name":"Somatic cell nuclear transfer","level":5,"score":0.9744704961776733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8403770923614502},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.8097655177116394},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.6834596991539001},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.640957236289978},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5920560956001282},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5481751561164856},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4914489984512329},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.47510039806365967},{"id":"https://openalex.org/C2779085176","wikidata":"https://www.wikidata.org/wiki/Q24721644","display_name":"Histone H4","level":4,"score":0.44328808784484863},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4288579225540161},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.42274805903434753},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.41450604796409607},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4134323000907898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3867078125476837},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.27352094650268555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20225048065185547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06645587086677551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006898","descriptor_name":"Hydroxylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019976","descriptor_name":"Cloning, Organism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021461","descriptor_name":"Animals, Outbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/cell.2009.0038","doi":"https://doi.org/10.1089/cell.2009.0038","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cell.2009.0038","pdf_url":null,"source":{"id":"https://openalex.org/S180034465","display_name":"Cellular Reprogramming","issn_l":"2152-4971","issn":["2152-4971","2152-4998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Reprogramming","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2842950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reprogram","raw_type":"Text"},{"id":"pmid:20132015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20132015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular reprogramming","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2842950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2842950","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reprogram","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5294313952","display_name":"Reproduction of Transgenic Pigs by Nuclear Transplantation","funder_award_id":"R01RR013438","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5564909358","display_name":"National Swine Resource and Research Center","funder_award_id":"U42RR018877","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W105272822","https://openalex.org/W1497453049","https://openalex.org/W1558122435","https://openalex.org/W1874007049","https://openalex.org/W1874881634","https://openalex.org/W1963559963","https://openalex.org/W1967769642","https://openalex.org/W1974127834","https://openalex.org/W1976371936","https://openalex.org/W1977050778","https://openalex.org/W1979055428","https://openalex.org/W1980537562","https://openalex.org/W1981744446","https://openalex.org/W1999874710","https://openalex.org/W2010765881","https://openalex.org/W2016696563","https://openalex.org/W2018966815","https://openalex.org/W2022550243","https://openalex.org/W2025239052","https://openalex.org/W2025960524","https://openalex.org/W2033110292","https://openalex.org/W2033767072","https://openalex.org/W2038507340","https://openalex.org/W2047015004","https://openalex.org/W2047220698","https://openalex.org/W2047837922","https://openalex.org/W2057430589","https://openalex.org/W2059950394","https://openalex.org/W2064050098","https://openalex.org/W2071953998","https://openalex.org/W2072638557","https://openalex.org/W2073157961","https://openalex.org/W2076962741","https://openalex.org/W2089899498","https://openalex.org/W2091236246","https://openalex.org/W2093155802","https://openalex.org/W2096083625","https://openalex.org/W2098066278","https://openalex.org/W2102098569","https://openalex.org/W2105208768","https://openalex.org/W2105718307","https://openalex.org/W2105825262","https://openalex.org/W2105916870","https://openalex.org/W2106844301","https://openalex.org/W2109057676","https://openalex.org/W2112485709","https://openalex.org/W2121837857","https://openalex.org/W2150515158","https://openalex.org/W2159547037","https://openalex.org/W2161080406","https://openalex.org/W2163046373","https://openalex.org/W2175806544","https://openalex.org/W2182683183","https://openalex.org/W4233036449"],"related_works":["https://openalex.org/W2405235593","https://openalex.org/W2161146417","https://openalex.org/W2028923989","https://openalex.org/W2005835438","https://openalex.org/W2561863336","https://openalex.org/W2314023571","https://openalex.org/W2153342546","https://openalex.org/W2164980960","https://openalex.org/W2020427027","https://openalex.org/W4309269409"],"abstract_inverted_index":{"Faulty":[0],"epigenetic":[1],"reprogramming":[2],"of":[3,13,35,46,76,102,109,173,195],"somatic":[4,22],"nuclei":[5],"is":[6],"likely":[7],"to":[8,56,127,145,159,166,193],"be":[9],"a":[10,190],"major":[11],"cause":[12],"low":[14],"success":[15],"observed":[16],"in":[17,38,87,90,189,197],"all":[18],"mammals":[19],"produced":[20],"through":[21],"cell":[23],"nuclear":[24],"transfer":[25],"(SCNT).":[26],"It":[27],"has":[28],"been":[29],"demonstrated":[30],"that":[31,63,115,194],"the":[32,73,100,123,128,146,151,179,196],"developmental":[33,74],"competence":[34,75],"SCNT":[36,78,111,125,174],"embryos":[37,79,126,175],"several":[39],"species":[40],"were":[41,140],"significantly":[42,121],"enhanced":[43,122],"via":[44],"treatment":[45,116,172],"histone":[47,58,180],"deacetylase":[48],"inhibitors":[49],"(HDACi)":[50],"such":[51],"as":[52,142],"trichostatin":[53],"A":[54],"(TSA)":[55],"increase":[57],"acetylation.":[59],"Here":[60],"we":[61,98],"report":[62],"50":[64],"nM":[65,119],"TSA":[66],"for":[67,107,161,168],"10":[68],"h":[69],"after":[70],"activation":[71],"increased":[72,150],"porcine":[77,110],"constructed":[80],"from":[81,155],"Landrace":[82,133,162,169],"fetal":[83],"fibroblast":[84,137],"cells":[85,138],"(FFCs)":[86],"vitro":[88,198],"and":[89,135,164],"vivo,":[91],"but":[92],"not":[93],"at":[94,185],"higher":[95],"concentrations.":[96],"Therefore,":[97],"optimized":[99],"application":[101],"another":[103],"novel":[104],"HDACi,":[105],"Scriptaid,":[106],"development":[108,124],"embryos.":[112,201],"We":[113],"found":[114],"with":[117,176],"500":[118],"Scriptaid":[120,149,177],"blastocyst":[129],"stage":[130],"when":[131],"outbred":[132],"FFCs":[134,163],"ear":[136],"(EFCs)":[139],"used":[141],"donors":[143],"compared":[144],"untreated":[147],"group.":[148],"overall":[152],"cloning":[153],"efficiency":[154],"0.4%":[156],"(untreated":[157],"group)":[158],"1.6%":[160],"0":[165],"3.7%":[167],"EFCs.":[170],"Moreover,":[171],"improved":[178],"acetylation":[181],"on":[182],"Histone":[183],"H4":[184],"lysine":[186],"8":[187],"(AcH4K8)":[188],"pattern":[191],"similar":[192],"fertilized":[199],"(IVF)":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}