{"id":"https://openalex.org/W2113553995","doi":"https://doi.org/10.1093/intimm/dxf089","title":"Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation","display_name":"Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation","publication_year":2002,"publication_date":"2002-09-30","ids":{"openalex":"https://openalex.org/W2113553995","doi":"https://doi.org/10.1093/intimm/dxf089","mag":"2113553995","pmid":"https://pubmed.ncbi.nlm.nih.gov/12356687"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/dxf089","doi":"https://doi.org/10.1093/intimm/dxf089","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxf089","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2113553995"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090414246","display_name":"Katsuaki Hoshino","orcid":"https://orcid.org/0000-0003-0493-4815","observed_orcids":["https://orcid.org/0000-0003-0493-4815"]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"K. Hoshino","raw_affiliation_strings":["Department of Host Defense and Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Host Defense and Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054121448","display_name":"Tsuneyasu Kaisho","orcid":"https://orcid.org/0000-0003-2616-1665","observed_orcids":["https://orcid.org/0000-0003-2616-1665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Kaisho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T. Iwabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Iwabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056230564","display_name":"Osamu Takeuchi","orcid":"https://orcid.org/0000-0002-1260-6232","observed_orcids":["https://orcid.org/0000-0002-1260-6232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Takeuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018553332","display_name":"Shizuo Akira","orcid":"https://orcid.org/0000-0001-7602-9617","observed_orcids":["https://orcid.org/0000-0001-7602-9617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Akira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090414246"],"corresponding_institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":6.9567,"has_fulltext":false,"cited_by_count":288,"citation_normalized_percentile":{"value":0.97867625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"10","first_page":"1225","last_page":"1231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.8550000190734863},{"id":"https://openalex.org/keywords/myd88-independent-signaling","display_name":"MyD88-independent signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ifn-alpha-beta-receptor","display_name":"IFN-alpha/beta receptor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.875},{"id":"https://openalex.org/keywords/irg1","display_name":"IRG1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cpg-dna","display_name":"CpG DNA","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7040770649909973},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.6753910779953003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6479099988937378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6094460487365723},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5960926413536072},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5845069885253906},{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.5820345282554626},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4573901891708374},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44101086258888245},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.4401557445526123},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3450677990913391},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29589569568634033},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2683115303516388},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2531121075153351},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.23793473839759827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20270785689353943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05881431698799133},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/intimm/dxf089","doi":"https://doi.org/10.1093/intimm/dxf089","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxf089","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmid:12356687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12356687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.498.6752","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.498.6752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intimm.oxfordjournals.org/content/14/10/1225.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1501690710","https://openalex.org/W1514540900","https://openalex.org/W1519843522","https://openalex.org/W1584930706","https://openalex.org/W1655860314","https://openalex.org/W1930598094","https://openalex.org/W1965971815","https://openalex.org/W1966772446","https://openalex.org/W1968134126","https://openalex.org/W1969501356","https://openalex.org/W1982443563","https://openalex.org/W1996120614","https://openalex.org/W2004829503","https://openalex.org/W2010118666","https://openalex.org/W2011103030","https://openalex.org/W2017883909","https://openalex.org/W2022986271","https://openalex.org/W2035209826","https://openalex.org/W2057809738","https://openalex.org/W2070597700","https://openalex.org/W2072075206","https://openalex.org/W2089077517","https://openalex.org/W2091554591","https://openalex.org/W2092250990","https://openalex.org/W2095194341","https://openalex.org/W2098901296","https://openalex.org/W2103565638","https://openalex.org/W2109148136","https://openalex.org/W2122506044","https://openalex.org/W2126439584","https://openalex.org/W2130322182","https://openalex.org/W2149082099","https://openalex.org/W2156788946","https://openalex.org/W2166676682"],"related_works":["https://openalex.org/W2006065188","https://openalex.org/W2141753982","https://openalex.org/W2162440021","https://openalex.org/W2066120874","https://openalex.org/W2013510722","https://openalex.org/W2141312109","https://openalex.org/W2074900897","https://openalex.org/W2086400782","https://openalex.org/W2079132454"],"abstract_inverted_index":{"Toll-like":[0],"receptor":[1,122],"(TLR)":[2],"can":[3,28,63,140,166],"activate":[4,29],"dendritic":[5],"cells":[6],"(DC)":[7],"through":[8],"common":[9],"signaling":[10,19,54,139,201,213,218],"pathways":[11],"requiring":[12],"a":[13],"cytoplasmic":[14],"adapter,":[15],"MyD88.":[16,184],"However,":[17,153,206],"the":[18,52,135,171],"is":[20,78,181],"differentially":[21],"regulated":[22],"among":[23],"TLR":[24],"family":[25],"members.":[26],"TLR4":[27,162,210],"MyD88-deficient":[30,97],"bone":[31],"marrow-derived":[32],"DC":[33],"(BMDC),":[34],"and":[35,42,96,111,127,146,149,235],"lead":[36],"to":[37,85,134,209],"induction":[38],"of":[39,44,58,100,129,144,151,190,229],"IFN-inducible":[40,102,147,191],"genes":[41,103,192],"up-regulation":[43,113,150],"co-stimulatory":[45],"molecules":[46],"such":[47],"as":[48,202],"CD40,":[49],"implying":[50],"that":[51],"MyD88-independent":[53],"pathway":[55],"functions":[56],"downstream":[57],"TLR4.":[59],"Because":[60],"these":[61,155],"effects":[62,156,237],"also":[64,141],"be":[65,167],"induced":[66,168],"by":[67,170],"type":[68,75,198,215,230],"I":[69,76,199,216,231],"IFN,":[70],"we":[71],"have":[72],"analyzed":[73],"whether":[74],"IFN":[77,200,217,232],"involved":[79],"in":[80,93,116,161,177,203,207,233],"TLR4-induced":[81],"responses.":[82],"In":[83,185],"response":[84],"lipopolysaccharide":[86],"(LPS),":[87],"IFN-beta":[88,145,164],"gene":[89,106],"expression":[90,143,165,189],"was":[91,109,114,195],"augmented":[92],"both":[94],"wild-type":[95],"BMDC.":[98],"Expression":[99],"all":[101,154],"except":[104,193],"immune-responsive":[105],"1":[107,131],"(IRG1)":[108],"abolished":[110],"CD40":[112,220],"decreased":[115],"LPS-stimulated":[117,204],"BMDC":[118],"lacking":[119],"either":[120,169],"IFN-alpha/beta":[121],"(IFN-alpha/betaR)":[123],"or":[124,173],"signal":[125],"transducer":[126],"activator":[128],"transcription":[130],"(STAT-1).":[132],"Similar":[133],"LPS":[136],"response,":[137],"TLR9":[138,178,212],"induce":[142],"genes,":[148],"CD40.":[152],"were":[157],"MyD88":[158],"dependent.":[159],"Thus,":[160],"signaling,":[163,179,211],"MyD88-dependent":[172],"-independent":[174],"pathway,":[175],"whereas,":[176],"it":[180],"dependent":[182,196],"on":[183,197,238],"CpG":[186],"DNA-stimulated":[187],"DC,":[188],"IRG1":[194],"DC.":[205,239],"contrast":[208],"requires":[214],"for":[219],"up-regulation.":[221],"Taken":[222],"together,":[223],"this":[224],"study":[225],"demonstrates":[226],"differential":[227],"involvement":[228],"TLR4-":[234],"TLR9-induced":[236]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
