{"id":"https://openalex.org/W2113308458","doi":"https://doi.org/10.1001/archinte.166.15.1571","title":"Efficacy and Safety of the Novel Selective Nicotinic Acetylcholine Receptor Partial Agonist, Varenicline, for Smoking Cessation","display_name":"Efficacy and Safety of the Novel Selective Nicotinic Acetylcholine Receptor Partial Agonist, Varenicline, for Smoking Cessation","publication_year":2006,"publication_date":"2006-08-14","ids":{"openalex":"https://openalex.org/W2113308458","doi":"https://doi.org/10.1001/archinte.166.15.1571","mag":"2113308458","pmid":"https://pubmed.ncbi.nlm.nih.gov/16908789"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.166.15.1571","doi":"https://doi.org/10.1001/archinte.166.15.1571","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.166.15.1571","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078495934","display_name":"Cheryl A. Oncken","orcid":"https://orcid.org/0000-0003-4828-2257","observed_orcids":["https://orcid.org/0000-0003-4828-2257"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheryl Oncken","raw_affiliation_strings":["University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. oncken@nso2.uchc.edu","University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. oncken@nso2.uchc.edu","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078495934"],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":null,"apc_paid":null,"fwci":41.7955,"has_fulltext":false,"cited_by_count":384,"citation_normalized_percentile":{"value":0.99911833,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"166","issue":"15","first_page":"1571","last_page":"1571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":0.9169999957084656},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.746999979019165},{"id":"https://openalex.org/keywords/abstinence-rates","display_name":"abstinence rates","score":0.6949999928474426},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.8270000219345093},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5809999704360962},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.9587938785552979},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.7165946960449219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6835919618606567},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.6532677412033081},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6179249882698059},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.603289008140564},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5494855046272278},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.4667750895023346},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42024660110473633},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.3724361062049866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2993287742137909},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.284959077835083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06731659173965454},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0667215883731842},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068580","descriptor_name":"Varenicline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016540","descriptor_name":"Smoking Cessation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/archinte.166.15.1571","doi":"https://doi.org/10.1001/archinte.166.15.1571","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.166.15.1571","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:16908789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16908789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.424.4620","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.4620","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.josephmatta.com/varenicline.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1977171463","https://openalex.org/W1993112595","https://openalex.org/W2021772758","https://openalex.org/W2033156615","https://openalex.org/W2060109300","https://openalex.org/W2071488745","https://openalex.org/W2101081697","https://openalex.org/W2110569081","https://openalex.org/W2118061336","https://openalex.org/W2128406057","https://openalex.org/W2155011514","https://openalex.org/W2394810266","https://openalex.org/W2417296417","https://openalex.org/W2464157024"],"related_works":["https://openalex.org/W7095659438","https://openalex.org/W2117389430","https://openalex.org/W1899529599","https://openalex.org/W2160546125","https://openalex.org/W1999197975","https://openalex.org/W2062006647","https://openalex.org/W2035097524","https://openalex.org/W2143238807","https://openalex.org/W2164386461","https://openalex.org/W2063004281"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,122],"selective":[2],"nicotinic":[3],"acetylcholine":[4],"receptor":[5],"partial":[6],"agonist,":[7],"varenicline":[8,29,68],"tartrate,":[9,69,241],"represents":[10],"a":[11,45],"novel":[12],"type":[13],"of":[14,27,219,223],"therapy":[15],"for":[16,51,107,138,152,227,251],"smoking":[17,53,113,252],"cessation.":[18,54,114,253],"This":[19,56],"study":[20,60],"evaluated":[21],"the":[22,37,127,148,168,173,193,199,228],"efficacy,":[23],"safety,":[24],"and":[25,42,143,147,172,198,233,244],"tolerability":[26],"4":[28,140],"dose":[30],"regimens,":[31],"2":[32,43],"with":[33,44,212],"progressive":[34],"dosing":[35,47,232],"over":[36],"first":[38],"week":[39],"(eg,":[40,49],"titrated)":[41],"fixed":[46],"schedule":[48],"non-titrated),":[50],"promoting":[52],"METHODS:":[55],"multicenter,":[57],"double-blind,":[58],"placebo-controlled":[59],"randomized":[61],"healthy":[62],"smokers":[63],"(aged":[64],"18-65":[65],"years)":[66],"to":[67,110,217,236],"0.5":[70,78,242],"mg":[71,79,87,95,243,246],"twice":[72,80,88,96,247],"daily":[73,81,89,97],"nontitrated":[74,90,231],"(n":[75,83,91,99,104],"=":[76,84,92,100,105],"129),":[77,93],"titrated":[82,98,229],"130),":[85,101],"1.0":[86,94,245],"or":[102],"placebo":[103,178,205],"129)":[106],"12":[108,146,161],"weeks":[109,139,153],"aid":[111],"in":[112,167,192,215],"A":[115],"40-week":[116],"follow-up":[117],"period":[118],"assessed":[119],"long-term":[120],"efficacy.":[121],"primary":[123],"efficacy":[124],"measures":[125],"were":[126,165,190,225],"carbon":[128],"monoxide-confirmed":[129],"4-week":[130],"continuous":[131,149,162],"quit":[132,163],"rates":[133,151,164,189],"by":[134],"pooled":[135],"dosage":[136],"group":[137,170,175,195,201],"through":[141,145,155,160,186],"7":[142],"9":[144,154,159,185],"abstinence":[150,188],"52.":[156],"RESULTS:":[157],"Weeks":[158,184],"greater":[166,191],"1.0-mg":[169,194],"(49.4%)":[171],"0.5-mg":[174,200],"(44.0%)":[176],"vs":[177,181,204,230],"(11.6%;":[179],"P<.001":[180],"both":[182],"doses).":[183],"52":[187],"(22.4%;":[196],"P<.001)":[197,203],"(18.5%;":[202],"(3.9%).":[206],"Varenicline":[207,240],"was":[208],"generally":[209],"well":[210],"tolerated,":[211],"nausea":[213,224],"occurring":[214],"16%":[216],"42%":[218],"varenicline-treated":[220],"subjects.":[221],"Reports":[222],"lower":[226],"infrequently":[234],"led":[235],"medication":[237],"discontinuation.":[238],"CONCLUSION:":[239],"daily,":[248],"is":[249],"efficacious":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
