{"id":"https://openalex.org/W2113187337","doi":"https://doi.org/10.1001/jama.2014.11061","title":"Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome","display_name":"Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome","publication_year":2014,"publication_date":"2014-08-31","ids":{"openalex":"https://openalex.org/W2113187337","doi":"https://doi.org/10.1001/jama.2014.11061","mag":"2113187337","pmid":"https://pubmed.ncbi.nlm.nih.gov/25173516"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2014.11061","doi":"https://doi.org/10.1001/jama.2014.11061","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2014.11061","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081943616","display_name":"Michelle L. O\u2019Donoghue","orcid":"https://orcid.org/0000-0002-8663-0067","observed_orcids":["https://orcid.org/0000-0002-8663-0067"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. O\u2019Donoghue","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267024","display_name":"Eugene Braunwald","orcid":"https://orcid.org/0000-0002-3472-626X","observed_orcids":["https://orcid.org/0000-0002-3472-626X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Braunwald","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062843291","display_name":"Harvey Douglas White","orcid":"https://orcid.org/0000-0001-7712-6750","observed_orcids":["https://orcid.org/0000-0001-7712-6750"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I2801418622","display_name":"Auckland City Hospital","ror":"https://ror.org/05e8jge82","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I2801418622","https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Harvey D. White","raw_affiliation_strings":["Green Lane Cardiovascular Service, Auckland City Hospital, Auckland University, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Green Lane Cardiovascular Service, Auckland City Hospital, Auckland University, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I2801418622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110209303","display_name":"Dylan P. Steen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan P. Steen","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034761484","display_name":"Mary Ann Lukas","orcid":"https://orcid.org/0000-0003-0791-5580","observed_orcids":["https://orcid.org/0000-0003-0791-5580"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann Lukas","raw_affiliation_strings":["Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010360425","display_name":"Elizabeth A. Tarka","orcid":"https://orcid.org/0000-0003-1680-0232","observed_orcids":["https://orcid.org/0000-0003-1680-0232"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Tarka","raw_affiliation_strings":["Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003831287","display_name":"Philippe Gabr\u00edel Steg","orcid":"https://orcid.org/0000-0001-6896-2941","observed_orcids":["https://orcid.org/0000-0001-6896-2941"]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"P. Gabriel Steg","raw_affiliation_strings":["D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Assistance Publique-H\u00f4pitaux de Paris, and Universit\u00e9 Paris-Diderot, Paris, France6NHLI Imperial College, ICMS Royal Brompton Hospital, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement Hospitalo-Universitaire FIRE, H\u00f4pital Bichat, Assistance Publique-H\u00f4pitaux de Paris, and Universit\u00e9 Paris-Diderot, Paris, France6NHLI Imperial College, ICMS Royal Brompton Hospital, United Kingdom","institution_ids":["https://openalex.org/I4210096640","https://openalex.org/I4210097159","https://openalex.org/I4210145170","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088024345","display_name":"Judith S. Hochman","orcid":"https://orcid.org/0000-0002-5889-5981","observed_orcids":["https://orcid.org/0000-0002-5889-5981"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith S. Hochman","raw_affiliation_strings":["Department of Medicine, NYU Langone Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, NYU Langone Medical Center, New York","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015202871","display_name":"Christoph Bode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Bode","raw_affiliation_strings":["Heart Center, Department for Cardiology and Angiology I, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center, Department for Cardiology and Angiology I, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088186128","display_name":"Aldo Pietro Maggioni","orcid":"https://orcid.org/0000-0003-2764-6779","observed_orcids":["https://orcid.org/0000-0003-2764-6779"]},"institutions":[{"id":"https://openalex.org/I4210095959","display_name":"Associazione Nazionale Medici Cardiologi Ospedalieri","ror":"https://ror.org/00pyc4352","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210095959"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aldo P. Maggioni","raw_affiliation_strings":["ANMCO Research Center, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ANMCO Research Center, Florence, Italy","institution_ids":["https://openalex.org/I4210095959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102922776","display_name":"KyungAh Im","orcid":"https://orcid.org/0000-0003-2185-6193","observed_orcids":["https://orcid.org/0000-0003-2185-6193"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KyungAh Im","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032802152","display_name":"Jennifer B. Shannon","orcid":"https://orcid.org/0009-0001-7266-2295","observed_orcids":["https://orcid.org/0009-0001-7266-2295"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer B. Shannon","raw_affiliation_strings":["Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103543720","display_name":"Richard Y. Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Y. Davies","raw_affiliation_strings":["Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085897222","display_name":"Sabina A. Murphy","orcid":"https://orcid.org/0000-0002-8231-3611","observed_orcids":["https://orcid.org/0000-0002-8231-3611"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabina A. Murphy","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037358069","display_name":"Sharon E. Crugnale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Crugnale","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107928205","display_name":"Stephen D. Wiviott","orcid":"https://orcid.org/0000-0002-4922-9880","observed_orcids":["https://orcid.org/0000-0002-4922-9880"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Wiviott","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090903599","display_name":"Marc P. Bonaca","orcid":"https://orcid.org/0000-0002-9860-3584","observed_orcids":["https://orcid.org/0000-0002-9860-3584"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc P. Bonaca","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David F. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Watson","raw_affiliation_strings":["Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274257","display_name":"W. Douglas Weaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Douglas Weaver","raw_affiliation_strings":["Henry Ford Heart and Vascular Institute, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Heart and Vascular Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063792624","display_name":"Patrick W.J.C. Serruys","orcid":"https://orcid.org/0000-0002-9636-1104","observed_orcids":["https://orcid.org/0000-0002-9636-1104","https://orcid.org/0000-0001-7321-1261"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick W. Serruys","raw_affiliation_strings":["Erasmus University, Thoraxcentrum, Rotterdam, the Netherlands13International Center for Circulatory Health, Imperial College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasmus University, Thoraxcentrum, Rotterdam, the Netherlands13International Center for Circulatory Health, Imperial College, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026602252","display_name":"Christopher Paul Cannon","orcid":"https://orcid.org/0000-0003-4596-2791","observed_orcids":["https://orcid.org/0000-0003-4596-2791"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Cannon","raw_affiliation_strings":["TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210159766"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":35.961,"has_fulltext":false,"cited_by_count":462,"citation_normalized_percentile":{"value":0.99833832,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"312","issue":"10","first_page":"1006","last_page":"1006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/darapladib","display_name":"darapladib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoprotein-associated-phospholipase-a2","display_name":"lipoprotein-associated phospholipase A2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/major-coronary-events","display_name":"major coronary events","score":0.9190000295639038},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.5910000205039978},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6380000114440918},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7480000257492065},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.5609999895095825},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.46000000834465027},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9661858081817627},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.7156633138656616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7020353078842163},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6622563600540161},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6499276161193848},{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.6248867511749268},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5856075882911682},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5792683959007263},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5212188959121704},{"id":"https://openalex.org/C2778704086","wikidata":"https://www.wikidata.org/wiki/Q693058","display_name":"Chest pain","level":2,"score":0.520297110080719},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.43968766927719116},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41601866483688354},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.2975042462348938},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.16886964440345764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06506261229515076},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004048","descriptor_name":"Diethylamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1001/jama.2014.11061","doi":"https://doi.org/10.1001/jama.2014.11061","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2014.11061","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:25173516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25173516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/76b8d590-8b91-4561-b051-2d117d018f86","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/76b8d590-8b91-4561-b051-2d117d018f86","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"O'Donoghue, M L, Braunwald, E, White, H D, Steen, D P, Lukas, M A, Tarka, E, Steg, P G, Hochman, J S, Bode, C, Maggioni, A P, Im, K, Shannon, J B, Davies, R Y, Murphy, S A, Crugnale, S E, Wiviott, S D, Bonaca, M P, Watson, D F, Weaver, W D, Serruys, P W, Cannon, C P & AUTHOR GROUP 2014, 'Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome The SOLID-TIMI 52 Randomized Clinical Trial', JAMA, vol. 312, no. 10, pp. 1006-1015. https://doi.org/10.1001/jama.2014.11061","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/073df9ab-90d5-4e87-a57e-ecabaa6f441e","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/073df9ab-90d5-4e87-a57e-ecabaa6f441e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sfera.unife.it:11392/2415716","doi":null,"is_oa":false,"landing_page_url":"http://jama.jamanetwork.com/data/Journals/JAMA/930764/joi140114.pdf","pdf_url":"http://jama.jamanetwork.com/data/Journals/JAMA/930764/joi140114.pdf","source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/611f39ea-f49c-43d5-83c9-30048f5faba4","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/effect-of-darapladib-on-major-coronary-events-after-an-acute-coronary-syndrome-the-solidtimi-52-randomized-clinical-trial(611f39ea-f49c-43d5-83c9-30048f5faba4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA, 312(10), 1006 - 1015. American Medical Association","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/073df9ab-90d5-4e87-a57e-ecabaa6f441e","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/073df9ab-90d5-4e87-a57e-ecabaa6f441e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA - Journal of the American Medical Association, 312(10), 1006 - 1015. American Medical Association","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/527548","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/527548","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/612990","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/612990","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1328071","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1328071","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:91441","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/effect-of-darapladib-on-major-coronary-events-after-an-acute-coronary-syndrome-the-solidtimi-52-randomized-clinical-trial(66133351-14e3-45ec-ae69-42722668e6a2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1547524180","https://openalex.org/W1572528121","https://openalex.org/W1586079541","https://openalex.org/W1966739013","https://openalex.org/W1975712574","https://openalex.org/W2049098647","https://openalex.org/W2063612356","https://openalex.org/W2063997037","https://openalex.org/W2084008596","https://openalex.org/W2085453879","https://openalex.org/W2099917925","https://openalex.org/W2105378753","https://openalex.org/W2110551379","https://openalex.org/W2114408062","https://openalex.org/W2116882603","https://openalex.org/W2126830306","https://openalex.org/W2152068506","https://openalex.org/W2152460160","https://openalex.org/W2157526825","https://openalex.org/W2170274940","https://openalex.org/W2272962241","https://openalex.org/W3170020307"],"related_works":["https://openalex.org/W7097357948","https://openalex.org/W2063612356","https://openalex.org/W2184634209","https://openalex.org/W2027476905","https://openalex.org/W2301635914","https://openalex.org/W2135848029","https://openalex.org/W2167630046","https://openalex.org/W2090159793","https://openalex.org/W2322986581","https://openalex.org/W2335631909"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Lipoprotein-associated":[1],"phospholipase":[2],"A2":[3],"(Lp-PLA2)":[4],"has":[5],"been":[6],"hypothesized":[7],"to":[8,16,86,286,306,329],"be":[9],"involved":[10],"in":[11,37,79,167,170,176,205,207,213,253,258,264,291],"atherogenesis":[12],"through":[13],"pathways":[14],"related":[15],"inflammation.":[17],"Darapladib":[18],"is":[19],"an":[20,40,68,288,319],"oral,":[21],"selective":[22],"inhibitor":[23],"of":[24,35,65,97,107,132,159,198,247,324,338,345],"the":[25,31,130,162,171,177,208,214,236,248,259,265,292,296,343],"Lp-PLA2":[26,325],"enzyme.":[27],"OBJECTIVE:":[28],"To":[29],"evaluate":[30],"efficacy":[32],"and":[33,114,174,211,262,302,333],"safety":[34],"darapladib":[36,89,172,209,260,293,327],"patients":[38,169,316],"after":[39],"acute":[41],"coronary":[42,127,133,141,347],"syndrome":[43],"(ACS)":[44],"event.":[45],"DESIGN,":[46],"SETTING,":[47],"AND":[48,120,313],"PARTICIPANTS:":[49],"SOLID-TIMI":[50],"52":[51],"was":[52,129],"a":[53,95,105,156],"multinational,":[54],"double-blind,":[55],"placebo-controlled":[56],"trial":[57],"that":[58],"randomized":[59,85],"13,026":[60],"participants":[61],"within":[62,335],"30":[63,336],"days":[64,337],"hospitalization":[66,339],"with":[67,326],"ACS":[69,320],"(non-ST-elevation":[70],"or":[71,92,139,202,252],"ST-elevation":[72],"myocardial":[73,144],"infarction":[74],"[MI])":[75],"at":[76,151,183,220,271],"868":[77],"sites":[78],"36":[80],"countries.":[81],"INTERVENTIONS:":[82],"Patients":[83,100,282],"were":[84,101,232,283],"either":[87],"once-daily":[88],"(160":[90],"mg)":[91],"placebo":[93,178,215,266,297],"on":[94],"background":[96],"guideline-recommended":[98],"therapy.":[99],"followed":[102],"up":[103],"for":[104,143,239,244],"median":[106,157],"2.5":[108,160],"years":[109],"between":[110,235],"December":[111,115],"7,":[112],"2009,":[113],"6,":[116],"2013.":[117],"MAIN":[118],"OUTCOMES":[119],"MEASURES:":[121],"The":[122,196],"primary":[123,163,249],"end":[124,164,242,250],"point":[125,165],"(major":[126],"events)":[128],"composite":[131,197],"heart":[134],"disease":[135],"(CHD)":[136],"death,":[137,200],"MI,":[138,201],"urgent":[140],"revascularization":[142],"ischemia.":[145],"Kaplan-Meier":[146],"event":[147],"rates":[148],"are":[149],"reported":[150],"3":[152,184,221,272],"years.":[153],"RESULTS:":[154],"During":[155],"duration":[158],"years,":[161],"occurred":[166,204],"903":[168],"group":[173,179,210,216,261,267,294,298],"910":[175],"(16.3%":[180],"vs":[181,218,269,295,300,310],"15.6%":[182],"years;":[185,222,273],"hazard":[186],"ratio":[187],"[HR],":[188],"1.00":[189],"[95%":[190,225,276],"CI,":[191,226,277],"0.91-1.09];":[192],"P":[193,228,279],"=":[194,229,280],".93).":[195],"cardiovascular":[199],"stroke":[203],"824":[206],"838":[212],"(15.0%":[217],"15.0%":[219],"HR,":[223,274],"0.99":[224],"0.90-1.09];":[227],".78).":[230],"There":[231],"no":[233],"differences":[234],"treatment":[237],"groups":[238],"additional":[240],"secondary":[241],"points,":[243],"individual":[245],"components":[246],"point,":[251],"all-cause":[254],"mortality":[255],"(371":[256],"events":[257],"395":[263],"[7.3%":[268],"7.1%":[270],"0.94":[275],"0.82-1.08];":[278],".40).":[281],"more":[284,304],"likely":[285,305],"report":[287,307],"odor-related":[289],"concern":[290],"(11.5%":[299],"2.5%)":[301],"also":[303],"diarrhea":[308],"(10.6%":[309],"5.6%).":[311],"CONCLUSIONS":[312],"RELEVANCE:":[314],"In":[315],"who":[317],"experienced":[318],"event,":[321],"direct":[322],"inhibition":[323],"added":[328],"optimal":[330],"medical":[331],"therapy":[332],"initiated":[334],"did":[340],"not":[341],"reduce":[342],"risk":[344],"major":[346],"events.":[348],"TRIAL":[349],"REGISTRATION:":[350],"clinicaltrials.gov":[351],"Identifier:":[352],"NCT01000727.":[353]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":47},{"year":2017,"cited_by_count":47},{"year":2016,"cited_by_count":51},{"year":2015,"cited_by_count":53},{"year":2014,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}