{"id":"https://openalex.org/W2113188331","doi":"https://doi.org/10.1093/molbev/msu262","title":"Testing the Role of Genetic Background in Parallel Evolution Using the Comparative Experimental Evolution of Antibiotic Resistance","display_name":"Testing the Role of Genetic Background in Parallel Evolution Using the Comparative Experimental Evolution of Antibiotic Resistance","publication_year":2014,"publication_date":"2014-09-16","ids":{"openalex":"https://openalex.org/W2113188331","doi":"https://doi.org/10.1093/molbev/msu262","mag":"2113188331","pmid":"https://pubmed.ncbi.nlm.nih.gov/25228081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4245821"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msu262","doi":"https://doi.org/10.1093/molbev/msu262","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msu262","pdf_url":"https://academic.oup.com/mbe/article-pdf/31/12/3314/13171063/msu262.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/mbe/article-pdf/31/12/3314/13171063/msu262.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002445097","display_name":"Tom Vogwill","orcid":"https://orcid.org/0000-0003-1044-6623","observed_orcids":["https://orcid.org/0000-0003-1044-6623"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tom Vogwill","raw_affiliation_strings":["Department of Zoology, University of Oxford, Oxford, United Kingdom craig.maclean@zoo.ox.ac.uk tom.vogwill@zoo.ox.ac.uk","Department of Zoology, University of Oxford , Oxford , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Oxford, Oxford, United Kingdom craig.maclean@zoo.ox.ac.uk tom.vogwill@zoo.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Zoology, University of Oxford , Oxford , United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089423978","display_name":"Mila Kojadinovic","orcid":"https://orcid.org/0000-0001-8110-3113","observed_orcids":["https://orcid.org/0000-0001-8110-3113"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210089214","display_name":"Bio\u00e9nerg\u00e9tique et Ing\u00e9nierie des Prot\u00e9ines","ror":"https://ror.org/0060xzr04","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210089214","https://openalex.org/I4210096427"]},{"id":"https://openalex.org/I4210100449","display_name":"Institut de Microbiologie de la M\u00e9diterran\u00e9e","ror":"https://ror.org/012t91r40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210100449"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mila Kojadinovic","raw_affiliation_strings":["CNRS, Aix-Marseille Universit\u00e9, Laboratoire de Bio\u00e9nerg\u00e9tique et Ing\u00e9nierie des Prot\u00e9ines, UMR 7281, IMM, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Aix-Marseille Universit\u00e9, Laboratoire de Bio\u00e9nerg\u00e9tique et Ing\u00e9nierie des Prot\u00e9ines, UMR 7281, IMM, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210089214","https://openalex.org/I4210100449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060774255","display_name":"Victoria Furi\u00f3","orcid":"https://orcid.org/0000-0002-0879-5798","observed_orcids":["https://orcid.org/0000-0002-0879-5798","https://orcid.org/0000-0001-5511-7722"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Furi\u00f3","raw_affiliation_strings":["Department of Zoology, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085336116","display_name":"R. Craig MacLean","orcid":"https://orcid.org/0000-0002-7941-813X","observed_orcids":["https://orcid.org/0000-0002-7941-813X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. Craig MacLean","raw_affiliation_strings":["Department of Zoology, University of Oxford, Oxford, United Kingdom craig.maclean@zoo.ox.ac.uk tom.vogwill@zoo.ox.ac.uk","Department of Zoology, University of Oxford , Oxford , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Oxford, Oxford, United Kingdom craig.maclean@zoo.ox.ac.uk tom.vogwill@zoo.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Zoology, University of Oxford , Oxford , United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002445097","https://openalex.org/A5085336116"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":{"value":3418,"currency":"USD","value_usd":3418},"fwci":2.5676,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.89615604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"31","issue":"12","first_page":"3314","last_page":"3323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12090","display_name":"Language and cultural evolution","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3316","display_name":"Cultural Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parallel-evolution","display_name":"parallel evolution","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.9769999980926514},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pseudomonas","display_name":"Pseudomonas","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rpob-mutations","display_name":"rpoB mutations","score":0.9449999928474426},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bacterial-growth-rate","display_name":"bacterial growth rate","score":0.6079999804496765},{"id":"https://openalex.org/keywords/molecular-adaptation","display_name":"molecular adaptation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/phenotypic-evolution","display_name":"phenotypic evolution","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2778340795","wikidata":"https://www.wikidata.org/wiki/Q24782946","display_name":"rpoB","level":4,"score":0.9423109889030457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9010619521141052},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.7508369088172913},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.6863201856613159},{"id":"https://openalex.org/C68775705","wikidata":"https://www.wikidata.org/wiki/Q903761","display_name":"Parallel evolution","level":4,"score":0.6743064522743225},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6613333821296692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6116042137145996},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6013542413711548},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5376341342926025},{"id":"https://openalex.org/C2992278830","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Adaptive evolution","level":3,"score":0.5003359317779541},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4933401644229889},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.45385512709617615},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.44813260436058044},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4453054964542389},{"id":"https://openalex.org/C2777949028","wikidata":"https://www.wikidata.org/wiki/Q25303868","display_name":"Rate of evolution","level":4,"score":0.4282742738723755},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.27544689178466797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24821320176124573},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.10016283392906189},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/molbev/msu262","doi":"https://doi.org/10.1093/molbev/msu262","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msu262","pdf_url":"https://academic.oup.com/mbe/article-pdf/31/12/3314/13171063/msu262.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:25228081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25228081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4245821","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4245821/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Evol","raw_type":"Text"},{"id":"pmh:oai:aura.abdn.ac.uk:2164/13832","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/84924973674","pdf_url":"https://hdl.handle.net/2164/13832","source":{"id":"https://openalex.org/S4306400966","display_name":"Aberdeen University Research Archive (Aberdeen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I195460627","host_organization_name":"University of Aberdeen","host_organization_lineage":["https://openalex.org/I195460627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1032.6664","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1032.6664","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mbe.oxfordjournals.org/content/31/12/3314.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.3840","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.3840","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dd/59/msu262.PMC4245821.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/molbev/msu262","doi":"https://doi.org/10.1093/molbev/msu262","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msu262","pdf_url":"https://academic.oup.com/mbe/article-pdf/31/12/3314/13171063/msu262.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6803367917","display_name":"The evolution of antibiotic resistance: integrating molecular mechanisms of resistance and evolutionary context","funder_award_id":"281591","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113188331.pdf","grobid_xml":"https://content.openalex.org/works/W2113188331.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W643399572","https://openalex.org/W1502467014","https://openalex.org/W1521785005","https://openalex.org/W1540799628","https://openalex.org/W1857653616","https://openalex.org/W1963957860","https://openalex.org/W1967902778","https://openalex.org/W1969042907","https://openalex.org/W1971154088","https://openalex.org/W1976227404","https://openalex.org/W1977852064","https://openalex.org/W1988182864","https://openalex.org/W1991265385","https://openalex.org/W1991601642","https://openalex.org/W1993646374","https://openalex.org/W2007339420","https://openalex.org/W2011882432","https://openalex.org/W2013410948","https://openalex.org/W2016185554","https://openalex.org/W2023379882","https://openalex.org/W2026666552","https://openalex.org/W2054606441","https://openalex.org/W2056981303","https://openalex.org/W2065645501","https://openalex.org/W2066554694","https://openalex.org/W2068372433","https://openalex.org/W2068712558","https://openalex.org/W2070498478","https://openalex.org/W2073556554","https://openalex.org/W2075205566","https://openalex.org/W2078641132","https://openalex.org/W2079637221","https://openalex.org/W2081485857","https://openalex.org/W2087189381","https://openalex.org/W2090640084","https://openalex.org/W2094961365","https://openalex.org/W2095820657","https://openalex.org/W2097107919","https://openalex.org/W2102616630","https://openalex.org/W2106791022","https://openalex.org/W2107505956","https://openalex.org/W2111211467","https://openalex.org/W2116436591","https://openalex.org/W2118609795","https://openalex.org/W2119404698","https://openalex.org/W2122402674","https://openalex.org/W2123101103","https://openalex.org/W2124443090","https://openalex.org/W2131473084","https://openalex.org/W2132543781","https://openalex.org/W2132926880","https://openalex.org/W2133102806","https://openalex.org/W2134479503","https://openalex.org/W2134766930","https://openalex.org/W2137890456","https://openalex.org/W2139076424","https://openalex.org/W2142618175","https://openalex.org/W2144950848","https://openalex.org/W2146449823","https://openalex.org/W2146581074","https://openalex.org/W2149615665","https://openalex.org/W2149797757","https://openalex.org/W2150469424","https://openalex.org/W2152749315","https://openalex.org/W2156128162","https://openalex.org/W2162093394","https://openalex.org/W2165854405","https://openalex.org/W2168038523","https://openalex.org/W4255218826"],"related_works":["https://openalex.org/W7095575398","https://openalex.org/W3118580478","https://openalex.org/W2493186172","https://openalex.org/W2152749315","https://openalex.org/W6948270502","https://openalex.org/W2161062708","https://openalex.org/W6948554393","https://openalex.org/W2887855209","https://openalex.org/W2118917020","https://openalex.org/W2134766930"],"abstract_inverted_index":{"Parallel":[0,161],"evolution":[1,5,25,62,117,125,163,170],"is":[2],"the":[3,7,15,42,49,71,80,99,106,112,146,150,201],"independent":[4],"of":[6,22,44,51,77,101,109,114,122,145,153,204],"same":[8,16],"phenotype":[9],"or":[10],"genotype":[11],"in":[12,40,74,97,149,167,180,206],"response":[13],"to":[14,70,105,158],"selection":[17,87],"pressure.":[18],"There":[19],"are":[20],"examples":[21],"parallel":[23,116,124,192],"molecular":[24,57,162,202],"across":[26,164],"divergent":[27,168],"genetic":[28,32,52,187],"backgrounds,":[29],"suggesting":[30],"that":[31,141,186],"background":[33,53],"may":[34],"not":[35],"play":[36],"an":[37],"important":[38],"role":[39],"determining":[41],"outcome":[43],"adaptation.":[45],"Here,":[46],"we":[47,139],"measure":[48],"influence":[50],"on":[54,177,200],"phenotypic":[55,147,169,193],"and":[56,103],"adaptation":[58,205],"by":[59,91],"combining":[60],"experimental":[61],"with":[63],"comparative":[64],"analysis.":[65],"We":[66],"selected":[67],"for":[68],"resistance":[69],"antibiotic":[72],"rifampicin":[73],"eight":[75],"strains":[76,132,165,190],"bacteria":[78],"from":[79],"genus":[81],"Pseudomonas":[82],"using":[83],"a":[84],"short":[85],"term":[86],"experiment.":[88],"Adaptation":[89],"occurred":[90],"47":[92],"mutations":[93,111,173],"at":[94],"conserved":[95],"sites":[96],"rpoB,":[98],"target":[100],"rifampicin,":[102],"due":[104],"high":[107],"diversity":[108],"possible":[110],"probability":[113,121],"within-strain":[115],"was":[118,126,156],"low.":[119],"The":[120],"between-strain":[123],"only":[127],"marginally":[128],"lower,":[129],"because":[130,171],"different":[131,175,181],"substituted":[133],"similar":[134],"rpoB":[135,172],"mutations.":[136],"In":[137],"contrast,":[138],"found":[140],"more":[142],"than":[143],"30%":[144],"variation":[148],"growth":[151,178],"rate":[152,179],"evolved":[154],"clones":[155],"attributable":[157],"among-strain":[159],"differences.":[160],"resulted":[166],"had":[174,196],"effects":[176],"strains.":[182],"This":[183],"study":[184],"shows":[185],"divergence":[188],"between":[189],"constrains":[191],"evolution,":[194],"but":[195],"little":[197],"detectable":[198],"impact":[199],"basis":[203],"this":[207],"system.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}