{"id":"https://openalex.org/W2113255254","doi":null,"title":"Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.","display_name":"Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2113255254","mag":"2113255254","pmid":"https://pubmed.ncbi.nlm.nih.gov/9850049"},"language":"en","primary_location":{"id":"pmid:9850049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9850049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Davies","raw_affiliation_strings":["Department of Neuro-Oncology and The Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA","Melanoma Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology and The Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Melanoma Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020581776","display_name":"Yiling Lu","orcid":"https://orcid.org/0000-0002-3662-2106","observed_orcids":["https://orcid.org/0000-0002-3662-2106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Lu","raw_affiliation_strings":["Systems Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026992122","display_name":"Tetsuro Sano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Sano","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089626387","display_name":"Xianjun Fang","orcid":"https://orcid.org/0000-0003-3764-7847","observed_orcids":["https://orcid.org/0000-0003-3764-7847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Fang","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102793497","display_name":"Ping Tang","orcid":"https://orcid.org/0000-0003-4336-4202","observed_orcids":["https://orcid.org/0000-0003-4336-4202"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Tang","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111625411","display_name":"Ruth LaPushin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R LaPushin","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025131780","display_name":"Dimpy Koul","orcid":"https://orcid.org/0000-0001-5297-9220","observed_orcids":["https://orcid.org/0000-0001-5297-9220"]},"institutions":[{"id":"https://openalex.org/I4210102457","display_name":"Center for Neuro-Oncology","ror":"https://ror.org/00z2tp793","country_code":"US","type":"facility","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210102457","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Koul","raw_affiliation_strings":["Neuro-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-Oncology","institution_ids":["https://openalex.org/I4210102457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110349126","display_name":"Robert Bookstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Bookstein","raw_affiliation_strings":["Merck"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082108617","display_name":"David Stokoe","orcid":"https://orcid.org/0000-0002-6333-5364","observed_orcids":["https://orcid.org/0000-0002-6333-5364"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Stokoe","raw_affiliation_strings":["University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111550344","display_name":"W.K. Alfred Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102457","display_name":"Center for Neuro-Oncology","ror":"https://ror.org/00z2tp793","country_code":"US","type":"facility","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210102457","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W K Yung","raw_affiliation_strings":["Neuro-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-Oncology","institution_ids":["https://openalex.org/I4210102457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G B Mills","raw_affiliation_strings":["Systems Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052687048","display_name":"Peter A. Steck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Steck","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5915,"has_fulltext":false,"cited_by_count":239,"citation_normalized_percentile":{"value":0.98615995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"58","issue":"23","first_page":"5285","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-phosphatase","display_name":"phosphatidylinositol phosphatase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.578000009059906},{"id":"https://openalex.org/keywords/anoikis","display_name":"anoikis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/adenovirus-mediated-gene-therapy","display_name":"adenoviral gene therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6359999775886536},{"id":"https://openalex.org/keywords/bad-phosphorylation","display_name":"Bad phosphorylation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.49300000071525574},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase-signaling","display_name":"phosphatidylinositol 3-kinase signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/u251-cells","display_name":"U251 cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9355190992355347},{"id":"https://openalex.org/C152000582","wikidata":"https://www.wikidata.org/wiki/Q567522","display_name":"Anoikis","level":4,"score":0.8124674558639526},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7518578171730042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6780784130096436},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6079155206680298},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5237612128257751},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5179018974304199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5120630860328674},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.43318936228752136},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4223319888114929},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2187405824661255},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.16070982813835144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10676252841949463}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9850049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9850049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2113255254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9850049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2835755569","display_name":"GLIOMAS--BIOLOGIC, MOLECULAR AND GENETIC STUDIES","funder_award_id":"P01CA055261","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3526263778","display_name":"PUTATIVE TUMOR SUPPRESSOR PTP1C IN BREAST CANCER","funder_award_id":"R01CA071418","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1489145507","https://openalex.org/W1561313993","https://openalex.org/W1565532031","https://openalex.org/W1602193081","https://openalex.org/W1756183899","https://openalex.org/W1935114338","https://openalex.org/W1969134590","https://openalex.org/W1973837499","https://openalex.org/W2004078164","https://openalex.org/W2019017173","https://openalex.org/W2068427129","https://openalex.org/W2076457965","https://openalex.org/W2094068658","https://openalex.org/W2097767970","https://openalex.org/W2129191040","https://openalex.org/W2132150602","https://openalex.org/W2137022580","https://openalex.org/W2140375000","https://openalex.org/W2156216950","https://openalex.org/W2161810908"],"related_works":["https://openalex.org/W1589359922","https://openalex.org/W1500180944","https://openalex.org/W1637251086","https://openalex.org/W1575628845","https://openalex.org/W2164158840","https://openalex.org/W1551696649","https://openalex.org/W2024220711","https://openalex.org/W1673025041","https://openalex.org/W2111752734","https://openalex.org/W2376504332"],"abstract_inverted_index":{"The":[0,94,116],"MMAC/PTEN":[1,98,119,175,191],"tumor":[2],"suppressor":[3],"gene":[4],"encodes":[5],"for":[6],"a":[7,151,198],"phosphatase":[8,17],"that":[9,170,188,205],"recently":[10],"has":[11],"been":[12],"shown":[13,42],"to":[14,43,53,147],"have":[15],"phosphotidylinositol":[16],"activity,":[18,88],"implicating":[19],"its":[20],"possible":[21,29],"involvement":[22],"in":[23,31,48,130,132,177],"phosphatidylinositol":[24],"3'-kinase-mediated":[25],"signaling.":[26],"To":[27],"investigate":[28],"alterations":[30],"growth":[32,45,108,183],"factor-mediated":[33,109],"signal":[34],"transduction,":[35],"an":[36,70],"adenovirus":[37],"containing":[38],"MMAC/PTEN,":[39],"Ad-MMAC,":[40],"previously":[41],"inhibit":[44],"and":[46,81,185,195],"tumorigenicity":[47],"glioma":[49,59,140],"cells,":[50],"was":[51,136],"used":[52],"acutely":[54],"express":[55],"the":[56,131,171,178],"transgene.":[57],"Human":[58],"cells":[60,135,141],"infected":[61,142,164],"with":[62,66,84,143,159,165,208],"Ad-MMAC":[63,144],"but":[64],"not":[65],"control":[67,160],"adenoviruses":[68],"exhibited":[69],"inhibition":[71,179],"of":[72,74,78,96,105,118,123,128,174,180,190],"phosphorylation":[73,122],"both":[75],"activating":[76],"residues":[77],"Akt,":[79],"Ser-473,":[80],"Thr-308,":[82],"along":[83],"Akt's":[85],"serine/threonine":[86],"kinase":[87],"without":[89],"significantly":[90,152,196],"altering":[91],"Akt":[92],"expression.":[93],"effects":[95],"functional":[97],"expression":[99],"were":[100,145],"relatively":[101],"specific,":[102],"because":[103],"members":[104],"several":[106],"other":[107],"signaling":[110],"pathways":[111],"showed":[112],"no":[113,126],"altered":[114],"responses.":[115],"presence":[117],"also":[120],"inhibited":[121],"BAD,":[124],"although":[125],"evidence":[127],"apoptosis":[129],"situ":[133],"treated":[134,158],"observed.":[137],"However,":[138],"U251":[139,156],"induced":[146],"undergo":[148],"anoikis":[149],"at":[150],"higher":[153],"rate":[154],"than":[155],"cels":[157],"viruses":[161],"or":[162],"mock":[163],"media.":[166],"These":[167],"results":[168,176],"demonstrate":[169],"acute":[172],"administration":[173],"Akt-mediated":[181],"signaling,":[182],"inhibition,":[184],"anoikis,":[186],"implying":[187],"loss":[189],"increases":[192],"cellular":[193,203],"proliferation":[194],"augments":[197],"cell's":[199],"survival":[200],"potential":[201],"during":[202],"processes":[204],"are":[206],"associated":[207],"malignancy.":[209]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
