{"id":"https://openalex.org/W2113582192","doi":"https://doi.org/10.1097/aln.0000000000000408","title":"An Enantiomerically Pure Formulation of Esmolol Attenuates Hypotension and Preserves Heart Rate Control in Dogs","display_name":"An Enantiomerically Pure Formulation of Esmolol Attenuates Hypotension and Preserves Heart Rate Control in Dogs","publication_year":2014,"publication_date":"2014-08-08","ids":{"openalex":"https://openalex.org/W2113582192","doi":"https://doi.org/10.1097/aln.0000000000000408","mag":"2113582192","pmid":"https://pubmed.ncbi.nlm.nih.gov/25105423"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000000408","doi":"https://doi.org/10.1097/aln.0000000000000408","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000000408","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/121/6/1184/484999/20141200_0-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/121/6/1184/484999/20141200_0-00016.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112827792","display_name":"Jeffrey S. McKee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey S. McKee","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111633709","display_name":"Barrett E. Rabinow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barrett E. Rabinow","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046156987","display_name":"Justin R. Daller","orcid":"https://orcid.org/0000-0002-1418-6681","observed_orcids":["https://orcid.org/0000-0002-1418-6681"]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin R. Daller","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001393643","display_name":"Benjamin D. Brooks","orcid":"https://orcid.org/0000-0001-7456-3074","observed_orcids":["https://orcid.org/0000-0001-7456-3074"]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Brooks","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bernhard Baumgartner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard Baumgartner","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055920792","display_name":"Priyanka Rohatgi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99484792","display_name":"Baxter (United States)","ror":"https://ror.org/02d6ew870","country_code":"US","type":"company","lineage":["https://openalex.org/I99484792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Rohatgi","raw_affiliation_strings":["From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Products, Baxter Healthcare Corporation, Round Lake, Illinois","institution_ids":["https://openalex.org/I99484792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112827792"],"corresponding_institution_ids":["https://openalex.org/I99484792"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.16787575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"121","issue":"6","first_page":"1184","last_page":"1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.20000000298023224,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esmolol","display_name":"esmolol","score":0.984000027179718},{"id":"https://openalex.org/keywords/s-enantiomer","display_name":"S-enantiomer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/r-enantiomer","display_name":"R-enantiomer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8679999709129333},{"id":"https://openalex.org/keywords/rate-control","display_name":"rate control","score":0.9340000152587891},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7630000114440918},{"id":"https://openalex.org/keywords/negative-inotropic-effect","display_name":"negative inotropic effect","score":0.9049999713897705},{"id":"https://openalex.org/keywords/left-ventricular-developed-pressure","display_name":"left ventricular developed pressure","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8840000033378601},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6890000104904175},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6140000224113464},{"id":"https://openalex.org/keywords/infusion-rate","display_name":"infusion rate","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cardiovascular-function","display_name":"cardiovascular function","score":0.4269999861717224},{"id":"https://openalex.org/keywords/beta-blocker-side-effects","display_name":"beta-blocker side effects","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2780996683","wikidata":"https://www.wikidata.org/wiki/Q418139","display_name":"Esmolol","level":4,"score":0.9977231025695801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7815759181976318},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6199376583099365},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6191592216491699},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4985313415527344},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46492815017700195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46063411235809326},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.44318264722824097},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.09424388408660889}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0000000000000408","doi":"https://doi.org/10.1097/aln.0000000000000408","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000000408","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/121/6/1184/484999/20141200_0-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:25105423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25105423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/aln.0000000000000408","doi":"https://doi.org/10.1097/aln.0000000000000408","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000000408","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/121/6/1184/484999/20141200_0-00016.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332558","display_name":"Baxter Healthcare Corporation","ror":"https://ror.org/02d6ew870"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113582192.pdf","grobid_xml":"https://content.openalex.org/works/W2113582192.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1877972625","https://openalex.org/W1902628286","https://openalex.org/W1965949370","https://openalex.org/W1968308007","https://openalex.org/W1989416854","https://openalex.org/W2013365742","https://openalex.org/W2022348739","https://openalex.org/W2029742165","https://openalex.org/W2037217720","https://openalex.org/W2038498480","https://openalex.org/W2040006738","https://openalex.org/W2065304512","https://openalex.org/W2076426690","https://openalex.org/W2084344933","https://openalex.org/W2089553847","https://openalex.org/W2102235008","https://openalex.org/W2129688375","https://openalex.org/W2136756415","https://openalex.org/W2141090286","https://openalex.org/W2142716209","https://openalex.org/W2143034699","https://openalex.org/W2159121887","https://openalex.org/W2314376203","https://openalex.org/W2324826299","https://openalex.org/W2955504961","https://openalex.org/W4237051689","https://openalex.org/W4407006169"],"related_works":["https://openalex.org/W2038498480","https://openalex.org/W2075458094","https://openalex.org/W2007717419","https://openalex.org/W275656065","https://openalex.org/W1979986109","https://openalex.org/W3115307026","https://openalex.org/W2014349518","https://openalex.org/W2390572563","https://openalex.org/W2045930291","https://openalex.org/W2036730723"],"abstract_inverted_index":{"BACKGROUND:":[0],"Esmolol":[1],"is":[2],"marketed":[3],"as":[4],"a":[5],"racemate":[6],"(RS-esmolol)":[7],"with":[8,49,136,158,232,253],"hypotension":[9,41,231],"being":[10],"the":[11,23,29,88,96,104,230],"most":[12],"frequently":[13],"reported":[14],"adverse":[15],"event.":[16],"Previously,":[17],"it":[18],"has":[19],"been":[20],"shown":[21],"that":[22],"S-enantiomer":[24,244],"(S-esmolol)":[25],"possesses":[26],"all":[27,111],"of":[28,45,54,101,107,246],"heart":[30],"rate":[31,97],"(HR)":[32],"control.":[33],"The":[34,52],"authors":[35],"studied":[36],"whether":[37],"S-esmolol":[38,57,93,198],"alone":[39],"mitigates":[40],"at":[42,64,94,125,144],"similar":[43,69,250],"degrees":[44],"HR":[46,70,108,225,251],"control":[47,71,109,252],"compared":[48,63,135],"RS-esmolol.":[50],"METHODS:":[51],"effects":[53],"RS-":[55],"and":[56,86,122,130,141,149,175,192,216],"on":[58],"blood":[59],"pressure":[60,168],"(BP)":[61],"were":[62,78],"multiple":[65],"infusion":[66,112],"rates":[67],"producing":[68],"in":[72,76,164],"dogs":[73],"(N=21).":[74],"Differences":[75],"BP":[77,116,157,183,207],"further":[79],"interrogated":[80],"by":[81,117,205],"monitoring":[82],"global":[83],"cardiovascular":[84],"function":[85],"included":[87],"R-enantiomer":[89,222],"(R-esmolol)":[90],"(N=3).":[91],"RESULTS:":[92],"half":[95],"(\u03bcg":[98],"kg":[99,133,152],"min)":[100],"RS-esmolol":[102,114,159],"provided":[103,223],"same":[105],"degree":[106],"over":[110],"rates.":[113],"lowered":[115],"3,":[118],"6,":[119],"11,":[120],"20,":[121],"38":[123],"mmHg":[124,143],"90,":[126],"300,":[127,147],"600,":[128],"1,000,":[129],"2,000":[131],"\u03bcg":[132,151],"min,":[134],"2,":[137],"4,":[138],"5,":[139],"10,":[140],"16":[142],"45,":[145],"150,":[146],"500,":[148],"1,000":[150],"min":[153],"for":[154],"S-esmolol.":[155],"Decreased":[156],"was":[160],"attributed":[161],"to":[162,229,236,239],"decreases":[163],"left":[165],"ventricular":[166],"developed":[167],"(LVDP)":[169],"(-34":[170],"mmHg),":[171,185,188,209,212],"LVdP/dt+max":[172,189,213],"(-702":[173],"mmHg/s),":[174,191,215],"cardiac":[176,193,217],"output":[177,194,218],"(-1":[178],"l/min).":[179,197,220],"R-esmolol":[180],"also":[181],"decreased":[182],"(-10":[184,187],"LVDP":[186,210],"(-241":[190],"(to":[195],"-0.2":[196],"reversed":[199],"these":[200],"trends":[201],"toward":[202],"pre-esmolol":[203],"values":[204],"increasing":[206],"(+13":[208],"(+12":[211],"(+76":[214],"(+0.4":[219],"CONCLUSIONS:":[221],"no":[224],"control,":[226],"but":[227],"contributed":[228],"RS-esmolol,":[233],"which":[234],"appears":[235],"be":[237],"due":[238],"negative":[240],"inotropy.":[241],"Thus,":[242],"an":[243],"formulation":[245],"esmolol":[247],"may":[248],"provide":[249],"less":[254],"hypotension.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}