{"id":"https://openalex.org/W2113545156","doi":"https://doi.org/10.1158/1541-7786.mcr-07-0366","title":"Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion","display_name":"Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2113545156","doi":"https://doi.org/10.1158/1541-7786.mcr-07-0366","mag":"2113545156","pmid":"https://pubmed.ncbi.nlm.nih.gov/18403633"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-07-0366","doi":"https://doi.org/10.1158/1541-7786.mcr-07-0366","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-07-0366","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059742725","display_name":"Dorina Belotti","orcid":"https://orcid.org/0000-0002-3868-9144","observed_orcids":["https://orcid.org/0000-0002-3868-9144"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dorina Belotti","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042344060","display_name":"Catia Calcagno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Catia Calcagno","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006968987","display_name":"Angela Garofalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Garofalo","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090751007","display_name":"Daniela Caronia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Caronia","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070893182","display_name":"Elena Riccardi","orcid":"https://orcid.org/0000-0002-3873-390X","observed_orcids":["https://orcid.org/0000-0002-3873-390X"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Riccardi","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000996905","display_name":"Raffaella Giavazzi","orcid":"https://orcid.org/0000-0001-5249-8208","observed_orcids":["https://orcid.org/0000-0001-5249-8208"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella Giavazzi","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018599202","display_name":"Giulia Taraboletti","orcid":"https://orcid.org/0000-0001-8780-5001","observed_orcids":["https://orcid.org/0000-0001-8780-5001"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Taraboletti","raw_affiliation_strings":["Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biology and Treatment of Metastasis, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy","institution_ids":["https://openalex.org/I19630809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19630809"],"apc_list":null,"apc_paid":null,"fwci":2.2215,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.89571538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"525","last_page":"534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vegf-inhibitors","display_name":"VEGF inhibitors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5120000243186951},{"id":"https://openalex.org/keywords/organ-specific-gene-expression","display_name":"organ-specific gene expression","score":0.49799999594688416},{"id":"https://openalex.org/keywords/peritoneal-xenograft","display_name":"peritoneal xenograft","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2775997469","wikidata":"https://www.wikidata.org/wiki/Q18029196","display_name":"MMP9","level":4,"score":0.7259063720703125},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7180982828140259},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6026641726493835},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.5910931825637817},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5808805823326111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5621006488800049},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5325798988342285},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.5298746824264526},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5244840979576111},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.45776987075805664},{"id":"https://openalex.org/C2776223131","wikidata":"https://www.wikidata.org/wiki/Q13033733","display_name":"Gelatinase A","level":3,"score":0.4530498683452606},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44804489612579346},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.44797977805137634},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.42960184812545776},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.42518681287765503},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32145336270332336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2920147180557251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2582883834838867},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.14306345582008362},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.12893790006637573},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.06217518448829651},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1541-7786.mcr-07-0366","doi":"https://doi.org/10.1158/1541-7786.mcr-07-0366","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-07-0366","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:18403633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18403633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.979.2157","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.979.2157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcr.aacrjournals.org/content/molcanres/6/4/525.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1542216227","https://openalex.org/W1574387449","https://openalex.org/W1604140953","https://openalex.org/W1649452503","https://openalex.org/W1734151292","https://openalex.org/W1773279845","https://openalex.org/W1965270832","https://openalex.org/W1969103696","https://openalex.org/W1971964548","https://openalex.org/W1972442218","https://openalex.org/W1972506105","https://openalex.org/W1977953284","https://openalex.org/W1978591675","https://openalex.org/W1983785395","https://openalex.org/W1985500792","https://openalex.org/W1987660792","https://openalex.org/W1998258610","https://openalex.org/W2003969086","https://openalex.org/W2013264198","https://openalex.org/W2021645028","https://openalex.org/W2026729384","https://openalex.org/W2030615367","https://openalex.org/W2039876086","https://openalex.org/W2047164016","https://openalex.org/W2052371470","https://openalex.org/W2053438624","https://openalex.org/W2058769205","https://openalex.org/W2059372143","https://openalex.org/W2089861713","https://openalex.org/W2095952603","https://openalex.org/W2096428903","https://openalex.org/W2096521047","https://openalex.org/W2099499481","https://openalex.org/W2100476458","https://openalex.org/W2109067479","https://openalex.org/W2116305904","https://openalex.org/W2116838015","https://openalex.org/W2126041400","https://openalex.org/W2126455718","https://openalex.org/W2129198104","https://openalex.org/W2142760959","https://openalex.org/W2146530991","https://openalex.org/W2166825418","https://openalex.org/W2283910894","https://openalex.org/W2288149417","https://openalex.org/W4243605909","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1972442218","https://openalex.org/W2385718596","https://openalex.org/W2381696880","https://openalex.org/W7095897291","https://openalex.org/W2359966707","https://openalex.org/W2099499481","https://openalex.org/W2335127818","https://openalex.org/W2390484712","https://openalex.org/W2013264198","https://openalex.org/W973062759"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2,178],"factor":[3],"(VEGF)":[4],"and":[5,77,154,169,188,199,219,227],"matrix":[6],"metalloproteinases":[7],"(MMP)":[8],"regulate":[9],"each":[10],"other,":[11],"contributing":[12],"to":[13,42,213,235],"tumor":[14,26,152,177,200,226,238],"progression.":[15],"We":[16],"have":[17],"previously":[18],"reported":[19],"that":[20,108],"MMP9":[21,118,135,165,197],"induces":[22],"the":[23,48,53,56,74,93,114,124,148,156,160,174,203,222,229],"release":[24],"of":[25,38,50,59,87,96,102,113,126,141,151,159,163,173,176,205,224,231],"VEGF,":[27],"promoting":[28],"ascites":[29],"formation":[30],"in":[31,73,92,123,144,167,183,202,221],"human":[32,67],"ovarian":[33,60,68,225],"carcinoma":[34],"xenografts.":[35],"The":[36,131,139,191],"aim":[37],"this":[39],"study":[40],"was":[41,120,137,171,181],"investigate":[43],"whether":[44],"tumor-derived":[45],"VEGF":[46,109,153,218,233],"regulated":[47],"expression":[49,112,119,166,198],"gelatinase":[51],"by":[52],"stroma,":[54],"influencing":[55],"invasive":[57],"properties":[58],"tumors.":[61,130,190,209],"Tumor":[62],"variants":[63],"derived":[64],"from":[65,89],"1A9":[66],"carcinoma,":[69],"stably":[70],"expressing":[71],"VEGF(121)":[72],"sense":[75],"(1A9-VS-1)":[76],"antisense":[78],"orientations":[79],"(1A9-VAS-3),":[80],"were":[81],"used.":[82],"In":[83],"vivo,":[84],"zymographic":[85],"analysis":[86],"tumors":[88,168],"1A9-VS-1":[90,129,208],"implanted":[91],"peritoneal":[94],"cavity":[95],"nude":[97],"mice":[98,127,184,206],"showed":[99],"higher":[100],"levels":[101,140,150],"gelatinases,":[103],"particularly":[104],"murine":[105],"MMP9,":[106],"indicating":[107],"stimulates":[110],"host":[111,134,142,164],"matrix-degrading":[115],"enzyme.":[116],"Murine":[117],"also":[121],"high":[122],"ovaries":[125,145,170,204],"bearing":[128,207],"effect":[132],"on":[133],"activity":[136],"organ-specific.":[138],"pro-MMP9":[143],"correlated":[146],"with":[147,155],"plasma":[149],"selective":[157],"invasion":[158,201],"ovaries.":[161],"Induction":[162],"independent":[172],"site":[175],"as":[179],"it":[180],"seen":[182],"carrying":[185],"both":[186],"intraperitoneal":[187],"subcutaneous":[189],"anti-VEGF":[192],"antibody":[193],"bevacizumab":[194],"(Avastin)":[195],"inhibited":[196],"These":[210],"findings":[211],"point":[212],"a":[214],"complex":[215],"cross-talk":[216],"between":[217],"MMPs":[220],"progression":[223],"suggest":[228],"possibility":[230],"using":[232],"inhibitors":[234],"affect":[236],"MMP-dependent":[237],"invasion.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}