{"id":"https://openalex.org/W2113458265","doi":"https://doi.org/10.3109/03639049809088526","title":"In Vivo Characteristics of Injectable Poly(DL-Lactic Acid) Microspheres for Long-Acting Drug Delivery","display_name":"In Vivo Characteristics of Injectable Poly(DL-Lactic Acid) Microspheres for Long-Acting Drug Delivery","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2113458265","doi":"https://doi.org/10.3109/03639049809088526","mag":"2113458265","pmid":"https://pubmed.ncbi.nlm.nih.gov/9876532"},"language":"en","primary_location":{"id":"doi:10.3109/03639049809088526","doi":"https://doi.org/10.3109/03639049809088526","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639049809088526","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002830537","display_name":"Daishiro Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]},{"id":"https://openalex.org/I4210164827","display_name":"Gunma University Hospital","ror":"https://ror.org/05kq1z994","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164827"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daishiro Kobayashi","raw_affiliation_strings":["Department of Urology, Gunma University School of Medicine, Japan","Dept. of Urology, Gunma University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gunma University School of Medicine, Japan","institution_ids":["https://openalex.org/I165735259","https://openalex.org/I4210164827"]},{"raw_affiliation_string":"Dept. of Urology, Gunma University School of Medicine, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052665566","display_name":"Satoru Tsubuku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126322","display_name":"Zeria Pharmaceutical (Japan)","ror":"https://ror.org/02j4jqr44","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210126322"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Tsubuku","raw_affiliation_strings":["Department of Pharmaceutical Research, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., 2512-1 Oshikiri, Kohnan-machi, Ohsatogun, Saitama, 360-01, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., 2512-1 Oshikiri, Kohnan-machi, Ohsatogun, Saitama, 360-01, Japan","institution_ids":["https://openalex.org/I4210126322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106183757","display_name":"Hidetoshi Yamanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetoshi Yamanaka","raw_affiliation_strings":["Department of Urology, Gunma University School of Medicine, Maebashi, Gunma, 371, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gunma University School of Medicine, Maebashi, Gunma, 371, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111473216","display_name":"Masaharu Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"government","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Asano","raw_affiliation_strings":["Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, 1233 Watanuki\u2010Machi, Takasaki, Gunma 370\u201012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, 1233 Watanuki\u2010Machi, Takasaki, Gunma 370\u201012, Japan","institution_ids":["https://openalex.org/I117197279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002771823","display_name":"Masaharu Miyajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Miyajima","raw_affiliation_strings":["Department of Urology, Gunma University School of Medicine, Maebashi, Gunma, 371, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Gunma University School of Medicine, Maebashi, Gunma, 371, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039494641","display_name":"Masaru Yoshida","orcid":"https://orcid.org/0000-0002-9220-4312","observed_orcids":["https://orcid.org/0000-0002-9220-4312"]},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"government","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Yoshida","raw_affiliation_strings":["Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, 1233 Watanuki\u2010Machi, Takasaki, Gunma 370\u201012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Material Development, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, 1233 Watanuki\u2010Machi, Takasaki, Gunma 370\u201012, Japan","institution_ids":["https://openalex.org/I117197279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2135,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75267423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"9","first_page":"819","last_page":"825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-d-l-lactide","display_name":"poly(D,L-lactide)","score":0.9179999828338623},{"id":"https://openalex.org/keywords/injectable-microspheres","display_name":"injectable microspheres","score":0.8259999752044678},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9490000009536743},{"id":"https://openalex.org/keywords/long-acting-drug-delivery","display_name":"long-acting drug delivery","score":0.8690000176429749},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.7490000128746033},{"id":"https://openalex.org/keywords/solvent-evaporation","display_name":"solvent evaporation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/prostate","display_name":"prostate","score":0.503000020980835},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/biodegradable-implants","display_name":"biodegradable implants","score":0.6340000033378601},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.699999988079071},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.8048913478851318},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7186858057975769},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.7020664811134338},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6470423936843872},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6285770535469055},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5587010979652405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48048391938209534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2719484567642212},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.11703354120254517},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09121504426002502},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08793014287948608},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06264588236808777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/03639049809088526","doi":"https://doi.org/10.3109/03639049809088526","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03639049809088526","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:9876532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9876532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Journal Article"},{"id":"mag:2240301525","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000173510","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1975950756","https://openalex.org/W1998501353","https://openalex.org/W2002670246","https://openalex.org/W2003030438","https://openalex.org/W2006482543","https://openalex.org/W2014311847","https://openalex.org/W2035945954","https://openalex.org/W2043823401","https://openalex.org/W2056200604","https://openalex.org/W2076608288","https://openalex.org/W2083529564","https://openalex.org/W2154918267","https://openalex.org/W2169487342","https://openalex.org/W2468777172"],"related_works":["https://openalex.org/W2025773553","https://openalex.org/W2124106526","https://openalex.org/W2053006212","https://openalex.org/W1968538141","https://openalex.org/W2333634072","https://openalex.org/W2015671363","https://openalex.org/W2364217639","https://openalex.org/W4395959937","https://openalex.org/W4281669494","https://openalex.org/W1996017656"],"abstract_inverted_index":{"Poly(DL-lactic":[0],"acid)":[1],"(PLA)":[2],"microspheres":[3,56],"containing":[4,57],"testosterone":[5],"(T)":[6],"were":[7,113],"prepared":[8],"by":[9],"the":[10,34,46,81,97,110],"solvent":[11],"evaporation":[12],"process":[13],"to":[14,75],"evaluate":[15],"their":[16],"physical":[17],"properties":[18],"such":[19],"as":[20],"size":[21],"distribution,":[22],"shape,":[23],"drug":[24,29,61,89,102],"content,":[25],"in":[26,37,49,80],"vivo":[27,50],"controlled":[28],"release,":[30],"pharmacological":[31],"influences":[32],"on":[33],"prostate":[35,92],"gland":[36,93],"castrated":[38],"rats,":[39],"and":[40,91],"histopathological":[41,106],"findings":[42,107],"of":[43,52,60,78,99],"tissues":[44],"surrounding":[45],"implants.":[47],"The":[48,105],"release":[51],"T":[53,79],"from":[54],"PLA":[55],"30":[58],"mg":[59],"obtained":[62,84],"with":[63,85],"chloroform":[64],"was":[65],"continued":[66],"over":[67],"a":[68,100],"6-week":[69],"period.":[70],"This":[71],"effect":[72],"is":[73],"attributed":[74],"high":[76],"dispersibility":[77],"device":[82],"when":[83],"chloroform.":[86],"Both":[87],"serum":[88],"levels":[90],"weight":[94],"recovery":[95],"suggested":[96],"effects":[98],"long-acting":[101],"delivery":[103],"system.":[104],"showed":[108],"that":[109],"devices":[111],"used":[112],"completely":[114],"degraded":[115],"10":[116],"weeks":[117],"after":[118],"injection.":[119]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}