{"id":"https://openalex.org/W2113576996","doi":"https://doi.org/10.4103/0250-474x.44591","title":"A pilot cross-over study to evaluate human oral bioavailability of BCM-95\u00aeCG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin","display_name":"A pilot cross-over study to evaluate human oral bioavailability of BCM-95\u00aeCG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2113576996","doi":"https://doi.org/10.4103/0250-474x.44591","mag":"2113576996","pmid":"https://pubmed.ncbi.nlm.nih.gov/20046768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792534"},"language":"en","primary_location":{"id":"doi:10.4103/0250-474x.44591","doi":"https://doi.org/10.4103/0250-474x.44591","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0250-474x.44591","pdf_url":null,"source":{"id":"https://openalex.org/S87963693","display_name":"Indian Journal of Pharmaceutical Sciences","issn_l":"0250-474X","issn":["0250-474X","1998-3743"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103133580","display_name":"Benny Antony","orcid":"https://orcid.org/0000-0002-7725-8822","observed_orcids":["https://orcid.org/0000-0002-7725-8822"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"B Antony","raw_affiliation_strings":["Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012283893","display_name":"Merina Benny","orcid":"https://orcid.org/0000-0002-0211-5982","observed_orcids":["https://orcid.org/0000-0002-0211-5982","https://orcid.org/0000-0002-7703-6509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Merina","raw_affiliation_strings":["Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050932011","display_name":"VS Iyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VS Iyer","raw_affiliation_strings":["Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye-683 101, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051834254","display_name":"N Judy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126009","display_name":"Little Flower Hospital & Research Centre","ror":"https://ror.org/0375jhj23","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210126009"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N Judy","raw_affiliation_strings":["Little Flower Hospital & Research Centre, Angamaly - 683 572, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Little Flower Hospital & Research Centre, Angamaly - 683 572, India","institution_ids":["https://openalex.org/I4210126009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036791138","display_name":"K Lennertz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125617","display_name":"Life Extension Foundation","ror":"https://ror.org/02vzd2x77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210125617"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Lennertz","raw_affiliation_strings":["Life Extension Foundation, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Extension Foundation, Florida, USA","institution_ids":["https://openalex.org/I4210125617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088503227","display_name":"Steven V. Joyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125617","display_name":"Life Extension Foundation","ror":"https://ror.org/02vzd2x77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210125617"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Joyal","raw_affiliation_strings":["Life Extension Foundation, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Extension Foundation, Florida, USA","institution_ids":["https://openalex.org/I4210125617"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103133580"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4961,"has_fulltext":false,"cited_by_count":279,"citation_normalized_percentile":{"value":0.87416501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"70","issue":"4","first_page":"445","last_page":"445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.7649999856948853},{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lecithin","display_name":"lecithin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/piperine","display_name":"piperine","score":1.0},{"id":"https://openalex.org/keywords/cross-over-study","display_name":"cross-over study","score":0.6000000238418579},{"id":"https://openalex.org/keywords/human-volunteers","display_name":"human volunteers","score":0.5180000066757202},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8425688743591309},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7984789609909058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5446261167526245},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.48257628083229065},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24183648824691772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18740305304527283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10905066132545471}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4103/0250-474x.44591","doi":"https://doi.org/10.4103/0250-474x.44591","is_oa":false,"landing_page_url":"https://doi.org/10.4103/0250-474x.44591","pdf_url":null,"source":{"id":"https://openalex.org/S87963693","display_name":"Indian Journal of Pharmaceutical Sciences","issn_l":"0250-474X","issn":["0250-474X","1998-3743"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2792534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharm Sci","raw_type":"Text"},{"id":"pmid:20046768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20046768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2792534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Pharm Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W74993898","https://openalex.org/W112445417","https://openalex.org/W340331798","https://openalex.org/W1604068141","https://openalex.org/W1664719478","https://openalex.org/W1828339576","https://openalex.org/W1977290655","https://openalex.org/W1978273172","https://openalex.org/W1991178530","https://openalex.org/W1991327193","https://openalex.org/W2008382270","https://openalex.org/W2019536742","https://openalex.org/W2028491158","https://openalex.org/W2031685643","https://openalex.org/W2033431239","https://openalex.org/W2036114299","https://openalex.org/W2043825885","https://openalex.org/W2047069988","https://openalex.org/W2054072505","https://openalex.org/W2078134305","https://openalex.org/W2080573554","https://openalex.org/W2080745163","https://openalex.org/W2082796818","https://openalex.org/W2082921392","https://openalex.org/W2089430646","https://openalex.org/W2092032160","https://openalex.org/W2092184065","https://openalex.org/W2095637939","https://openalex.org/W2100093977","https://openalex.org/W2115586774","https://openalex.org/W2117316894","https://openalex.org/W2118935736","https://openalex.org/W2128151632","https://openalex.org/W2138508372","https://openalex.org/W2141116781","https://openalex.org/W2144698171","https://openalex.org/W2146962477","https://openalex.org/W2154748960","https://openalex.org/W2156234074","https://openalex.org/W2157067671","https://openalex.org/W2169238639","https://openalex.org/W2169972304","https://openalex.org/W2189011617","https://openalex.org/W2398548305"],"related_works":["https://openalex.org/W2923782909","https://openalex.org/W3179009274","https://openalex.org/W4225392410","https://openalex.org/W4220714789","https://openalex.org/W7024479082","https://openalex.org/W7133208771","https://openalex.org/W3154383957","https://openalex.org/W4416340944","https://openalex.org/W4389145627","https://openalex.org/W2910421569"],"abstract_inverted_index":{"Curcumin,":[0],"the":[1,61,88,98,102,108,127,146,179,183],"bioactive":[2],"component":[3],"of":[4,13,27,33,48,54,81,91,110,143,166,178,186],"turmeric,":[5],"Curcuma":[6],"longa":[7],"has":[8,64,93,205],"an":[9],"exceptionally":[10],"wide":[11],"spectrum":[12],"activities":[14,47],"including":[15],"antioxidant,":[16],"anti-inflammatory":[17],"and":[18,21,41,149,156,196],"anti-cancer":[19],"properties,":[20],"is":[22],"currently":[23],"under":[24],"different":[25],"phases":[26],"clinical":[28,104],"trials":[29],"for":[30,50,207,210],"various":[31,211],"types":[32,53],"soft":[34],"tissue":[35],"cancers.":[36],"However,":[37],"although":[38],"in":[39,60,126,132],"vitro":[40],"animal":[42],"studies":[43],"have":[44],"shown":[45,171],"anticancer":[46],"curcumin":[49,86,123,195],"virtually":[51],"all":[52],"human":[55,62,119],"cancers,":[56],"its":[57,67,75],"poor":[58],"bioavailability":[59,77,99,109,185],"body":[63],"severely":[65],"limited":[66],"application":[68,209],"to":[69,73,96,106,172,193,200],"these":[70],"diseases.":[71,213],"Methods":[72],"increase":[74,97],"oral":[76],"are":[78],"a":[79,112,140,164],"subject":[80],"intense":[82],"current":[83],"research.":[84],"Reconstituting":[85],"with":[87,163],"non-curcuminoid":[89],"components":[90],"turmeric":[92],"been":[94],"found":[95],"substantially.":[100],"In":[101],"present":[103],"study":[105,180],"determine":[107],"curcuminoids,":[111],"patented":[113],"formulation,":[114],"BCM-95((R))CG":[115,155,187,203],"was":[116,124,134,160,169,189],"tested":[117],"on":[118],"volunteer":[120],"group.":[121,129],"Normal":[122],"used":[125],"control":[128,147],"Curcumin":[130],"content":[131],"blood":[133],"estimated":[135],"at":[136],"periodical":[137],"intervals.":[138],"After":[139],"washout":[141],"period":[142],"two":[144],"weeks":[145],"group":[148,151],"drug":[150],"were":[152],"crossed":[153],"over":[154],"curcumin,":[157],"respectively.":[158],"It":[159],"also":[161],"compared":[162,192,199],"combination":[165],"curcumin-lecithin-piperine":[167,201],"which":[168],"earlier":[170],"provide":[173],"enhanced":[174],"bioavailability.":[175],"The":[176],"results":[177],"indicate":[181],"that":[182],"relative":[184],"(Biocurcumax)":[188],"about":[190,197],"6.93-fold":[191],"normal":[194],"6.3-fold":[198],"formula.":[202],"thus,":[204],"potential":[206],"widespread":[208],"chronic":[212]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
