{"id":"https://openalex.org/W2112901722","doi":"https://doi.org/10.1001/2013.jamainternmed.438","title":"Supratherapeutic Dosing of Acetaminophen Among Hospitalized Patients","display_name":"Supratherapeutic Dosing of Acetaminophen Among Hospitalized Patients","publication_year":2012,"publication_date":"2012-11-13","ids":{"openalex":"https://openalex.org/W2112901722","doi":"https://doi.org/10.1001/2013.jamainternmed.438","mag":"2112901722","pmid":"https://pubmed.ncbi.nlm.nih.gov/23401887"},"language":"en","primary_location":{"id":"doi:10.1001/2013.jamainternmed.438","doi":"https://doi.org/10.1001/2013.jamainternmed.438","is_oa":false,"landing_page_url":"https://doi.org/10.1001/2013.jamainternmed.438","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016290671","display_name":"Li Zhou","orcid":"https://orcid.org/0000-0003-3874-4833","observed_orcids":["https://orcid.org/0000-0003-3874-4833"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Li Zhou","raw_affiliation_strings":["Information Systems, Partners HealthCare System Inc, Wellesley, Massachusetts 02481, USA. Lzhou2@partners.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Systems, Partners HealthCare System Inc, Wellesley, Massachusetts 02481, USA. Lzhou2@partners.org","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015504652","display_name":"Saverio M. Maviglia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saverio M. Maviglia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012508473","display_name":"Lisa M. Mahoney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa M. Mahoney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067748702","display_name":"FRANK Y. CHANG","orcid":"https://orcid.org/0000-0003-1774-9926","observed_orcids":["https://orcid.org/0000-0003-1774-9926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033742702","display_name":"Endel John Orav","orcid":"https://orcid.org/0000-0002-8886-7252","observed_orcids":["https://orcid.org/0000-0002-8886-7252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. John Orav","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066318724","display_name":"Joseph Michael Plasek","orcid":"https://orcid.org/0000-0002-9686-3876","observed_orcids":["https://orcid.org/0000-0002-9686-3876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Plasek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036773838","display_name":"Laura J. Boulware","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J. Boulware","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110167589","display_name":"Hong Xiang Lou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Lou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036110536","display_name":"David Westfall Bates","orcid":"https://orcid.org/0000-0001-6268-1540","observed_orcids":["https://orcid.org/0000-0001-6268-1540","https://orcid.org/0000-0003-4850-2360","https://orcid.org/0000-0001-7438-9491","https://orcid.org/0000-0002-3105-156X","https://orcid.org/0000-0001-5440-6039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David W. Bates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107502733","display_name":"Roberto A. Rocha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto A. Rocha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016290671"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6723,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89555424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"172","issue":"22","first_page":"1721","last_page":"1721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9200000166893005},{"id":"https://openalex.org/keywords/supratherapeutic-dosing","display_name":"supratherapeutic dosing","score":0.996999979019165},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.7689999938011169},{"id":"https://openalex.org/keywords/drug-exposure","display_name":"drug exposure","score":0.37700000405311584},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8519999980926514},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6629999876022339},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.781000018119812},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.38499999046325684},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.44600000977516174},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.6579999923706055},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9308834075927734},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.888400673866272},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8610997200012207},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5333789587020874},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4696941375732422},{"id":"https://openalex.org/C2776877392","wikidata":"https://www.wikidata.org/wiki/Q2572879","display_name":"acetaminophen overdose","level":4,"score":0.44351309537887573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44186750054359436},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33063751459121704},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.06636416912078857},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007297","descriptor_name":"Inpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008404","descriptor_name":"Massachusetts","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/2013.jamainternmed.438","doi":"https://doi.org/10.1001/2013.jamainternmed.438","is_oa":false,"landing_page_url":"https://doi.org/10.1001/2013.jamainternmed.438","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:23401887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23401887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.254.8455","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.254.8455","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://archinte.ama-assn.org/data/Journals/INTEMED/0/2013.jamainternmed.438.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.258.3460","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.258.3460","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://archinte.ama-assn.org/data/Journals/INTEMED/0/2013.jamainternmed.438.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W74938066","https://openalex.org/W1552039880","https://openalex.org/W1977691789","https://openalex.org/W1979020366","https://openalex.org/W1979757243","https://openalex.org/W1981596765","https://openalex.org/W1984934101","https://openalex.org/W2000066924","https://openalex.org/W2018672238","https://openalex.org/W2026375486","https://openalex.org/W2036491373","https://openalex.org/W2058358917","https://openalex.org/W2095188959","https://openalex.org/W2127682016","https://openalex.org/W2140207879","https://openalex.org/W2144450770","https://openalex.org/W2150377937","https://openalex.org/W2163790438","https://openalex.org/W2333982488","https://openalex.org/W2411856512","https://openalex.org/W3027796947","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7100147018","https://openalex.org/W7216426886","https://openalex.org/W3093993810","https://openalex.org/W2184216512","https://openalex.org/W3173558145","https://openalex.org/W2098863657","https://openalex.org/W4404190965","https://openalex.org/W2197557153","https://openalex.org/W2940285062","https://openalex.org/W2095188959"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,18],"investigated":[2],"acetaminophen":[3,13,53,58,86,179,289,308],"use":[4],"and":[5,50,73,89,99,110,117,157,227,273,276],"identify":[6],"factors":[7,106,304],"contributing":[8],"to":[9,31,46,131,181,297],"supratherapeutic":[10,90,108,119,198,307],"dosing":[11,91,199,287,309],"of":[12,25,124,133,149,159,169,178,197,288,301],"in":[14,112,202,274,310],"hospitalized":[15,94,311],"patients.":[16,312],"METHODS:":[17],"retrospectively":[19],"reviewed":[20],"the":[21,138,166,247,299],"electronic":[22],"health":[23],"records":[24,60],"adult":[26],"patients":[27,127,150,160,211,217],"who":[28,51,151,229],"were":[29,79,129,152],"admitted":[30],"2":[32],"academic":[33],"tertiary":[34],"care":[35,278],"hospitals":[36],"(hospital":[37],"A":[38,122,193,204,256],"amd":[39],"hospital":[40,67,203],"B)":[41],"from":[42,75],"June":[43],"1,":[44],"2010,":[45,49],"August":[47],"31,":[48],"received":[52,230],"during":[54],"their":[55],"hospitalization.":[56],"Patients'":[57],"administration":[59,65],"(including":[61],"drug":[62],"name,":[63],"dose,":[64],"time,":[66],"units,":[68],"etc),":[69],"demographic":[70],"data,":[71],"diagnoses,":[72],"results":[74],"liver":[76,113,163],"function":[77,114],"tests":[78],"obtained.":[80],"The":[81],"main":[82],"outcome":[83],"measures":[84],"included":[85],"exposure":[87],"rate":[88,92],"among":[93],"patients,":[95],"hazard":[96],"ratios":[97],"(HRs)":[98],"95%":[100],"confidence":[101],"intervals":[102],"(CIs)":[103],"for":[104,107,261],"risk":[105,196,258,303],"dosing,":[109],"changes":[111],"test":[115],"before":[116],"after":[118],"dosing.":[120],"RESULTS:":[121],"total":[123],"14":[125],"411":[126],"(60.7%)":[128],"exposed":[130],"acetaminophen,":[132],"whom":[134],"955":[135],"(6.6%)":[136],"exceeded":[137,165],"4":[139],"g":[140,171],"per":[141,172],"day":[142],"maximum":[143],"recommended":[144,167],"dose.":[145],"In":[146],"addition,":[147],"22.3%":[148],"65":[153],"years":[154],"or":[155,246],"older":[156],"17.6%":[158],"with":[161,293],"chronic":[162],"diseases":[164],"limit":[168],"3":[170],"day.":[173],"Patients":[174],"receiving":[175],"excessive":[176],"doses":[177],"tended":[180],"have":[182],"significant":[183],"alkaline":[184],"phosphatase":[185],"elevations,":[186],"although":[187],"causal":[188],"relationship":[189],"cannot":[190],"be":[191],"concluded.":[192],"significantly":[194,291],"higher":[195],"was":[200,259,290],"observed":[201],"(HR,":[205,212,222,233,241,251,268,280],"1.6":[206],"[95%":[207,214,224,235,243,253,270,282],"CI,":[208,215,225,236,254,271,283],"1.4-1.8]),":[209],"white":[210],"1.5":[213],"1.3-1.7]),":[216],"diagnosed":[218],"as":[219],"having":[220],"osteoarthritis":[221],"1.4":[223],"1.3-1.6]),":[226],"those":[228],"scheduled":[231],"administrations":[232,267],"16.6":[234],"13.5-20.6]),":[237],"multiple":[238,294],"product":[239],"formulations":[240],"2.4":[242],"CI":[244],"2.0-2.9]),":[245],"500-mg":[248],"strength":[249],"formulation":[250],"1.9":[252],"1.5-2.3]).":[255],"lower":[257],"found":[260],"pro":[262],"re":[263],"nata":[264],"(as":[265],"needed)":[266],"0.7":[269],"0.6-0.9])":[272],"nonsurgical":[275],"non\u2013intensive":[277],"units":[279],"0.6":[281],"0.5-0.7]).":[284],"CONCLUSIONS:":[285],"Supratherapeutic":[286],"associated":[292],"factors.":[295],"Interventions":[296],"reduce":[298],"incidence":[300],"some":[302],"may":[305],"prevent":[306]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
