{"id":"https://openalex.org/W2113203318","doi":null,"title":"Sleep apnoea and hypertension: proof at last?","display_name":"Sleep apnoea and hypertension: proof at last?","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2113203318","mag":"2113203318","pmid":"https://pubmed.ncbi.nlm.nih.gov/11514706","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1765982"},"language":"en","primary_location":{"id":"pmid:11514706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11514706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1765982/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018887395","display_name":"John R. Stradling","orcid":"https://orcid.org/0000-0003-4971-5018","observed_orcids":["https://orcid.org/0000-0003-4971-5018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Stradling","raw_affiliation_strings":["Oxford Centre for Respiratory Medicine, Oxford Radcliffe Trust, Oxford OX3 7LJ, UK. john.stradling@ndm.ox.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxford Centre for Respiratory Medicine, Oxford Radcliffe Trust, Oxford OX3 7LJ, UK. john.stradling@ndm.ox.ac.uk","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026183673","display_name":"Justin Pepperell","orcid":"https://orcid.org/0000-0002-9734-7179","observed_orcids":["https://orcid.org/0000-0002-9734-7179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Pepperell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103389854","display_name":"Robert J.O. Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3398,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.30732861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56 Suppl 2","issue":null,"first_page":"ii45","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-apnea","display_name":"sleep apnea","score":0.906000018119812},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.878000020980835},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/apnea-hypopnea-index","display_name":"apnea-hypopnea index","score":0.9869999885559082},{"id":"https://openalex.org/keywords/wisconsin-sleep-cohort-study","display_name":"Wisconsin Sleep Cohort Study","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6669999957084656},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5109999775886536},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9225876331329346},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.7317957878112793},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6247852444648743},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.5929874777793884},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5848388075828552},{"id":"https://openalex.org/C2777711342","wikidata":"https://www.wikidata.org/wiki/Q957217","display_name":"Hypopnea","level":4,"score":0.5728287100791931},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5535712838172913},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.5221163034439087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48431625962257385},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.480964332818985},{"id":"https://openalex.org/C2776377968","wikidata":"https://www.wikidata.org/wiki/Q618736","display_name":"Apnea\u2013hypopnea index","level":4,"score":0.47499313950538635},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.4455295503139496},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38406240940093994},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3465803861618042},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:11514706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11514706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1765982","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1765982/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"mag:2113203318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11514706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1765982","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1765982/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W14557554","https://openalex.org/W119190672","https://openalex.org/W168313197","https://openalex.org/W169626964","https://openalex.org/W579778697","https://openalex.org/W1515772793","https://openalex.org/W1592920100","https://openalex.org/W1976904550","https://openalex.org/W1994333278","https://openalex.org/W1994381724","https://openalex.org/W1996692474","https://openalex.org/W2001186029","https://openalex.org/W2001338531","https://openalex.org/W2002835567","https://openalex.org/W2003268912","https://openalex.org/W2008266617","https://openalex.org/W2008470188","https://openalex.org/W2013784113","https://openalex.org/W2018281450","https://openalex.org/W2019222330","https://openalex.org/W2025174591","https://openalex.org/W2028139576","https://openalex.org/W2030171505","https://openalex.org/W2035557978","https://openalex.org/W2056145208","https://openalex.org/W2060494048","https://openalex.org/W2063874268","https://openalex.org/W2067844870","https://openalex.org/W2075726900","https://openalex.org/W2075990046","https://openalex.org/W2082845722","https://openalex.org/W2093907459","https://openalex.org/W2118855061","https://openalex.org/W2121969402","https://openalex.org/W2127030366","https://openalex.org/W2137125252","https://openalex.org/W2137497420","https://openalex.org/W2137715034","https://openalex.org/W2139480984","https://openalex.org/W2139704316","https://openalex.org/W2141659719","https://openalex.org/W2141960731","https://openalex.org/W2142261310","https://openalex.org/W2147102905","https://openalex.org/W2157359185","https://openalex.org/W2158950904","https://openalex.org/W2162659138","https://openalex.org/W2162747978","https://openalex.org/W2167210570","https://openalex.org/W2176199499","https://openalex.org/W2217495265","https://openalex.org/W2283785438","https://openalex.org/W2333343699","https://openalex.org/W2335449614","https://openalex.org/W2337160971","https://openalex.org/W2340342319","https://openalex.org/W2397471157","https://openalex.org/W2411515190","https://openalex.org/W2416764494","https://openalex.org/W2437231277","https://openalex.org/W2546647298","https://openalex.org/W3139758241"],"related_works":["https://openalex.org/W2335449614","https://openalex.org/W2127030366","https://openalex.org/W2063874268","https://openalex.org/W7096723888","https://openalex.org/W2139704316","https://openalex.org/W2072935881","https://openalex.org/W2035557978","https://openalex.org/W2041326638","https://openalex.org/W1603697792","https://openalex.org/W3195110820"],"abstract_inverted_index":{"Background:":[0],"Sleep-disordered":[1],"breathing":[2,35,266,289],"is":[3,290],"prevalent":[4],"in":[5,18,77,92,303],"the":[6,29,51,81,93,113,132,137,143,174,189,193,270,304],"general":[7,305],"population":[8],"and":[9,36,66,71,122,159,164,169,240,269,299],"has":[10],"been":[11],"linked":[12],"to":[13,142,173,204,212,227,235,245,292],"chronically":[14],"elevated":[15],"blood":[16,42,63],"pressure":[17,43],"cross-sectional":[19],"epidemiologic":[20],"studies.":[21],"We":[22,57,259],"performed":[23],"a":[24,40,261,294],"prospective,":[25],"population-based":[26],"study":[27,140],"of":[28,44,53,75,80,90,95,97,118,120,126,134,167,177,181,195,210,233,251,272,280],"association":[30,263],"between":[31,264],"objectively":[32],"measured":[33],"sleep-disordered":[34,61,108,265,288],"hypertension":[37,135,154,196,273,298],"(defined":[38],"as":[39,110,219],"laboratory-measured":[41],"at":[45,69,136,146,186,197,217,267],"least":[46],"140/90":[47],"mm":[48],"Hg":[49],"or":[50,253],"use":[52,166],"antihypertensive":[54],"medications).":[55],"Methods:":[56],"analyzed":[58],"data":[59],"on":[60],"breathing,":[62,109],"pressure,":[64],"habitus,":[65],"health":[67],"history":[68],"baseline":[70,147,153,218,268],"after":[72,87,150],"four":[73,274],"years":[74,89,275],"follow-up":[76,91,139,198],"709":[78],"participants":[79],"Wisconsin":[82],"Sleep":[83],"Cohort":[84],"Study":[85],"(and":[86],"eight":[88],"case":[94],"184":[96],"these":[98],"participants).":[99],"Participants":[100],"were":[101,148,199],"assessed":[102],"overnight":[103],"by":[104,112],"18-channel":[105],"polysomnography":[106],"for":[107,131,152,192,297],"defined":[111],"apnea-hypopnea":[114,144,179,208,231,249],"index":[115,145,180,209,232,250],"(the":[116],"number":[117],"episodes":[119],"apnea":[121],"hypopnea":[123],"per":[124,184,215,238,256],"hour":[125,185,216],"sleep).":[127],"The":[128,284],"odds":[129,190],"ratios":[130,191],"presence":[133,194,271],"four-year":[138],"according":[141],"estimated":[149],"adjustment":[151],"status,":[155],"body-mass":[156],"index,":[157],"neck":[158],"waist":[160],"circumference,":[161],"age,":[162],"sex,":[163],"weekly":[165],"alcohol":[168],"cigarettes.":[170],"Results:":[171],"Relative":[172],"reference":[175],"category":[176],"an":[178,207,230,248],"0":[182],"events":[183,214,237,255],"base":[187],"line,":[188],"1.42":[200],"(95%":[201,224,242],"CI":[202,225,243],"1.13":[203],"1.78)":[205],"with":[206,221,229,247],"0.1":[211],"4.9":[213],"compared":[220],"none,":[222],"2.03":[223],"1.29":[226],"3.17)":[228],"5.0":[234],"14.9":[236],"hour,":[239],"2.89":[241],"1.46":[244],"5.64)":[246],"15.0":[252],"more":[254],"hour.":[257],"Conclusions:":[258],"found":[260],"dose-response":[262],"later":[276],"that":[277,287],"was":[278],"independent":[279],"known":[281],"confounding":[282],"factors.":[283],"findings":[285],"suggest":[286],"likely":[291],"be":[293],"risk":[295],"factor":[296],"consequent":[300],"cardiovascular":[301],"morbidity":[302],"population.":[306],"(N":[307],"Engl":[308],"J":[309],"Med":[310],"2000;342:1378\u201084)":[311]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
