{"id":"https://openalex.org/W2113254108","doi":"https://doi.org/10.1177/1362361311427154","title":"Advancing paternal age and simplex autism","display_name":"Advancing paternal age and simplex autism","publication_year":2011,"publication_date":"2011-12-16","ids":{"openalex":"https://openalex.org/W2113254108","doi":"https://doi.org/10.1177/1362361311427154","mag":"2113254108","pmid":"https://pubmed.ncbi.nlm.nih.gov/22180389"},"language":"en","primary_location":{"id":"doi:10.1177/1362361311427154","doi":"https://doi.org/10.1177/1362361311427154","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1362361311427154","pdf_url":null,"source":{"id":"https://openalex.org/S1824407","display_name":"Autism","issn_l":"1362-3613","issn":["1362-3613","1461-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012904924","display_name":"Connor Morrow Puleo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Morrow Puleo","raw_affiliation_strings":["Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091358950","display_name":"James Schmeidler","orcid":"https://orcid.org/0000-0002-2134-8984","observed_orcids":["https://orcid.org/0000-0002-2134-8984"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"James Schmeidler","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA and King\u2019s College London, UK","King's College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA and King\u2019s College London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I98704320"]},{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086216270","display_name":"Abraham Reichenberg","orcid":"https://orcid.org/0000-0003-2729-8575","observed_orcids":["https://orcid.org/0000-0003-2729-8575"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Abraham Reichenberg","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA and King\u2018s College London, UK","Psychosis Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA and King\u2018s College London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Psychosis Studies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016983099","display_name":"A\ufefflexander Kolevzon","orcid":"https://orcid.org/0000-0001-8129-2671","observed_orcids":["https://orcid.org/0000-0001-8129-2671"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kolevzon","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039366746","display_name":"Latha Valluripalli Soorya","orcid":"https://orcid.org/0000-0002-0414-4533","observed_orcids":["https://orcid.org/0000-0002-0414-4533"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Latha V Soorya","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037444292","display_name":"Joseph D. Buxbaum","orcid":"https://orcid.org/0000-0001-8898-8313","observed_orcids":["https://orcid.org/0000-0001-8898-8313"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D Buxbaum","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103164644","display_name":"Jeremy M. Silverman","orcid":"https://orcid.org/0000-0001-5899-128X","observed_orcids":["https://orcid.org/0000-0001-5899-128X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy M Silverman","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.4046,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.79235447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"16","issue":"4","first_page":"367","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paternal-age","display_name":"paternal age","score":0.9100000262260437},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9369999766349792},{"id":"https://openalex.org/keywords/de-novo-mutations","display_name":"de novo mutations","score":0.8619999885559082},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6959999799728394},{"id":"https://openalex.org/keywords/maternal-age","display_name":"maternal age","score":0.7419999837875366},{"id":"https://openalex.org/keywords/family-structure","display_name":"family structure","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7782114744186401},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7589330673217773},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.6948210000991821},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6087026596069336},{"id":"https://openalex.org/C3020279770","wikidata":"https://www.wikidata.org/wiki/Q7144548","display_name":"Paternal age","level":4,"score":0.4437254071235657},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4049198627471924},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3395957350730896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14668545126914978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11888903379440308}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002659","descriptor_name":"Child Development Disorders, Pervasive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002659","descriptor_name":"Child Development Disorders, Pervasive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010331","descriptor_name":"Paternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014429","descriptor_name":"Twins, Dizygotic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014430","descriptor_name":"Twins, Monozygotic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/1362361311427154","doi":"https://doi.org/10.1177/1362361311427154","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1362361311427154","pdf_url":null,"source":{"id":"https://openalex.org/S1824407","display_name":"Autism","issn_l":"1362-3613","issn":["1362-3613","1461-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism","raw_type":"journal-article"},{"id":"pmid:22180389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22180389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism : the international journal of research and practice","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.975.3959","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.975.3959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://aut.sagepub.com/content/16/4/367.full.pdf","raw_type":"text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/01edfab6-84e8-49f0-811b-58c931f090e1","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/01edfab6-84e8-49f0-811b-58c931f090e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Puleo, C M, Schmeidler, J, Reichenberg, A, Kolevzon, A, Soorya, L V, Buxbaum, J D & Silverman, J M 2012, 'Advancing paternal age and simplex autism', Autism, vol. 16, no. 4, pp. 367-380. https://doi.org/10.1177/1362361311427154","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W576288626","https://openalex.org/W1555175985","https://openalex.org/W1971084700","https://openalex.org/W1971321176","https://openalex.org/W1978365312","https://openalex.org/W1980309199","https://openalex.org/W1985840371","https://openalex.org/W2002216794","https://openalex.org/W2014925500","https://openalex.org/W2020431602","https://openalex.org/W2021949850","https://openalex.org/W2055373079","https://openalex.org/W2065361002","https://openalex.org/W2069605278","https://openalex.org/W2082075709","https://openalex.org/W2083547139","https://openalex.org/W2100077364","https://openalex.org/W2112143532","https://openalex.org/W2122345676","https://openalex.org/W2136248611","https://openalex.org/W2140462713","https://openalex.org/W2144446993","https://openalex.org/W2150806772","https://openalex.org/W2151125622","https://openalex.org/W2151566815","https://openalex.org/W2157460679","https://openalex.org/W2160990611","https://openalex.org/W2163177727","https://openalex.org/W2283062430","https://openalex.org/W4238753169","https://openalex.org/W4244111379","https://openalex.org/W4300870773"],"related_works":["https://openalex.org/W7099907222","https://openalex.org/W2063115430","https://openalex.org/W2092502175","https://openalex.org/W7160302196","https://openalex.org/W2122345676","https://openalex.org/W1713509593","https://openalex.org/W2065361002","https://openalex.org/W2153064836","https://openalex.org/W7008131004","https://openalex.org/W2100077364"],"abstract_inverted_index":{"De":[0],"novo":[1,107],"events":[2,108],"appear":[3],"more":[4,82,121,137],"common":[5],"in":[6,21,35,47,114,117,123],"female":[7],"and":[8,15,68],"simplex":[9,36,74,86],"autism":[10],"spectrum":[11],"disorder":[12],"(ASD)":[13],"cases":[14,43,79,133],"may":[16,109],"underlie":[17],"greater":[18],"ASD":[19,42,78,102],"risk":[20,140],"older":[22],"fathers'":[23],"offspring.":[24],"This":[25],"study":[26],"examined":[27],"whether":[28],"advancing":[29],"paternal":[30,66,88],"age":[31,67,89],"predicts":[32],"an":[33],"increase":[34,93],"(n":[37,44],"=":[38,45],"90)":[39],"versus":[40],"multiplex":[41],"587)":[46],"677":[48],"participants":[49],"(340":[50],"families).":[51],"Whether":[52],"or":[53],"not":[54,97],"controlling":[55],"for":[56,94],"maternal":[57],"age,":[58],"results":[59],"support":[60],"a":[61],"significant":[62],"interaction":[63],"of":[64,70,131],"linear":[65],"sex":[69],"the":[71,92,127],"child":[72],"on":[73],"family":[75],"type.":[76],"Female":[77],"were":[80],"significantly":[81],"likely":[83],"to":[84,126,135],"be":[85,110],"as":[87],"increased,":[90],"but":[91],"males":[95,115],"was":[96],"significant.":[98],"Findings":[99],"suggest":[100],"that":[101],"arising":[103],"from":[104],"non-familial,":[105],"de":[106],"far":[111],"less":[112],"prominent":[113],"than":[116],"females,":[118],"even":[119],"if":[120],"prevalent":[122],"males,":[124],"due":[125],"substantially":[128],"larger":[129],"number":[130],"male":[132],"attributable":[134],"other,":[136],"strongly":[138],"male-biased":[139],"factors.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}