{"id":"https://openalex.org/W2113017980","doi":null,"title":"[DRD4 polymorphism and the association with mental disorders].","display_name":"[DRD4 polymorphism and the association with mental disorders].","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2113017980","mag":"2113017980","pmid":"https://pubmed.ncbi.nlm.nih.gov/15981960"},"language":"es","primary_location":{"id":"pmid:15981960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043866075","display_name":"Ana Julia Aguirre\u2010Samudio","orcid":"https://orcid.org/0000-0002-6674-5641","observed_orcids":["https://orcid.org/0000-0002-6674-5641"]},"institutions":[{"id":"https://openalex.org/I4210154708","display_name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","ror":"https://ror.org/05qjm2261","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210154708"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ana Julia Aguirre-Samudio","raw_affiliation_strings":["Departamento de Gen\u00e9tica Psiqui\u00e1trica, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente, M\u00e9xico, DF. ajua@servidor.unam.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00e9tica Psiqui\u00e1trica, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente, M\u00e9xico, DF. ajua@servidor.unam.mx","institution_ids":["https://openalex.org/I4210154708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028287374","display_name":"Humberto Nicolini","orcid":"https://orcid.org/0000-0003-2494-0067","observed_orcids":["https://orcid.org/0000-0003-2494-0067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Humberto Nicolini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3106,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.45428157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"57","issue":"1","first_page":"65","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drd4-gene","display_name":"DRD4 gene","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dopamine-d4-receptor","display_name":"dopamine D4 receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vntr-polymorphism","display_name":"VNTR polymorphism","score":0.8399999737739563},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/novelty-seeking","display_name":"novelty seeking","score":0.9850000143051147},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.6570000052452087},{"id":"https://openalex.org/keywords/psychiatric-genetics","display_name":"psychiatric genetics","score":0.6589999794960022},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2776529864","wikidata":"https://www.wikidata.org/wiki/Q4368945","display_name":"Novelty seeking","level":4,"score":0.630042314529419},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5578601360321045},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5055954456329346},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4815562069416046},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.4744197726249695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36523866653442383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3610668182373047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3379305303096771},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3278402090072632},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30253493785858154},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2580074667930603},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15076175332069397},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10947012901306152},{"id":"https://openalex.org/C61644593","wikidata":"https://www.wikidata.org/wiki/Q80157","display_name":"Temperament","level":3,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050638","descriptor_name":"Receptors, Dopamine D4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15981960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"English Abstract"},{"id":"mag:2113017980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W130947350","https://openalex.org/W163504149","https://openalex.org/W1964057706","https://openalex.org/W1966745635","https://openalex.org/W1971671044","https://openalex.org/W1973118113","https://openalex.org/W1973678939","https://openalex.org/W1975590817","https://openalex.org/W1977375680","https://openalex.org/W1979581644","https://openalex.org/W1991189774","https://openalex.org/W1991965466","https://openalex.org/W1997914870","https://openalex.org/W2001515224","https://openalex.org/W2003882735","https://openalex.org/W2008047653","https://openalex.org/W2009920684","https://openalex.org/W2022486591","https://openalex.org/W2024054703","https://openalex.org/W2026395566","https://openalex.org/W2030905853","https://openalex.org/W2040133201","https://openalex.org/W2046774478","https://openalex.org/W2047320236","https://openalex.org/W2053529553","https://openalex.org/W2054251181","https://openalex.org/W2056866499","https://openalex.org/W2059230444","https://openalex.org/W2065034964","https://openalex.org/W2074423743","https://openalex.org/W2077291675","https://openalex.org/W2080845329","https://openalex.org/W2083299361","https://openalex.org/W2086707501","https://openalex.org/W2091447278","https://openalex.org/W2093566021","https://openalex.org/W2105400917","https://openalex.org/W2113918287","https://openalex.org/W2115543229","https://openalex.org/W2120483845","https://openalex.org/W2120981636","https://openalex.org/W2126701473","https://openalex.org/W2128254658","https://openalex.org/W2142925705","https://openalex.org/W2162865128","https://openalex.org/W2164478468","https://openalex.org/W2311350462","https://openalex.org/W2341649589","https://openalex.org/W2391961436","https://openalex.org/W2419289533"],"related_works":["https://openalex.org/W2055050900","https://openalex.org/W7096865135","https://openalex.org/W2381868061","https://openalex.org/W7099833971","https://openalex.org/W2072415263","https://openalex.org/W1998328497","https://openalex.org/W2079106474","https://openalex.org/W2418291252","https://openalex.org/W2029616402","https://openalex.org/W2162486797"],"abstract_inverted_index":{"The":[0,83,101,146,177],"dopamine":[1],"D4":[2],"receptor":[3],"(DRD4)":[4],"is":[5,180],"the":[6,17,34,63,73,80,89,92,98,122,134,215],"most":[7],"important":[8],"gene":[9,27,93,103,127,179],"in":[10,16,33,62,95,112,139,152,169,189,204],"psychiatric":[11],"genetics":[12,216],"since":[13],"its":[14,129,199],"involvement":[15],"physiology":[18],"of":[19,43,46,79,91,108,125,136,191,218],"behavior,":[20],"pharmacology":[21],"response":[22],"and":[23,72,117,128,143,195,198,208,222],"psychopathology.":[24],"DRD4's":[25],"sequence":[26],"present":[28],"some":[29,140],"polymorphism":[30,148,200],"such":[31,173],"as":[32,174],"exon":[35,64],"3":[36],"constituted":[37],"from":[38,51],"2":[39],"to":[40,68,213],"10":[41],"copies":[42],"repetitive":[44],"sequences":[45],"48":[47],"base":[48],"pair":[49],"(bp),":[50],"class":[52],"variable":[53],"number":[54],"tandem":[55],"repeats":[56],"(VNTR).":[57],"An":[58],"additional":[59],"genetic":[60,182],"variant":[61],"1":[65],"presents":[66],"polymorphisms":[67],"12":[69],"bp":[70],"VNTR,":[71],"variation":[74],"-521":[75,84],"C":[76,99],"by":[77],"T":[78,85],"promoter":[81],"region.":[82],"allele":[86],"can":[87,201],"reduce":[88],"efficiency":[90],"expression":[94],"comparison":[96],"with":[97,131,154,164],"allele.":[100],"DRD4":[102,126,147,178],"codes":[104],"a":[105,181,187],"protein":[106],"transmembranal":[107],"7":[109],"domains,":[110],"distributed":[111],"front":[113],"cortex,":[114],"striatum,":[115],"hypothalamus":[116],"hippocampus.":[118],"This":[119],"review":[120],"discusses":[121],"biological":[123],"significance":[124],"perspective":[130],"emphasis":[132],"on":[133],"impact":[135],"association":[137,153,205],"studies":[138],"illness":[141],"mental":[142,193,220],"behavioral":[144,171,196],"traits.":[145,223],"has":[149],"been":[150],"studied":[151],"illnesses":[155],"like":[156],"schizophrenia,":[157],"attention":[158],"deficit":[159],"hyperactivity":[160],"disorder":[161],"(ADHD),":[162],"obsessive-compulsive":[163],"tics,":[165],"bipolar":[166],"manic-depressive":[167],"disorder,":[168],"addition":[170],"traits":[172],"novelty":[175],"seeking.":[176],"marker":[183],"that":[184],"could":[185],"play":[186],"role":[188],"etiology":[190],"different":[192],"illness,":[194],"traits,":[197],"be":[202],"used":[203],"studies,":[206],"epigenetic":[207],"pharmacogenomic":[209],"analysis":[210],"for":[211],"help":[212],"understand":[214],"basis":[217],"both":[219],"disorders":[221]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}