{"id":"https://openalex.org/W2112364739","doi":"https://doi.org/10.1177/1352458509355071","title":"The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain","display_name":"The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain","publication_year":2009,"publication_date":"2009-12-09","ids":{"openalex":"https://openalex.org/W2112364739","doi":"https://doi.org/10.1177/1352458509355071","mag":"2112364739","pmid":"https://pubmed.ncbi.nlm.nih.gov/20007426"},"language":"en","primary_location":{"id":"doi:10.1177/1352458509355071","doi":"https://doi.org/10.1177/1352458509355071","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458509355071","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000425996","display_name":"Elvira Ramil","orcid":"https://orcid.org/0000-0003-0785-3826","observed_orcids":["https://orcid.org/0000-0003-0785-3826"]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Ramil","raw_affiliation_strings":["Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043033718","display_name":"Antonio S\u00e1nchez","orcid":"https://orcid.org/0000-0001-7168-6175","observed_orcids":["https://orcid.org/0000-0001-7168-6175"]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"AJ S\u00e1nchez","raw_affiliation_strings":["Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060071651","display_name":"Paz Gonz\u00e1lez-P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Gonz\u00e1lez-P\u00e9rez","raw_affiliation_strings":["Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005422126","display_name":"Alfredo Rodr\u00edguez Antig\u00fcedad","orcid":"https://orcid.org/0000-0001-5975-725X","observed_orcids":["https://orcid.org/0000-0001-5975-725X"]},"institutions":[{"id":"https://openalex.org/I4210092871","display_name":"Hospital de Basurto","ror":"https://ror.org/00j4pze04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210092871","https://openalex.org/I4210125364"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Rodr\u00edguez-Antig\u00fcedad","raw_affiliation_strings":["Servicio de Neurolog\u00eda, Hospital de Basurto, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Neurolog\u00eda, Hospital de Basurto, Bilbao, Spain","institution_ids":["https://openalex.org/I4210092871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042257482","display_name":"Natalia G\u00f3mez\u2010Lozano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N. G\u00f3mez-Lozano","raw_affiliation_strings":["Laboratorio de Citogen\u00e9tica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Citogen\u00e9tica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Ortiz","raw_affiliation_strings":["Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Arroyo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Arroyo","raw_affiliation_strings":["MS Unit, Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MS Unit, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110169747","display_name":"V. De Las Heras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V. De las Heras","raw_affiliation_strings":["MS Unit, Hospital Cl\u00ednico San Carlos, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MS Unit, Hospital Cl\u00ednico San Carlos, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044698710","display_name":"Carlos Vilches","orcid":"https://orcid.org/0000-0002-0300-9225","observed_orcids":["https://orcid.org/0000-0002-0300-9225"]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Vilches","raw_affiliation_strings":["Laboratorio de Inmunogen\u00e9tica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Inmunogen\u00e9tica, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110070038","display_name":"A. Garc\u00eda-Merino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Garc\u00eda-Merino","raw_affiliation_strings":["Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain","institution_ids":["https://openalex.org/I4210105637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":2.081,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.85241453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"2","first_page":"139","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cnr1-gene","display_name":"CNR1 gene","score":0.9549999833106995},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.765999972820282},{"id":"https://openalex.org/keywords/primary-progressive-multiple-sclerosis","display_name":"primary progressive multiple sclerosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.7770000100135803},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9279999732971191},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7120000123977661},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7953888177871704},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7706921100616455},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.700897216796875},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5589292049407959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4939318299293518},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.46590501070022583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4441906213760376},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4310363531112671},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4216885566711426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38328665494918823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36816561222076416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34384506940841675},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2659341096878052},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.204633891582489}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/1352458509355071","doi":"https://doi.org/10.1177/1352458509355071","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458509355071","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},{"id":"pmid:20007426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20007426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis (Houndmills, Basingstoke, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W9642608","https://openalex.org/W1654380405","https://openalex.org/W1965659637","https://openalex.org/W1966057511","https://openalex.org/W1968740815","https://openalex.org/W1969242791","https://openalex.org/W1975921008","https://openalex.org/W1981067823","https://openalex.org/W1982463566","https://openalex.org/W1989956307","https://openalex.org/W1991500494","https://openalex.org/W2011517654","https://openalex.org/W2015065060","https://openalex.org/W2021453619","https://openalex.org/W2023633507","https://openalex.org/W2037884912","https://openalex.org/W2042094529","https://openalex.org/W2044200061","https://openalex.org/W2046062863","https://openalex.org/W2049190566","https://openalex.org/W2050453710","https://openalex.org/W2058995358","https://openalex.org/W2062497321","https://openalex.org/W2064128689","https://openalex.org/W2075894678","https://openalex.org/W2088210122","https://openalex.org/W2097717578","https://openalex.org/W2103019360","https://openalex.org/W2105490558","https://openalex.org/W2112165124","https://openalex.org/W2112924959","https://openalex.org/W2116562654","https://openalex.org/W2119114298","https://openalex.org/W2128919016","https://openalex.org/W2139344244","https://openalex.org/W2141763311","https://openalex.org/W2158031884","https://openalex.org/W2158067162","https://openalex.org/W2164973029","https://openalex.org/W2165031951","https://openalex.org/W2165892706","https://openalex.org/W2315406395","https://openalex.org/W2325198227"],"related_works":["https://openalex.org/W2024524188","https://openalex.org/W2016399551","https://openalex.org/W7096861598","https://openalex.org/W2158067162","https://openalex.org/W2967604931","https://openalex.org/W1989708860","https://openalex.org/W2049190566","https://openalex.org/W1917179331","https://openalex.org/W2984852934","https://openalex.org/W2248556174"],"abstract_inverted_index":{"Different":[0],"studies":[1],"point":[2],"to":[3,25,168],"the":[4,7,36,40,58,62,114,138],"implication":[5],"of":[6,17,21,30,51,61,69,116,140],"endocannabinoid":[8],"system":[9],"in":[10,57,65,107,113,128,137,155],"multiple":[11],"sclerosis":[12],"(MS)":[13],"and":[14,72,79,98,112,157,164],"animal":[15],"models":[16],"MS.":[18],"The":[19],"purpose":[20],"this":[22],"study":[23],"was":[24,166],"evaluate":[26],"a":[27,48,101,131],"possible":[28],"association":[29],"MS":[31,70,81,86],"with":[32,83,100,130,149],"polymorphic":[33],"markers":[34],"at":[35],"CNR1":[37,63,180],"gene,":[38,64],"encoding":[39],"cannabinoid":[41],"1":[42],"(CB(1))":[43],"receptor.":[44],"We":[45],"have":[46],"performed":[47],"genetic":[49],"analysis":[50,139],"an":[52],"AAT":[53,169],"repeat":[54,170],"microsatellite":[55],"localized":[56],"downstream":[59],"region":[60],"two":[66],"case-control":[67],"groups":[68,118,142],"patients":[71,82,148],"healthy":[73],"controls":[74],"(HC)":[75],"from":[76],"Spain":[77],"(Madrid":[78],"Bilbao).":[80],"primary":[84],"progressive":[85],"(PPMS)":[87],"had":[88],"more":[89],"commonly":[90],"long":[91,174],"((AAT)":[92],">":[93,176],"or":[94,177],"=":[95,110,120,145,178],"(13))":[96],"alleles":[97,123],"genotypes":[99,181],"significant":[102,132],"difference":[103,133],"for":[104,134,187],"genotype":[105,158],"7/8":[106],"Madrid":[108],"(p":[109,119,144],"0.043)":[111],"sum":[115],"both":[117,141],"0.016);":[121],"short":[122],"were":[124,160],"less":[125],"frequently":[126],"found":[127],"PPMS":[129],"allele":[135,156],"5":[136],"together":[143],"0.039).":[146],"In":[147,172],"relapsing":[150],"MS,":[151],"no":[152],"consistent":[153],"differences":[154],"distribution":[159],"found.":[161],"Disease":[162],"severity":[163],"progression":[165],"unrelated":[167],"variations.":[171],"conclusion,":[173],"(AAT)":[175],"(13)":[179],"could":[182],"behave":[183],"as":[184],"risk":[185],"factors":[186],"PPMS.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}