{"id":"https://openalex.org/W2113454762","doi":"https://doi.org/10.3389/fphys.2013.00246","title":"Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels","display_name":"Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2113454762","doi":"https://doi.org/10.3389/fphys.2013.00246","mag":"2113454762","pmid":"https://pubmed.ncbi.nlm.nih.gov/24062691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3771311"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2013.00246","doi":"https://doi.org/10.3389/fphys.2013.00246","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2013.00246","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2013.00246/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2013.00246/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101725655","display_name":"Bo Kong","orcid":"https://orcid.org/0000-0002-5281-9603","observed_orcids":["https://orcid.org/0000-0002-5281-9603"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bo Kong","raw_affiliation_strings":["Department of Surgery, Technische Universit\u00e4t M\u00fcnchen Munich, Germany","Department of Surgery, Technische Universit\u00e4t Munchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Technische Universit\u00e4t M\u00fcnchen Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Technische Universit\u00e4t Munchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051815148","display_name":"Chengjia Qia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chengjia Qia","raw_affiliation_strings":["Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015386151","display_name":"Mert Erkan","orcid":"https://orcid.org/0000-0002-2753-0234","observed_orcids":["https://orcid.org/0000-0002-2753-0234"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mert Erkan","raw_affiliation_strings":["Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031667128","display_name":"Jorg H. Kleeff","orcid":"https://orcid.org/0000-0003-3432-6669","observed_orcids":["https://orcid.org/0000-0003-3432-6669"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Kleeff","raw_affiliation_strings":["Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089550509","display_name":"Christoph W. Michalski","orcid":"https://orcid.org/0000-0003-3520-1040","observed_orcids":["https://orcid.org/0000-0003-3520-1040"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph W. Michalski","raw_affiliation_strings":["Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089550509"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.9631,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.71956522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"246","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.21410000324249268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.45100000500679016},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.972000002861023},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.824999988079071},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8431340456008911},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8078842163085938},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7241671085357666},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6622787117958069},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6169655919075012},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5743138790130615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238642692565918},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4570768475532532},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4193158745765686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2677808701992035},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.18528246879577637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13693004846572876}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fphys.2013.00246","doi":"https://doi.org/10.3389/fphys.2013.00246","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2013.00246","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2013.00246/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2770404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3771311","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3771311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3771311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:24062691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24062691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.9830","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.9830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c0/02/fphys-04-00246.PMC3771311.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:945b80daab0a40ccac7099d95cc7d31b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/945b80daab0a40ccac7099d95cc7d31b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 4 (2013)","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1210765","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1210765","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1510525","doi":null,"is_oa":true,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1510525","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2013.00246","doi":"https://doi.org/10.3389/fphys.2013.00246","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2013.00246","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2013.00246/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113454762.pdf","grobid_xml":"https://content.openalex.org/works/W2113454762.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1499834471","https://openalex.org/W1967108243","https://openalex.org/W1967487924","https://openalex.org/W1968248545","https://openalex.org/W1969831578","https://openalex.org/W1970000275","https://openalex.org/W1978909523","https://openalex.org/W1981703791","https://openalex.org/W1982907830","https://openalex.org/W1992724001","https://openalex.org/W1994987533","https://openalex.org/W1995091371","https://openalex.org/W1998560601","https://openalex.org/W2005166958","https://openalex.org/W2009187135","https://openalex.org/W2014988241","https://openalex.org/W2018159884","https://openalex.org/W2023947368","https://openalex.org/W2025830885","https://openalex.org/W2027651810","https://openalex.org/W2028897202","https://openalex.org/W2029869071","https://openalex.org/W2031960993","https://openalex.org/W2033275550","https://openalex.org/W2036840154","https://openalex.org/W2043281296","https://openalex.org/W2050259170","https://openalex.org/W2055966597","https://openalex.org/W2057139407","https://openalex.org/W2061270600","https://openalex.org/W2062197280","https://openalex.org/W2063163336","https://openalex.org/W2063921865","https://openalex.org/W2064446750","https://openalex.org/W2066135299","https://openalex.org/W2069269337","https://openalex.org/W2072569792","https://openalex.org/W2080952734","https://openalex.org/W2090982381","https://openalex.org/W2092328174","https://openalex.org/W2118758371","https://openalex.org/W2122768765","https://openalex.org/W2124441017","https://openalex.org/W2128822546","https://openalex.org/W2129176863","https://openalex.org/W2129506905","https://openalex.org/W2129917557","https://openalex.org/W2134703818","https://openalex.org/W2135470678","https://openalex.org/W2143295396","https://openalex.org/W2144520999","https://openalex.org/W2145436041","https://openalex.org/W2150707479","https://openalex.org/W2150951327","https://openalex.org/W2152795950","https://openalex.org/W2158103448","https://openalex.org/W2161817637","https://openalex.org/W2164034599","https://openalex.org/W2165057232","https://openalex.org/W2272116607","https://openalex.org/W4229933927","https://openalex.org/W6817462612"],"related_works":["https://openalex.org/W7100482627","https://openalex.org/W3212099711","https://openalex.org/W2397520720","https://openalex.org/W2552325207","https://openalex.org/W4308718743","https://openalex.org/W4210537655","https://openalex.org/W4380030048","https://openalex.org/W7004865666","https://openalex.org/W4393096638","https://openalex.org/W2944883406"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"is":[4,159],"a":[5,42,77,147],"devastating":[6],"disease":[7,11],"without":[8],"clearly":[9],"known":[10],"causes.":[12],"Recent":[13],"epidemiological":[14],"and":[15,28,91,125,133,151],"animal":[16],"studies":[17],"suggest":[18],"that":[19,34,161],"the":[20,109,144],"supplementation":[21],"of":[22,60,76,79,98,146,154],"dietary":[23],"antioxidants":[24],"(e.g.,":[25,51],"vitamins":[26],"C":[27],"E)":[29],"decreases":[30],"cancer":[31,127,134],"risk,":[32],"implying":[33],"increased":[35],"reactive":[36],"oxygen":[37],"species":[38],"(ROS)":[39],"may":[40,166],"play":[41],"role":[43],"in":[44,56,121,126],"pancreatic":[45,122],"carcinogenesis.":[46],"However,":[47],"oncogenic":[48,72,170],"Kras":[49,73],"mutations":[50],"Kras(G12D)),":[52],"which":[53],"are":[54],"present":[55],"more":[57],"than":[58],"90%":[59],"PDAC,":[61],"have":[62,140],"been":[63,141],"proven":[64],"to":[65,100,117,169],"foster":[66],"low":[67,118,137,162],"intracellular":[68,149,163],"ROS":[69,113,119,138,164],"levels.":[70],"Here,":[71],"activates":[74],"expression":[75],"series":[78],"anti-oxidant":[80],"genes":[81],"via":[82],"Nrf2":[83],"(nuclear":[84],"factor,":[85],"erythroid":[86],"derived":[87],"2,":[88],"like":[89],"2)":[90],"also":[92],"mediates":[93],"an":[94],"unusual":[95],"metabolic":[96],"pathway":[97],"glutamine":[99],"generate":[101],"NADPH.":[102],"This":[103],"can":[104],"then":[105],"be":[106],"used":[107],"as":[108],"reducing":[110],"power":[111],"for":[112],"detoxification,":[114],"leading":[115],"collectively":[116],"levels":[120,139,165],"pre-neoplastic":[123],"cells":[124,132],"cells.":[128],"In":[129],"adult":[130],"stem":[131,135],"cells,":[136],"associated":[142],"with":[143,152],"formation":[145],"proliferation-permissive":[148],"environment":[150],"perseverance":[153],"self-renewal":[155],"capacities.":[156],"Therefore,":[157],"it":[158],"conceivable":[160],"contribute":[167],"significantly":[168],"Kras-mediated":[171],"PDAC":[172],"formation.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
