{"id":"https://openalex.org/W2113266152","doi":"https://doi.org/10.1161/atvb.35.suppl_1.460","title":"Abstract 460: Three Dimensional Quantification of Angiotensin II-Induced Abdominal Aortic Aneurysms Using High Frequency Ultrasound","display_name":"Abstract 460: Three Dimensional Quantification of Angiotensin II-Induced Abdominal Aortic Aneurysms Using High Frequency Ultrasound","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2113266152","doi":"https://doi.org/10.1161/atvb.35.suppl_1.460","mag":"2113266152"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.35.suppl_1.460","doi":"https://doi.org/10.1161/atvb.35.suppl_1.460","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.35.suppl_1.460","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058865628","display_name":"Amelia R. Adelsperger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia R Adelsperger","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064482798","display_name":"Alexa A Yrineo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Yrineo","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064774422","display_name":"Evan H. Phillips","orcid":"https://orcid.org/0000-0002-9182-9513","observed_orcids":["https://orcid.org/0000-0002-9182-9513"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Phillips","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009057632","display_name":"Fredrick Damen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredrick Damen","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011020950","display_name":"A. Nicole Blaize","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A N Blaize","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113664533","display_name":"Clifford M. Babbey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Babbey","raw_affiliation_strings":["Cntr for Aortic Disease, Indiana Univ-Purdue Univ Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Aortic Disease, Indiana Univ-Purdue Univ Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081727206","display_name":"Michael Murphey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Murphey","raw_affiliation_strings":["Cntr for Aortic Disease, Indiana Univ-Purdue Univ Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cntr for Aortic Disease, Indiana Univ-Purdue Univ Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035272806","display_name":"Craig J. Goergen","orcid":"https://orcid.org/0000-0001-8883-7953","observed_orcids":["https://orcid.org/0000-0001-8883-7953"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Goergen","raw_affiliation_strings":["Engineering, Purdue Univ, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering, Purdue Univ, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.925000011920929},{"id":"https://openalex.org/keywords/high-frequency-ultrasound","display_name":"high-frequency ultrasound","score":0.6869999766349792},{"id":"https://openalex.org/keywords/3d-ultrasound","display_name":"3D ultrasound","score":0.609000027179718},{"id":"https://openalex.org/keywords/aortic-dissection","display_name":"aortic dissection","score":0.7250000238418579},{"id":"https://openalex.org/keywords/false-lumen","display_name":"false lumen","score":0.7799999713897705},{"id":"https://openalex.org/keywords/true-lumen","display_name":"true lumen","score":0.800000011920929},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8539999723434448},{"id":"https://openalex.org/keywords/aneurysm-progression","display_name":"aneurysm progression","score":0.7459999918937683},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.7764129042625427},{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.7670156359672546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7467559576034546},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.5899683237075806},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.5469877123832703},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4839499294757843},{"id":"https://openalex.org/C3017458007","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"High frequency ultrasound","level":3,"score":0.4545047879219055},{"id":"https://openalex.org/C2779993142","wikidata":"https://www.wikidata.org/wiki/Q594660","display_name":"Aortic dissection","level":3,"score":0.4264412522315979},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.4226384460926056},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.4177636504173279},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.41117459535598755},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3154463768005371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3070219159126282},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.30445048213005066},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09367841482162476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.35.suppl_1.460","doi":"https://doi.org/10.1161/atvb.35.suppl_1.460","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvb.35.suppl_1.460","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7015667336","https://openalex.org/W4285041193","https://openalex.org/W4285503277","https://openalex.org/W2016140300","https://openalex.org/W2738520229","https://openalex.org/W4302404152","https://openalex.org/W1415890143","https://openalex.org/W173478877","https://openalex.org/W2012740979","https://openalex.org/W2525988959"],"abstract_inverted_index":{"Abdominal":[0],"aortic":[1,207],"aneurysms":[2],"(AAAs)":[3],"are":[4,10],"localized":[5],"pathological":[6],"vessel":[7],"dilations":[8],"and":[9,129,135,141,160,209],"the":[11,18,81,137,171,182,214],"13th":[12],"leading":[13],"cause":[14],"of":[15,68,133,153,206,216],"death":[16],"in":[17,23,37,80,173,212,219],"U.S.":[19],"While":[20],"AAA":[21,46,145],"expansion":[22,176,185],"patients":[24],"is":[25,57,168,201],"traditionally":[26],"assessed":[27],"with":[28,110],"2D":[29],"ultrasound":[30,38,51,75,95,200],"by":[31],"measuring":[32],"transverse":[33],"diameters,":[34],"recent":[35],"advancements":[36],"techniques":[39],"now":[40],"make":[41],"it":[42],"feasible":[43,204],"to":[44,54,72,76,102,170],"quantify":[45,130],"volumes":[47,132],"noninvasively.":[48],"High":[49,93],"frequency":[50,94],"(typically":[52],"up":[53],"40":[55],"MHz)":[56],"ideal":[58],"for":[59,120],"rodent":[60],"imaging":[61],"when":[62],"investigating":[63],"experimental":[64],"aneurysms.":[65,92],"The":[66],"purpose":[67],"this":[69],"study":[70],"was":[71,100],"use":[73],"3D":[74,131,199],"measure":[77,205],"aneurysm":[78,163],"progression":[79],"apolipoprotein-E-deficient":[82],"(apoE-/-)/angiotensin":[83],"II":[84],"(AngII)":[85],"mouse":[86],"model":[87],"that":[88,186,198],"create":[89],"suprarenal":[90],"dissecting":[91],"(40":[96],"MHz,":[97],"Vevo2100,":[98],"VisualSonics)":[99],"used":[101],"collect":[103],"images":[104],"from":[105,112],"C57BL/6":[106],"apoE-/-":[107],"mice":[108],"infused":[109],"AngII":[111],"subcutaneously":[113],"implanted":[114],"osmotic":[115],"mini":[116],"pumps":[117],"(1000":[118],"ng/kg/min)":[119],"28":[121],"days":[122,158,192],"(n=6).":[123],"We":[124],"could":[125],"clearly":[126],"visualize,":[127],"segment,":[128],"AAAs":[134],"visualize":[136],"dissection":[138],"between":[139,157],"medial":[140],"adventitial":[142],"layers.":[143],"Total":[144],"volume":[146,208],"increased":[147],"steadily":[148],"at":[149],"an":[150],"average":[151],"rate":[152],"0.51\u00b10.32":[154],"mm3/day":[155],"(mean\u00b1SE)":[156],"3":[159],"14":[161,191],"after":[162],"formation":[164],"(Figure":[165],"1).":[166],"This":[167],"similar":[169],"increase":[172],"false":[174],"lumen":[175,184],"(0.42\u00b10.30":[177],"mm3/day),":[178],"but":[179],"higher":[180],"than":[181],"true":[183],"remained":[187],"relatively":[188],"constant":[189],"over":[190],"(0.09\u00b10.06":[193],"mm3/day).":[194],"These":[195],"data":[196],"suggest":[197],"a":[202],"technically":[203],"has":[210],"utility":[211],"evaluating":[213],"efficacy":[215],"therapeutic":[217],"agents":[218],"animal":[220],"models.":[221]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}