{"id":"https://openalex.org/W2113016707","doi":"https://doi.org/10.1002/bies.201000046","title":"ERAD ubiquitin ligases","display_name":"ERAD ubiquitin ligases","publication_year":2010,"publication_date":"2010-08-30","ids":{"openalex":"https://openalex.org/W2113016707","doi":"https://doi.org/10.1002/bies.201000046","mag":"2113016707","pmid":"https://pubmed.ncbi.nlm.nih.gov/20806269"},"language":"en","primary_location":{"id":"doi:10.1002/bies.201000046","doi":"https://doi.org/10.1002/bies.201000046","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.201000046","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022859541","display_name":"Martin Mehnert","orcid":"https://orcid.org/0000-0001-7753-1596","observed_orcids":["https://orcid.org/0000-0001-7753-1596"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Mehnert","raw_affiliation_strings":["Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001922195","display_name":"Thomas Sommer","orcid":"https://orcid.org/0000-0001-9990-5202","observed_orcids":["https://orcid.org/0000-0001-9990-5202"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Sommer","raw_affiliation_strings":["Department of Biology, Humboldt University, Berlin, Germany","Max-Delbru\u0308ck Center for Molecular Medicine, Robert-Ro\u0308ssle-Str., Berlin, Germany","Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Humboldt University, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Max-Delbru\u0308ck Center for Molecular Medicine, Robert-Ro\u0308ssle-Str., Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036147408","display_name":"Ernst Jarosch","orcid":"https://orcid.org/0000-0001-8522-1045","observed_orcids":["https://orcid.org/0000-0001-8522-1045"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ernst Jarosch","raw_affiliation_strings":["Max-Delbru\u0308ck Center for Molecular Medicine, Robert-Ro\u0308ssle-Str., Berlin, Germany","Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbru\u0308ck Center for Molecular Medicine, Robert-Ro\u0308ssle-Str., Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Max-Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Str., Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001922195","https://openalex.org/A5036147408"],"corresponding_institution_ids":["https://openalex.org/I205582932","https://openalex.org/I39343248"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.7171,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.56942004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"32","issue":"10","first_page":"905","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.30570000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9120000004768372},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8379999995231628},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8949999809265137},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.9453438520431519},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8434681296348572},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7108657360076904},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6871496438980103},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.5908317565917969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5718228816986084},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5489920377731323},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5225358009338379},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.5037984251976013},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.48215028643608093},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.43034815788269043},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.32338428497314453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3041621744632721},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.2544347941875458},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07130071520805359}],"mesh":[{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/bies.201000046","doi":"https://doi.org/10.1002/bies.201000046","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.201000046","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:20806269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20806269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:11172","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/11172/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W33225797","https://openalex.org/W1481795283","https://openalex.org/W1814017524","https://openalex.org/W1964706050","https://openalex.org/W1965839025","https://openalex.org/W1974004166","https://openalex.org/W1976560794","https://openalex.org/W1976601347","https://openalex.org/W1981625315","https://openalex.org/W1983463562","https://openalex.org/W1984672567","https://openalex.org/W1986675822","https://openalex.org/W1992315987","https://openalex.org/W2000447975","https://openalex.org/W2007209781","https://openalex.org/W2007600548","https://openalex.org/W2008559063","https://openalex.org/W2010478265","https://openalex.org/W2014697177","https://openalex.org/W2015519581","https://openalex.org/W2017776769","https://openalex.org/W2018515506","https://openalex.org/W2019498660","https://openalex.org/W2022345195","https://openalex.org/W2023397454","https://openalex.org/W2026639615","https://openalex.org/W2027706325","https://openalex.org/W2029119458","https://openalex.org/W2031488588","https://openalex.org/W2034133901","https://openalex.org/W2035349696","https://openalex.org/W2035535713","https://openalex.org/W2036333455","https://openalex.org/W2038647843","https://openalex.org/W2040434321","https://openalex.org/W2042447745","https://openalex.org/W2044330780","https://openalex.org/W2044685169","https://openalex.org/W2049732271","https://openalex.org/W2051881845","https://openalex.org/W2054682698","https://openalex.org/W2064609154","https://openalex.org/W2067072165","https://openalex.org/W2070628955","https://openalex.org/W2073726493","https://openalex.org/W2074001520","https://openalex.org/W2079261384","https://openalex.org/W2080088714","https://openalex.org/W2081490799","https://openalex.org/W2081731224","https://openalex.org/W2086558971","https://openalex.org/W2089328676","https://openalex.org/W2094940518","https://openalex.org/W2100251862","https://openalex.org/W2109679459","https://openalex.org/W2110685895","https://openalex.org/W2110780830","https://openalex.org/W2111415532","https://openalex.org/W2111858828","https://openalex.org/W2114953435","https://openalex.org/W2115564529","https://openalex.org/W2115977447","https://openalex.org/W2121576917","https://openalex.org/W2122550753","https://openalex.org/W2128347862","https://openalex.org/W2130368151","https://openalex.org/W2134025840","https://openalex.org/W2143735332","https://openalex.org/W2145174769","https://openalex.org/W2145275647","https://openalex.org/W2152726884","https://openalex.org/W2153693056","https://openalex.org/W2160698849","https://openalex.org/W2161911724","https://openalex.org/W2164390141","https://openalex.org/W2165019570","https://openalex.org/W2169221124","https://openalex.org/W2169869172","https://openalex.org/W2169910669"],"related_works":["https://openalex.org/W7073796763","https://openalex.org/W4292283911","https://openalex.org/W4385463105","https://openalex.org/W2033792193","https://openalex.org/W2583716456","https://openalex.org/W2115093402","https://openalex.org/W1981551685","https://openalex.org/W1966526764","https://openalex.org/W2051881845","https://openalex.org/W37241425"],"abstract_inverted_index":{"In":[0,76],"eukaryotic":[1],"cells":[2],"terminally":[3],"misfolded":[4,103],"proteins":[5],"of":[6,56,63,74,88,94,102],"the":[7,13,36,52,60,77,85,92,100,106,109],"secretory":[8,37],"pathway":[9,38],"are":[10,68],"retarded":[11],"in":[12,20,35,51,70],"endoplasmic":[14],"reticulum":[15],"(ER)":[16],"and":[17,43,48,97],"subsequently":[18],"degraded":[19],"a":[21],"ubiquitin-proteasome-dependent":[22],"manner.":[23],"This":[24],"highly":[25],"conserved":[26],"process":[27],"termed":[28],"ER-associated":[29],"protein":[30],"degradation":[31],"(ERAD)":[32],"ensures":[33,91],"homeostasis":[34],"by":[39],"disposing":[40],"faulty":[41],"polypeptides":[42,104],"preventing":[44],"their":[45],"deleterious":[46],"accumulation":[47],"eventual":[49],"aggregation":[50],"cell.":[53],"The":[54],"focus":[55],"this":[57],"paper":[58],"is":[59],"functional":[61],"description":[62],"membrane-bound":[64],"ubiquitin":[65],"ligases,":[66],"which":[67],"involved":[69],"all":[71],"critical":[72],"steps":[73],"ERAD.":[75],"end":[78],"we":[79],"want":[80],"to":[81],"speculate":[82],"on":[83],"how":[84],"modular":[86],"architecture":[87],"these":[89],"entities":[90],"specificity":[93],"substrate":[95],"selection":[96],"possibly":[98],"accomplishes":[99],"transport":[101],"from":[105],"ER":[107],"into":[108],"cytoplasm.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}