{"id":"https://openalex.org/W2113245366","doi":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","title":"Dissection of Ras-Dependent Signaling Pathways Controlling Aggressive Tumor Growth of Human Fibrosarcoma Cells: Evidence for a Potential Novel Pathway","display_name":"Dissection of Ras-Dependent Signaling Pathways Controlling Aggressive Tumor Growth of Human Fibrosarcoma Cells: Evidence for a Potential Novel Pathway","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2113245366","doi":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","mag":"2113245366","pmid":"https://pubmed.ncbi.nlm.nih.gov/11094080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/102186"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.20.24.9294-9306.2000","doi":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102186/pdf/mb009294.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006042186","display_name":"Swati Gupta","orcid":"https://orcid.org/0000-0002-3727-6647","observed_orcids":["https://orcid.org/0000-0002-3727-6647"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati Gupta","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","Department of Microbiology and Molecular Genetics, College of Medicine, University of California-Irvine, Irvine, California 92697-4025, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California-Irvine, Irvine, California 92697-4025, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039148532","display_name":"Rina Plattner","orcid":"https://orcid.org/0000-0002-9728-3224","observed_orcids":["https://orcid.org/0000-0002-9728-3224"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rina Plattner","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine, Irvine, California 92697-4025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine, Irvine, California 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina","Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 275992"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina","institution_ids":["https://openalex.org/I4390039329"]},{"raw_affiliation_string":"Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 275992","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052269548","display_name":"Eric J. Stanbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Stanbridge","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine, Irvine, California 92697-4025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, College of Medicine, University of California\u2014Irvine, Irvine, California 92697-4025","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2034,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.7767926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"24","first_page":"9294","last_page":"9306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ht1080-cells","display_name":"HT1080 cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mek-activation","display_name":"MEK activation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/raf-mek-erk-pathway","display_name":"Raf/MEK/ERK pathway","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pathway-crosstalk","display_name":"pathway crosstalk","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumorigenic-phenotype","display_name":"tumorigenic phenotype","score":0.7149999737739563},{"id":"https://openalex.org/keywords/aggressive-tumor-growth","display_name":"aggressive tumor growth","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dominant-negative-ras","display_name":"dominant negative Ras","score":0.7059999704360962},{"id":"https://openalex.org/keywords/jnk-activation","display_name":"JNK activation","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2777751087","wikidata":"https://www.wikidata.org/wiki/Q5636047","display_name":"HT1080","level":3,"score":0.892585039138794},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8188153505325317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7663862109184265},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5922375917434692},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5822818279266357},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5614491701126099},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.5600559711456299},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5126211047172546},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5065127611160278},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.504670262336731},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5038382411003113},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47902148962020874},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4494211971759796},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38094404339790344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33075612783432007},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28188180923461914},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26959988474845886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24932244420051575},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.20742523670196533}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.20.24.9294-9306.2000","doi":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.24.9294-9306.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:102186","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102186","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102186/pdf/mb009294.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1254561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102186","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:11094080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11094080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:vd66w701b","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/5eq3-2537","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and Cellular Biology, 20(24)","raw_type":"Article"},{"id":"doi:10.17615/5eq3-2537","doi":"https://doi.org/10.17615/5eq3-2537","is_oa":true,"landing_page_url":"https://doi.org/10.17615/5eq3-2537","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:102186","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102186","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102186/pdf/mb009294.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3213701810","display_name":null,"funder_award_id":"CA 69515","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3937408585","display_name":"EVALUATION OF DOMINANTLY-ACTING RAS ONCOGENES","funder_award_id":"5r01ca069515-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113245366.pdf","grobid_xml":"https://content.openalex.org/works/W2113245366.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W33234896","https://openalex.org/W1481746756","https://openalex.org/W1506096984","https://openalex.org/W1507248692","https://openalex.org/W1585517331","https://openalex.org/W1823067696","https://openalex.org/W1859616051","https://openalex.org/W1873642659","https://openalex.org/W1899552864","https://openalex.org/W1956661481","https://openalex.org/W1979016878","https://openalex.org/W1980303501","https://openalex.org/W1988088718","https://openalex.org/W1989009382","https://openalex.org/W1989480480","https://openalex.org/W1992723078","https://openalex.org/W1993163893","https://openalex.org/W1995819749","https://openalex.org/W2001521752","https://openalex.org/W2001522352","https://openalex.org/W2013743651","https://openalex.org/W2016955301","https://openalex.org/W2036103078","https://openalex.org/W2042629507","https://openalex.org/W2046867705","https://openalex.org/W2063921652","https://openalex.org/W2065004493","https://openalex.org/W2068842251","https://openalex.org/W2074937633","https://openalex.org/W2085931606","https://openalex.org/W2096791952","https://openalex.org/W2100409527","https://openalex.org/W2111817213","https://openalex.org/W2112533411","https://openalex.org/W2112668385","https://openalex.org/W2115701574","https://openalex.org/W2115779497","https://openalex.org/W2119011939","https://openalex.org/W2130813854","https://openalex.org/W2136627244","https://openalex.org/W2138523931","https://openalex.org/W2146055738","https://openalex.org/W2156872475","https://openalex.org/W2159594827","https://openalex.org/W2172010546","https://openalex.org/W2172062652","https://openalex.org/W2339383883","https://openalex.org/W2409277110","https://openalex.org/W2414424578","https://openalex.org/W2430099497"],"related_works":["https://openalex.org/W7097771697","https://openalex.org/W2031856282","https://openalex.org/W1540646778","https://openalex.org/W2115779497","https://openalex.org/W1873642659","https://openalex.org/W2119011939","https://openalex.org/W2071034573","https://openalex.org/W1975475567","https://openalex.org/W2613285175","https://openalex.org/W2036992277"],"abstract_inverted_index":{"Activation":[0],"of":[1,12,30,48,69,98,101,119,148,156,173,190,196,207,223,235],"multiple":[2],"signaling":[3],"pathways":[4,32],"is":[5,181,240],"required":[6],"to":[7,44,135,153,159,184,230],"trigger":[8],"the":[9,46,52,70,79,102,128,154,170,174,186,205,212,216,233,243],"full":[10],"spectrum":[11],"in":[13,16,38,124,127,129,140,197,226,232],"vitro":[14,130],"and":[15,42,73,88,105,133,215],"vivo":[17],"phenotypic":[18,131,199],"traits":[19,132],"associated":[20],"with":[21,91,111],"neoplastic":[22],"transformation":[23],"by":[24],"oncogenic":[25],"Ras.":[26],"To":[27],"determine":[28],"which":[29,63,77],"these":[31,112],"are":[33],"important":[34],"for":[35,242],"N-ras":[36,71,81],"tumorigenesis":[37],"human":[39,58],"cancer":[40],"cells":[41,90,158,228],"also":[43,203],"investigate":[45],"possibility":[47,206],"cross":[49,209],"talk":[50,210],"among":[51],"pathways,":[53],"we":[54,115,165],"have":[55,84,166,202],"utilized":[56],"a":[57,136,194],"fibrosarcoma":[59],"cell":[60,113],"line":[61],"(HT1080),":[62],"contains":[64],"an":[65,160,236],"endogenous":[66],"mutated":[67],"allele":[68],"gene,":[72],"its":[74],"derivative":[75],"(MCH603c8),":[76],"lacks":[78],"mutant":[80,95,120],"allele.":[82],"We":[83,142,201],"stably":[85],"transfected":[86],"MCH603c8":[87,157,227],"HT1080":[89],"activating":[92],"or":[93,177,218],"dominant-negative":[94],"cDNAs,":[96],"respectively,":[97],"various":[99],"components":[100],"Raf,":[103],"Rac,":[104,176],"RhoA":[106,178,219],"pathways.":[107],"In":[108],"previous":[109],"studies":[110],"lines":[114],"showed":[116],"that":[117,145,168,239],"loss":[118],"Ras":[121],"function":[122],"results":[123],"dramatic":[125],"changes":[126],"conversion":[134,155],"weakly":[137],"tumorigenic":[138,162,188,245],"phenotype":[139,189],"vivo.":[141],"report":[143],"here":[144],"only":[146],"overexpression":[147,222],"activated":[149,224],"MEK":[150,225],"contributed":[151],"significantly":[152],"aggressive":[161,187,244],"phenotype.":[163,246],"Furthermore,":[164],"demonstrated":[167,204],"blocking":[169],"constitutive":[171],"activation":[172,234],"Raf-MEK,":[175],"pathway":[179,214],"alone":[180],"not":[182],"sufficient":[183],"block":[185],"HT1080,":[191],"despite":[192],"affecting":[193],"number":[195],"vitro-transformed":[198],"traits.":[200],"bidirectional":[208],"between":[211],"Raf-MEK-ERK":[213],"Rac-JNK":[217],"pathway.":[220],"Finally,":[221],"appears":[229],"result":[231],"as-yet-unidentified":[237],"target(s)":[238],"critical":[241]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
