{"id":"https://openalex.org/W2113524772","doi":"https://doi.org/10.1074/jbc.m113.526087","title":"The Yeast Anaerobic Response Element AR1b Regulates Aerobic Antifungal Drug-dependent Sterol Gene Expression","display_name":"The Yeast Anaerobic Response Element AR1b Regulates Aerobic Antifungal Drug-dependent Sterol Gene Expression","publication_year":2013,"publication_date":"2013-10-26","ids":{"openalex":"https://openalex.org/W2113524772","doi":"https://doi.org/10.1074/jbc.m113.526087","mag":"2113524772","pmid":"https://pubmed.ncbi.nlm.nih.gov/24163365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3853293"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.526087","doi":"https://doi.org/10.1074/jbc.m113.526087","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.526087","pdf_url":"http://www.jbc.org/article/S0021925820554100/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820554100/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081030603","display_name":"Christina Ebert","orcid":"https://orcid.org/0000-0003-0985-3547","observed_orcids":["https://orcid.org/0000-0003-0985-3547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Gallo-Ebert","raw_affiliation_strings":["From the Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017495581","display_name":"Melissa Donigan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Donigan","raw_affiliation_strings":["Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049321991","display_name":"Hsing\u2010Yin Liu","orcid":"https://orcid.org/0000-0001-7662-6390","observed_orcids":["https://orcid.org/0000-0001-7662-6390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsing-Yin Liu","raw_affiliation_strings":["Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078920485","display_name":"Florencia L. Pascual","orcid":"https://orcid.org/0000-0001-6786-0863","observed_orcids":["https://orcid.org/0000-0001-6786-0863"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florencia Pascual","raw_affiliation_strings":["Department of Food Science, Rutgers Center for Lipid Research and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Rutgers Center for Lipid Research and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014213088","display_name":"Melissa T. Manners","orcid":"https://orcid.org/0000-0001-7241-9423","observed_orcids":["https://orcid.org/0000-0001-7241-9423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Manners","raw_affiliation_strings":["Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004477312","display_name":"Devanshi Pandya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devanshi Pandya","raw_affiliation_strings":["Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Swanson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Swanson","raw_affiliation_strings":["Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023204052","display_name":"Denise Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Gallagher","raw_affiliation_strings":["Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Venenum Biodesign, Genesis Biotechnology Group, Hamilton, New Jersey 08690","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367118","display_name":"Weiwei Chen","orcid":"https://orcid.org/0000-0001-7681-3962","observed_orcids":["https://orcid.org/0000-0001-7681-3962","https://orcid.org/0000-0002-9682-0315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WeiWei Chen","raw_affiliation_strings":["Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015880535","display_name":"George M. Carman","orcid":"https://orcid.org/0000-0003-4951-8233","observed_orcids":["https://orcid.org/0000-0003-4951-8233"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Carman","raw_affiliation_strings":["Department of Food Science, Rutgers Center for Lipid Research and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Rutgers Center for Lipid Research and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061116054","display_name":"Joseph T. Nickels","orcid":"https://orcid.org/0000-0001-9984-3056","observed_orcids":["https://orcid.org/0000-0001-9984-3056"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph T. Nickels","raw_affiliation_strings":["Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Metabolic Disorders, Genesis Biotechnology Group, Hamilton, New Jersey 08691","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061116054"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.1492,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56400128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"288","issue":"49","first_page":"35466","last_page":"35477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sterol-response-element","display_name":"sterol response element","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ergosterol-biosynthesis","display_name":"ergosterol biosynthesis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.8100000023841858},{"id":"https://openalex.org/keywords/azole-antifungals","display_name":"azole antifungals","score":0.9480000138282776},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8220000267028809},{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/systemic-fungal-infection","display_name":"systemic fungal infection","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.9368763566017151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6671457290649414},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.63104647397995},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5919266939163208},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.5821834802627563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5617339611053467},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5164799690246582},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.5025351047515869},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.49694374203681946},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4317835569381714},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4174676835536957},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41277217864990234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.379523903131485},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.2526807188987732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2417300045490265},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11206498742103577},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000332","descriptor_name":"Aerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041221","descriptor_name":"Candida glabrata","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m113.526087","doi":"https://doi.org/10.1074/jbc.m113.526087","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.526087","pdf_url":"http://www.jbc.org/article/S0021925820554100/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3225593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3853293","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3853293","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3853293","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:24163365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24163365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11675682760004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/The-Yeast-Anaerobic-Response-Element-AR1b/991031716807604646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.526087","doi":"https://doi.org/10.1074/jbc.m113.526087","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.526087","pdf_url":"http://www.jbc.org/article/S0021925820554100/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G359592649","display_name":null,"funder_award_id":"HL-67401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3658246943","display_name":"Phospholipid metabolism and membrane function","funder_award_id":"R37GM028140","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G521722822","display_name":"Mechanisms Regulating Sterol Biosynthesis","funder_award_id":"R01HL067401","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5360626966","display_name":"Phospholipid Metabolism and Membrane Function","funder_award_id":"R01GM028140","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G620947315","display_name":null,"funder_award_id":"GM-28140","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113524772.pdf","grobid_xml":"https://content.openalex.org/works/W2113524772.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1485185856","https://openalex.org/W1527303490","https://openalex.org/W1553049210","https://openalex.org/W1556918753","https://openalex.org/W1559808711","https://openalex.org/W1566478858","https://openalex.org/W1648080802","https://openalex.org/W1652753186","https://openalex.org/W1671325546","https://openalex.org/W1726796702","https://openalex.org/W1866742568","https://openalex.org/W1965893642","https://openalex.org/W1970761589","https://openalex.org/W1971071885","https://openalex.org/W1971209284","https://openalex.org/W1973782344","https://openalex.org/W1980493512","https://openalex.org/W1986887947","https://openalex.org/W1990547365","https://openalex.org/W1992404471","https://openalex.org/W1995193554","https://openalex.org/W1999899846","https://openalex.org/W2021754429","https://openalex.org/W2026524456","https://openalex.org/W2032439358","https://openalex.org/W2033692327","https://openalex.org/W2034798029","https://openalex.org/W2039999119","https://openalex.org/W2040589276","https://openalex.org/W2055315631","https://openalex.org/W2059370408","https://openalex.org/W2062983075","https://openalex.org/W2068772709","https://openalex.org/W2074007751","https://openalex.org/W2086019998","https://openalex.org/W2086922902","https://openalex.org/W2091767998","https://openalex.org/W2096963938","https://openalex.org/W2102651270","https://openalex.org/W2102703208","https://openalex.org/W2103887971","https://openalex.org/W2104761994","https://openalex.org/W2108552532","https://openalex.org/W2108846692","https://openalex.org/W2109287119","https://openalex.org/W2109476076","https://openalex.org/W2110895138","https://openalex.org/W2124479692","https://openalex.org/W2125823722","https://openalex.org/W2126362614","https://openalex.org/W2129494864","https://openalex.org/W2130716475","https://openalex.org/W2143820120","https://openalex.org/W2143839871","https://openalex.org/W2144115774","https://openalex.org/W2144807652","https://openalex.org/W2145757273","https://openalex.org/W2153101930","https://openalex.org/W2158241162","https://openalex.org/W2159654630","https://openalex.org/W2159939027","https://openalex.org/W2160849328","https://openalex.org/W2162171804","https://openalex.org/W2163476686","https://openalex.org/W2167347342","https://openalex.org/W2168812832","https://openalex.org/W2169755129","https://openalex.org/W2186230891","https://openalex.org/W2191688201","https://openalex.org/W2409786930","https://openalex.org/W6637082717"],"related_works":["https://openalex.org/W3043173157","https://openalex.org/W2127080406","https://openalex.org/W4206580508","https://openalex.org/W4305015950","https://openalex.org/W2108846692","https://openalex.org/W1648080802","https://openalex.org/W2147739065","https://openalex.org/W2160849328","https://openalex.org/W2110895138","https://openalex.org/W2053715559"],"abstract_inverted_index":{"Saccharomyces":[0],"cerevisiae":[1,143],"ergosterol":[2,104,175],"biosynthesis,":[3,105],"like":[4],"cholesterol":[5],"biosynthesis":[6,35],"in":[7,33,86,96,101,171,188],"mammals,":[8],"is":[9,54,80],"regulated":[10],"at":[11],"the":[12,57,87,136,165,199],"transcriptional":[13],"level":[14],"by":[15,108],"a":[16,23,99,238],"sterol":[17,34,47],"feedback":[18],"mechanism.":[19],"Yeast":[20],"studies":[21,162],"defined":[22],"7-bp":[24,51],"consensus":[25,52],"sterol-response":[26],"element":[27],"(SRE)":[28],"common":[29],"to":[30,56,71,98,154,173,195,225,241],"genes":[31,208],"involved":[32],"and":[36,41,66,124,126,129,145,150,156],"two":[37,81,200],"transcription":[38,45],"factors,":[39],"Upc2":[40,65,128,182],"Ecm22,":[42],"which":[43],"direct":[44,91,137],"of":[46,120,139,205],"biosynthetic":[48],"genes.":[49],"The":[50,112],"SRE":[53,73],"identical":[55],"anaerobic":[58,83,167],"response":[59,97],"element,":[60],"AR1c.":[61],"Data":[62],"indicate":[63,180],"that":[64,78,90,164,181],"Ecm22":[67,130],"function":[68],"through":[69],"binding":[70,138],"this":[72],"site.":[74],"We":[75,133],"now":[76],"show":[77,163],"it":[79],"novel":[82,239],"AR1b":[84,113,155,168,186],"elements":[85,114,169,187,202,221],"UPC2":[88,121,166,185],"promoter":[89,161],"global":[92],"ERG":[93,191,207],"gene":[94,122,176,192],"expression":[95,123,193,204],"block":[100],"de":[102],"novo":[103],"brought":[106],"about":[107],"antifungal":[109,213,227,235],"drug":[110],"treatment.":[111],"are":[115],"absolutely":[116],"required":[117],"for":[118,131,190,210,234],"auto-induction":[119],"protein":[125],"require":[127],"function.":[132],"further":[134],"demonstrate":[135],"recombinant":[140],"expressed":[141],"S.":[142],"ScUpc2":[144],"pathogenic":[146],"Candida":[147,151],"albicans":[148],"CaUpc2":[149],"glabrata":[152],"CgUpc2":[153],"SRE/AR1c":[157],"elements.":[158],"Recombinant":[159],"endogenous":[160],"act":[170],"trans":[172],"regulate":[174],"expression.":[177],"Our":[178],"results":[179],"must":[183],"occupy":[184],"order":[189],"induction":[194],"take":[196],"place.":[197],"Thus,":[198],"UPC2-AR1b":[201],"drive":[203],"all":[206],"necessary":[209],"maintaining":[211],"normal":[212],"susceptibility,":[214],"as":[215],"wild":[216],"type":[217],"cells":[218],"lacking":[219],"these":[220,231],"have":[222],"increased":[223],"susceptibility":[224],"azole":[226],"drugs.":[228],"Therefore,":[229],"targeting":[230],"specific":[232],"sites":[233],"therapy":[236],"represents":[237],"approach":[240],"treat":[242],"systemic":[243],"fungal":[244],"infections.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
