{"id":"https://openalex.org/W2112378033","doi":"https://doi.org/10.1667/rr2276.1","title":"Photoactivated Hypericin Induces Downregulation of HER2 Gene Expression","display_name":"Photoactivated Hypericin Induces Downregulation of HER2 Gene Expression","publication_year":2010,"publication_date":"2010-11-08","ids":{"openalex":"https://openalex.org/W2112378033","doi":"https://doi.org/10.1667/rr2276.1","mag":"2112378033","pmid":"https://pubmed.ncbi.nlm.nih.gov/21175347"},"language":"en","primary_location":{"id":"doi:10.1667/rr2276.1","doi":"https://doi.org/10.1667/rr2276.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr2276.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015134356","display_name":"Peter Sol\u00e1r","orcid":"https://orcid.org/0000-0002-1287-2979","observed_orcids":["https://orcid.org/0000-0002-1287-2979"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Sol\u00e1r","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Faculty of Sciences, PJ \u0160af\u00e1rik University, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Faculty of Sciences, PJ \u0160af\u00e1rik University, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051249346","display_name":"Peter Ferenc","orcid":"https://orcid.org/0000-0002-9611-7419","observed_orcids":["https://orcid.org/0000-0002-9611-7419"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Ferenc","raw_affiliation_strings":["aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053329693","display_name":"J\u00e1n Kova\u013a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"J\u00e1n Koval'","raw_affiliation_strings":["aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052717896","display_name":"Jarom\u00edr Mike\u0161","orcid":"https://orcid.org/0000-0002-9941-7855","observed_orcids":["https://orcid.org/0000-0002-9941-7855"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jarom\u00edr Mike\u0161","raw_affiliation_strings":["aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078464437","display_name":"Zuzana Sol\u00e1rov\u00e1","orcid":"https://orcid.org/0000-0002-4212-5720","observed_orcids":["https://orcid.org/0000-0002-4212-5720"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Zuzana Sol\u00e1rov\u00e1","raw_affiliation_strings":["bGeriatric Nursing Clinic, Faculty of Medicine, P.J. \u0160af\u00e1rik University, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bGeriatric Nursing Clinic, Faculty of Medicine, P.J. \u0160af\u00e1rik University, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I204881574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059140373","display_name":"Gabriela Hr\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-6994-8751","observed_orcids":["https://orcid.org/0000-0002-6994-8751"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210105051","display_name":"Institute of Parasitology of the Slovak Academy of Sciences","ror":"https://ror.org/01c7rrt10","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210105051"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Gabriela Hr\u010dkov\u00e1","raw_affiliation_strings":["cParasitological Institute of the Slovak Academy of Sciences, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cParasitological Institute of the Slovak Academy of Sciences, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210105051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111467545","display_name":"Benjamin L. Fulton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin L. Fulton","raw_affiliation_strings":["dNasoPhlex Slovakia, s.r.o., Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dNasoPhlex Slovakia, s.r.o., Ko\u0161ice, Slovakia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038375683","display_name":"Peter Fedoro\u010dko","orcid":"https://orcid.org/0000-0002-1138-6282","observed_orcids":["https://orcid.org/0000-0002-1138-6282"]},"institutions":[{"id":"https://openalex.org/I204881574","display_name":"University of Pavol Jozef \u0160af\u00e1rik","ror":"https://ror.org/039965637","country_code":"SK","type":"education","lineage":["https://openalex.org/I204881574"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Peter Fedoro\u010dko","raw_affiliation_strings":["aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Cellular and Molecular Biology, Faculty of Sciences, P.J. \u0160af\u00e1rik University, Ko\u0161ice,","institution_ids":["https://openalex.org/I204881574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2607,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82253421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"175","issue":"1","first_page":"51","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypericin","display_name":"hypericin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9729999899864197},{"id":"https://openalex.org/keywords/trolox","display_name":"Trolox","score":0.9890000224113464},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5979999899864197},{"id":"https://openalex.org/keywords/skbr3","display_name":"SKBR3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2778432610","wikidata":"https://www.wikidata.org/wiki/Q425409","display_name":"Hypericin","level":2,"score":0.9263597726821899},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8445137739181519},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.7516894340515137},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.7276026606559753},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5677645802497864},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5515779852867126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5443475246429443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5363961458206177},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4878230392932892},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4642093777656555},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4319016933441162},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3025892972946167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29807019233703613},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2936819791793823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2847300171852112},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2776772379875183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23466792702674866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23089063167572021},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.22335439920425415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18995961546897888},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1693669557571411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10222676396369934},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026082","descriptor_name":"Singlet Oxygen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1667/rr2276.1","doi":"https://doi.org/10.1667/rr2276.1","is_oa":false,"landing_page_url":"https://doi.org/10.1667/rr2276.1","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:21175347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21175347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"},{"id":"pmh:10.1667/RR2276.1","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1667/RR2276.1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W143651898","https://openalex.org/W1525133146","https://openalex.org/W1574463874","https://openalex.org/W1595980271","https://openalex.org/W1599285204","https://openalex.org/W1791153000","https://openalex.org/W1973664129","https://openalex.org/W1996724130","https://openalex.org/W2003905042","https://openalex.org/W2004455118","https://openalex.org/W2009218955","https://openalex.org/W2016079171","https://openalex.org/W2016223517","https://openalex.org/W2036752075","https://openalex.org/W2036991741","https://openalex.org/W2042518976","https://openalex.org/W2053088766","https://openalex.org/W2054082482","https://openalex.org/W2068527843","https://openalex.org/W2070346762","https://openalex.org/W2071648543","https://openalex.org/W2090020685","https://openalex.org/W2091210609","https://openalex.org/W2092853256","https://openalex.org/W2114069561","https://openalex.org/W2121954422","https://openalex.org/W2131654458","https://openalex.org/W2147993424","https://openalex.org/W2156857326","https://openalex.org/W2409312805"],"related_works":["https://openalex.org/W1595980271","https://openalex.org/W2557444779","https://openalex.org/W2016223517","https://openalex.org/W2151137637","https://openalex.org/W2082013901","https://openalex.org/W2046310894","https://openalex.org/W2078905963","https://openalex.org/W1968379411","https://openalex.org/W3201987948","https://openalex.org/W3137159898"],"abstract_inverted_index":{"Photodynamic":[0],"therapy":[1],"is":[2,21],"an":[3],"alternative":[4],"method":[5],"for":[6,99,132],"cancer":[7,135],"treatment":[8],"in":[9,36,72,84,141],"which":[10,95],"a":[11,15,97],"photosensitizer":[12],"exposed":[13],"to":[14],"light":[16],"source":[17],"of":[18,48,54,105,108,121],"suitable":[19],"wavelength":[20],"excited":[22],"and":[23,68,74],"can":[24],"subsequently":[25],"react":[26],"through":[27],"free":[28,33],"radical":[29],"mechanisms.":[30],"Recently,":[31],"oxygen":[32,92,110],"radical-mediated":[34],"changes":[35],"gene":[37],"expression":[38,53,86,138],"have":[39,127],"been":[40],"established.":[41],"The":[42,80],"present":[43],"study":[44],"shows":[45],"the":[46,52,55,66,69,90,106,118],"effect":[47],"photoactivated":[49,122],"hypericin":[50],"on":[51],"human":[56],"epidermal":[57],"growth":[58],"factor":[59],"receptor":[60],"2":[61],"(HER2)":[62],"oncogene":[63],"at":[64,130],"both":[65],"mRNA":[67,85],"protein":[70],"level":[71],"SKBR-3":[73],"MCF-7":[75],"breast":[76,134],"adenocarcinoma":[77],"cell":[78],"lines.":[79],"photodynamic":[81],"therapy-induced":[82],"decrease":[83],"was":[87],"reversed":[88],"by":[89,112],"singlet":[91,100],"scavenger":[93],"trolox,":[94],"supports":[96],"role":[98],"oxygen.":[101],"In":[102],"addition,":[103],"prevention":[104],"generation":[107],"reactive":[109],"species":[111],"pretreatment":[113],"with":[114,136,143],"trolox":[115],"effectively":[116],"blocked":[117],"antiproliferation":[119],"activity":[120],"hypericin.":[123],"These":[124],"results":[125],"may":[126],"important":[128],"implications":[129],"least":[131],"recurrent":[133],"HER2":[137],"alone":[139],"or":[140],"combination":[142],"conventional":[144],"therapies.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
