{"id":"https://openalex.org/W2113000200","doi":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","title":"Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver","display_name":"Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W2113000200","doi":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","mag":"2113000200","pmid":"https://pubmed.ncbi.nlm.nih.gov/11991997","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/137014"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.76.11.5692-5700.2002","doi":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/137014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060587776","display_name":"Huang\u2010Ge Zhang","orcid":"https://orcid.org/0000-0001-9665-9202","observed_orcids":["https://orcid.org/0000-0001-9665-9202"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huang-Ge Zhang","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology","Veterans Administration Medical Center, Birmingham, Alabama 35233","Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]},{"raw_affiliation_string":"Veterans Administration Medical Center, Birmingham, Alabama 35233","institution_ids":["https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111820797","display_name":"Jinfu Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinfu Xie","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052044401","display_name":"Liang Xu","orcid":"https://orcid.org/0000-0001-9196-4232","observed_orcids":["https://orcid.org/0000-0001-9196-4232","https://orcid.org/0000-0002-2700-4840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Xu","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044997024","display_name":"PingAr Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pingar Yang","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035305169","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0002-2469-6933","observed_orcids":["https://orcid.org/0000-0002-2469-6933","https://orcid.org/0009-0005-3956-9645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039210082","display_name":"Sheher L. Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheher Sun","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongming Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongming Wang","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":["Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089728692","display_name":"Hui\u2010Chen Hsu","orcid":"https://orcid.org/0000-0002-0317-5725","observed_orcids":["https://orcid.org/0000-0002-0317-5725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Chen Hsu","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006554324","display_name":"John D. Mountz","orcid":"https://orcid.org/0000-0001-9061-3158","observed_orcids":["https://orcid.org/0000-0001-9061-3158"]},"institutions":[{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Mountz","raw_affiliation_strings":["Division of Clinical Immunology and Rheumatology","Veterans Administration Medical Center, Birmingham, Alabama 35233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Rheumatology","institution_ids":[]},{"raw_affiliation_string":"Veterans Administration Medical Center, Birmingham, Alabama 35233","institution_ids":["https://openalex.org/I4210115616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8291,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.90633016,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"76","issue":"11","first_page":"5692","last_page":"5700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.734000027179718},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4350000023841858},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.6050000190734863},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.5009999871253967},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor","display_name":"TNF receptor","score":0.5830000042915344},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.6449999809265137},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7489902377128601},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6908047795295715},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6587380766868591},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5801804065704346},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5470524430274963},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5349428057670593},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5126494765281677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5106280446052551},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4545457065105438},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4366443157196045},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4356020987033844},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43016090989112854},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4256761074066162},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.42253467440605164},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.41764673590660095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40222588181495667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3989041745662689},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17611628770828247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06283131241798401}],"mesh":[{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053220","descriptor_name":"Receptors, TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.76.11.5692-5700.2002","doi":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.11.5692-5700.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:137014","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/137014","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11991997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11991997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.7123","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.7123","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/76/11/5692.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:137014","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/137014","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G466692966","display_name":null,"funder_award_id":"N01AR62224","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8778901479","display_name":"ABLATION OF IMMUNE RESPONSE TO ADENOVIRUS VECTORS","funder_award_id":"R01AI042900","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G953121256","display_name":"DEFECTIVE FAS APOPTOSIS DURING AGING","funder_award_id":"R01AG011653","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310431","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205"},{"id":"https://openalex.org/F4320312852","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1499346340","https://openalex.org/W1528349069","https://openalex.org/W1530653975","https://openalex.org/W1536078889","https://openalex.org/W1557807759","https://openalex.org/W1558416075","https://openalex.org/W1575059030","https://openalex.org/W1599806854","https://openalex.org/W1602985750","https://openalex.org/W1623305982","https://openalex.org/W1656756019","https://openalex.org/W1929630117","https://openalex.org/W1968896160","https://openalex.org/W1971670779","https://openalex.org/W1973469936","https://openalex.org/W1974342849","https://openalex.org/W1975336660","https://openalex.org/W1978306626","https://openalex.org/W1979273971","https://openalex.org/W1991464867","https://openalex.org/W1997296254","https://openalex.org/W2007498454","https://openalex.org/W2009821747","https://openalex.org/W2017614842","https://openalex.org/W2032782394","https://openalex.org/W2037681980","https://openalex.org/W2046079641","https://openalex.org/W2047168565","https://openalex.org/W2049312704","https://openalex.org/W2056217426","https://openalex.org/W2067534266","https://openalex.org/W2073013917","https://openalex.org/W2075632202","https://openalex.org/W2075809552","https://openalex.org/W2079263000","https://openalex.org/W2083458702","https://openalex.org/W2089684638","https://openalex.org/W2101259651","https://openalex.org/W2102717208","https://openalex.org/W2102986716","https://openalex.org/W2119326933","https://openalex.org/W2120180999","https://openalex.org/W2120943145","https://openalex.org/W2130988210","https://openalex.org/W2132127523","https://openalex.org/W2132898771","https://openalex.org/W2133916339","https://openalex.org/W2140288892","https://openalex.org/W2144789797","https://openalex.org/W2146750306","https://openalex.org/W2158547369","https://openalex.org/W2161261662","https://openalex.org/W2166835758","https://openalex.org/W3206934974","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W4232873942","https://openalex.org/W2160957161","https://openalex.org/W1965915712","https://openalex.org/W2169434000","https://openalex.org/W2042683898","https://openalex.org/W2160348462","https://openalex.org/W2127757123","https://openalex.org/W2765108717","https://openalex.org/W2090864647","https://openalex.org/W2158547369"],"abstract_inverted_index":{"A":[0],"major":[1],"limitation":[2],"of":[3,16,45,116,126,143,162,174,193,201,207,217],"adenovirus":[4],"(Ad)":[5],"gene":[6,21,92,222],"therapy":[7,22,93,223],"product":[8,94],"expression":[9,95,146,179],"in":[10,96,147,180,224],"the":[11,17,20,35,42,51,64,97,100,139,148,181,225],"liver":[12],"is":[13,26,114],"subsequent":[14],"elimination":[15,25],"hepatocytes":[18,46,62],"expressing":[19],"product.":[23],"This":[24],"caused":[27],"by":[28,50,55],"both":[29],"necrosis":[30,66],"and":[31,37,73,78,90,130,137,141,155,166,168,204,209,214],"apoptosis":[32,125,133],"related":[33],"to":[34,41,152],"innate":[36,52],"cell-mediated":[38],"immune":[39,53],"response":[40,54],"Ad.":[43],"Apoptosis":[44],"can":[47,198,219],"be":[48],"induced":[49],"signaling":[56,86],"through":[57,87],"death":[58,74],"domain":[59,75],"receptors":[60,76],"on":[61],"including":[63],"tumor":[65],"factor":[67],"alpha":[68],"(TNF-alpha)":[69],"receptor":[70],"(TNFR),":[71],"Fas,":[72],"DR4":[77],"DR5.":[79],"We":[80],"have":[81],"previously":[82],"shown":[83],"that":[84,107,186],"blocking":[85,153],"TNFR":[88],"enhances":[89,138],"prolongs":[91],"liver.":[98,149,182,226],"In":[99,150],"present":[101],"study,":[102],"we":[103],"constructed":[104],"an":[105],"Ad":[106,212,221],"produces":[108,189],"a":[109,190],"soluble":[110],"DR5-Fc":[111,191],"(AdsDR5),":[112],"which":[113,175],"capable":[115,192],"neutralizing":[117,194],"TNF-related":[118],"apoptosis-inducing":[119],"ligand":[120],"(TRAIL).":[121],"AdsDR5":[122,159,188,197,218],"prevents":[123],"TRAIL-mediated":[124],"CD3-activated":[127],"T":[128],"cells":[129,203],"decreases":[131,160,169],"hepatocyte":[132],"after":[134,211],"AdCMVLacZ":[135],"administration":[136,216],"level":[140],"duration":[142],"lacZ":[144],"transgene":[145,178],"addition":[151],"TRAIL":[154],"directly":[156],"inhibiting":[157],"apoptosis,":[158],"production":[161],"gamma":[163],"interferon":[164],"(IFN-gamma)":[165],"TNF-alpha":[167,210],"NK":[170,202],"cell":[171],"activation,":[172],"all":[173],"limit":[176],"Ad-mediated":[177],"These":[183],"results":[184],"indicate":[185],"(i)":[187],"TRAIL,":[195],"(ii)":[196],"reduce":[199,205],"activation":[200],"induction":[206],"IFN-gamma":[208],"administration,":[213],"(iii)":[215],"enhance":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
